GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMAGALA 1226 bp ss-mRNA PRI 26-MAY-1991
DEFINITION Human alpha-galactosidase A cDNA.
ACCESSION D00039 N00039
KEYWORDS alpha-GalA; galactosidase.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1226)
AUTHORS Bishop,D.F., Calhoun,D.H., Bernstein,H.S., Hantzopoulos,P.,
Quinn,M. and Desnick,R.J.
TITLE Human alpha-galactosidase A: Nucleotide sequence of a cDNA clone
encoding the mature enzyme
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83, 4859-4863 (1986)
STANDARD full automatic
COMMENT SWISS-PROT; P06280; AGAL$HUMAN.
The complete nucleotide sequence has been determinated for a cDNA
clone comtaining the full-length coding region for the mature
lysosomal form of human alpha-galactosidase A (alpha-GalA). That
insert contained a 1226-base-pair sequence with an open reading
(predicted molecular weight ; 45,356) and the last 5 amino acids of
propeptide sequence. The poly(A) signals AATACA and ATTAAA occurred
28 and 11 nucleotides prior to the TAA stop codon , respectively.
The predicted amino acid sequence was colinear with 86
nonoverlapping residues (22%of the mature subunit) determinated
from the purified mature enzyme. Searches of nucpeic acid and
protein data bases did not reveal significant homology even with
the limited sequences available for mammalian lysosomal enzymes.
From EMBL entry HSAGALA; dated 22-APR-1990.
FEATURES Location/Qualifiers
CDS 18..1212
/note="human mature alpha-Galactosidase A subumit peptide"
/codon_start=18
BASE COUNT 332 a 269 c 312 g 313 t
ORIGIN
1 tccctggggc tagagcactg gacaatggat tggcaaggac gcctaccatg ggctggctgc
61 actgggagcg cttcatgtgc aaccttgact gccaggaaga gccagattcc tgcatcagtg
121 agaagctctt catggagatg gcagagctca tggtctcaga aggctggaag gatgcaggtt
181 atgagtacct ctgcattgat gactgttgga tggctcccca aagagattca gaaggcagac
241 ttcaggcaga ccctcagcgc tttcctcatg ggattcgcca gctagctaat tatgttcaca
301 gcaaaggact gaagctaggg atttatgcag atgttggaaa taaaacctgc gcaggcttcc
361 ctgggagttt tggatactac gacattgatg cccagacctt tgctgactgg ggagtagatc
421 tgctaaaatt tgatggttgt tactgtgaca gtttggaaaa tttggcagat ggttataagc
481 acatgtcctt ggccctgaat aggactggca gaagcattgt gtactcctgt gagtggcctc
541 tttatatgtg gccctttcaa aagcccaatt atacagaaat ccgacagtac tgcaatcact
601 ggcgaaattt tgctgacatt gatgattcct ggaaaagtat aaagagtatc ttggactgga
661 catcttttaa ccaggagaga attgttgatg ttgctggacc agggggttgg aatgacccag
721 atatgttagt gattggcaac tttggcctca gctggaatca gcaagtaact cagatggccc
781 tctgggctat catggctgct cctttattca tgtctaatga cctccgacac atcagccctc
841 aagccaaagc tctccttcag gataaggacg taattgccat caatcaggac cccttgggca
901 agcaagggta ccagcttaga cagggagaca actttgaagt gtgggaacga cctctctcag
961 gcttagcctg ggctgtagct atgataaacc ggcaggagat tggtggacct cgctcttata
1021 ccatcgcagt tgcttccctg ggtaaaggag tggcctgtaa tcctgcctgc ttcatcacac
1081 agctcctccc tgtgaaaagg aagctagggt tctatgaatg gacttcaagg ttaagaagtc
1141 acataaatcc cacaggcact gttttgcttc agctagaaaa tacaatgcag atgtcattaa
1201 aagacttact ttaaaaaaaa aaaaaa
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