GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVI 594 bp ds-DNA PRI 23-MAY-1991 DEFINITION Human Ig germline heavy chain gene V-region (V11). ACCESSION X05712 KEYWORDS immunoglobulin; immunoglobulin heavy chain; immunoglobulin heavy chain subgroup vh-iv; variable region. SOURCE Human placental DNA, clone V(11). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 594) AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T. TITLE A novel family of variable region genes of the human immunoglobulin heavy chain JOURNAL J. Mol. Biol. 195, 761-768 (1987) STANDARD simple staff_review COMMENT [1] enum. 1 to 594. Data kindly reviewed (24-NOV-1987) by HONJO T. EMBL features not translated to GenBank features: key from to description SITE <1 >594 primary transcript of V-region of heavy chain SITE 412 459 cdr 2 (AA 51 - 66) IVS 556 >594 intron II SITE 558 563 recombination signal SITE 586 594 recombination signal FEATURES Location/Qualifiers CDS join(123..168,251..555) /partial /note="Ig H chain V-region (V11) precursor" sig_peptide join(123..168,251..261) /note="Ig H chain signal peptide" exon <123..168 /note="Ig H chain V-region (V11) precursor, exon 1 /hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'" sig_peptide 123..168 /note="Ig H chain signal peptide, exon 1" intron 169..250 /note="Ig H chain intron A" sig_peptide 251..261 /note="Ig H chain signal peptide, exon 2" exon 251..>555 /note="Ig H chain V-region (V11) precursor, exon 2" mat_peptide 262..>555 /partial /note="Ig H chain V-region (V11)" BASE COUNT 141 a 170 c 160 g 123 t ORIGIN Chromosome 14. 1 ccacctacat gcaaatcctc gcttaggcac ccacaggaaa ccaccacaca tttccttaaa 61 ttcagggtcc agctcacatg ggaaatactt tctgagagct catggacctc ctgcacaaga 121 acatgaaaca cctgtggttc tttctcctcc tggtggcagc tcccagatgt gagtatctca 181 gggatccaga catgaagata ggggaggtgc ctctgatccc agggctcact gtgggtctct 241 ctgttcacag gggtcctgtc ccaggtgcag ctgcaggagt cgggcccagg actggtgaag 301 ccttcggaga ccctgtccct cacctgcgtt gtctctggtg gctccatcag cagtagtaac 361 tggtggagct gggtccgcca gcccccaggg aaggggctgg agtggattgg ggaaatctat 421 catagtggga accccaacta caacccgtcc ctcaagagtc gagtcaccat atcaatagac 481 aagtccaaga accaattctc cctgaagctg agctctgtga ccgccgcgga cacggccgtg 541 tattactgtg cgagagacac atgagggagg tgagtgtgag cccagacaca aacc //
GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVJ 624 bp ds-DNA PRI 23-MAY-1991 DEFINITION Human Ig germline heavy chain gene V-region (V12G-1). ACCESSION X05714 KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain; immunoglobulin heavy chain subgroup vh-iv; variable region. SOURCE Human placental DNA, clone V(12G-1). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 624) AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T. TITLE A novel family of variable region genes of the human immunoglobulin heavy chain JOURNAL J. Mol. Biol. 195, 761-768 (1987) STANDARD simple staff_review COMMENT Data kindly reviewed (24-NOV-1987) by HONJO T. EMBL features not translated to GenBank features: key from to description TRANSCR <1 >624 primary transcript of V-region of heavy chain SITE 380 397 pot. complementarity determining region 1 (cdr 1; AA 31 - 36) SITE 440 487 cdr 2 (AA 51 - 66) IVS 584 >624 iII SITE 586 592 recombination signal SITE 616 624 recombination signal FEATURES Location/Qualifiers CDS join(151..196,279..583) /partial /note="Ig H chain V-region (V12G-1) precursor" sig_peptide join(151..196,279..289) /note="Ig H chain V-region signal peptide" exon <151..196 /note="Ig H chain V-region (V12G-1) precursor, exon 1 /hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'" sig_peptide 151..196 /note="Ig H chain V-region signal peptide, exon 1" intron 197..278 /note="Ig H chain intron" sig_peptide 279..289 /note="Ig H chain V-region signal peptide, exon 2" exon 279..>583 /note="Ig H chain V-region (V12G-1) precursor, exon 2" mat_peptide 290..>583 /partial /note="Ig H chain V-region (V12G-1)" BASE COUNT 141 a 179 c 168 g 136 t ORIGIN Chromosome 14. 1 catccctttt cacctctcca tacagaggca ccacccacat gcaaatctca cttaggcacc 61 caagggaaac catcacacat ttccttaaat tcagggtcct gctcacatgg gaaatacttt 121 ctgagagctc tggacctcct gtgcaagaac atgaaacacc tgtggttctt cctcctgctg 181 gtggcagctc ccagatgtga gtgtctcaag gctgcagaca tggagatatg ggaggtgcct 241 ctgagcccag ggctcactgt gggtctctct gttcacaggg gtcctgtccc aggtgcagct 301 gcaggagtcg ggcccaggac tggtgaagcc ttcggacacc ctgtccctca cctgcgctgt 361 ctctggttac tccatcagca gtagtaactg gtggggctgg atccggcagc ccccagggaa 421 gggactggag tggattgggt acatctatta tagtgggagc acctactaca acccgtccct 481 caagagtcga gtcaccatgt cagtagacac gtccaagaac cagttctccc tgaagctgag 541 ctctgtgacc gccgtggaca cggccgtgta ttactgtgcg agaaacacag tgaggggagg 601 tgagtgtgag cccagacaca aacc //