GenBank-Updates@genbank.bio.net (05/25/91)
LOCUS SERERYAB 20235 bp ds-DNA PLN 25-MAY-1991
DEFINITION S.erythraea second and third ORF's of eryA gene, complete cds.
ACCESSION M63677
KEYWORDS 6-deoxyerythronolide B; acyl carrier protein; acyltransferase;
beta-ketoacyl-ACP synthase I; beta-ketoreductase; dehydratase;
enoyl reductase; eryA gene.
SOURCE Saccharopolyspora erythraea () DNA.
ORGANISM Saccharopolyspora erythraea
Prokaryota; Bacteria; Firmicutes; Nocardioform actinomycetes.
REFERENCE 1 (bases 1 to 20235)
AUTHORS Donadio,S., Staver,M.J., McAlpine,J.B., Swanson,S.J. and Katz,L.
TITLE Modular Organization of Genes Required for Complex Polyketide
Biosynthesis
JOURNAL Science 252, 675-679 (1991)
STANDARD full automatic
FEATURES Location/Qualifiers
CDS 19..10722
/note="eryA ORF2 encoding modules 3 & 4 for
6-deoxyerythronolide B formation6-deoxyerythronolide B
formation"
/gene="eryA"
/codon_start=19
misc_feature 19..4470
/function="'approximate span of module 3'"
misc_feature 97..1482
/function="'approximate span of beta-ketoacyl ACP synthase
of module 3'"
misc_feature 1693..2670
/function="'approximate span of acyltransferase domain of
module 3'"
misc_feature 3406..3921
/function="'approximate span of beta-ketoreductase domain
of module 3, possibly non-functional'"
misc_feature 4171..4428
/function="'approximate span of acyl carrier domain of
module 3'"
misc_feature 4471..10722
/function="'approximate span of module 4'"
misc_feature 4471..5847
/function="'approximate span of beta-ketoacyl ACP synthase
domain of module 4'"
misc_feature 6054..7026
/function="'approximate span of acyltransferase domain of
module 4'"
misc_feature 7165..9216
/function="'approximate span of dehydratase and
enoylreductase domains of module 4'"
misc_feature 9433..9984
/function="'approximate span of beta-ketoreductase domain
of module 4'"
misc_feature 10225..10483
/function="'approximate span of acyl carrier domain of
module 4'"
CDS 10723..20235
/note="ORF3 encoding modules 5 & 6 for
6-deoxyerythronolide B formation"
/gene="eryA"
/codon_start=10723
misc_feature 10723..15165
/function="'approximate span of module 5'"
misc_feature 10831..12174
/function="'approximate span of beta-ketoacyl ACP
synthasedomain of module 5'"
misc_feature 12379..13350
/function="'approximate span of acyltransferase domain of
module 5'"
misc_feature 14062..14610
/function="'approximate span of beta-ketoreductase domain
of module 5'"
misc_feature 14857..15114
/function="'approximate span of acyl carrier domain of
module 5'"
misc_feature 15166..20235
/function="'approximate span of module 6'"
misc_feature 15172..16569
/function="'approximate span of beta-ketoacyl ACP
synthasedomain of module 6'"
misc_feature 16768..17721
/function="'approximate span of acyltransferase domain of
module 6 '"
misc_feature 18379..18921
/function="'approximate span of beta-ketoreductase domain
of module 6'"
misc_feature 19149..19398
/function="'approximate span of acy carrier domain of
module 6'"
misc_feature 19492..20235
/function="'approximate span of thioesterase domain of
module 6'"
BASE COUNT 2534 a 7194 c 7767 g 2740 t
ORIGIN
1 ccgccgattg gagaaaaggt gactgacagc gagaaggtgg cggagtacct ccgtcgggcg
61 acgctcgacc tgcgtgccgc ccggcagcgc atccgcgagc tggaatccga cccgatcgcc
121 atcgtcagca tggcctgccg cctgccgggc ggggtgaaca ccccgcagcg gctgtgggag
181 ctgctgcgcg agggcggtga gacgctgtcg ggcttcccca ccgaccgggg ctgggacctg
