GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVK 628 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human Ig germline H chain gene V-region (V2-1).
ACCESSION X05715
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup vh-iv; variable region.
SOURCE Human placental DNA, clone V(2-1).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 628)
AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T.
TITLE A novel family of variable region genes of the human immunoglobulin
heavy chain
JOURNAL J. Mol. Biol. 195, 761-768 (1987)
STANDARD simple staff_review
COMMENT
[1] enum. 1 to 628.
Data kindly reviewed (24-NOV-1987) by HONJO T.
EMBL features not translated to GenBank features:
key from to description
TRANSCR <1 >628 primary transcript of V-region of
heavy chain
SITE 381 401 pot. complementarity determining
region cdr 1 (AA 31 - 37)
SITE 444 491 pot. cdr 2 (AA 52 - 67)
IVS 588 >628 intron II
SITE 590 596 recombination signal
SITE 620 628 recombination signal
FEATURES Location/Qualifiers
CDS join(152..197,280..587)
/partial
/note="Ig H chain V-region (V2-1) precursor"
sig_peptide join(152..197,280..290)
/note="Ig H chain signal peptide"
exon <152..197
/note="Ig H chain V-region (V2-1) precursor, exon 1
/hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'"
sig_peptide 152..197
/note="Ig H chain signal peptide, exon 1"
intron 198..279
/note="Ig H chain intron A"
sig_peptide 280..290
/note="Ig H chain signal peptide, exon 2"
exon 280..>587
/note="Ig H chain V-region (V2-1) precursor, exon 2"
mat_peptide 291..>587
/partial
/note="Ig H chain V-region (V2-1)"
BASE COUNT 142 a 179 c 166 g 141 t
ORIGIN Chromosome 14.
1 catccctttt cactgctccg tacaaacgca ccacccccat gcaaatcctc acttaggcgc
61 ccacaggaag ccaccacaca tttccttaaa ttcaggtcca actcataagg gaaatacttt
121 ctgagagctc atggatctca tgtgcaagaa catgaagcac ctgtggttct tcctcctgct
181 ggtggcggct cccagatgtg aatgtttcta ggatgcagac atggagatat gggaggtgcc
241 tctgatccca gggctcactg tgggtttttc tgttcacagg ggtcctgtcc cagctgcagc
301 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg
361 tctctggtgg ctccatcagc agtagtagtt actactgggg ctggatccgc cagcccccag
421 ggaaggggct ggagtggatt gggagtatct attatagtgg gagcacctac tacaacccgt
481 ccctcaagag tcgagtcacc atatccgtag acacgtccaa gaaccacttc tccctgaagc
541 tgagctctgt gaccgccgca gacacggctg tgtattactg tgcgagagac acagtgaggg
601 gaggtgagtg tgagcccaga cacaaacc
//GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVL 623 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human Ig germline H chain gene V-region (V58).
ACCESSION X05716
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup vh-iv; variable region.
SOURCE Human placental DNA, clone V(58).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 623)
AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T.
TITLE A novel family of variable region genes of the human immunoglobulin
heavy chain
JOURNAL J. Mol. Biol. 195, 761-768 (1987)
STANDARD simple staff_review
COMMENT
[1] enum. 1 to 623.
Data kindly reviewed (24-NOV-1987) by HONJO T.
EMBL features not translated to GenBank features:
key from to description
TRANSCR <1 >623 primary transcript of V-region of
heavy chain
MSG 281 582 exon 2
SITE 379 396 pot. complementarity determining
region 1 (cdr 1; AA 30 - 35)
SITE 439 486 pot. cdr 2 (50 - 65)
IVS 583 >623 intron II
SITE 585 591 recombination signal
SITE 615 623 recombination signal
FEATURES Location/Qualifiers
CDS join(153..198,281..582)
/partial
/note="Ig H chain V-region (V58) precursor"
sig_peptide join(153..198,281..291)
/note="Ig H chain signal peptide"
exon <153..198
/note="Ig H chain V-region (V58) precursor, exon 1
/hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'"
sig_peptide 153..198
/note="Ig H chain signal peptide"
intron 199..280
/note="Ig H chain intron A"
sig_peptide 281..291
/note="Ig H chain signal peptide"
exon 281..>582
/note="Ig H chain V-region (V58) precursor, exon 2"
mat_peptide 292..>582
/partial
/note="Ig H chain V-region (V58)"
BASE COUNT 145 a 175 c 165 g 138 t
ORIGIN
1 cctccttttt cacctctccg tacaaaggca ccacccacat gcaaatcctt acttaagcac
61 ccacaggaaa tgactacaca tttccttaaa ttcagggtcc agctcacatg ggaagtgctt
121 tctgagagct catggacctc ctgcacaaga acatgaaaca cctgtggttc ttcctcctcc
181 tggtggcagc tcccagatgt gagtgtctca ggaatgcgga tatgaagaaa tggaagttgc
241 ctctgatccc agggctcact gtgggtttct ctgttcacag gggtcctgtc ccaggtgcag
301 ctacagcagt ggggcgcagg actgttgaag ccttcggaga ccctgtccct cacctgcgct
361 gtctatggtg ggtccgtcag tggttactac tggagctgga tccggcagcc cccagggaag
421 gggctggagt ggattgggta tatctattat agtgggagca ccaacaacaa cccctccctc
481 aagagtcgag ccaccatatc agtagacacg tccaagaacc agttctccct gaacctgagc
541 tctgtgaccg ccgcggacac ggccgtgtat tgctgtgcga gagacacagt gaggggaggt
601 gagtgtgagc ccagacaaaa acc
//GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVM 626 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human Ig germline H chain gene V-region (V79).
