GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMP450 1218 bp ss-mRNA PRI 22-MAY-1991
DEFINITION Human mRNA for cytochrome P-450IID (clone pMP32)
ACCESSION X16865
KEYWORDS cytochrome; cytochrome P-450; polymorphism.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1218)
AUTHORS Miles,J.S.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1218)
AUTHORS Gough,A.C., Miles,J.S., Spurr,N.K., Moss,J.E., Gaedigk,A.,
Eichelbaum,M. and Wolf,C.R.
TITLE Identification of the primary gene defect at the cytochrome P450
CYP2D locus
JOURNAL Nature 347, 773-776 (1991)
STANDARD full automatic
COMMENT *source: tissue=liver; clone=pMP32; **map: chromosome=22; See
<Y00300> for active P-450IID sequence. See also <X16866> and
<X16867> for other sequences exhibiting P-450IID polymorphism.
From EMBL 26 entry HSP450; dated 28-MAR-1991.
FEATURES Location/Qualifiers
misc_feature 8..1125
/note="P-450IID sequence"
polyA_site 1202..1202
/note="polyA site"
BASE COUNT 229 a 401 c 344 g 244 t
ORIGIN
1 gaattccggg cccgcgtggc gcgagcagag gcgcttctcc gtctccacct tgcgcaactt
61 gggcctgggc aagaagtcgc tggagcagtg ggtgaccgag gaggccgcct gcctttgtgc
121 cgccttcgcc aaccactccg acgccccttt cgccccaacg gtctcttgga caaagccgtg
181 agcaacgtga tcgcctccct cacctgcggg cgccgcttcg agtacgacga ccctcgcttc
241 ctcaggctgc tggacctagc tcaggaggga ctgaaggagg agtcgggctt tctgcgcgag
301 gtgctgaatg ctgtccccgt cctcctgcat atcccagcgc tggctggcaa ggtcctacgc
361 ttccaaaagg ctttcctgac ccagctggat gagctgctaa ctgagcacag gatgacctgg
421 gacccagccc agcccccccg agacctgact gaggccttcc tggcagagat ggagaaggcc
481 aaggggaacc ctgagagcag cttcaatgat gagaacctgc gcatagtggt ggctgacctg
541 ttctctgccg ggatggtgac cacctcgacc acgctggcct ggggcctcct gctcatgatc
601 ctacatccgg atgtgcagcg ccgtgtccaa caggagatcg acgacgtgat agggcaggtg
661 cggcgaccag agatgggtga ccaggctcac atgccctaca ccactgccgt gattcatgag
721 gtgcagcgct ttggggacat cgtccccctg ggtgtgaccc atatgacatc ccgtgacatc
781 gaagtacagg gcttccgcat ccctaaggga acgacactca tcaccaacct gtcatcggtg
841 ctgaaggatg aggccgtctg ggagaagccc ttccgcttcc accccgaaca cttcctggat
901 gcccagggcc actttgtgaa gccggaggcc ttcctgcctt tctcagcagg ccgccgtgca
961 tgcctcgggg agcccctggc ccgcatggag ctcttcctct tcttcacctc cctgctgcag
1021 cacttcagct tctcggtgcc cactggacag ccccggccca gccaccatgg tgtctttgct
1081 ttcctggtga ccccatcccc ctatgagctt tgtgctgtgc cccgctagaa tggggtacct
1141 agtccccagc ctgctcccta gccagaggct ctaatgtaca ataaagcaat gtggtagttc
1201 caaaaaaaaa aggaattc
//GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMP450II 1315 bp ss-mRNA PRI 22-MAY-1991
DEFINITION Human mRNA for cytochrome P-450IID (clone pMP33)
ACCESSION X16866
KEYWORDS cytochrome; cytochrome P-450; polymorphism.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1315)
AUTHORS Miles,S.J.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Gough,A.C., Miles,J.S., Spurr,N.K., Moss,J.E., Gaedigk,A.,
Eichelbaum,M. and Wolf,C.R.
TITLE Identification of the primary gene defect at the cytochrome P450
CYP2D locus
JOURNAL Nature 347, 773-776 (1991)
STANDARD full staff_review
COMMENT *source: tissue=liver; clone=pMP33; **map: chromosome=22; See
<Y00300> for active P-450IID sequence. See also <X16865> and
<X16867> for other sequences exhibiting P-450IID polymorphism.
From EMBL 26 entry HSP450II; dated 28-MAR-1991.