241 gcgcggctgc accaccccga cccggacaac cccggtacca gctacgtcga caagggcggg
301 ttcctcgacg acgcggcggg cttcgacgcg gagttcttcg gcgtctcgcc gcgcgaggcc
361 gcggccatgg acccgcagca gcggctgctg ctggagacga gctgggagct ggtggagaac
421 gccggcatcg acccgcactc gctgcgcggt accgcgaccg gcgtcttcct cggagtggcg
481 aagttcggct acggcgagga caccgccgcg gcggaggacg tcgagggcta ctcggtcacc
541 ggtgtggcgc ccgcggtcgc ctccggccgc atctcctaca ccatgggcct ggaggggccg
601 tcgatcagcg tcgacaccgc gtgctcgtcg tcgctggtgg cgctgcacct ggcggtcgag
661 tcgctgcgca agggcgagtc gtcgatggcg gtcgtcggcg gtgccgcggt gatggcgacc
721 ccgggggtgt tcgtcgactt cagccggcag cgcgcgctcg ccgccgacgg gcggtcgaag
781 gcgttcggtg ccggcgccga cgggttcggc ttctccgaag gcgtcaccct ggtcctgctc
841 gagcggctgt cggaggcgcg gcgaaacggg cacgaggtgc tggcggtggt tcgcggctcg
901 gcgctcaacc aggacggggc cagcaacggg ctttccgcgc cgagcgggcc cgcgcagcgc
961 agggtcatcc ggcaggccct cgagagctgc ggtctggagc ccggcgacgt cgacgcggtg
1021 gaggcgcacg gcaccggtac ggcgctcggc gacccgatcg aggcgaacgc gctgctggac
1081 acctacggcc gcgaccgcga cgccgaccgg ccgctctggc tgggctcggt gaagtccaac
1141 atcggccaca cccaggcggc agcgggcgtc accggcctgc tgaaggtggt cctggcgctg
1201 cgcaacgggg aactgcccgc gaccctgcac gtcgaggagc ccacgccgca cgtcgactgg
1261 tcgtccggcg gcgtggcgct gctggcgggc aaccagccgt ggcggcgcgg cgagcggact
1321 cggcgcgccc gtgtttccgc gttcgggatc agcgggacga atgcgcacgt gatcgtcgag
1381 gaagctcctg agcgcgagca ccgggagacc accgcgcacg acggccgacc ggttccgctg
1441 gtggtgtccg cgcgcacgac ggcggcgttg cgggcgcagg ccgcccagat cgccgagctg
1501 ctcgaacgcc cggacgccga cctcgccggg gtcgggctgg gcctggccac gacccgcgcc
1561 cgccacgagc accgcgccgc cgtggtggca tcgacccgcg aggaagcggt gcgcggactg
1621 cgggagatcg ccgccggtgc cgcgacggcc gacgccgtgg tcgagggcgt caccgaggtg
1681 gacgggcgca acgtcgtctt cctgttcccg gggcagggtt cgcaatgggc cggcatgggt
1741 gccgagctgc tgtcgtcgtc gccggtgttc gccgggaaga tccgggcctg cgacgagtcg
1801 atggccccga tgcaggactg gaaggtctcc gacgtgctgc gtcaggcgcc gggggcgccg
1861 ggcctggacc gggtcgacgt ggtgcagccg gtgttgttcg cggtgatggt gtcgctggcg
1921 gagctgtggc gctcgtacgg cgtggagccc gcggcggtcg tggggcactc gcagggcgag
1981 atcgccgccg cgcacgtcgc cggggcgctc acgttggagg acgcggcgaa gctcgtcgtg
2041 ggccgcagcc gcctgatgcg gtcgctctcc ggggagggcg gcatggccgc cgtcgcgctg
2101 ggcgaggccg cggtgcgcga gcgcctgcgg ccgtggcagg accggctctc ggtggccgcg
2161 gtcaacggtc cccggtcggt cgtggtctcc ggcgagcccg gcgcgctgcg ggcgttttcc
2221 gaggactgcg cggccgaggg catccgcgtc cgcgacatcg acgtggacta cgcctcgcac
2281 tcgccgcaga tcgagcgggt ccgcgaggaa ctcctcgaaa cgaccggcga catcgcgccg
2341 cgcccggcgc gggtgacgtt ccactccact gtggagtcgc ggtctatgga cggcaccgag
2401 ctggatgccc ggtactggta ccgcaacctg cgcgagacgg tgcgcttcgc cgacgccgtg
2461 acgcggctgg cggagtcggg atacgacgcg ttcatcgagg tcagcccgca tccggtcgtg
2521 gtccaggccg tcgaggaggc ggtcgaagag gctgacggtg ccgaagacgc ggtcgtagtc
2581 ggctcgctgc accgcgacgg cggtgacctc tcggccttcc tgcggtcgat ggccaccgcg
2641 cacgtgtccg gtgtggacat caggtgggac gtcgctctgc ccggcgccgc gcccttcgcg
2701 ctgccgacgt atccgttcca gcgcaagcgc tactggctcc agcccgccgc acccgccgcc
2761 gcctccgacg agctggccta ccgcgtttcc tggactccga tcgaaaagcc ggagtcggga
2821 aacctggacg gcgactggtt ggttgtcaca cccctcatca gtccggagtg gacggaaatg
2881 ctgtgcgagg ccatcaacgc caacggtggc agggcgttgc gctgcgaggt ggacacgtcc
2941 gcttcgcgca ctgagatggc ccaggccgtc gcacaggccg gaacgggatt ccggggcgtg
3001 ctctcgttgc tgtcgtcgga cgaatccgcc tgccgtccgg gggttcctgc cggtgcggtc
3061 ggcctgctca ccctggtcca ggcgctgggc gatgccgggg tcgacgcacc ggtgtggtgc
