GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMIGFIRR 4989 bp ss-mRNA PRI 22-MAY-1991 DEFINITION Human mRNA for insulin-like growth factor I receptor ACCESSION X04434 M24599 KEYWORDS glycoprotein; insulin receptor; insulin-like growth factor I receptor; membrane glycoprotein; receptor; tyrosine kinase. SOURCE Homo sapiens RNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 4989) AUTHORS Ullrich,A., Gray,A., Tam,A.W., Yang-Feng,T., Tsubokawa,M., Collins,C., Henzel,W., Bon,T.L., Kathuria,S., Chen,E., Jakobs,S., Francke,U., Ramachandran,J. and Fujita-Yamaguchi,Y. TITLE Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural dererminants that define functional specificity JOURNAL EMBO J. 5, 2503-2512 (1986) STANDARD full automatic COMMENT SWISS-PROT; P08069; IG1R$HUMAN. *source: tissue=placenta; library=(lamda)gt10; *source: clone= (lambda)IGF-1-R.85, (lambda)IGF-1-R.76; From EMBL 26 entry HSIGFIRR; dated 28-MAR-1991. FEATURES Location/Qualifiers sig_peptide 32..121 CDS 32..4132 /product="IGF-I receptor" /codon_start=32 mat_peptide 122..4132 /note="IGF-I receptor" misc_feature 122..2251 /note="alpha-subunit (AA 1 - 710)" misc_feature 182..190 /note="pot.N-linked glycosylation site (AA 21 - 23)" misc_feature 335..343 /note="pot.N-linked glycostlation site (AA 72 - 74)" misc_feature 434..442 /note="pot.N-linked glycostlation site (AA 105 - 107)" misc_feature 761..769 /note="pot.N-linked glycostlation site (AA 214 - 216)" misc_feature 971..979 /note="pot.N-linked glycostlation site (AA 284 - 286)" misc_feature 1280..1288 /note="pot.N-linked glycostlation site (AA 387 - 389)" misc_feature 1343..1351 /note="pot.N-linked glycosylation site (AA 408 - 410)" misc_feature 1631..1639 /note="pot.N-linked glycostlation site (AA 504 - 506)" misc_feature 1850..1858 /note="pot.N-linked glycosylation site (AA 577 - 579)" misc_feature 1895..1903 /note="pot.N-linked glycosylation site (AA 592 - 594)" misc_feature 1949..1957 /note="pot.N-linked glycosylation site (AA 610 - 612)" misc_feature 2240..2251 /note="putative proreceptor processing site (AA 707 - 710)" misc_feature 2252..4132 /note="beta-subunit (AA 711 - 1337)" misc_feature 2270..2278 /note="pot.N-linked glycosylation site (AA 717 - 719]" misc_feature 2297..2305 /note="pot.N-linked glycosylation site (AA 726 - 728)" misc_feature 2321..2329 /note="pot.N-linked glycosylation site (AA 734 - 736)" misc_feature 2729..2737 /note="pot.N-linked glycosylation site (AA 870 - 872)" misc_feature 2768..2776 /note="pot.N-linked glycosylation site (AA 883 - 885)" misc_feature 2837..2908 /note="transmembrane region (AA 906 - 929)" misc_feature 2918..2926 /note="pot.N-linked glycosylation site (AA 933 - 935)" misc_feature 3047..3049 /note="pot.ATP binding site (AA 976)" misc_feature 3053..3055 /note="pot.ATP binding site (AA 978)" misc_feature 3062..3064 /note="pot.ATP binding site (AA 981)" misc_feature 3128..3130 /note="pot.ATP binding site (AA 1003)" BASE COUNT 1216 a 