GenBank-Updates@genbank.bio.net (05/25/91)
LOCUS HUMP450AL 2936 bp ss-mRNA PRI 25-MAY-1991
DEFINITION Human CYPXIB2 gene for aldosterone synthase.
ACCESSION X54741
KEYWORDS CYPXIB2 gene; aldosterone.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2936)
AUTHORS Kawamoto,T.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Kawamoto,T., Mitsuuchi,Y., Ohnishi,T., Ichikawa,Y., Yokoyama,Y.,
Sumimoto,H., Toda,K., Miyahara,K., Kuribayashi,I., Nakao,K.,
Hosoda,K., Yamamoto,Y., Imura,H. and Shizuta,Y.
TITLE Cloning and expression of a cDNA for human cytochrome P-450(aldo)
as related to primary aldosteronism
JOURNAL Biochem. Biophys. Res. Commun. 173, 309-316 (1990)
STANDARD full staff_review
COMMENT *source: tissue=adrenal tumor; library=lambda gt10;
Data kindly reviewed (28-FEB-1991) by Kawamoto T.
From EMBL 26 entry HSP450AL; dated 16-APR-1991.
FEATURES Location/Qualifiers
mat_peptide 4..1512
/product="aldosterone synthase (P-450aldo)"
/gene="human CYPXIB2"
CDS 4..1515
/product="aldosterone synthase (P-450aldo)"
/gene="human CYPXIB2"
/codon_start=4
polyA_signal 2919..2924
BASE COUNT 608 a 872 c 829 g 627 t
ORIGIN
1 ggaatggcac tcagggcaaa ggcagaggtg tgcgtggcag cgccctggct gtccctgcaa
61 agggcacggg cactgggcac tagagccgct cgggccccta ggacggtgct gccgtttgaa
121 gccatgcccc agcatccagg caacaggtgg ctgaggctgc tgcagatctg gagggagcag
181 ggttatgagc acctgcacct ggagatgcac cagaccttcc aggagctggg gcccattttc
241 aggtacaact tgggaggacc acgcatggtg tgtgtgatgc tgccggagga tgtggagaag
301 ctgcaacagg tggacagcct gcatccctgc aggatgatcc tggagccctg ggtggcctac
361 agacaacatc gtgggcacaa atgtggcgtg ttcttgttga atgggcctga atggcgcttc
421 aaccgattgc ggctgaaccc agatgtgctg tcgcccaagg ccgtgcagag gttcctcccg
481 atggtggatg cagtggccag ggacttctcc caggccctga agaagaaggt gctgcagaac
541 gcccggggga gcctgaccct ggacgtccag cccagcatct tccactacac catagaagcc
601 agcaacttag ctctttttgg agagcggctg ggcctggttg gccacagccc cagttctgcc
661 agcctgaact tcctccatgc cctggaggtc atgttcaaat ccaccgtcca gctcatgttc
721 atgcccagga gcctgtctcg ctggatcaga cccaaggtgt ggaaggagca ctttgaggcc
781 tgggactgca tcttccagta cggtgacaac tgtatccaga aaatctacca ggaactggcc
841 ttcaaccgcc ctcaacacta cacaggcatc gtggcagagc tcctgttgaa ggcggaactg
901 tcactagaag ccatcaaggc caactctatg gaactcactg cagggagcgt ggacacgaca
961 gcgtttccct tgctgatgac gctctttgag ctggctcgga accccgacgt gcagcagatc
1021 ctgcgccagg agagcctggc cgccgcagcc agcatcagtg aacatcccca gaaggcaacc
1081 accgagctgc ccttgctgcg ggcggccctc aaggagacct tgcggctcta ccctgtgggt
1141 ctgtttttgg agcgagtggt gagctcagac ttggtgcttc agaactacca catcccagct
1201 gggacattgg tacaggtttt cctctactcg ctgggtcgca atgccgcctt gttcccgagg
1261 cctgagcggt ataatcccca gcgctggcta gacatcaggg gctccggcag gaacttccac
1321 cacgtgccct ttggctttgg catgcgccag tgcctcgggc ggcgcctggc agaggcagag
1381 atgctgctgc tgctgcacca cgtgctgaag cacttcctgg tggagacact aactcaagag
1441 gacataaaga tggtctacag cttcatattg aggcctggca cgtcccccct cctcactttc
1501 agagcgatta actagtcttg catctgcacc cagggtccca gcctggccac cagcttccct
1561 ctgcctgacc ccaggccacc tgtcttctct cccacatgca cagcttcctg agtcacccct
1621 ctgtccagcc agctcctgca caaatggaac tccccagggc ctccaggact ggggcttgcc
1681 aggcttgtca aatagcaagg ccagggcaca gctggagacg atcttgctgg cagggcctgg
1741 ccttgtcccc agccccacct ggccccttct ccagcaagca gtgccctctg gacagcttga
1801 ctctactccc agcgctggct ccaggctcct catgaggcca tgcaagggtg ctgtgatttt
1861 gtcccttgcc ttcctgccta gtctcacatg tccctgtccc tctcgccctg gccagggcct
1921 ctgtgcagac agtgtcagag tcattaagcg ggatcccagc atctcagagt ccagtcaagt
1981 tccctcctgc agcctgaccc caggcagctc gagcatgccc tgagctctct gaaagttgtc
2041 accctggaat acgatcctgc agggtagact aaaaaggccc ctgtggtcac ttatcctgac
2101 acattttcaa gtgatacaac tgagtctcga ggggcgtgtg ttccccagct gatcatgtca
2161 gcctcatgcc ccaggcctcg tctttcatgg accaggtctt gttcaagcag cgagtgttgg
2221 gtcctctgct tcctgagctg tcccctggag aaggtcccga ggatgctgtc aggagatgga
2281 agagtcatgt ggggtgggaa cctggggtgt ggttccagaa atgtttttgg caacaggaga
2341 gacaggattg ggccaacaag gactcagatg agttttattg actcattcct ctggttgata
2401 cggagccatg tcatgtgcca cgacctgggg tgggcacagg gaggctgcag ttccctacgt
2461 gaacctgcct tgggcctcat ctgctcctag cccagcagag agagttgacc cctcctgaac
2521 tggccactcc ccagtgctcc tgtgcaggga taggaagtgc cccagggtga gaacgtgccc
2581 agccacatca tctttatctc ctgggatttt cattagggca aagatctcag cagccagctc
2641 ctggtagctg atgaggatca gagcgtttgt tcccccatga aaggggaaat acttaggtaa
2701 tcattccagg tgtgttcagt agttccagga ctcagggact caggccagtc accctgtgac
2761 cgcaggttgc tttcccaccc tgggcaatgc agtgcagcat gggaaaggaa taagggggca
2821 acaaggtgca cagacctcag agatggcttc cttgtttatg gggctctcac agatacccat
2881 ccaactcctc tagtcagcac tagatcatgg gatcctaaaa taaaccttgg aaaaat
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