GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMACTH 8658 bp ds-DNA PRI 26-MAY-1991
DEFINITION Human gene coding for ACTH and beta-LPH precursors. Gene codes for
the common precursor of the pituitary hormones corticotropin (ACTH)
and beta-lipotropin (beta-LPH).
ACCESSION V01510
KEYWORDS corticotropin; lipotropin; opiomelanocortin; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 8658)
AUTHORS Takahashi,H., Hakamata,Y., Watanabe,Y., Kikuno,R., Miyata,T. and
Numa,S.
JOURNAL Unpublished (1983)
STANDARD full automatic
REFERENCE 2 (bases 1 to 8658)
AUTHORS Takahashi,H., Hakamata,Y., Watanabe,Y., Kikuno,R., Miyata,T. and
Numa,S.
TITLE Complete nucleotide sequence of the human corticotropin
beta-lipotropin precursor gene
JOURNAL Nucleic Acids Res. 11, 6847-6858 (1983)
STANDARD full automatic
COMMENT EPD; 07105; Hs POMC (ACTH,b'LPH).
From EMBL entry HSACTH; dated 18-DEC-1990.
FEATURES Location/Qualifiers
CDS join(4495..4626,7513..8181)
/codon_start=4495
precursor_RNA 681..8658
/note="primary transcript"
mRNA 681..766
/note="exon 1 (nontranslated)"
intron 767..4474
/note="intron I"
misc_feature 1086..1405
/note="Alu family repeat"
mRNA 4475..4626
/note="exon 2"
intron 4627..7512
/note="intron II"
misc_feature 5334..5657
/note="Alu family repeat"
misc_feature 6511..6658
/note="Alu family repeat"
misc_feature 6776..7112
/note="Alu family repeat"
mRNA 7513..8345
/note="exon 3"
BASE COUNT 2105 a 2225 c 2229 g 2099 t
ORIGIN
1 ctgctcttca cagcatcacc ctctccccat ttaatggttt aggttaacag gactttttcc
61 ttgaggcttg ggacacggaa gggagcctcc cctaaaccag gcccttggag agcaggcccc
121 aggggagcag tgcaactcac cttcacaccc acaagacggc tcctgacttc tgctccctcc
181 tcccctcccc aaagtggaac agagagaata tgattcccca cgacttccac atcacagttt
241 ccaaacaatg gggaaatcgg aggcctcccc gtgtgcagac ggtgatattt accgccaaat
301 gcgaaccagg cagatgccag ccccagcacg cacgcaggta acttcaccct cgcctcaacg
361 acctcagagg ctgcccggcc tgccccacac gggggtgcta agcctcccgc ccgttctaag
421 cggagaccca acgccatcca taattaagtt cttcctgagg gcgagcggcc aggtgcgcct
481 tcggcaggac agtgctaatt ccagcccctt tccagcgcgt ctccccgcgc tcgtcccccg
541 tctggaagcc cccctcccac gccccgcggc cccccttccc ctggcccggg gagctgctcc
601 ttgtgctgcc gggaaggtca aagtcccgcg cccaccagga gagctcggca agtatataag
661 gacagaggag cgcgggacca agcggcggcg aaggagggga agaagagccg cgaccgagag
721 aggccgccga gcgtccccgc cctcagagag cagcctcccg agacaggtaa gggcgcagcg
781 tgggggaccc gtgctctttc cccgggatcc cctgtccccg tcctcgcgat gcagtcggcc
841 ggctccggct ccgaaggcgg acctgggcgc ctctggctct ccgcggtccc gagttctcga
901 caaactttct gcgccgactg cggcatgaga agccgccagt agctgagctg gagggcccac
961 gtccggcccc tgggcggacg gccgcgaagc tgcaggcgct gtctccaggg agccggcggc
1021 ctcctctccc ccaggggctc gcggcggtcc ggaggctccg agagcttgct aggaggtctt
1081 gggacaaccc ggtctttttt tttttttttg agacggagtt tcgctcttgt tgcccatgct
1141 ggagagcaaa ggggtgatct ctgctcaccg caaccttcgc ctcccgggtt caagcgattc
1201 tcctgcttca gcctcccgag tagctgggat tacaggcatg cgccaccacg cccggctaat
