GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMIGFIRR 4989 bp ss-mRNA PRI 22-MAY-1991
DEFINITION Human mRNA for insulin-like growth factor I receptor
ACCESSION X04434 M24599
KEYWORDS glycoprotein; insulin receptor;
insulin-like growth factor I receptor; membrane glycoprotein;
receptor; tyrosine kinase.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4989)
AUTHORS Ullrich,A., Gray,A., Tam,A.W., Yang-Feng,T., Tsubokawa,M.,
Collins,C., Henzel,W., Bon,T.L., Kathuria,S., Chen,E., Jakobs,S.,
Francke,U., Ramachandran,J. and Fujita-Yamaguchi,Y.
TITLE Insulin-like growth factor I receptor primary structure: comparison
with insulin receptor suggests structural dererminants that define
functional specificity
JOURNAL EMBO J. 5, 2503-2512 (1986)
STANDARD full automatic
COMMENT SWISS-PROT; P08069; IG1R$HUMAN.
*source: tissue=placenta; library=(lamda)gt10; *source: clone=
(lambda)IGF-1-R.85, (lambda)IGF-1-R.76;
From EMBL 26 entry HSIGFIRR; dated 28-MAR-1991.
FEATURES Location/Qualifiers
sig_peptide 32..121
CDS 32..4132
/product="IGF-I receptor"
/codon_start=32
mat_peptide 122..4132
/note="IGF-I receptor"
misc_feature 122..2251
/note="alpha-subunit (AA 1 - 710)"
misc_feature 182..190
/note="pot.N-linked glycosylation site (AA 21 - 23)"
misc_feature 335..343
/note="pot.N-linked glycostlation site (AA 72 - 74)"
misc_feature 434..442
/note="pot.N-linked glycostlation site (AA 105 - 107)"
misc_feature 761..769
/note="pot.N-linked glycostlation site (AA 214 - 216)"
misc_feature 971..979
/note="pot.N-linked glycostlation site (AA 284 - 286)"
misc_feature 1280..1288
/note="pot.N-linked glycostlation site (AA 387 - 389)"
misc_feature 1343..1351
/note="pot.N-linked glycosylation site (AA 408 - 410)"
misc_feature 1631..1639
/note="pot.N-linked glycostlation site (AA 504 - 506)"
misc_feature 1850..1858
/note="pot.N-linked glycosylation site (AA 577 - 579)"
misc_feature 1895..1903
/note="pot.N-linked glycosylation site (AA 592 - 594)"
misc_feature 1949..1957
/note="pot.N-linked glycosylation site (AA 610 - 612)"
misc_feature 2240..2251
/note="putative proreceptor processing site (AA 707 -
710)"
misc_feature 2252..4132
/note="beta-subunit (AA 711 - 1337)"
misc_feature 2270..2278
/note="pot.N-linked glycosylation site (AA 717 - 719]"
misc_feature 2297..2305
/note="pot.N-linked glycosylation site (AA 726 - 728)"
misc_feature 2321..2329
/note="pot.N-linked glycosylation site (AA 734 - 736)"
misc_feature 2729..2737
/note="pot.N-linked glycosylation site (AA 870 - 872)"
misc_feature 2768..2776
/note="pot.N-linked glycosylation site (AA 883 - 885)"
misc_feature 2837..2908
/note="transmembrane region (AA 906 - 929)"
misc_feature 2918..2926
/note="pot.N-linked glycosylation site (AA 933 - 935)"
misc_feature 3047..3049
/note="pot.ATP binding site (AA 976)"
misc_feature 3053..3055
/note="pot.ATP binding site (AA 978)"
misc_feature 3062..3064
/note="pot.ATP binding site (AA 981)"
misc_feature 3128..3130
/note="pot.ATP binding site (AA 1003)"
