GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVI 594 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human Ig germline heavy chain gene V-region (V11).
ACCESSION X05712
KEYWORDS immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup vh-iv; variable region.
SOURCE Human placental DNA, clone V(11).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 594)
AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T.
TITLE A novel family of variable region genes of the human immunoglobulin
heavy chain
JOURNAL J. Mol. Biol. 195, 761-768 (1987)
STANDARD simple staff_review
COMMENT
[1] enum. 1 to 594.
Data kindly reviewed (24-NOV-1987) by HONJO T.
EMBL features not translated to GenBank features:
key from to description
SITE <1 >594 primary transcript of V-region of
heavy chain
SITE 412 459 cdr 2 (AA 51 - 66)
IVS 556 >594 intron II
SITE 558 563 recombination signal
SITE 586 594 recombination signal
FEATURES Location/Qualifiers
CDS join(123..168,251..555)
/partial
/note="Ig H chain V-region (V11) precursor"
sig_peptide join(123..168,251..261)
/note="Ig H chain signal peptide"
exon <123..168
/note="Ig H chain V-region (V11) precursor, exon 1
/hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'"
sig_peptide 123..168
/note="Ig H chain signal peptide, exon 1"
intron 169..250
/note="Ig H chain intron A"
sig_peptide 251..261
/note="Ig H chain signal peptide, exon 2"
exon 251..>555
/note="Ig H chain V-region (V11) precursor, exon 2"
mat_peptide 262..>555
/partial
/note="Ig H chain V-region (V11)"
BASE COUNT 141 a 170 c 160 g 123 t
ORIGIN Chromosome 14.
1 ccacctacat gcaaatcctc gcttaggcac ccacaggaaa ccaccacaca tttccttaaa
61 ttcagggtcc agctcacatg ggaaatactt tctgagagct catggacctc ctgcacaaga
121 acatgaaaca cctgtggttc tttctcctcc tggtggcagc tcccagatgt gagtatctca
181 gggatccaga catgaagata ggggaggtgc ctctgatccc agggctcact gtgggtctct
241 ctgttcacag gggtcctgtc ccaggtgcag ctgcaggagt cgggcccagg actggtgaag
301 ccttcggaga ccctgtccct cacctgcgtt gtctctggtg gctccatcag cagtagtaac
361 tggtggagct gggtccgcca gcccccaggg aaggggctgg agtggattgg ggaaatctat
421 catagtggga accccaacta caacccgtcc ctcaagagtc gagtcaccat atcaatagac
481 aagtccaaga accaattctc cctgaagctg agctctgtga ccgccgcgga cacggccgtg
541 tattactgtg cgagagacac atgagggagg tgagtgtgag cccagacaca aacc
//GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVJ 624 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human Ig germline heavy chain gene V-region (V12G-1).
ACCESSION X05714
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup vh-iv; variable region.
SOURCE Human placental DNA, clone V(12G-1).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 624)
AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T.
TITLE A novel family of variable region genes of the human immunoglobulin
heavy chain
JOURNAL J. Mol. Biol. 195, 761-768 (1987)
STANDARD simple staff_review
COMMENT Data kindly reviewed (24-NOV-1987) by HONJO T.
EMBL features not translated to GenBank features:
key from to description
TRANSCR <1 >624 primary transcript of V-region of
heavy chain
SITE 380 397 pot. complementarity determining
region 1 (cdr 1; AA 31 - 36)
SITE 440 487 cdr 2 (AA 51 - 66)
IVS 584 >624 iII
SITE 586 592 recombination signal
SITE 616 624 recombination signal
FEATURES Location/Qualifiers
CDS join(151..196,279..583)
/partial
/note="Ig H chain V-region (V12G-1) precursor"
sig_peptide join(151..196,279..289)
/note="Ig H chain V-region signal peptide"
exon <151..196
/note="Ig H chain V-region (V12G-1) precursor, exon 1
/hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'"
sig_peptide 151..196
/note="Ig H chain V-region signal peptide, exon 1"
intron 197..278
/note="Ig H chain intron"
sig_peptide 279..289
/note="Ig H chain V-region signal peptide, exon 2"
exon 279..>583
/note="Ig H chain V-region (V12G-1) precursor, exon 2"
mat_peptide 290..>583
/partial
/note="Ig H chain V-region (V12G-1)"
BASE COUNT 141 a 179 c 168 g 136 t
ORIGIN Chromosome 14.
1 catccctttt cacctctcca tacagaggca ccacccacat gcaaatctca cttaggcacc
61 caagggaaac catcacacat ttccttaaat tcagggtcct gctcacatgg gaaatacttt
121 ctgagagctc tggacctcct gtgcaagaac atgaaacacc tgtggttctt cctcctgctg
181 gtggcagctc ccagatgtga gtgtctcaag gctgcagaca tggagatatg ggaggtgcct
241 ctgagcccag ggctcactgt gggtctctct gttcacaggg gtcctgtccc aggtgcagct
301 gcaggagtcg ggcccaggac tggtgaagcc ttcggacacc ctgtccctca cctgcgctgt
361 ctctggttac tccatcagca gtagtaactg gtggggctgg atccggcagc ccccagggaa
421 gggactggag tggattgggt acatctatta tagtgggagc acctactaca acccgtccct
481 caagagtcga gtcaccatgt cagtagacac gtccaagaac cagttctccc tgaagctgag
541 ctctgtgacc gccgtggaca cggccgtgta ttactgtgcg agaaacacag tgaggggagg
601 tgagtgtgag cccagacaca aacc
//