1261 ttttgtattt ttagtagtga cggagtttct ccatgttggt caggctggtc tcaaactccc
1321 gacaacaggt gatccgcccg ccttggcccc ccaaagttct ggcattacag gcgcgagcca
1381 ccgcccccgg ccagcccggt cttttagtat ctcttgctcc cagtttccag gataggtgtc
1441 acatcttgaa agtcaaattc catacacgct atcgcaaatt aatgttggaa acggggcagc
1501 agagaaaagg ataaaagtca taatgaacgc cctgccttcc ggattttttc ggattcagac
1561 ccctgaatcc ttgtttcctt gcccacctta gcgcacccga ggtggccgcg ctatgataat
1621 tacatgataa ctgggtcaat tacaatgcag aatagttggg tctcttctct ccaagaccta
1681 gctggggtta aaaacaggtg gccggggcgg gagctgtcct agatcctgaa acgcactgtc
1741 tagtttcgga tgccctcaac agaaccgggg tggacggttt atggcgcaga tcctgggttg
1801 agggcacggg cagccatttg gaatgatcaa ggctcaggta aggggcgttt ccagcgaagg
1861 agagacagtc cacttggcat ttggattccc caaattcttc atgtttaaat ggggcaggga
1921 gggttcttac agaatggctg gaaggagcca aggaaaataa aagtgtgtgt ggattttttt
1981 tgtgtgtgtg tcagtttata aactctgcac agattatggc cactttaatg acttactgtt
2041 cctttgatgc ttttgttata ggactcgatg catgtatgtc atggtgtaag gacaaaactc
2101 ggcccctgtg ctcctctaat ctttacaaaa ggtcatggcc agcgtgcagt tttacagtaa
2161 caagcaaaat gatttgttga gctcatagag agcccctcac acctatgaag ttctaataag
2221 tgtagttcta ctataaagtt aatctcagga tgagcaaatt tcaagtttct atttttccag
2281 agctttccat ttttggatta taatactttc cctacttaaa aaagcacaac atttgatatt
2341 tccccaataa tttgttgctt taaaaatgac acaaaaggta ctatttgttc attgtagaga
2401 actgaaaata cacataagca aatacacata cacataagca aaatatacaa tacaaacaca
2461 agaccatctt tcagggaaga atctgaagtt ttagcaatag cagccatcta accagtttag
2521 caacagaata taagctctga gagggtggga gtgaatatgt taccacattg tacaacacag
2581 cacatagggc ataaggaggg gaaatgctct ctggggcttt ccaggaaggc ctgaagtcat
2641 tgcttctagc aaatggaaat cactccagag tagttatctt tgacaagaat tgaaatataa
2701 ttgagggaac tatcagacct gtaagatttt gttttttcct ttactaatat gttactttac
2761 atttgcattt ggtgacatac gtaactacca tttttctgtg actgtaacat ctgggcattt
2821 ttcagagcta aatgtgctat ggtcaacttg gagctttaat ctaattgcct ggtccaccaa
2881 gttctggctg tgtacttgaa tagatcactg gcagggtaca atgggaacag cctgtccctt
2941 ggagccagga gaggacacca aggttgacca aagctcgttc agttgcccct ttagccgaag
3001 cgcacctggg ccagtcactg gctgccagtg ccatctaatg gctgctctga aaatgctcag
3061 ccttgcccgg caacccttca gaagctagca ccgtgcaggc ccagcgcctg gggaataggg
3121 cgagggtggg gtagagagaa ggaagtggcc tcctgaagta gaaatcagcg cttcagagga
3181 ctttcacttc caaagcctcc cctatataaa aaagatttgg cccacgcctc cccaaatgag
3241 agatttattt taggcaaact tattttaaaa tgccagcgtt cattaggagt gacaagacac
3301 ttagtcatcc acgctttaat gtgaattact tttctcatct aattacattt ctttctagca
3361 gctggctgag aagatcttct gaaatccaaa atgattgtag ggttggcggt gagctgatct
3421 ccggcctcga ggtggcttca gggggcccac ctggttaagg gaaatttggc agtgcgaggg
3481 tagtgctgga gagaggggtg ggtacagggg gctaggggca ccatggatgc cccctcctta
3541 ctgtcccctg gtgtcttgac ctcagcttct gcccacaggc acttgctgga ttctccaaaa
3601 gtatctgcag tggctgttcc accaggaggt aattcccttc tggtctcttt cccctccaca
3661 tctgcatcct cttcaaatcc tgccatttca gaccacattt gagagctcta gagaacaaga
