GenBank-Updates@genbank.bio.net (05/25/91)
LOCUS HUMAPOA2B 1755 bp ds-DNA PRI 25-MAY-1991
DEFINITION Human DNA for apolipoprotein A-II
ACCESSION X02619
KEYWORDS apolipoprotein; apolipoprotein A-II;
restriction fragment linked polymorphism; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1755)
AUTHORS Lackner,K.J., Law,S.W. and Brewer,H.B.
TITLE The human apolipoprotein A-II gene: complete nucleic acid sequence
and genomic organization
JOURNAL Nucleic Acids Res. 13, 4597-4608 (1985)
STANDARD full automatic
COMMENT SWISS-PROT; P02652; APA2$HUMAN.
*source: library=placental lambda Charon28;
From EMBL 26 entry HSAPOA2B; dated 24-APR-1991.
FEATURES Location/Qualifiers
promoter 119..127
/note="pot. CAT box"
repeat_unit 133..140
/note="inverted repeat a"
repeat_unit 143..150
/note="inverted repeat a'"
promoter 169..174
/note="pot. TATA box"
precursor_RNA 198..1540
/note="primary transcript"
mRNA 198..231
/note="exon 1"
intron 232..413
/note="intron I"
mRNA 414..489
/note="exon 2"
CDS 438..498
/note="precursor potein"
/codon_start=438
CDS 438..489
/note="signal peptide (aa -18 to -2) (489 is 1st base in
codon)"
/codon_start=438
intron 490..782
/note="intron II"
misc_feature 745..776
/note="GT(16) repeat, pot. z-DNA region"
mRNA 783..915
/note="exon 3"
CDS 783..915
/note="precursor protein"
/codon_start=783
CDS 783..784
/note="signal peptide (aa -1) (783 is 2nd base in codon)"
/codon_start=783
CDS 785..915
/note="proapolipoprotein A-II (aa 1-44) (915 is 2nd base
in codon)"
/codon_start=785
CDS 785..799
/note="propeptide (aa 1-5)"
/codon_start=785
CDS 800..915
/note="mature apolipoprotein A-II (aa 6-44) (915 is 2nd
base in codon)"
/codon_start=800
intron 916..1310
/note="intron III"
mRNA 1311..1540
/note="exon 4"
CDS 1311..1425
/note="mature apolipoprotein A-II (aa 45-82) (1311 is 3rd
base in codon)"
/codon_start=1311
misc_feature 1521..1526
/note="put. polyA signal"
polyA_site 1540..1540
/note="polyA site"
BASE COUNT 449 a 434 c 496 g 376 t
ORIGIN
1 gcctccacta agagctgtac cccctgcctc tcaccccatc accatgagtc ttcatgtgct
61 tgtcctctcc tcccccattt ctccaacttg tttatcctca cataatcccg ccccactggg
121 cccatccata gtccctgtca cctgacaggg ggtgggtaaa cagacaggta tatagcccct
181 tcctctccag ccaaggcagg cacagacacc aaggacagag acgctggcta ggtaagataa
241 ggaggtaaga taaggaggca agatgtgtga gcagcatcca aagaggcttg ggcttcagtt
301 gtggagaggg agagagctag gttggaatgg gcagcaggta gggagatccc tggggaggag
361 ctgaagccca tttggcttca gtgtccccca aacccccacc accctcttcc taggccgccc
421 tccccactgt taccaacatg aagctgctcg cagcaactgt gctactcctc accatctgca
481 gccttgaagg tgggtgtgat atggagaggg ggccaaaagg gagaatgtgc tggtggttat
541 agctacctat ctgcctgtgc tcttatatcc aggtctggca accaaagggc tcaaaaggaa
601 gatcattccc tctctaaagc ccagaaagcc catccaaaga tctggctgga tacctttttg
661 gggagggggc agagagctgg ggtgggtact ggcagaggta tggcaggagg ccaggattca
721 ctgctgtgga cccagctgaa aagagtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgggc
781 aggagctttg gttcggagac aggcaaagga gccatgtgtg gagagcctgg tttctcagta
841 cttccagacc gtgactgact atggcaagga cctgatggag aaggtcaaga gcccagagct
901 tcaggccgag gccaagtaag tctcagggca aggggttcag gggctgtgga actgtggaga
961 gaaagaaggg aagatgagag gtcccacaga agtctgaacc caggggtggg gattagggca
1021 gattaggctt aaattgcaga gaaaaagtat ttcatcaccc aaagatccca cacgtctctt
1081 agatagagag gaacagcaag aactgggcct tgaatttcag tctctagagt ctgtccctct
1141 acctagcaaa ggtcttgact ctattcctac ctaggggctt tgccatgcga tggaccaggc
1201 actagagttt ggggacctga gtcagtctgc tctgacctcc caccaccacc aaggcccctg
1261 ccagtgccta gggtccctca gattaaactc taatcccctc acctatccag gtcttacttt
1321 gaaaagtcaa aggagcagct gacacccctg atcaagaagg ctggaacgga actggttaac
1381 ttcttgagct atttcgtgga acttggaaca cagcctgcca cccagtgaag tgtccagacc
1441 attgtcttcc aaccccagct ggcctctaga acacccactg gccagtccta gagctcctgt
1501 ccctacccac tctttgctac aataaatgct gaatgaatcc agctctgagc ctggtatgtt
1561 tgggggactg ggaaaagtag gggagtaagg gaggagaaga ggaaggaaaa ggaaaaatct
1621 gcttctagaa ggagagaggt ttgagtgtgg aggggtgaag aaaggattga agacacaact
1681 gatgaaaatg acaggatgag ggtgccatga ttctccaaac ccagagtctc ctacagcttg
1741 ggcacgactc tgcag
//