GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMTCBYV 800 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human T-cell receptor rearranged beta chain gene V-region (V-D-J)
V-beta-MT1-1.
ACCESSION M11954
KEYWORDS T-cell receptor; T-cell receptor beta-chain; diversity region;
joining region; processed gene; variable region; variable region.
SOURCE Human adult T-cell leukemia cell line MT-1 DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 800)
AUTHORS Ikuta,K., Ogura,T., Shimizu,A. and Honjo,T.
TITLE Low frequency of somatic mutation in beta-chain variable region
genes of human T-cell receptors
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 7701-7705 (1985)
STANDARD simple staff_review
FEATURES Location/Qualifiers
exon <47..107
/note="T-cell receptor V-region (V-D-J), exon 1
/nomgen='TCRB' /map='7q32 or 7q35'
/hgml_locus_uid='LP0151Q'"
CDS join(47..107,413..772)
/partial
/note="T-cell receptor V-region (V-D-J)"
/codon_start=47
intron 108..412
/note="TCRB intron A"
exon 413..>772
/note="T-cell receptor V-region (V-D-J), exon 2"
misc_recomb 715^716
/note="V-region end/D-region start"
misc_recomb 726^727
/note="D-region end/J-region start"
intron 773..>800
/note="intron J-C"
BASE COUNT 170 a 201 c 247 g 182 t
ORIGIN Chromosome 7.
1 ggtcacaact ctccccagag aaggtggtgt gaggccatca cggaagatgc tgctgcttct
61 gctgcttctg gggccaggta taagcctcct tctacctggg agcttgggtg ggcatgtgcg
121 tgtgttggca tggtcaagtg gtggccagca gggttgcaat gtggattgtt tatgctcatc
181 gaagggagag ggagaggccc tgctctctag aggtgtaaat ggtaaggtga aagccgccgg
241 tcagaggaga tgggggatta tggccctagg gagatgacgg gaagattgca caaaacaaac
301 aggactctcc aggagctggg agcacaggga gggagtgagg ctcagctctg cctggcgtcc
361 tgtctgactc ggctcccact gggctctcct ctctctctgg cttctgtctc agcaggctcc
421 gggcttggtg ctgtcgtctc tcaacatccg agctgggtta tctgtaagag tggaacctct
481 gtgaagatcg agtgccgttc cctggacttt caggccacaa ctatgttttg gtatcgtcag
541 ttcccgaaac agagtctcat gctgatggca acttccaatg agggctgcaa ggccacatac
601 gagcaaggcg tcgagaagga caagtttctc atcaaccatg caagcctgac cttgtccact
661 ctgacagtga ccagtgccca tcctgaagac agcagcttct acatctgcag tgctaaacta
721 gtaggtacag atacgcagta ttttggccca ggcacccggc tgacagtgct cggtaagcgg
781 gggctcccgt gaagcccggg
//GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMTCBYX 600 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human T-cell receptor rearranged beta chain gene V-region (V)
V-beta-MT1-2.
ACCESSION M11957
KEYWORDS T-cell receptor; T-cell receptor beta-chain; processed gene;
pseudogene; variable region; variable region.
SOURCE Human adult T-cell leukemia cell line MT1 DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 600)
AUTHORS Ikuta,K., Ogura,T., Shimizu,A. and Honjo,T.
TITLE Low frequency of somatic mutation in beta-chain variable region
genes of human T-cell receptors
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 7701-7705 (1985)
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS 412..562
/pseudo
/note="pseudo T-cell receptor V-region"
/codon_start=412
misc_recomb 501^502
/note="pseudo V-region end/D-region start"
misc_recomb 516^517
/note="D-region end/J-region start"
BASE COUNT 173 a 131 c 146 g 150 t
ORIGIN Chromosome 7.
1 agcttcattc ctgcctcttg tctggctcag cacatattgg tcataaaaca tattctggtt
61 gtaatataga actttatatt ctgactctga aacttgataa actgaaattt cagtgacacc
121 agcattcatg gacattgtgg ctaaaaagag agaacttagg aaatatactg atgtgtaacc
181 accagaaaaa ggcttaatgt agggtctagc aaaccaagtt caaggacgtc atacctgcac
241 ccatgacatg cctattccaa agaggcaaaa agctatagaa cagagaagtc aatggctggt
301 gagttcatgg tggtgtctcg gtgttggtgt tagctctgtt caggctgtta gaagaacaca
361 cagcggagaa ataatccagt caatgattca aggcaatcgt cttggaggaa gtgacttcta
421 aattggtcta tgaaggagaa tctcccccat tcctggagtc gcccagtcca gacctctctg
481 tacatttgca ccagcagtcc atggactagc gggattacag atacgcagta ttttggccca
541 ggcacccggc tgacagtgct cggtaagcgg gggctcccgt gaagccccgg aactggggag
//GenBank-Updates@genbank.bio.net (05/23/91)
LOCUS HUMTCBYU 600 bp ds-DNA PRI 23-MAY-1991
DEFINITION Human T-cell receptor rearranged beta chain gene V-region (V-D-J)
V-beta-ATL12-2.
ACCESSION M11952
KEYWORDS T-cell receptor; T-cell receptor beta-chain; diversity region;
joining region; processed gene; variable region; variable region.
SOURCE Human peripheral blood lymphocyte cell line ATL-12 DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 600)
AUTHORS Ikuta,K., Ogura,T., Shimizu,A. and Honjo,T.
TITLE Low frequency of somatic mutation in beta-chain variable region
genes of human T-cell receptors
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 7701-7705 (1985)
STANDARD simple staff_review
FEATURES Location/Qualifiers
exon <21..69
/note="T-cell receptor beta-chain V-region (V-D-J), exon 1
/nomgen='TCRB' /map='7q32 or 7q35'
/hgml_locus_uid='LP0151Q'"
CDS join(21..69,207..560)
/partial
/note="T-cell receptor beta-chain V-region (V-D-J)"
/codon_start=21
intron 70..206
/note="TCRB intron A"
exon 207..>560
/note="T-cell receptor beta-chain V-region (V-D-J), exon
2"
misc_recomb 503^504
/note="V-region end/D-region start"
misc_recomb 515^516
/note="D-region end/J-region start"
intron 561..>600
/note="intron J-C"
BASE COUNT 124 a 143 c 169 g 164 t
ORIGIN Chromosome 7.
1 catcctggcc tgaccctgcc atgggcacca ggctcctctg ctgggtggtc ctgggtttcc
61 tagggacagg tgagtcctca gaacaccaag tagtttcatt ttttctgttt gtaggtgtgt
121 gtgtgtgaga gagtggttgt gtgtgtgtgt gtgtatgatg actacaaata ttttccttat
181 tctgttgcca aattctattt ccacagatca cacaggtgct ggagtctccc agtcccctag
241 gtacaaagtc gcaaagagag gacaggatgt agctctcagg tgtgatccaa tttcgggtca
301 tgtatccctt ttttggtacc aacaggccct ggggcagggg ccagagtttc tgacttattt
361 ccagaatgaa gctcaactag acaaatcggg gctgcccagt gatcgcttct ttgcagaaag
421 gcctgaggga tccgtctcca ctctgaagat ccagcgcaca cagcaggagg actccgccgt
481 gtatctctgt gccagcagct tagggggggg gggcaatcag ccccagcatt ttggtgatgg
541 gactcgactc tccatcctag gtaagttgca gaatcagggt ggtatggcca ttgtcccttg
//