3721 catctgacac gtgacgtgtc cagaagatga gccagatttc aaagaactga gatctgcttt
3781 aaaaacgaag ctctccaaag ttactggagt ctgggtaata gtgatcacca gagtaatttg
3841 tgtgcaggac atcaaatcag gctgctcgaa atgctgccta aattggccag tggttttatt
3901 tgcttttctg tcaacctaat attcatagga aatagagttt cagaggaatg ataggatcct
3961 ggtggaataa aaagggaaaa gaccatcttg agcaggagtt tcagggtcct ccgtttttcc
4021 caagttactt tcactcctga gatcttgcat gttagaacta cagcttaatg tagtgaaata
4081 ggaaagttct ctgttaggag cttagcctta ccttgtcatg gacattaaag taattgtctc
4141 tctttgggct tcaattttcc catctctcat gggaagggct gaaccaagca atccccaaaa
4201 tagcttccag ccttaacctt tttaggggtc tcgtttaaat agaagataac agggaaatgg
4261 tcacagttta cccaggtcca ttccctcctc cttatcacaa cttataccac cgctgtactg
4321 cacacctcct ttctcagcat tgctgctgtc cttaaaatgc ctttaactcc acaagagagt
4381 gtgttgttaa tgttggctca aggtccttcc tggtgagtgg ccaacattgt tttgctcctt
4441 gcaggggtcc caccaatctt gtttgcttct gcagagcctc agcctgcctg gaagatgccg
4501 agatcgtgct gcagccgctc gggggccctg ttgctggcct tgctgcttca ggcctccatg
4561 gaagtgcgtg gctggtgcct ggagagcagc cagtgtcagg acctcaccac ggaaagcaac
4621 ctgctggtac gtgggccatg actgccatct tggcttagac attagatggg actggagctg
4681 ggaaagctca aaagaaaagg gtgtggggaa agggaaattc attcccagtg ataggcgtga
4741 ttcaatccag ggcaggagca aaactttgca gtgaagtaag aaatgggaga agaaatcagg
4801 gaaggaagca gcttcaggga gaggggttga gtccacaatt tctgcttggt tatccttact
4861 tcttgcccca tcttttatgg agaccttgaa ccctttaagc tagagatggt gctataagag
4921 caataatgga cccctcaatc tattctgtac tttacatctt tagcttccca aactattcct
4981 ttttaagaag ctcatatcac ttgccatttt cattccatat ttcttaccct tttatctact
5041 accggttgca aaaccagcca ggtagttctt caaatcatct ctggaagaag gaaaaaccag
5101 gggccctttt ttttttttct ttaattggtg ccaaatgtct catgtttatt ctggaggact
5161 ggccttctgc tgtgttcctc tacagtcttt ccagagcatg tgaaggcctt tgcatcaggc
5221 aggagctccc tccaggtcac cacagggtgt atgtatctgc ctgtgggggg tgtgtgtgtg
5281 tgtgtgttgg ggggcataaa tgagtaatga tgccaaatcc agagattaaa aggcacactg
5341 agaccaggcg agatggctca tggctgtaat cccagcactt ttagatgcta aggtgggagg
5401 attgcttgag cccagggatt caagacaagc ctgggcaaca tagtgagacc tccacttcta
5461 caaaaaataa aaaagttagc cagatgtggt ggcatgtgcc tgtagtccta gctacttggg
5521 aggttcactt gaggccagga gtctgacgac acagtaagct atgatcacac cattgcactc
5581 cagtctgggt aacagaatga gaccttgtct caaaacaaaa caaaatgaaa caaacaaaca
5641 aacaaacccc catactgtta gtgtcagtga ccggaatttt aatcttgttg ccatcacctg
5701 gcaggtgctg agggtggaat gtacataact acattctgtg tattttgtca atgcagaagc
5761 tgagttaagg tgaagataga atgaggtcct caaagacaca gaccagtttt catgtgtaat
5821 ataaaataga aacaaagagc ccaggggatt ctgtgagttc cagtttggaa agacccaaga
5881 gtctcttgac ttgagacacc cacagcacag ctcaccaggg agggtgcact ggacacagtc
5941 aggacccatg ggttctagac ccagttttga ggtgtgggac cttgaccagg tcctatcacc
6001 tctctgagtc tcctgtttca ctatctgtcc acgggagggg agtgtaaatt agttttttcc
6061 attgttaacg ttccacagag ttgtaattct gaacacctgg agtaggcaat gtccagctca
6121 acagagtggg taggatcctt ttattttctc ctttgctatt cccaagaaag agagcagcca
