GenBank-Updates@genbank.bio.net (05/25/91)
LOCUS HUMIGFACI 7260 bp ss-mRNA PRI 25-MAY-1991
DEFINITION Human IGF-I mRNA for insulin-like growth factor I
ACCESSION X57025
KEYWORDS insulin-like growth factor i.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 7260)
AUTHORS Steenbergh,P.H.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 7260)
AUTHORS Steenbergh,P.H., Koonen-Reemst,A., Cleutjens,C. and Sussenbach,J.S.
TITLE Complete nucleotide sequence of the high molecular weight human
IGF-I mRNA
JOURNAL Biochem. Biophys. Res. Commun. 175, 507-514 (1991)
STANDARD full automatic
COMMENT From EMBL 26 entry HSIGFACI; dated 26-APR-1991.
FEATURES Location/Qualifiers
mRNA 1..7260
/gene="IGF-I"
/evidence=EXPERIMENTAL
exon 1..229
/number=1
/evidence=EXPERIMENTAL
sig_peptide 167..310
/gene="IGF-I"
/evidence=EXPERIMENTAL
CDS 167..628
/product="insulin-like growth factor I"
/gene="IGF-I"
/evidence=EXPERIMENTAL
/codon_start=167
exon 230..386
/number=2
/evidence=EXPERIMENTAL
mat_peptide 311..520
/product="insulin-like growth factor I"
/gene="IGF-I"
/evidence=EXPERIMENTAL
exon 387..568
/number=3
/evidence=EXPERIMENTAL
exon 569..7236
/number=5
/evidence=EXPERIMENTAL
polyA_signal 861..865
/note="1.1 kb mRNA"
/evidence=EXPERIMENTAL
repeat_unit 3986..4026
/note="CA-repeat"
/evidence=EXPERIMENTAL
repeat_unit 5926..6215
/rpt_family="AluI"
/evidence=EXPERIMENTAL
polyA_signal 7205..7210
/note="7.6 kb mRNA"
/evidence=EXPERIMENTAL
BASE COUNT 2330 a 1415 c 1240 g 2275 t
ORIGIN
1 tcactgtcac tgctaaattc agagcagatt agagcctgcg caatggaata aagtcctcaa
61 aattgaaatg tgacattgct ctcaacatct cccatctctc tggatttcct tttgcttcat
121 tattcctgct aaccaattca ttttcagact ttgtacttca gaagcaatgg gaaaaatcag
181 cagtcttcca acccaattat ttaagtgctg cttttgtgat ttcttgaagg tgaagatgca
241 caccatgtcc tcctcgcatc tcttctacct ggcgctgtgc ctgctcacct tcaccagctc
301 tgccacggct ggaccggaga cgctctgcgg ggctgagctg gtggatgctc ttcagttcgt
361 gtgtggagac aggggctttt atttcaacaa gcccacaggg tatggctcca gcagtcggag
421 ggcgcctcag acaggcatcg tggatgagtg ctgcttccgg agctgtgatc taaggaggct
481 ggagatgtat tgcgcacccc tcaagcctgc caagtcagct cgctctgtcc gtgcccagcg
541 ccacaccgac atgcccaaga cccagaagga agtacatttg aagaacgcaa gtagagggag
601 tgcaggaaac aagaactaca ggatgtagga agaccctcct gaggagtgaa gagtgacatg
661 ccaccgcagg atcctttgct ctgcacgagt tacctgttaa actttggaac acctaccaaa
721 aaataagttt gataacattt aaaagatggg cgtttccccc aatgaaatac acaagtaaac
781 attccaacat tgtctttagg agtgatttgc accttgcaaa aatggtcctg gagttggtag
841 attgctgttg atcttttatc aataatgttc tatagaaaag aaaaaaaaat atatatatat
901 atatatctta gtccctgcct ctcaagagcc acaaatgcat gggtgttgta tagatccagt
961 tgcactaaat tcctctctga atcttggctg ctggagccat tcattcagca accttgtcta
1021 agtggtttat gaattgtttc cttatttgca cttctttcta cacaactcgg gctgtttgtt
1081 ttacagtgtc tgataatctt gttagtctat acccaccacc tcccttcata acctttatat
1141 ttgccgaatt tggcctcctc aaaagcagca gcaagtcgtc aagaagcaca ccaattctaa
1201 cccacaagat tccatctgtg gcatttgtac caaatataag ttggatgcat tttattttag
1261 acacaaagct ttatttttcc acatcatgct tacaaaaaag aataatgcaa atagttgcaa
1321 ctttgaggcc aatcattttt aggcatatgt tttaaacata gaaagtttct tcaactcaaa
1381 agagttcctt caaatgatga gttaatgtgc aacctaatta gtaactttcc tctttttatt
1441 ttttccatat agagcactat gtaaatttag catatcaatt atacaggata tatcaaacag
1501 tatgtaaaac tctgtttttt agtataatgg tgctattttg tagtttgtta tatgaaagag
1561 tctggccaaa acggtaatac gtgaaagcaa aacaataggg gaagcctgga gccaaagatg