3121 ctgacccagg gtgcggtccg cactcccgcc gacgacgacc tcgcccggcc tgcgcagacc
3181 accgcgcacg gcttcgcgca ggtcgccggg ctggagctgc cgggccgctg gggcggtgtg
3241 gtcgacctgc ccgaatcggt cgacgacgcg gcgctgcgtc tgctcgtggc agtcctgcgc
3301 ggcggcggcc gtgccgagga ccacctcgcg gtccgggacg gccgcctcca cggccgtcgc
3361 gtcgtccgcg caagcctgcc gcagtccggc tcgcggagct ggaccccgca cgggaccgtg
3421 ctggtcaccg gcgcggcgag ccccgtcggc gaccaactgg tgcggtggct cgccgaccgg
3481 ggagccgagc ggctggtgct ggccggagcc tgtccgggcg acgacctgct ggccgcggtc
3541 gaggaagcgg gcgcatcggc cgtcgtgtgc gcccaggacg cggcggcgct gcgcgaggcg
3601 ctcggcgacg agccggtgac cgcgctcgtg cacgccggaa ccctgacgaa cttcggcagc
3661 atcagcgaag tcgcaccgga ggagttcgcc gagacgatcg cggccaagac cgcgttgctc
3721 gccgtgctgg acgaagtcct cggcgaccgg gccgtcgagc gggaggtcta ctgctcgtcg
3781 gtcgccggga tctggggcgg cgccgggatg gccgcctacg cggcaggcag cgcctacctc
3841 gacgcgctgg ccgagcacca ccgcgcgcgg ggccgctcgt gcacctcggt cgcctggacg
3901 ccgtgggcgc tgccgggcgg ggcggtggac gacggctacc tgcgggaacg cggactgcgc
3961 agcctctccg ccgacagggc gatgcgcacc tgggagcggg tgctggccgc cgggccggtg
4021 tcggtcgcgg tggccgacgt ggactggccg gtgctcagcg aaggcttcgc cgccacccgg
4081 ccgaccgcgc tgttcgccga actcgccggc cgcggcggac aggcggaggc cgagccggac
4141 agcggaccga ccggcgagcc ggcacaacgg ctcgcggggc tttccccgga cgagcagcag
4201 gaaaacctgc tcgaactcgt cgcgaacgcg gttgccgagg tgcttggcca cgagtccgcc
4261 gccgagatca acgtgcgccg cgcgttcagc gagctcggac tcgactcgct caacgcgatg
4321 gccctgcgca agcgcctgtc ggcgagcacc ggcctgcggc tgcccgcgtc gctggtgttc
4381 gaccacccca ccgtcaccgc gctcgcgcag cacctgcgcg cccggctcgt cggtgacgcc
4441 gaccaggccg cggtgcgcgt cgtcggcgcg gccgacgagt ccgagcccat cgccatcgtc
4501 ggcatcggct gccgtttccc cggcggcatc ggctcgcccg agcagttgtg gcgggtgctg
4561 gccgagggcg cgaacctcac caccggcttc ccggccgacc ggggctggga catcgggcgg
4621 ctctaccacc cggacccgga caaccccggc accagctacg tggacaaggg cgggttcctc
4681 accgacgcgg cggatttcga cccgggcttc ttcggcatca cgccccgcga agcgctggcg
4741 atggacccgc agcagcgcct catgctggag acggcgtggg aggcagtgga acgcgcgggc
4801 atcgaccccg acgccctgcg aggcaccgac accggcgtct tcgtcggcat gaacggccag
4861 tcctacatgc agctgctggc cggtgaggcc gaacgcgtcg acggctacca gggcctcgga
4921 aactccgcga gcgtgctctc cgggcgcatc gcctacacct tcggctggga gggcccggcg
4981 ctgacggtgg acaccgcgtg ctcgtcctcg ctggtcggca tccacctcgc gatgcaggcg
5041 ctgcggcgcg gtgagtgctc cctggcgctg gccggcggcg tcacggtcat gtccgacccg
5101 tacaccttcg tcgacttcag cacgcagcgc gggctcgcct ccgacggtcg ctgcaaggcg
5161 ttctccgcgc gggccgacgg cttcgcgctg tcggaaggcg tcgccgcgct ggtgctggag
5221 ccgctttccc gggcgcgcgc caacgggcac caggtgctgg ccgtgctgcg cggcagcgcg
5281 gtcaaccagg acggtgccag caacggtctc gccgctccca acggcccgtc gcaggagcgg
5341 gtgatccggc aggcgctcgc cgcttcgggc gtgccggccg cggacgtcga cgtcgtggag
5401 gcgcacggga cgggcaccga gctcggcgac ccgatcgagg ccggcgcgct catcgcgacc
5461 tacggccagg accgcgaccg gccgctgcgg ctcggctcgg tgaagaccaa catcggccac
5521 acccaggccg cggcgggcgc cgcgggcgtg atcaaggtcg tgctggcgat gcggcacggg
5581 atgctgcccc ggtcgttgca cgccgacgag ctgtccccgc acatcgactg ggagtcgggg
5641 gccgtggagg tgctgcgcga ggaggtgccg tggccggcgg gtgagcgccc ccggcgggcg
5701 ggggtgtcgt ccttcggcgt cagcggaacc aacgcgcacg tgatcgtcga agaggcacca
5761 gcagagcagg aggccgcccg caccgagcgc ggtccgctgc cgttcgtgct gtccggccgc
5821 agcgaagccg tggtcgcggc ccaggcccgc gcgctcgccg agcacctgcg cgacaccccg
5881 gagctcggcc tgaccgacgc ggcgtggacg ctcgcgaccg gcagggcgcg gttcgacgtg
5941 cgagccgccg tgctcggcga cgaccgcgcg ggcgtgtgcg cggagctgga cgcgctggcc
