GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMTCBYW 600 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human T-cell receptor aberrantly rearranged beta chain gene
V-region (V-D-J) V-beta-ATL12-1.
ACCESSION M11956
KEYWORDS T-cell receptor; T-cell receptor beta-chain; processed gene;
pseudogene; variable region; variable region.
SOURCE Human adult T-cell leukemia cell line ATL12 DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 600)
AUTHORS Ikuta,K., Ogura,T., Shimizu,A. and Honjo,T.
TITLE Low frequency of somatic mutation in beta-chain variable region
genes of human T-cell receptors
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 7701-7705 (1985)
STANDARD simple staff_review
COMMENT Aberrantly rearranged because of the extra nucleotide in the leader
peptide and the frameshift mutation in V-D-J recombination.
FEATURES Location/Qualifiers
CDS join(24..73,187..524)
/note="pseudo T-cell receptor beta-chain V-region (V-D-J)"
/codon_start=24
exon 24..73
/pseudo
/note="pseudo T-cell receptor beta-chain V-region (V-D-J),
exon 1 /nomgen='TCRB' /map='7q32 or 7q35'
/hgml_locus_uid='LP0151Q'"
misc_feature 73..73
/note="aberrantly inserted extra nucleotide"
intron 74..186
/note="pseudo TCRB intron A"
exon 187..524
/pseudo
/note="pseudo T-cell receptor beta-chain V-region (V-D-J),
exon 2"
intron 525..>600
/note="intron J-C (no splice consensus sequence)"
BASE COUNT 151 a 144 c 143 g 162 t
ORIGIN Chromosome 7.
1 tacgatttct ttctgagcca accatgtgcc tcagacttct ctgctgtgtg gccatttctt
61 tctggggagc caggtaaggc cctgttctga actggttgaa tttcagttcc aagactctct
121 ccggtggctg cagtatcaag ctccctcctg cgctttttct acagctgctc tctccttcct
181 ccacaggctc cacggacacc aaggtcaccc agagacctag acttctggtc aaagcaagtg
241 aacagaaagc aaagatggat tgtgttccta taaaagcaca tagttatgtt tactggtatc
301 gtaagaagct ggaagaagag ctcaagtttt tggtttactt tcagaatgaa gaacttattc
361 agaaagcaga aataatcaat gagcgatttt tagcccaatg ctccaaaaac tcatcctgta
421 ccttggagat ccagtccacg gagtcagggg acacagcact gtatttctgt gccagcagca
481 aagcttgtac gagggggagg ggatcagccc cagcattttg gtgatgggac tcgactctcc
541 atcctaggta agttgcagaa tcagggtggt atggccattg tcccttgaag gcagagttct
//