BASE COUNT 1216 a 1371 c 1320 g 1082 t
ORIGIN
1 tttttttttt ttttgagaaa gggaatttca tcccaaataa aaggaatgaa gtctggctcc
61 ggaggagggt ccccgacctc gctgtggggg ctcctgtttc tctccgccgc gctctcgctc
121 tggccgacga gtggagaaat ctgcgggcca ggcatcgaca tccgcaacga ctatcagcag
181 ctgaagcgcc tggagaactg cacggtgatc gagggctacc tccacatcct gctcatctcc
241 aaggccgagg actaccgcag ctaccgcttc cccaagctca cggtcattac cgagtacttg
301 ctgctgttcc gagtggctgg cctcgagagc ctcggagacc tcttccccaa cctcacggtc
361 atccgcggct ggaaactctt ctacaactac gccctggtca tcttcgagat gaccaatctc
421 aaggatattg ggctttacaa cctgaggaac attactcggg gggccatcag gattgagaaa
481 aatgctgacc tctgttacct ctccactgtg gactggtccc tgatcctgga tgcggtgtcc
541 aataactaca ttgtggggaa taagccccca aaggaatgtg gggacctgtg tccagggacc
601 atggaggaga agccgatgtg tgagaagacc accatcaaca atgagtacaa ctaccgctgc
661 tggaccacaa accgctgcca gaaaatgtgc ccaagcacgt gtgggaagcg ggcgtgcacc
721 gagaacaatg agtgctgcca ccccgagtgc ctgggcagct gcagcgcgcc tgacaacgac
781 acggcctgtg tagcttgccg ccactactac tatgccggtg tctgtgtgcc tgcctgcccg
841 cccaacacct acaggtttga gggctggcgc tgtgtggacc gtgacttctg cgccaacatc
901 ctcagcgccg agagcagcga ctccgagggg tttgtgatcc acgacggcga gtgcatgcag
961 gagtgcccct cgggcttcat ccgcaacggc agccagagca tgtactgcat cccttgtgaa
1021 ggtccttgcc cgaaggtctg tgaggaagaa aagaaaacaa agaccattga ttctgttact
1081 tctgctcaga tgctccaagg atgcaccatc ttcaagggca atttgctcat taacatccga
1141 cgggggaata acattgcttc agagctggag aacttcatgg ggctcatcga ggtggtgacg
1201 ggctacgtga agatccgcca ttctcatgcc ttggtctcct tgtccttcct aaaaaacctt
1261 cgcctcatcc taggagagga gcagctagaa gggaattact ccttctacgt cctcgacaac
1321 cagaacttgc agcaactgtg ggactgggac caccgcaacc tgaccatcaa agcagggaaa
1381 atgtactttg ctttcaatcc caaattatgt gtttccgaaa tttaccgcat ggaggaagtg
1441 acggggacta aagggcgcca aagcaaaggg gacataaaca ccaggaacaa cggggagaga
1501 gcctcctgtg aaagtgacgt cctgcatttc acctccacca ccacgtcgaa gaatcgcatc
1561 atcataacct ggcaccggta ccggccccct gactacaggg atctcatcag cttcaccgtt
1621 tactacaagg aagcaccctt taagaatgtc acagagtatg atgggcagga tgcctgcggc
1681 tccaacagct ggaacatggt ggacgtggac ctcccgccca acaaggacgt ggagcccggc
1741 atcttactac atgggctgaa gccctggact cagtacgccg tttacgtcaa ggctgtgacc
1801 ctcaccatgg tggagaacga ccatatccgt ggggccaaga gtgagatctt gtacattcgc
1861 accaatgctt cagttccttc cattcccttg gacgttcttt cagcatcgaa ctcctcttct
1921 cagttaatcg tgaagtggaa ccctccctct ctgcccaacg gcaacctgag ttactacatt
1981 gtgcgctggc agcggcagcc tcaggacggc tacctttacc ggcacaatta ctgctccaaa
2041 gacaaaatcc ccatcaggaa gtatgccgac ggcaccatcg acattgagga ggtcacagag
2101 aaccccaaga ctgaggtgtg tggtggggag aaagggcctt gctgcgcctg ccccaaaact
2161 gaagccgaga agcaggccga gaaggaggag gctgaatacc gcaaagtctt tgagaatttc
2221 ctgcacaact ccatcttcgt gcccagacct gaaaggaagc ggagagatgt catgcaagtg
2281 gccaacacca ccatgtccag ccgaagcagg aacaccacgg ccgcagacac ctacaacatc
2341 accgacccgg aagagctgga gacagagtac cctttctttg agagcagagt ggataacaag
2401 gagagaactg tcatttctaa ccttcggcct ttcacattgt accgcatcga tatccacagc