6001 gagggccgcc cgtcggccga cgccgtcgcg ccggtgacct ccgcgccgcg caagccggtc
6061 ctggtcttcc ccggccaggg cgcgcagtgg gtcggcatgg cacgcgatct gctggaatcc
6121 tccgaggtgt tcgccgagtc gatgagccgg tgcgccgagg cgctctcgcc gcacaccgac
6181 tggaagttgc tcgacgtcgt ccgcggcgac ggcggtcccg acccgcacga gcgcgtcgac
6241 gtgctccagc cggtgctctt ctcgatcatg gtctcgctgg ccgagctgtg gcgcgcgcac
6301 ggcgtgaccc cggccgccgt cgtcggccac tcgcagggcg agatcgccgc ggcgcacgtg
6361 gcgggcgcgc tgtcgctgga agccgccgcg aaggtggtgg ccctgcgcag ccaggtgttg
6421 cgcgagctcg acgaccaggg cggcatggtg tcggtcggcg cgtcccgcga cgagctggag
6481 accgtgctcg cgcgctggga cggccgtgtc gcggtggccg ccgtgaacgg gcctggcacc
6541 agcgtcgttg ccgggccgac cgcggagctg gacgagttct tcgccgaggc cgaggcgcgg
6601 gagatgaagc cgcgccggat cgccgtgcgc tacgcctccc actccccgga ggtggcgcgc
6661 atcgaggacc ggctcgcggc cgagctgggc accatcaccg ccgtgcgggg ctcggtgccg
6721 ctgcactcca cggtgaccgg cgaggtcatc gacacctccg cgatggacgc ctcctactgg
6781 taccgcaacc tgcgccgacc agtgctcttc gagcaggcgg tgcgcggtct ggtcgagcag
6841 ggcttcgaca ccttcgtcga ggtgagcccg cacccggtgc tgctgatggc ggtcgaggag
6901 accgccgagc acgcgggcgc ggaagtcacc tgcgtgccga cgctgcgccg cgagcagagc
6961 ggaccgcacg agttcctgcg caacctgctg cgggctcacg tgcacggcgt cggcgccgac
7021 ctgcgtccgg cggtggccgg gggacggccg gccgagctgc ccacctaccc gttcgaacac
7081 cagcgcttct ggccgcggcc gcaccggccc gccgacgtct cggcgctggg cgtgcgcggc
7141 gcggagcacc cgctgctgct cgccgcggtc gacgtgccgg gccacggcgg tgcggtgttc
7201 accggaaggc tttccaccga cgagcagccg tggctggccg aacacgtcgt gggcggccgg
7261 acgctggtgc cgggcagcgt cctggtcgat ctcgcgctcg ccgcgggtga ggacgtcggg
7321 ctgccggtcc tggaggaact ggtgttgcaa cggccgctgg tgctggccgg ggcgggggcg
7381 ctgctgcgca tgtcggtcgg cgcgcccgac gagtcggggc ggcggacgat cgacgtccac
7441 gccgccgaag acgtggccga cctcgccgac gcgcagtggt cgcagcacgc caccgggacg
7501 ctcgcgcagg gcgtcgccgc gggtccgagg gataccgagc agtggccgcc ggaggacgcc
7561 gtccgcatcc cgctcgacga ccactacgac ggcctcgccg agcagggcta cgagtacgga
7621 ccgtcgttcc aggccctgcg agccgcgtgg cgcaaggacg actcggtcta cgccgaggtg
7681 tccatcgcgg cggacgagga aggttacgcg ttccacccgg tgctgctcga cgccgtggcg
7741 cagacgctca gcctgggcgc cctcggcgag ccgggcgggg gaaagctgcc gttcgcgtgg
7801 aacaccgtga ccctgcacgc ctccggggcg acctcggtgc gggtcgtggc gacgcccgcc
7861 ggggcggacg cgatggccct gcgggtcacc gacccggcag gccacctggt cgccacggtc
7921 gactcgctgg tcgtccgcag caccggggag aagtgggagc agcccgaacc gcgcggtggc
7981 gagggcgagc tgcacgctct ggactgggga cggctagccg agcccggctc gaccggtcgt
8041 gtggtcgcgg ccgatgcctc ggacctcgac gccgtcctgc ggtccggtga acccgaaccc
8101 gacgcggtcc tggtccgcta cgaacccgaa ggcgacgacc cccgcgccgc ggcccgccac
8161 ggcgtcctct gggccgccgc gctcgtgcgc cgctggctcg aacaggagga gctgccgggc
8221 gcgacgctgg tcatcgccac gtccggcgcg gtcaccgtgt ccgacgacga cagcgttccc
8281 gaacccggcg ccgccgcgat gtggggcgtg atccgctgtg cgcaggccga gtcgccggac
8341 cggttcgtgc tcctcgacac cgacgcggaa cctgggatgc tgcctgcggt tccggacaac
8401 ccgcagctcg cgttgcgcgg cgacgacgtc ttcgtgccgc gcctctcgcc gctcgcacct
8461 tccgcgctga cgcttccggc aggcacccaa cgtctcgtgc cgggtgacgg ggcgatcgac
8521 tccgtggcct tcgagcccgc acccgacgtc gagcagccgc tccgggcggg cgaggtccgg
8581 gtggacgtgc gcgccaccgg agtcaacttc cgcgacgtcc tcctcgcact cggcatgtat
8641 ccgcagaagg cggacatggg caccgaggcc gccggtgtcg tcacggcggt cggaccggac
8701 gtggacgcct tcgcgccggg agaccgggtg ctcggcctgt tccagggagc cttcgcgccg
8761 atcgcggtca ccgatcaccg gctcctcgca cgagtgccgg acggctggag cgacgccgac
8821 gccgcggccg tgcccatcgc ctacaccacg gcgcattacg cgctgcacga tctcgcgggg