FEATURES Location/Qualifiers
misc_feature 659..661
/note="ATG start codon"
misc_feature 839..902
/note="insertion seqence corresponding to part of intron
I"
misc_feature 1227..1227
/note="single bp deletion compared with active P450IID
sequence"
BASE COUNT 293 a 418 c 336 g 268 t
ORIGIN
1 gaattccgga agcctaactt cctccaacac aggaggaagg agagtgtccc ctgggtgctg
61 acccattgtg gggacgcatg tctgtccagt ccgtgtccaa caggagatcg acgacgtgat
121 agggcaggtg cggcgaccag agatgggtga ccaggctcac atgccctaca ccactgccgt
181 gattcacgag gtgcagcgct ttggggacat catccccctg agtgtgaccc atatgacatc
241 ccgtgacatc gaagtacagg gcttccgcat ccctaaggga acgacactca tcaccaacct
301 gtcatcggtg ctgaaggatg aggccgtctg gaagaagccc ttccgcttcc accccgaaca
361 cttcctggat gcccagggcc actttgtgaa gccggaggcc ttcctgcctt tctcagcagg
421 ccgccgtgca tgcctcgggg agcccctggc ccgcatggag ctcttcctct tcttcacctc
481 cctgctgcag cacttcagct tctccgtggc cgccggacag ccccggccca gccactctcg
541 tgtcgtcagc tttctggtga ccccatcccc ctacgagctt tgtgctgtgc cccgctagaa
601 tggggtacct agtccccagc ctgctcccta gccagaggct ctaatgtaca ataaagcaat
661 gtggtagttc caacttgggt cccctgctca cgccctcgtt gggagtcatc ctcctcaggg
721 caaccccatc ccctgcctca ttcctgctta ccccaccgcc tggccgcatt tgagacgggt
781 acgttgaggc tgagcagatg tcagttaccc ttgcccataa tcccatgtcc cccactgacc
841 caactctgac tgcccagatt ggtgacaagg actacattgt cctggcatgt ggggaagggg
901 ccagaatggg ctgactagag gtgtcagtca gccctggatg tggtggagag ggcaggactc
961 agcctggagg cccatatttc aggcctaact cagcccaccc cacatcaggg acagcagtcc
1021 tgccagcacc atcacaacag tcacctccct tcatatatga caccccaaaa tggaagacaa
1081 atcatgtcag ggagctatat gccagggcta cctcccaggg ctcagtcggc aggtgccaga
1141 acattccctg ggaaggcccc aggaaaaccc aggaccgagc caccgccctc agcctgtcac
1201 cttgtgtcca aaattggtgg gttcttggtc tcactgactt caagaatgaa gccgtggacc
1261 tcacggtgag tgttacagtt cttaaaaaaa aaaaaaaaaa aaaaaaaagg aattc
//GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMP450IID 1563 bp ss-mRNA PRI 22-MAY-1991
DEFINITION Human mRNA for cytochrome P-450IID (clone pMP34)
ACCESSION X16867
KEYWORDS cytochrome; cytochrome P-450; polymorphism.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1563)
AUTHORS Miles,S.J.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Gough,A.C., Miles,J.S., Spurr,N.K., Moss,J.E., Gaedigk,A.,
Eichelbaum,M. and Wolf,C.R.
TITLE Identification of the primary gene defect at the cytochrome P450
CYP2D locus
JOURNAL Nature 347, 773-776 (1991)
STANDARD full staff_review
COMMENT *source: tissue=liver; clone=pMP34; **map: chromosome=22; See
<Y00300> for active P-450IID sequence. See also <X16865> and
<X16866> for other sequences exhibiting P-450IID polymorphism.
From EMBL 26 entry HSP450IID; dated 28-MAR-1991.
FEATURES Location/Qualifiers
intron 1..89
/note="part of intron 6"
misc_feature 90..598
/note="coding region"
3'UTR 673..1315
/note="extended 3' non-coding region, compared to active
P450II sequence, y00300"
BASE COUNT 288 a 428 c 449 g 398 t
ORIGIN
1 gaattccttg ggcagtatat acaggctcta ttactcttgg tgtttcattc acaaatgtta
61 tggctcctga agtgtgatat aaaactttaa cttctttggc ttgctcccat ggatgaggca
121 tgttctctaa caattttaag atcgcgtgcg gtaaatactt tagggcgcct agaaaagcct
181 ttttatcagt attgtacatt ttggaggcca tgtcactgtg agtattaata atctttcgca
241 gatgttccgg tggcatctcg gctttaggag tatataaatt gcttctcttt gcctttttgg
301 tcattttttt tgcatgcttc cttgattttc gagtgacgaa agaagctttt cctatgtcca
361 gttttctctt tccatgtaat tctactttct tttctgcttt attctctaat tcatctagac
421 ctggaggggg cggtggcggt ggtaatgtga agtccacaat ttcttcagcg tttatttcga
481 agttgcttgg aggaggtggt ggaggcggaa gaaatgtatc ctcatttacc gatgatggca
541 ccatcggatt atccagttct tcgatctcgt atccaggcgg tggtggtggt ggtggtggaa
601 gtgctaagtc gctgtcctct tcaaaaccag gaggagccca tttggtagtg aggcaggtat
661 ggggctagaa gcactggtgc ccctggccgt gatagtggcc atcttcctgc tcctggtgga
721 cctgatgcac cggcgccaac gctgggctgc acgctactca ccaggccccc tgccactgcc
781 cgggctgggc aacctgctgc atgtggactt ccagaacaca ccatactgct tcgaccaggt
841 gagggaggag gtcctggagg gcggcagagg tgctgaggtc ccctaccaga agcaaacatg
901 gatgttcgcg ccgcttcggg gacgtgttca gcctgcagct ggcctggacg ccggtggtcg
961 tgctcaatgg gctggcggcc gtgcgcgagg cgatggtgac ccgcggcgag gacacggccg
1021 accgcccgcc tgtgcccatc acccagatcc tgggtttcgg gccgcgttcc caaggggtgt
1081 tcctggcgcg ctatgggccc gcgtggcgcg agcagaggcg cttctccgtc tccaccttgc
1141 gcaacttggg cctgggcaag aagtcgctgg agcagtgggt gaccgaggag gccgcctgcc
1201 tttgtgccgc cttcgccaac cactccgacg cccctttcgc cccaacggtc tcttggacaa
1261 agccgtgagc aacgtgatcg cctccctcac ctgcgggcgc cgcttcgagt acgacgaccc
1321 tcgcttcctc aggctgctgg acctagctca ggagggactg aaggaggagt cgggctttct
1381 gcgcgaggtg ctgaatgctg tccccgtcct cctgcatatc ccagcgctgg ctggcaaggt
1441 cctacgcttc caaaaggctt tcctgaccca gctggatgag ctgctaactg agcacaggat
1501 gacctgggac ccagcccagc ccccccgaga cctgactgtc accatcccgg cagagaggaa
1561 ttc
//