1371 c 1320 g 1082 t ORIGIN 1 tttttttttt ttttgagaaa gggaatttca tcccaaataa aaggaatgaa gtctggctcc 61 ggaggagggt ccccgacctc gctgtggggg ctcctgtttc tctccgccgc gctctcgctc 121 tggccgacga gtggagaaat ctgcgggcca ggcatcgaca tccgcaacga ctatcagcag 181 ctgaagcgcc tggagaactg cacggtgatc gagggctacc tccacatcct gctcatctcc 241 aaggccgagg actaccgcag ctaccgcttc cccaagctca cggtcattac cgagtacttg 301 ctgctgttcc gagtggctgg cctcgagagc ctcggagacc tcttccccaa cctcacggtc 361 atccgcggct ggaaactctt ctacaactac gccctggtca tcttcgagat gaccaatctc 421 aaggatattg ggctttacaa cctgaggaac attactcggg gggccatcag gattgagaaa 481 aatgctgacc tctgttacct ctccactgtg gactggtccc tgatcctgga tgcggtgtcc 541 aataactaca ttgtggggaa taagccccca aaggaatgtg gggacctgtg tccagggacc 601 atggaggaga agccgatgtg tgagaagacc accatcaaca atgagtacaa ctaccgctgc 661 tggaccacaa accgctgcca gaaaatgtgc ccaagcacgt gtgggaagcg ggcgtgcacc 721 gagaacaatg agtgctgcca ccccgagtgc ctgggcagct gcagcgcgcc tgacaacgac 781 acggcctgtg tagcttgccg ccactactac tatgccggtg tctgtgtgcc tgcctgcccg 841 cccaacacct acaggtttga gggctggcgc tgtgtggacc gtgacttctg cgccaacatc 901 ctcagcgccg agagcagcga ctccgagggg tttgtgatcc acgacggcga gtgcatgcag 961 gagtgcccct cgggcttcat ccgcaacggc agccagagca tgtactgcat cccttgtgaa 1021 ggtccttgcc cgaaggtctg tgaggaagaa aagaaaacaa agaccattga ttctgttact 1081 tctgctcaga tgctccaagg atgcaccatc ttcaagggca atttgctcat taacatccga 1141 cgggggaata acattgcttc agagctggag aacttcatgg ggctcatcga ggtggtgacg 1201 ggctacgtga agatccgcca ttctcatgcc ttggtctcct tgtccttcct aaaaaacctt 1261 cgcctcatcc taggagagga gcagctagaa gggaattact ccttctacgt cctcgacaac 1321 cagaacttgc agcaactgtg ggactgggac caccgcaacc tgaccatcaa agcagggaaa 1381 atgtactttg ctttcaatcc caaattatgt gtttccgaaa tttaccgcat ggaggaagtg 1441 acggggacta aagggcgcca aagcaaaggg gacataaaca ccaggaacaa cggggagaga 1501 gcctcctgtg aaagtgacgt cctgcatttc acctccacca ccacgtcgaa gaatcgcatc 1561 atcataacct ggcaccggta ccggccccct gactacaggg atctcatcag cttcaccgtt 1621 tactacaagg aagcaccctt taagaatgtc acagagtatg atgggcagga tgcctgcggc 1681 tccaacagct ggaacatggt ggacgtggac ctcccgccca acaaggacgt ggagcccggc 1741 atcttactac atgggctgaa gccctggact cagtacgccg tttacgtcaa ggctgtgacc 1801 ctcaccatgg tggagaacga ccatatccgt ggggccaaga gtgagatctt gtacattcgc 1861 accaatgctt cagttccttc cattcccttg gacgttcttt cagcatcgaa ctcctcttct 1921 cagttaatcg tgaagtggaa ccctccctct ctgcccaacg gcaacctgag ttactacatt 1981 gtgcgctggc agcggcagcc tcaggacggc tacctttacc ggcacaatta ctgctccaaa 2041 gacaaaatcc ccatcaggaa gtatgccgac ggcaccatcg acattgagga ggtcacagag 2101 aaccccaaga ctgaggtgtg tggtggggag aaagggcctt gctgcgcctg ccccaaaact 2161 gaagccgaga agcaggccga gaaggaggag gctgaatacc gcaaagtctt tgagaatttc 2221 ctgcacaact ccatcttcgt gcccagacct gaaaggaagc ggagagatgt catgcaagtg 2281 gccaacacca ccatgtccag ccgaagcagg aacaccacgg ccgcagacac ctacaacatc 2341 accgacccgg aagagctgga gacagagtac cctttctttg agagcagagt ggataacaag 2401 gagagaactg tcatttctaa ccttcggcct ttcacattgt accgcatcga tatccacagc 2461 tgcaaccacg aggctgagaa gctgggctgc