8881 ctgcgcgcgg gtcagtcggt gctcatccac gcagcggcag gcggtgtcgg catggcggcc
8941 gtcgcgctgg cccgccgagc gggggcggag gtgttggcca ccgccggccc ggccaagcac
9001 gggacgctgc gggcgctcgg tctcgacgac gagcacatcg cttcctcccg ggagaccggt
9061 ttcgcccgga agttccggga gcgcaccgga ggccgcggcg tggacgtggt gctcaactcg
9121 ctcaccgggg aactgctcga cgagtccgcg gatctgctcg ccgaggacgg cgtcttcgtc
9181 gagatgggca agaccgacct gcgggacgcc ggggacttcc ggggccgata cgccccgttc
9241 gacctcggcg aggcgggtga cgaccggctc ggggagatcc tgcgcgaggt cgtcggcctg
9301 ctgggcgccg gggagctcga ccggctcccg gtatcggcgt gggagctggg atccgcgccc
9361 gcggcgttgc agcacatgag ccggggcagg cacgtcggca agctcgtgct gacccagccc
9421 gcgccggtgg acccggacgg cacggtgctg atcacgggtg gcaccggcac gctcggacgg
9481 ctgctcgcgc gccacctcgt caccgagcac ggcgtgcggc acctgctgct ggtcagcagg
9541 cgcggcgcgg acgcgccggg ttccgacgag ctgcgcgcgg agatcgagga cttgggcgcg
9601 tccgcggaga tcgcggcttg cgacaccgcc gaccgcgacg cgctttcggc gctgctggac
9661 gggctgcccc ggccgctgac cggtgtcgtg cacgcggcgg gtgtgctggc cgacgggctg
9721 gtcacctcca tcgacgagcc ggcggtggag caggtgctgc gcgccaaggt cgacgcggcg
9781 tggaacctgc acgagctgac cgcgaacacc ggtctgagct tcttcgtgct gttctcgtcc
9841 gcggcgtcgg tgctagccgg cccggggcag ggcgtgtacg cggccgcgaa cgagtcgctc
9901 aacgcgctgg ctgccctccg gaggacgcgc ggccttcccg cgaaggcgct cggatgggga
9961 ctgtgggcgc aggccagcga gatgaccagc ggactcggcg accgcatcgc ccggaccggg
10021 gtcgccgcgc tgccgaccga gcgggcgctc gcactgttcg acagcgccct gcgccgcggc
10081 ggtgaggtcg tgttcccgct gtccatcaac cgttccgcgc tgcgcagggc cgagttcgtg
10141 ccggaggtcc tgcgcggcat ggtcagggcg aagctgcgcg ccgccgggca ggccgaggcg
10201 gcagggccga acgtggtcga ccggctcgcc ggtcggtccg agtccgacca ggtcgccggg
10261 ctggccgaac tggtgcgttc acacgcggcg gcggtctccg ggtacggctc ggccgaccag
10321 ctccccgagc gcaaggcgtt caaggacctc ggtttcgact cgctggccgc ggtggagctg
10381 cgcaaccgcc tcggtaccgc gaccggcgtg cggctgccca gcacgttggt gttcgaccac
10441 ccgactccgc tggcggtggc cgaacacctg cgggacaggc tgttcgcggc ctcaccggcg
10501 gtggacatcg gcgaccggct ggacgagctg gagaaggcgc tcgaagccct gtccgccgag
10561 gacgggcacg acgacgtggg ccagcgcctg gagtcgctgc tgcgccggtg gaacagcagg
10621 cgggcggacg ccccgagcac gtccgcgatc agcgaggacg ccagtgacga cgagctgttc
10681 tcgatgctcg accagcggtt cggcggggga gaggacctgt agatgagcgg tgacaacggc
10741 atgaccgagg aaaagctccg gcgctacctc aagcgcaccg tcaccgagct cgactcggtg
10801 accgcgcgcc tgcgtgaagt cgagcaccgg gccggtgagc cgatcgcgat cgtcggcatg
10861 gcgtgccggt tccccggcga cgtggactcg ccggagtcgt tctgggagtt cgtgtccggc
10921 ggcggggacg ccatcgcgga ggcccccgcc gaccgcggct gggagccgga ccccgacgcg
10981 cggctgggcg ggatgctcgc ggccgcgggc gacttcgacg cgggcttctt cgggatctcg
11041 ccgcgcgagg cgctggcgat ggacccgcag cagcggatca tgctggagat ctcgtgggag
11101 gcgctggagc gcgccggcca cgatccggtg tccctgcgcg gcagcgcgac cggggtgttc
11161 accggtgtcg gcaccgtgga ctacggcccg cgacccgacg aggccccgga cgaggtcctg
11221 ggctacgtcg gcaccggcac cgcctccagc gtcgcctccg gccgggtcgc ctactgcctg
11281 ggcctggaag gcccggcgat gaccgtcgac accgcctgtt cctccgggct caccgccctg
11341 cacctggcga tggagtcgct gcgccgggac gagtgcggcc tggcgctggc cggcggcgtg
11401 acggtgatga gcagtcccgg ggcgttcacc gagttccgca gccagggcgg gctcgccgcc
11461 gacggccgct gcaagccgtt ctcgaaggcc gccgacgggt tcggcctggc cgagggtgcc
11521 ggggtcctgg tgctgcaacg gctgtcggcc gcgcggcggg agggcagacc ggtgctggcc
11581 gtgctgcggg gctcggcggt caaccaggac ggcgccagca acgggctgac cgcgccgagc
11641 ggacccgcgc agcagcgggt catccgccgg gcgctggaga acgccggtgt ccgggcgggc
11701 gacgtcgact acgtggaggc ccacggcacc ggcaccaggc tgggcgaccc catcgaggtg