1621 acacaagggg aagggtactg aaaacaccat ccatttggga aagaaggcaa agtcccccca
1681 gttatgcctt ccaagaggaa cttcagacac aaaagtccac tgatgcaaat tggactggcg
1741 agtccagaga ggaaactgtg gaatggaaaa agcagaaggc taggaatttt agcagtcctg
1801 gtttcttttt ctcatggaag aaatgaacat ctgccagctg tgtcatggac tcaccactgt
1861 gtgaccttgg gcaagtcact tcacctctct gtgcctcagt ttcctcatct gcaaaatggg
1921 ggcaatatgt catctaccta cctcaaaggg gtggtataag gtttaaaaag ataaagattc
1981 agattttttt accctgggtt gctgtaaggg tgcaacatca gggcgcttga gttgctgaga
2041 tgcaaggaat tctataaata acccattcat agcatagcta gagattggtg aattgaatgc
2101 tcctgacatc tcagttcttg tcagtgaagc tatccaaata actggccaac tagttgttaa
2161 aagctaacag ctcaatctct taaaacactt ttcaaaatat gtgggaagca tttgattttc
2221 aatttgattt tgaattctgc atttggtttt atgaatacaa agataagtga aaagagagaa
2281 aggaaaagaa aaaggagaaa aacaaagaga tttctaccag tgaaagggga attaattact
2341 ctttgttagc actcactgac tcttctatgc agttactaca tatctagtaa aaccttgttt
2401 aatactataa ataatattct attcattttg aaaaacacaa tgattccttc ttttctaggc
2461 aatataagga aagtgatcca aaatttgaaa tattaaaata atatctaata aaaagtcaca
2521 aagttatctt ctttaacaaa ctttactctt attcttagct gtatatacat ttttttaaaa
2581 agtttgttaa aatatgcttg actagagttt cagttgaaag gcaaaaactt ccatcacaac
2641 aagaaatttc ccatgcctgc tcagaagggt agcccctagc tctctgtgaa tgtgttttat
2701 ccattcaact gaaaattggt atcaagaaag tccactggtt agtgtactag tccatcatag
2761 cctagaaaat gatccctatc tgcagatcaa gattttctca ttagaacaat gaattatcca
2821 gcattcagat ctttctagtc accttagaac tttttggtta aaagtaccca ggcttgatta
2881 tttcatgcaa attctatatt ttacattctt ggaaagtcta tatgaaaaac aaaaataaca
2941 tcttcagttt ttctcccact gggtcacctc aaggatcaga ggccaggaaa aaaaaaaaag
3001 actccctgga tctctgaata tatgcaaaaa gaaggcccca tttagtggag ccagcaatcc
3061 tgttcagtca acaagtattt taactctcag tccaacatta tttgaattga gcacctcaag
3121 catgcttagc aatgttctaa tcactatgga cagatgtaaa agaaactata catcattttt
3181 gccctctgcc tgttttccag acatacaggt tctgtggaat aagatactgg actcctcttc
3241 ccaagatggc acttcttttt atttcttgtc cccagtgtgt accttttaaa attattccct
3301 ctcaacaaaa ctttataggc agtcttctgc agacttaaca tgttttctgt catagttaga
3361 tgtgataatt ctaagagtgt ctatgactta tttccttcac ttaattctat ccacagtcaa
3421 aaatccccca aggaggaaag ctgaaagatg caactgccaa tattatcttt cttaactttt
3481 tccaacacat aatcctctcc aactggatta taaataaatt gaaaataact cattatacca
3541 attcactatt ttatttttta atgaattaaa actagaaaac aaattgatgc aaaccctgga
3601 agtcagttga ttactatata ctacagcaga atgactcaga tttcatagaa aggagcaacc
3661 aaaatgtcac aaccaaaact ttacaagctt tgcttcagaa ttagattgct ttataattct
3721 tgaatgaggc aatttcaaga tatttgtaaa agaacagtaa acattggtaa gaatgagctt
3781 tcaactcata ggcttatttc caatttaatt gaccatactg gatacttagg tcaaatttct
3841 gttctctctt gcccaaataa tattaaagta ttatttgaac tttttaagat gaggcagttc
3901 ccctgaaaaa gttaatgcag ctctccatca gaatccactc ttctagggat atgaaaatct
3961 cttaacaccc accctacata cacagacaca cacacacaca cacacacaca cacacacaca
4021 cacacattca ccctaaggat ccaatggaat actgaaaaga aatcacttcc ttgaaaattt
4081 tattaaaaaa caaacaaaca aacaaaaagc ctgtccaccc ttgagaatcc ttcctctcct
4141 tggaacgtca atgtttgtgt agatgaaacc atctcatgct ctgtggctcc agggtttctg
4201 ttactatttt atgcacttgg gagaaggctt agaataaaag atgtagcaca ttttgctttc
4261 ccatttattg tttggccagc tatgccaatg tggtgctatt gtttctttaa gaaagtactt
4321 gactaaaaaa aaaagaaaaa aagaaaaaaa agaaagcata gacatatttt tttaaagtat
4381 aaaaacaaca attctataga tagatggctt aataaaatag cattaggtct atctagccac