ACCESSION X05713
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup vh-iv; variable region.
SOURCE Human placentral DNA, clone V(79).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 626)
AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T.
TITLE A novel family of variable region genes of the human immunoglobulin
heavy chain
JOURNAL J. Mol. Biol. 195, 761-768 (1987)
STANDARD simple staff_review
COMMENT
[1] enum. 1 to 626.
Data kindly reviewed (24-NOV-1987) by HONJO T.
EMBL features not translated to GenBank features:
key from to description
TRANSCR <1 >626 primary transcript of V-region of
V region of heavy chain
SITE 382 399 pot. complementarity determining
region (cdr 1; AA 31 - 36)
SITE 442 489 pot. cdr 2 (AA 51 - 66)
IVS 586 >626 intron II
SITE 588 594 recombination signal
SITE 618 626 recombination signal
FEATURES Location/Qualifiers
CDS join(153..198,281..585)
/partial
/note="Ig H chain V-region (V79) precursor"
sig_peptide join(153..198,281..291)
/note="Ig H chain V-region signal peptide"
exon <153..198
/note="Ig H chain V-region (V79) precursor, exon 1
/hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'"
sig_peptide 153..198
/note="Ig H chain V-region signal peptide, exon 1"
intron 199..280
/note="Ig H chain intron A"
sig_peptide 281..291
/note="Ig H chain V-region signal peptide, exon 2"
exon 281..>585
/note="Ig H chain V-region (V79) precursor, exon 2"
mat_peptide 292..>585
/partial
/note="Ig H chain V-region (V79)"
BASE COUNT 141 a 180 c 172 g 133 t
ORIGIN Chromosome 14.
1 catccctttt cacctcttta tacaaaggca ccacctacat gcaaatcctc acttaggcac
61 ccacaggaaa ccaccacaca tttccttaaa ttcagggtcc agctcacatg ggaaatactt
121 tctgagagct catgggcctc ctgcacaaga acatgaaaca cctgtggttc ttcctcctcc
181 tggtggcagc tcccagatgt gagtgtctca aggctgcaga catgggggta tgggaggtgc
241 ctctgatccc agggctcact gtgggtctct ctgttcacag gggtcctgtc tcaggtgcag
301 ctgcaggagt cgggcccagg actggtgaag cctccgggga ccctgtccct cacctgcgct
361 gtctctggtg gctccatcag cagtagtaac tggtggagtt gggtccgcca gcccccaggg
421 aaggggctgg agtggattgg ggaaatctat catagtggga gcaccaacta caacccgtcc
481 ctcaagagtc gagtcaccat atcagtagac aagtccaaga accagttctc cctgaagctg
541 agctctgtga ccgccgcgga cacggccgtg tattgctgtg cgagagacac agtgagggga
601 ggtgagtgtg agcccagaca caaacc
//GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMIGHVN 622 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human Ig germline H chain gene V-region (V71-4).
ACCESSION X05711
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup vh-iv; variable region.
SOURCE Human placental DNA, clone V(71-4).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 622)
AUTHORS Lee,K.H., Matsuda,F., Kinashi,T., Kodaira,M. and Honjo,T.
TITLE A novel family of variable region genes of the human immunoglobulin
heavy chain
JOURNAL J. Mol. Biol. 195, 761-768 (1987)
STANDARD simple staff_review
COMMENT Data kindly reviewed (24-NOV-1987) by HONJO T.
EMBL features not translated to GenBank features:
key from to description
IVS 582 >622 intron II
SITE 584 590 recombination signal
SITE 614 622 recombination signal
FEATURES Location/Qualifiers
CDS join(152..197,280..581)
/partial
/note="Ig H chain V-region (V71-4) precursor"
sig_peptide join(152..197,280..290)
/note="Ig H chain signal peptide"
exon <152..197
/note="Ig H chain V-region (V71-4) precursor, exon 1
/hgml_locus_uid='LK0080M' /nomgen='IGHV' /map='14q32.33'"
sig_peptide 152..197
/note="Ig H chain signal peptide, exon 1"
intron 198..279
/note="Ig H chain intron A"
sig_peptide 280..290
/note="Ig H chain signal peptide, exon 2"
exon 280..>581
/note="Ig H chain V-region (V71-4) precursor, exon 2"
mat_peptide 291..>581
/partial
/note="Ig H chain V-region (V71-4)"
BASE COUNT 144 a 180 c 160 g 138 t
ORIGIN Chromosome 14.
1 cctccttttt cacctctcca tacaaaggca ccacccacat gcaaatcctc acttaagcac
61 ccacaggaaa ccaccacaca tttccttaaa ttcaggttcc agctcacatg ggaaatactt
121 tctgagagct ctggacctcc tgtgcaagaa catgaaacat ctgtggttct tccttctcct
181 ggtggcagct cccagatgtg agtatctcag ggatccagac atggggatat gggaggtgcc
241 tctgatccca gggctcactg tgggtctctc tgttcacagg ggtcctgtcc caggtgcagc
301 tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc acctgcactg
361 tctctggtgg ctccgtcagt agttactact ggagctggat ccggcagccc ccagggaagg
421 gactggagtg gattgggtat atctattaca gtgggagcac caactacaac ccctccctca
481 agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg aagctgagct
541 ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agacacagtg aggggaggtg
601 agtgtgagcc cagacaaaaa cc
//