11761 cacgcgctgc tctcgaccta cggcgcggaa cgcgacccgg acgatccact gtggatcggt
11821 tcggtcaagt ccaacattgg ccacacccag gccgccgccg gcgtcgccgg ggtgatgaag
11881 gcggtgctgg cgctgcggca cggcgagatg ccgcgcacgc tgcacttcga cgagccctcg
11941 ccgcagatcg agtgggacct gggcgcggtg tcggtggtgt cgcaggcgcg gtcgtggccc
12001 gccggcgaga ggccccgcag ggcgggcgtc tcctcgttcg gcatcagcgg caccaacgcg
12061 cacgtcatcg tcgaagaggc gcccgaggcc gacgagcccg agccggcacc cgactcgggt
12121 ccggtcccgc tggtgttgtc cggccgcgac gagcaggcga tgcgggcgca ggcgggacgg
12181 ctggcagacc acctcgcccg cgagccgcgg aactcgttgc gcgacaccgg tttcacgctg
12241 gccacccgcc gcagcgcgtg ggagcaccgc gcggtggtgg tcggcgaccg cgacgacgcc
12301 ctcgccgggc tgcgcgcggt ggccgacggc cgcatcgccg accggacggc caccgggcag
12361 gcccgaactc gccgcggcgt cgcgatggtg ttccccggcc agggcgcgca gtggcagggg
12421 atggcccgcg acctgctgcg ggagtcgcag gtattcgccg actcgatccg cgactgcgag
12481 cgggcgctgg ccccgcacgt cgactggtcg ctgaccgacc tgctcagcgg cgcgcgaccg
12541 ctggaccggg tcgacgtcgt ccagcccgcg ctcttcgccg tcatggtgtc gctggcggcg
12601 ctgtggcgct cccacggcgt cgagcccgcc gcggtcgtcg gccactcgca gggcgagatc
12661 gccgccgcgc acgtcgccgg cgcgctcacc ctggaggacg ccgccaagct cgtcgcggtc
12721 cggagccggg tcctggcccg gctcggcggc cagggcggca tggcgtcgtt cgggctgggc
12781 accgagcagg cggccgaacg gatcgggcgc ttcgcgggcg cgctctccat cgcctcggtc
12841 aacggccccc ggtcggtcgt cgtcgcgggg gagagcgggc cgctggacga gctgatcgcc
12901 gagtgcgagg ccgaaggcat aacggcgcgc cgcatccccg tcgactacgc ctcccactca
12961 ccgcaggtgg agtcgctgcg cgaggagctg ctgaccgagc tggcgggcat ctccccggtg
13021 tcggcggacg tggcgctcta ctcgaccacg accgggcagc ccatcgacac cgccacgatg
13081 gacaccgcct actggtacgc gaacctgcgc gagcaggtcc gcttccagga cgcgacgcgg
13141 cagctcgccg aggcggggtt cgacgcgttc gtcgaggtca gcccgcatcc ggtgctgacc
13201 gtcggcatcg aggccacgct ggactccgcg ctcccggccg acgccggcgc ctgcgtcgtg
13261 ggcaccctgc ggcgggaccg cggcggcctg gccgacttcc acaccgcgct cggcgaggcg
13321 tacgcgcagg gcgtggaggt cgactggagc cccgccttcg ccgacgcgcg gccggtcgag
13381 ctgcccgtct acccgttcca gcggcagcgg tactggctgc ccatccccac cggcgggcgc
13441 gcacgggacg aggacgacga ctggcgctac caggtcgtat ggcgggaagc cgagtgggag
13501 agcgcttcgc tggccggacg cgtgctgctg gtgaccggac cgggcgtgcc gtccgagttg
13561 tcggacgcca tccgaagtgg actggagcag agcggtgcga cggtcctgac ctgcgacgtg
13621 gaatcccgtt cgaccatcgg caccgcactg gaggccgccg acaccgacgc tctgtccact
13681 gtggtgtcgc tgctgtcccg cgacggcgag gccgtcgatc cgtcgctgga cgcgctcgcc
13741 ctggtccagg ccctcggagc ggccggggtc gaagcaccgc tgtgggtgct gacccgcaac
13801 gccgtgcagg tggccgacgg cgaactggtc gatccggcgc aggccatggt gggcggtctc
13861 ggccgcgtgg tcggcatcga gcagccgggg cgctggggcg gtctggtgga cctggtcgac
13921 gccgatgccg cgtcgatccg gtcgctggcc gcggtgctgg cggacccgcg cggcgaggag
13981 caggtcgcga tccgggcgga cgggatcaag gtggcgaggc tcgtgcccgc ccccgcccgc
14041 gccgcacgca cccgctggag ccctcgcggc accgtgctgg tcaccggcgg caccggaggg
14101 atcggcgcgc acgtcgcccg ctggctggcc cgctcgggcg ccgagcacct ggtgctgctg
14161 ggcaggcgcg gtgccgacgc acccggcgcg tccgagctga gggaggagct gaccgcgctc
14221 ggcacgggcg tgaccatcgc cgcctgcgac gtcgccgacc gggcgcggct cgaagcggtg
14281 ctcgccgcgg agcgcgccga gggacgcacg gtcagcgccg tgatgcacgc ggcgggggtt
14341 tccacgtcca cgcccctcga cgacctcacc gaagccgagt tcaccgagat cgccgacgtg
14401 aaggtgcgcg gcaccgtcaa cctggacgag ctctgcccgg acctcgacgc gttcgtgttg
14461 ttctcctcca acgcgggcgt gtggggcagt ccggggctcg cctcctacgc ggcggccaac
14521 gccttcctcg acggcttcgc gcggcggcgc cggagcgagg gcgcgccggt gacgtccatc