6181 gtgagctttt catcttttta tcactgaaaa ctcaaggctg cagcctatgc agccattttc
6241 ctaagctaat atgtaccaca atagagtcct ctagggacaa ggagcagaga cacaggttcc
6301 acagacggtg caatggaaat aacgctagct ttccacccct ccctccagtc agaatgagat
6361 tacagggaaa taagcttgcc ccagagctca ctgggggatc tctcagaaat cagctcagaa
6421 gtcgtgaaag aaccaaggtg cagttttgga ggcttagtgc agagatggag ctggggtagg
6481 gcataaagta ggttttccat cactgaggta aggttgaggc attatttttt attttttgtt
6541 tatttattta tttttttgag acggagtctc gctctatcac ccaggctgga gtgcagtggc
6601 gcgatctccc ctcactgcaa gctccacctc ccaggttcac acaggttgaa gcattattaa
6661 aaatatgttt aaaaatatgg gccctagtag ccagacttct atcacctgga gagattatcc
6721 cccaaatttc agccccactc ccctcctgga cttgaattaa accatatgta tttattcaat
6781 attcttttta tttatttatt tatttttttg agacggagtc ttgctctgtt gccctggctg
6841 gagtgtggag tgcagtggtg tgatcttggc tcactgcaac ctctacctcc caggttcaag
6901 cggttctcct gcctcaggct ccagagtagc tgggattaca ggcgcccgcc accacaccca
6961 gcttatttat ttatttatac tagagatggt atttcaccat agttggccag gctggtcttg
7021 aactcctgac ctcatgtgat ctgcctgcct tggcctccca aagtgctggg attataggtg
7081 tgagccacca tgcccggccc tcaatattca ttaagtgcca acaactacca cccgtctgcc
7141 tttcttggag ccactccttt atgtcaggca tatgacagta agactttggt cctgttcaca
7201 aaagctaggg gtggctagat ggctagacaa accatggaat gggatgggaa gtgtgttgca
7261 gttgccagca gaagcatgaa ggggatggga caaaagaggc ggtggcaaga tcttagatgc
7321 ccacgagtgc caagaaagca ggtgggcaga cctgctctgt agggaggcct cgacgcttga
7381 cacgcccgac actgtgccct gtgtcctcgg cacgtggcga gggcggccag ggcctaggcg
7441 cagtgacggg cgcggcagcc gggccggggt gcggggcacg ggctgccctc atgccctcgc
7501 gtcttccccc aggagtgcat ccgggcctgc aagcccgacc tctcggccga gactcccatg
7561 ttcccgggaa atggcgacga gcagcctctg accgagaacc cccggaagta cgtcatgggc
7621 cacttccgct gggaccgatt cggccgccgc aacagcagca gcagcggcag cagcggcgca
7681 gggcagaagc gcgaggacgt ctcagcgggc gaagactgcg gcccgctgcc tgagggcggc
7741 cccgagcccc gcagcgatgg tgccaagccg ggcccgcgcg agggcaagcg ctcctactcc
7801 atggagcact tccgctgggg caagccggtg ggcaagaagc ggcgcccagt gaaggtgtac
7861 cctaacggcg ccgaggacga gtcggccgag gccttccccc tggagttcaa gagggagctg
7921 actggccagc gactccggga gggagatggc cccgacggcc ctgccgatga cggcgcaggg
7981 gcccaggccg acctggagca cagcctgctg gtggcggccg agaagaagga cgagggcccc
8041 tacaggatgg agcacttccg ctggggcagc ccgcccaagg acaagcgcta cggcggtttc
8101 atgacctccg agaagagcca gacgcccctg gtgacgctgt tcaaaaacgc catcatcaag
8161 aacgcctaca agaagggcga gtgagggcac agcgggcccc agggctaccc tcccccagga
8221 ggtcgacccc aaagcccctt gctctcccct gccctgctgc cgcctcccag cctggggggt
8281 cgtggcagat aatcagcctc ttaaagctgc ctgtagttag gaaataaaac ctttcaaatt
8341 tcacatccac ctctgacttt gaatgtaaac tgtgtgaata aagtaaaaat acgtagccgt
8401 caaataacag cagcatggat cggaggagca cagtggtttc catgcggtag gatatttcac
8461 aggacttagt gagcgtgaaa ggaaaatgtg cttcctgccc ccacccccaa atggatcttc
8521 gagggatcag atagtttggg tgaaggcaca gggtggctcc agcacctcta ggatggccgt
8581 attttccaca cactccactg agtgggagac tgctcagcta gcacacgtgt aaaggcagga
8641 ttcctgcaag agtgaccc
//