GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMAGALA 1226 bp ss-mRNA PRI 26-MAY-1991 DEFINITION Human alpha-galactosidase A cDNA. ACCESSION D00039 N00039 KEYWORDS alpha-GalA; galactosidase. SOURCE Homo sapiens RNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 1226) AUTHORS Bishop,D.F., Calhoun,D.H., Bernstein,H.S., Hantzopoulos,P., Quinn,M. and Desnick,R.J. TITLE Human alpha-galactosidase A: Nucleotide sequence of a cDNA clone encoding the mature enzyme JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83, 4859-4863 (1986) STANDARD full automatic COMMENT SWISS-PROT; P06280; AGAL$HUMAN. The complete nucleotide sequence has been determinated for a cDNA clone comtaining the full-length coding region for the mature lysosomal form of human alpha-galactosidase A (alpha-GalA). That insert contained a 1226-base-pair sequence with an open reading (predicted molecular weight ; 45,356) and the last 5 amino acids of propeptide sequence. The poly(A) signals AATACA and ATTAAA occurred 28 and 11 nucleotides prior to the TAA stop codon , respectively. The predicted amino acid sequence was colinear with 86 nonoverlapping residues (22%of the mature subunit) determinated from the purified mature enzyme. Searches of nucpeic acid and protein data bases did not reveal significant homology even with the limited sequences available for mammalian lysosomal enzymes. From EMBL entry HSAGALA; dated 22-APR-1990. FEATURES Location/Qualifiers CDS 18..1212 /note="human mature alpha-Galactosidase A subumit peptide" /codon_start=18 BASE COUNT 332 a 269 c 312 g 313 t ORIGIN 1 tccctggggc tagagcactg gacaatggat tggcaaggac gcctaccatg ggctggctgc 61 actgggagcg cttcatgtgc aaccttgact gccaggaaga gccagattcc tgcatcagtg 121 agaagctctt catggagatg gcagagctca tggtctcaga aggctggaag gatgcaggtt 181 atgagtacct ctgcattgat gactgttgga tggctcccca aagagattca gaaggcagac 241 ttcaggcaga ccctcagcgc tttcctcatg ggattcgcca gctagctaat tatgttcaca 301 gcaaaggact gaagctaggg atttatgcag atgttggaaa taaaacctgc gcaggcttcc 361 ctgggagttt tggatactac gacattgatg cccagacctt tgctgactgg ggagtagatc 421 tgctaaaatt tgatggttgt tactgtgaca gtttggaaaa tttggcagat ggttataagc 481 acatgtcctt ggccctgaat aggactggca gaagcattgt gtactcctgt gagtggcctc 541 tttatatgtg gccctttcaa aagcccaatt atacagaaat ccgacagtac tgcaatcact 601 ggcgaaattt tgctgacatt gatgattcct ggaaaagtat aaagagtatc ttggactgga 661 catcttttaa ccaggagaga attgttgatg ttgctggacc agggggttgg aatgacccag 721 atatgttagt gattggcaac tttggcctca gctggaatca gcaagtaact cagatggccc 781 tctgggctat catggctgct cctttattca tgtctaatga cctccgacac atcagccctc 841 aagccaaagc tctccttcag gataaggacg taattgccat caatcaggac cccttgggca 901 agcaagggta ccagcttaga cagggagaca actttgaagt gtgggaacga cctctctcag 961 gcttagcctg ggctgtagct atgataaacc ggcaggagat tggtggacct cgctcttata 1021 ccatcgcagt tgcttccctg ggtaaaggag tggcctgtaa tcctgcctgc ttcatcacac 1081 agctcctccc tgtgaaaagg aagctagggt tctatgaatg gacttcaagg ttaagaagtc 1141 acataaatcc cacaggcact gttttgcttc agctagaaaa tacaatgcag atgtcattaa 1201 aagacttact ttaaaaaaaa aaaaaa //