14581 gcctgggggc tctgggccgg gcagaacatg gccggggacg agggcggcga gtacctgcgc
14641 agccagggcc tgcgggccat ggacccggat cgggccgtcg aggaactgca catcaccctc
14701 gaccacggtc agacgtccgt gtcggtcgtg gacatggatc gcaggcggtt cgtcgagctg
14761 ttcaccgcgg cccggcaccg gccgctgttc gacgagatcg ccggtgcccg ggcggaagcc
14821 cggcagagcg aggagggccc ggcgctcgcc cagcggctcg cggcgctgtc gacggccgag
14881 aggcgcgagc acctcgccca cctgatccgc gccgaggtcg ccgcggtgct cggccacggc
14941 gacgacgcgg cgatcgaccg cgaccgcgcc ttccgcgacc tcggcttcga ctccatgacc
15001 gccgtcgacc tgcggaaccg gctcgccgcg gtgaccgggg tgcgggaagc cgcgacggtg
15061 gtcttcgacc acccgaccat cacccggctc gccgaccact acctggagcg gctcgtcggc
15121 gcagcagagg cggagcaagc cccggcgctc gtgcgcgagg tgccgaagga tgccgacgac
15181 ccgatcgcga tcgtcggcat ggcctgccgc ttccccggcg gcgtgcacaa ccccggtgag
15241 ctgtgggagt tcatcgtcgg ccgcggagac gccgtgacgg agatgcccac cgaccgcggc
15301 tgggacctcg acgcgctgtt cgaccccgac ccgcagcgcc acggaaccag ctactcgcga
15361 cacggcgcgt tcctcgacgg ggccgccgac ttcgacgcgg cgttcttcgg gatctcgccg
15421 cgcgaggcgc tggcgatgga cccgcagcag cgccaggtcc tggaaacgac gtgggagctg
15481 ttcgagaacg ccggcatcga cccgcactcg ctgcggggca gcgacaccgg cgtcttcctc
15541 ggcgccgcgt accagggcta cggccaggac gcggtggtgc ccgaggacag cgagggctac
15601 ctgctcaccg gcaactcctc cgccgtggtg tccggccggg tcgcctacgt gctggggctg
15661 gaaggccccg cggtcacggt ggacacggcg tgttcgtcgt cgttggtggc cttgcattcg
15721 gcgtgtgggt cgttgcgtga cggtgactgc ggtcttgcgg tggccggtgg tgtgtcggtg
15781 atggcgggcc cggaggtgtt caccgagttc tcccgccagg gcggcttggc cgtggacggg
15841 cgctgcaagg cgttctccgc ggaggccgac ggcttcggtt tcgccgaggg cgtcgcggtg
15901 gtcctgctcc agcggttgtc cgacgcccgc agggcgggtc gccaggtgct cggcgtggtc
15961 gcgggctcgg cgatcaacca ggacggcgcg agcaacggtc tcgcggcgcc gagcggcgtc
16021 gcccagcagc gcgtgatccg caaggcgtgg gcgcgtgcgg ggatcaccgg cgcggatgtg
16081 gccgtggtgg aggcgcatgg gaccggtacg cggctgggcg atccggtgga ggcgtcggcg
16141 ttgctggcta cttacggcaa gtcgcgcggg tcgtcgggcc cggtgctgct gggttcggtg
16201 aagtcgaaca tcggtcacgc gcaggcggcc gcgggtgtcg cgggcgtgat caaggtggtc
16261 ctggggttga accgcggcct ggtgccgccg atgctctgcc gcggcgagcg gtcgccgctg
16321 atcgaatggt cctcgggtgg tgtggaactt gccgaggccg tgagcccgtg gcctccggcc
16381 gcggacgggg tgcgccgggc cggtgtgtcg gcgttcgggg tgagcgggac gaacgcgcac
16441 gtgatcatcg ccgagccccc ggagcccgag ccgctgccgg aacccggacc ggtgggcgtg
16501 ctggccgctg cgaactcggt gcccgtactg ctgtcggcca ggaccgagac cgcgttggca
16561 gcgcaggcgc ggctcctgga gtccgcagtg gacgactcgg ttccgttgac ggcattggct
16621 tccgcgctgg ccaccggacg cgcccacctg ccgcgtcgtg cggcgttgct ggcaggcgac
16681 cacgaacagc tccgcgggca gttgcgagcg gtcgccgagg gcgttgcggc tcccggtgcc
16741 accaccggaa ccgcctccgc cggcggcgtg gttttcgtct tcccaggtca gggtgctcag
16801 tgggagggca tggcccgggg cttgctctcg gtccccgtct tcgccgagtc gatcgccgag
16861 tgcgatgcgg tgttgtcgga ggtggccggg ttctcggcct ccgaagtgct ggagcagcgt
16921 ccggacgcgc cgtcgctgga gcgggtcgac gtcgtacagc cggtgttgtt ctccgtgatg
16981 gtgtcgctgg cgcggctgtg gggcgcttgc ggagtcagcc cctcggccgt catcggccat
17041 tcgcagggcg agatcgccgc cgcggtggtg gccggggtgt tgtcgctgga ggacggcgtg
17101 cgcgtcgtgg ccctgcgcgc gaaggcgttg cgtgcgctgg cgggcaaggg cggcatggtc
17161 tcgttggcgg ctcccggtga acgcgcccgc gcgctgatcg caccgtggga ggaccggatc
17221 tccgtcgcgg cggtcaactc cccgtcctcg gtcgtggtct ccggcgatcc ggaggcgctg
17281 gccgaactcg tcgcacgttg cgaggacgag ggcgtgcgcg ccaagacgct cccggtggac
17341 tacgcctcgc actcccgcca cgtcgaggag atccgcgaga cgatcctcgc cgacctcgac