2461 tgcaaccacg aggctgagaa gctgggctgc agcgcctcca acttcgtctt tgcaaggact
2521 atgcccgcag aaggagcaga tgacattcct gggccagtga cctgggagcc aaggcctgaa
2581 aactccatct ttttaaagtg gccggaacct gagaatccca atggattgat tctaatgtat
2641 gaaataaaat acggatcaca agttgaggat cagcgagaat gtgtgtccag acaggaatac
2701 aggaagtatg gaggggccaa gctaaaccgg ctaaacccgg ggaactacac agcccggatt
2761 caggccacat ctctctctgg gaatgggtcg tggacagatc ctgtgttctt ctatgtccag
2821 gccaaaacag gatatgaaaa cttcatccat ctgatcatcg ctctgcccgt cgctgtcctg
2881 ttgatcgtgg gagggttggt gattatgctg tacgtcttcc atagaaagag aaataacagc
2941 aggctgggga atggagtgct gtatgcctct gtgaacccgg agtacttcag cgctgctgat
3001 gtgtacgttc ctgatgagtg ggaggtggct cgggagaaga tcaccatgag ccgggaactt
3061 gggcaggggt cgtttgggat ggtctatgaa ggagttgcca agggtgtggt gaaagatgaa
3121 cctgaaacca gagtggccat taaaacagtg aacgaggccg caagcatgcg tgagaggatt
3181 gagtttctca acgaagcttc tgtgatgaag gagttcaatt gtcaccatgt ggtgcgattg
3241 ctgggtgtgg tgtcccaagg ccagccaaca ctggtcatca tggaactgat gacacggggc
3301 gatctcaaaa gttatctccg gtctctgagg ccagaaatgg agaataatcc agtcctagca
3361 cctccaagcc tgagcaagat gattcagatg gccggagaga ttgcagacgg catggcatac
3421 ctcaacgcca ataagttcgt ccacagagac cttgctgccc ggaattgcat ggtagccgaa
3481 gatttcacag tcaaaatcgg agattttggt atgacgcgag atatctatga gacagactat
3541 taccggaaag gaggcaaagg gctgctgccc gtgcgctgga tgtctcctga gtccctcaag
3601 gatggagtct tcaccactta ctcggacgtc tggtccttcg gggtcgtcct ctgggagatc
3661 gccacactgg ccgagcagcc ctaccagggc ttgtccaacg agcaagtcct tcgcttcgtc
3721 atggagggcg gccttctgga caagccagac aactgtcctg acatgctgtt tgaactgatg
3781 cgcatgtgct ggcagtataa ccccaagatg aggccttcct tcctggagat catcagcagc
3841 atcaaagagg agatggagcc tggcttccgg gaggtctcct tctactacag cgaggagaac
3901 aagctgcccg agccggagga gctggacctg gagccagaga acatggagag cgtccccctg
3961 gacccctcgg cctcctcgtc ctccctgcca ctgcccgaca gacactcagg acacaaggcc
4021 gagaacggcc ccggccctgg ggtgctggtc ctccgcgcca gcttcgacga gagacagcct
4081 tacgcccaca tgaacggggg ccgcaagaac gagcgggcct tgccgctgcc ccagtcttcg
4141 acctgctgat ccttggatcc tgaatctgtg caaacagtaa cgtgtgcgca cgcgcagcgg
4201 ggtggggggg gagagagagt tttaacaatc cattcacaag cctcctgtac ctcagtggat
4261 cttcagttct gcccttgctg cccgcgggag acagcttctc tgcagtaaaa cacatttggg
4321 atgttccttt tttcaatatg caagcagctt tttattccct gcccaaaccc ttaactgaca
4381 tgggccttta agaaccttaa tgacaacact taatagcaac agagcacttg agaaccagtc
4441 tcctcactct gtccctgtcc ttccctgttc tccctttctc tctcctctct gcttcataac
4501 ggaaaaataa ttgccacaag tccagctggg aagccctttt tatcagtttg aggaagtggc
4561 tgtccctgtg gccccatcca accactgtac acacccgcct gacaccgtgg gtcattacaa
4621 aaaaacacgt ggagatggaa atttttacct ttatctttca cctttctagg gacatgaaat
4681 ttacaaaggg ccatcgttca tccaaggctg ttaccatttt aacgctgcct aattttgcca
4741 aaatcctgaa ctttctccct catcggcccg gcgctgattc ctcgtgtccg gaggcatggg
4801 tgagcatggc agctggttgc tccatttgag agacacgctg gcgacacact ccgtccatcc
4861 gactgcccct gctgtgctgc tcaaggccac aggcacacag gtctcattgc ttctgactag
4921 attattattt gggggaactg gacacaatag gtctttctct cagtgaaggt ggggagaagc
4981 tgaaccggc
//