4441 caccaccttt caacttttta tcactcacaa gtagtgtact gttcaccaaa ttgtgaattt
4501 gggggtgcag gggcaggagt tggaaatttt ttaaagttag aaggctccat tgttttgttg
4561 gctctcaaac ttagcaaaat tagcaatata ttatccaatc ttctgaactt gatcaagagc
4621 atggagaata aacgcgggaa aaaagatctt ataggcaaat agaagaattt aaaagataag
4681 taagttcctt attgattttt gtgcactctg ctctaaaaca gatattcagc aagtggagaa
4741 aataagaaca aagagaaaaa atacatagat ttacctgcaa aaaatagctt ctgccaaatc
4801 ccccttgggt attctttggc atttactggt ttatagaaga cattctccct tcacccagac
4861 atctcaaaga gcagtagctc tcatgaaaag caatcactga tctcatttgg gaaatgttgg
4921 aaagtatttc cttatgagat gggggttatc tactgataaa gaaagaattt atgagaaatt
4981 gttgaaagag atggctaaca atctgtgaag attttttgtt tcttggtttt gttttttttt
5041 ttttttttac tttatacagt ctttatgaat ttcttaatgt tcaaaatgac ttggttcttt
5101 tcttcttttt tttatatcag aatgaggaat aataagttaa acccacatag actctttaaa
5161 actataggct agatagaaat gtatgtttga cttgttgaag ctataatcag actatttaaa
5221 atgttttgct atttttaatc ttaaaagatt gtgctaattt attagagcag aacctgtttg
5281 gctctcctca gaagaaagaa tctttccatt caaatcacat ggctttccac caatattttc
5341 aaaagataaa tctgatttat gcaatggcat catttatttt aaaacagaag aattgtgaaa
5401 gtttatgccc ctcccttgca aagaccataa agtccagatc tggtaggggg gcaacaacaa
5461 aaggaaaatg ttgttgattc ttggttttgg attttgtttt gttttcaatg ctagtgttta
5521 atcctgtagt acatatttgc ttattgctat tttaatattt tataagacct tcctgttagg
5581 tattagaaag tgatacatag atatcttttt tgtgtaattt ctatttaaaa aagagagaag
5641 actgtcagaa gctttaagtg catatggtac aggataaaga tatcaattta aataaccaat
5701 tcctatctgg aacaatgctt ttgtttttta aagaaacctc tcacagataa gacagaggcc
5761 caggggattt ttgaagctgt ctttattctg cccccatccc aacccagccc ttattatttt
5821 agtatctgcc tcagaatttt atagagggct gaccaagctg aaactctaga attaaaggaa
5881 cctcactgaa aacatatatt tcacgtgttc cctctctttt ttttcctttt tgtgagatgg
5941 ggtctcgcac tgtcccccag gctggagtgc agtggcatga tctcggctca ctgcaacctc
6001 cacctcctgg gtttaagcga ttctcctgcc tcagcctcct gagtagctgg gattacaggc
6061 acccaccact atgcccggct aattttttgg atttttaata gagacggggt tttaccatgt
6121 tggccaggtt ggactcaaac tcctgacctt gtgatttgcc cgcctcagcc tcccaaattg
6181 ctgggattac aggcatgagc caccacaccc tgcccatgtg ttccctctta atgtatgatt
6241 acatggatct taaacatgat ccttctctcc tcattcttca actatctttg atggggtctt
6301 tcaaggggaa aaaaatccaa gcttttttaa agtaaaaaaa aaaaaagaga ggacacaaaa
6361 ccaaatgtta ctgctcaact gaaatatgag ttaagatgga gacagagttt ctcctaataa
6421 ccggagctga attacctttc actttcaaaa acatgacctt ccacaatcct tagaatctgc
6481 ctttttttat attactgagg cctaaaagta aacattactc attttatttt gcccaaaatg
6541 cactgatgta aagtaggaaa aataaaaaca gagctctaaa atccctttca agccacccat
6601 tgaccccact caccaactca tagcaaagtc acttctgtta atcccttaat ctgattttgt
6661 ttggatattt atcttgtacc cgctgctaaa cacactgcag gagggactct gaaacctcaa
6721 gctgtctact tacatctttt atctgtgtct gtgtatcatg aaaatgtcta ttcaaaatat
6781 caaaaccttt caaatatcac gcagcttata ttcagtttac ataaaggccc caaataccat
6841 gtcagatctt tttggtaaaa gagttaatga actatgagaa ttgggattac atcatgtatt
6901 ttgcctcatg tatttttatc acacttatag gccaagtgtg ataaataaac ttacagacac
6961 tgaattaatt tcccctgcta ctttgaaacc agaaaataat gactggccat tcgttacatc
7021 tgtcttagtt gaaaagcata ttttttatta aattaattct gattgtattt gaaattatta
7081 ttcaattcac ttatggcaga ggaatatcaa tcctaatgac ttctaaaaat gtaactaatt
7141 gaatcattat cttacattta ctgtttaata agcatatttt gaaaatgtat ggctagagtg
7201 tcataataaa atggtatatc tttctttagt aattacaaaa aaaaaaaaaa aaaaaaaaaa
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