17401 ggcatctccg cgcggcgtgc cgccatcccg ctctactcca cgctgcacgg cgaacggcgc
17461 gacggcgccg acatgggtcc gcggtactgg tacgacaacc tgcgctccca ggtgcgcttc
17521 gacgaggcgg tctcggccgc cgtcgccgac ggtcacgcca ccttcgtcga gatgagcccg
17581 cacccggtgc tcaccgcggc ggtgcaggag atcgccgcgg acgccgtggc catcgggtcg
17641 ctgcaccgcg acaccgcgga ggagcacctg atcgccgagc tcgcccgggc gcacgtgcac
17701 ggcgtggccg tggactggcg gaacgtcttc ccggcggcac ctccggtggc gctgcccaac
17761 tacccgttcg agccccagcg gtactggctc gcgccggagg tgtccgacca gctcgccgac
17821 agccgctacc gcgtcgactg gcgaccgctg gccaccacgc cggtggacct ggaaggcggc
17881 ttcctggtcc acgggtccgc accggagtcg ctgaccagcg cagtcgagaa ggccggaggc
17941 cgcgtcgtgc cggtcgcctc ggccgaccgc gaagcctcgg cggccctgcg ggaggtgccg
18001 ggcgaggtcg ccggcgtgct ctcggtccac accggcgccg caacgcacct cgccctgcac
18061 cagtcgctgg gtgaggccgg cgtgcgggcc ccgctctggc tggtcaccag ccgagcggtc
18121 gcgctcgggg agtccgagcc ggtcgatccc gagcaggcga tggtgtgggg tctcgggcgc
18181 gtcatgggcc tggagacccc ggaacggtgg ggcggtctgg tggacctgcc cgccgaaccc
18241 gcgccggggg acggcgaggc gttcgtcgcc tgcctcggcg cggacggcca cgaggaccag
18301 gtcgcgatcc gtgaccacgc ccgctacggc cgccgcctcg tccgcgcccc gctgggcacc
18361 cgcgagtcga gctgggagcc ggcgggcacg gcgctggtca ccggcggcac cggtgcgctc
18421 ggcggccacg tcgcccgcca cctcgccagg tgcggggtgg aggacctggt gctggtcagc
18481 aggcgcggcg tcgacgctcc cggcgcggcc gagctggaag ccgaactggt cgccctcggc
18541 gcgaagacga ccatcaccgc ctgcgacgtg gccgaccgcg agcagctctc caagctgctg
18601 gaagaactgc gcgggcaggg acgtccggtg cggaccgtcg tgcacaccgc cggggtgccc
18661 gaatcgaggc cgctgcacga gatcggcgag ctggagtcgg tctgcgcggc gaaggtgacc
18721 ggggcccggc tgctcgacga gctgtgcccg gacgccgaga ccttcgtcct gttctcgtcc
18781 ggagcggggg tgtggggcag tgcgaacctc ggcgcctact ccgcggccaa cgcctacctc
18841 gacgcgctgg cccaccgccg ccgtgcggaa ggccgtgcgg cgacgtccgt cgcgtggggc
18901 gcctgggcgg gcgagggcat ggccaccggc gacctcgagg ggctcacccg gcgcggcctg
18961 cgcccgatgg cgcccgagcg cgcgatccgc gcgctgcacc aggcgctgga caacggcgac
19021 acgtgcgttt cgatcgccga cgtcgactgg gaggccttcg cggtcggctt caccgccgcc
19081 cggccgcgtc cgctgctgga cgagctcgtc acgccggcgg tgggggccgt ccccgcggtg
19141 caggcggccc cggcgcggga gatgacgtcg caggagttgc tggagttcac gcactcgcac
19201 gtcgcggcga tcctcgggca ttccagcccg gacgcggtcg ggcaggacca gccgttcacc
19261 gagctcggct tcgactcgct gaccgcggtc gggctgcgca accagctcca gcaggccacc
19321 gggctcgcgc tgcccgcgac cctggtgttc gagcacccca cggtccgcag gttggccgac
19381 cacataggac agcagctcga cagcgggact cccgcccggg aagcgagcag cgctcttcgc
19441 gacggctacc ggcaggcggg cgtgtcgggc agggtccggt cctacctcga cctgctggcg
19501 gggctgtcgg acttccgcga gcacttcgac ggctccgacg ggttctccct cgatctcgtg
19561 gacatggccg acggtcccgg agaggtcacg gtgatctgct gcgcgggaac ggcggcgatc
19621 tccggtccgc acgagttcac ccggctcgcc ggggcgctgc gcggaatcgc tccggttcgg
19681 gccgtgcccc agcccggcta cgaggagggc gaacctctgc cgtcgtcgat ggcggcggtg
19741 gcggcggtgc aggccgatgc ggtcatcagg acacaggggg acaagccgtt cgtggtggcc
19801 ggtcactccg cgggggcact gatggcctac gcgctggcga ccgaactgct cgatcgcggg
19861 cacccgccac gcggtgtcgt cctgatcgac gtctacccgc ccggtcacca ggacgcgatg
19921 aacgcctggc tggaggagct gaccgccacg ctgttcgacc gcgagacggt gcggatggac
19981 gacaccaggc tcaccgccct gggcgcctac gaccgcctca ccggtcagtg gcgaccccgg
20041 gaaaccgggc tgccgacgct gctggtcagc gccggcgagc cgatgggtcc gtggcccgac
20101 gacagctgga agccgacgtg gcccttcgag cacgacaccg tcgccgtccc cggcgaccac
20161 ttcacgatgg tgcaggaaca cgccgacgcg atcgcgcggc acatcgacgc ctggctgggc
20221 ggagggaatt catga
//