agcgcctcca acttcgtctt tgcaaggact 2521 atgcccgcag aaggagcaga tgacattcct gggccagtga cctgggagcc aaggcctgaa 2581 aactccatct ttttaaagtg gccggaacct gagaatccca atggattgat tctaatgtat 2641 gaaataaaat acggatcaca agttgaggat cagcgagaat gtgtgtccag acaggaatac 2701 aggaagtatg gaggggccaa gctaaaccgg ctaaacccgg ggaactacac agcccggatt 2761 caggccacat ctctctctgg gaatgggtcg tggacagatc ctgtgttctt ctatgtccag 2821 gccaaaacag gatatgaaaa cttcatccat ctgatcatcg ctctgcccgt cgctgtcctg 2881 ttgatcgtgg gagggttggt gattatgctg tacgtcttcc atagaaagag aaataacagc 2941 aggctgggga atggagtgct gtatgcctct gtgaacccgg agtacttcag cgctgctgat 3001 gtgtacgttc ctgatgagtg ggaggtggct cgggagaaga tcaccatgag ccgggaactt 3061 gggcaggggt cgtttgggat ggtctatgaa ggagttgcca agggtgtggt gaaagatgaa 3121 cctgaaacca gagtggccat taaaacagtg aacgaggccg caagcatgcg tgagaggatt 3181 gagtttctca acgaagcttc tgtgatgaag gagttcaatt gtcaccatgt ggtgcgattg 3241 ctgggtgtgg tgtcccaagg ccagccaaca ctggtcatca tggaactgat gacacggggc 3301 gatctcaaaa gttatctccg gtctctgagg ccagaaatgg agaataatcc agtcctagca 3361 cctccaagcc tgagcaagat gattcagatg gccggagaga ttgcagacgg catggcatac 3421 ctcaacgcca ataagttcgt ccacagagac cttgctgccc ggaattgcat ggtagccgaa 3481 gatttcacag tcaaaatcgg agattttggt atgacgcgag atatctatga gacagactat 3541 taccggaaag gaggcaaagg gctgctgccc gtgcgctgga tgtctcctga gtccctcaag 3601 gatggagtct tcaccactta ctcggacgtc tggtccttcg gggtcgtcct ctgggagatc 3661 gccacactgg ccgagcagcc ctaccagggc ttgtccaacg agcaagtcct tcgcttcgtc 3721 atggagggcg gccttctgga caagccagac aactgtcctg acatgctgtt tgaactgatg 3781 cgcatgtgct ggcagtataa ccccaagatg aggccttcct tcctggagat catcagcagc 3841 atcaaagagg agatggagcc tggcttccgg gaggtctcct tctactacag cgaggagaac 3901 aagctgcccg agccggagga gctggacctg gagccagaga acatggagag cgtccccctg 3961 gacccctcgg cctcctcgtc ctccctgcca ctgcccgaca gacactcagg acacaaggcc 4021 gagaacggcc ccggccctgg ggtgctggtc ctccgcgcca gcttcgacga gagacagcct 4081 tacgcccaca tgaacggggg ccgcaagaac gagcgggcct tgccgctgcc ccagtcttcg 4141 acctgctgat ccttggatcc tgaatctgtg caaacagtaa cgtgtgcgca cgcgcagcgg 4201 ggtggggggg gagagagagt tttaacaatc cattcacaag cctcctgtac ctcagtggat 4261 cttcagttct gcccttgctg cccgcgggag acagcttctc tgcagtaaaa cacatttggg 4321 atgttccttt tttcaatatg caagcagctt tttattccct gcccaaaccc ttaactgaca 4381 tgggccttta agaaccttaa tgacaacact taatagcaac agagcacttg agaaccagtc 4441 tcctcactct gtccctgtcc ttccctgttc tccctttctc tctcctctct gcttcataac 4501 ggaaaaataa ttgccacaag tccagctggg aagccctttt tatcagtttg aggaagtggc 4561 tgtccctgtg gccccatcca accactgtac acacccgcct gacaccgtgg gtcattacaa 4621 aaaaacacgt ggagatggaa atttttacct ttatctttca cctttctagg gacatgaaat 4681 ttacaaaggg ccatcgttca tccaaggctg ttaccatttt aacgctgcct aattttgcca 4741 aaatcctgaa ctttctccct catcggcccg gcgctgattc ctcgtgtccg gaggcatggg 4801 tgagcatggc agctggttgc tccatttgag agacacgctg gcgacacact ccgtccatcc 4861 gactgcccct gctgtgctgc tcaaggccac aggcacacag gtctcattgc ttctgactag 4921 attattattt gggggaactg gacacaatag gtctttctct cagtgaaggt ggggagaagc 4981 tgaaccggc //