GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMANFPRE 2583 bp ds-DNA PRI 26-MAY-1991
DEFINITION Human gene for atrial natriuretic factor (hANF) precursor
ACCESSION X01471
KEYWORDS Alu repetitive sequence; atrial natriuretic factor; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2583)
AUTHORS Greenberg,B.D., Bencen,G.H., Seilhamer,J.J., Lewicki,J.A. and
Fiddes,J.C.
TITLE Nucleotide sequence of the gene encoding human atrial natriuretic
factor precursor
JOURNAL Nature 312, 656-658 (1984)
STANDARD full automatic
COMMENT SWISS-PROT; P01160; ANF$HUMAN.
Data kindly reviewed (12-FEB-1986) by J.C. Fiddes
From EMBL entry HSANFPRE; dated 18-DEC-1990.
FEATURES Location/Qualifiers
CDS join(645..692,815..1141,2235..2237)
/product="ANF propeptide"
/codon_start=645
promoter 235..243
/note="pot. CCAAT-box"
promoter 342..350
/note="pot. CCAAT-box"
promoter 442..447
/note="put. TATA-box"
sig_peptide 570..644
intron 693..814
/note="intron"
intron 1142..2234
/note="intron"
misc_feature 1283..1297
/note="pot. binding site for glucocorticoid receptor"
misc_feature 1356..1646
/note="Alu-repeat sequence"
misc_feature 1647..1942
/note="Alu repeat sequence"
misc_feature 2509..2514
/note="put. polyadenylation signal"
polyA_site 2537..2537
/note="put. polyadenylation site"
BASE COUNT 647 a 641 c 740 g 555 t
ORIGIN
1 ggatccattt gtctcgggct gctggctgcc tgccatttcc tcctctccac ccttatttgg
61 aggccctgac agctgagcca caaacaaacc aggggagctg ggcaccagca agcgtcaccc
121 tctgtttccc cgcacggtac cagcgtcgag gagaaagaat cctgaggcac ggcggtgaga
181 taaccaagga ctctttttta ctcttctcac acctttgaag tgggagcctc ttgagtcaaa
241 tcagtaagaa tgcggctctt gcagctgagg gtctgggggg ctgttggggc tgcccaaggc
301 agagaggggc tgtgacaagc cctgcggatg ataactttaa aagggcatct cctgctggct
361 tctcacttgg cagctttatc actgcaagtg acagaatggg gagggttctg tctctcctgc
421 gtgcttggag agctgggggg ctataaaaag aggcggcact gggcagctgg gagacaggga
481 cagacgtagg ccaagagagg ggaaccagag aggaaccaga ggggagagac agagcagcaa
541 gcagtggatt gctccttgac gacgccagca tgagctcctt ctccaccacc accgtgagct
601 tcctcctttt actggcattc cagctcctag gtcagaccag agctaatccc atgtacaatg
661 ccgtgtccaa cgcagacctg atggatttca aggtagggcc aggaaagcgg gtgcagtctg
721 gggccagggg gctttctgat gctgtgctca ctcctcttga tttcctccaa gtcagtgagg
781 tttatccctt tccctgtatt ttccttttct aaagaatttg ctggaccatt tggaagaaaa
841 gatgccttta gaagatgagg tcgtgccccc acaagtgctc agtgagccga atgaagaagc
901 gggggctgct ctcagccccc tccctgaggt gcctccctgg accggggaag tcagcccagc
961 ccagagagat ggaggtgccc tcgggcgggg cccctgggac tcctctgatc gatctgccct
1021 cctaaaaagc aagctgaggg cgctgctcac tgcccctcgg agcctgcgga gatccagctg
1081 cttcgggggc aggatggaca ggattggagc ccagagcgga ctgggctgta acagcttccg
1141 ggtaagagga actggggatg gaaatgggat gggatggaca ctactgggag acaccttcag
1201 caggaaaggg accaatgcag aagctcattc cctctcaagt ttctgcccca acacccagag
1261 tgccccatgg gtgtcaggac atgccatcta ttgtccttag ctagtctgct gagaaaatgc
1321 ttaaaaaaaa aagggggggg gctgggcacg gtcgtcacgc ctgtaatccc agcactttgg
1381 gaggccaggc agcggatcat gaggtcaaga gatcaagact atcctggcca acatggtgaa
1441 accccagctc tactaaaaat acaaaaatta gctgggtgtg tggcgggcac ctgtactctc
1501 agctacttgg gaggctgagg caggagaatc acttgaaccc aggaggcaga ggttgcagtg
1561 agcagagatc acgccactgc agtccagcct aggtgataga gcgagactgt ctcaaaaaaa
1621 aaaaaaaaag gccaggcgcg gtggctcacg cctgtaatcc cagcgctttg ggaggccaag
1681 gcgggtggat cacgaggtca ggagatggag accatcctgg ctaacacggt gaaaccccgt
1741 ctctactaaa aatacaaaaa attagccagg cgtggtggca ggcgcctgta agtcctagct
1801 actccggagg ctgaggcagg agaatggcgt gaacccggga ggcggagctt gcagtgagca
1861 gagatggcac cactgcactc cagcctgggc gacagagcaa gactccgtct caaaaaaaaa
1921 aaaaaaaaaa gcaactgcca ctagcactgg gaaattaaaa tattcataga gccaagttat
1981 ctttgcatgg ctgattagca gttcatattc ctccccagaa ttgcaagatc ctgaagggct
2041 taagtgaaat ttactctgat gagtaacttg cttatcaatt catgaagctc agagggtcat
2101 caggctgggg tgggggccgg tgggaagcag gtggtcagta atcaagttca gaggatgggc
2161 acactcatac atgaagctga cttttccagg acagccaggt caccaagcca gatatgtctg
2221 tgttctcttt gcagtactga agataacagc cagggaggac aagcagggct gggcctaggg
2281 acagactgca agaggctcct gtcccctggg gtctctgctg catttgtgtc atcttgttgc
2341 catggagttg tgatcatccc atctaagctg cagcttcctg tcaacacttc tcacatctta
2401 tgctaactgt agataaagtg gtttgatggt gacttcctcg cctctcccac cccatgcatt
2461 aaattttaag gtagaacctc acctgttact gaaagtggtt tgaaagtgaa taaacttcag
2521 caccatggac agaagacaaa tgcctgcgtt ggtgtgcttt ctttcttctt gggaagagaa
2581 ttc
//