GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMAROMAT 2966 bp ss-mRNA PRI 26-MAY-1991
DEFINITION Human mRNA for aromatase (estrogen synthetase)
ACCESSION X13589
KEYWORDS aromatase; estrogen synthetase.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2966)
AUTHORS Harada,N.
TITLE Cloning of a complete cDNA encoding human aromatase: immunochemical
identification and sequence analysis
JOURNAL Biochem. Biophys. Res. Commun. 156, 725-732 (1988)
STANDARD full automatic
COMMENT SWISS-PROT; P11511; CPV1$HUMAN.
*source: tissue=placenta; library=lambda-gt11;
From EMBL entry HSAROMAT; dated 21-JAN-1990.
FEATURES Location/Qualifiers
CDS 125..1633
/note="aromatase (AA 1-503)"
/codon_start=125
misc_feature 158..166
/note="pot. N-linked glycosylation site"
misc_feature 662..670
/note="pot. N-linked glycosylation site"
misc_feature 1013..1021
/note="pot. N-linked glycosylation site"
misc_feature 1409..1453
/note="heme-binding domain"
polyA_site 2966..2966
/note="polyA site"
BASE COUNT 881 a 645 c 635 g 805 t
ORIGIN
1 gaacacgtgg aggcaaacag gaaggtgaag aagaacttat cctatcagga cggaaggtcc
61 tgtgctcggg atcttccaga cgtcgcgact ctaaattgcc ccctctgagg tcaaggaaca
121 caagatggtt ttggaaatgc tgaacccgat acattataac atcaccagca tcgtgcctga
181 agccatgcct gctgccacca tgccagtcct gctcctcact ggcctttttc tcttggtgtg
241 gaattatgag ggcacatcct caataccagg tcctggctac tgcatgggaa ttggacccct
301 catctcccac ggcagattcc tgtggatggg gatcggcagt gcctgcaact actacaaccg
361 ggtatatgga gaattcatgc gagtctggat ctctggagag gaaacactca ttatcagcaa
421 gtcctcaagt atgttccaca taatgaagca caatcattac agctctcgat tcggcagcaa
481 acttgggctg cagtgcatcg gtatgcatga gaaaggcatc atatttaaca acaatccaga
541 gctctggaaa acaactcgac ccttctttat gaaagctctg tcaggccccg gccttgttcg
601 tatggtcaca gtctgtgctg aatccctcaa aacacatctg gacaggttgg aggaggtgac
661 caatgaatcg ggctatgtgg acgtgttgac ccttctgcgt cgtgtcatgc tggacacctc
721 taacacgctc ttcttgagga tccctttgga cgaaagtgct atcgtggtta aaatccaagg
781 ttattttgat gcatggcaag ctctcctcat caaaccagac atcttcttta agatttcttg
841 gctatacaaa aagtatgaga agtctgtcaa ggatttgaaa gatgccatag aagttctgat
901 agcagaaaaa agacgcagga tttccacaga agagaaactg gaagaatgta tggactttgc
961 cactgagttg attttagcag agaaacgtgg tgacctgaca agagagaatg tgaaccagtg
1021 catattggaa atgctgatcg cagctcctga caccatgtct gtctctttgt tcttcatgct
1081 atttctcatt gcaaagcacc ctaatgttga agaggcaata ataaaggaaa tccagactgt
1141 tattggtgag agagacataa agattgatga tatacaaaaa ttaaaagtga tggaaaactt
1201 catttatgag agcatgcggt accagcctgt cgtggacttg gtcatgcgca aagccttaga
1261 agatgatgta atcgatggct acccagtgaa aaaggggaca aacattatcc tgaatattgg
1321 aaggatgcac agactcgagt ttttccccaa acccaatgaa tttactcttg aaaattttgc
1381 aaagaatgtt ccttataggt actttcagcc atttggcttt gggccccgtg gctgtgcagg
1441 aaagtacatc gccatggtga tgatgaaagc catcctcgtt acacttctga gacgattcca
1501 cgtgaagaca ttgcaaggac agtgtgttga gagcatacag aagatacacg acttgtcctt
1561 gcacccagat gagactaaaa acatgctgga aatgatcttt accccaagaa gctcagacag
1621 gtgtctggaa cactagagaa ggctggtcag tacccactct ggagcatttc tcatcagtag
1681 ttcacataca aatcatccat ccttgccaat agtgtcatcc tcacagtgaa cactcagtgg
1741 cccatggcat tttataggca tacctcctat gggttgtccc aagctaggtg ctattggtca
1801 tctgctcctg ttcacaccag agaaccaggc tacaagagaa aaagcagagg ccaagagttt
1861 gagggagaaa tagtcggtga agaaaccgta tccataaaag acccgattcc accaaatgtg
1921 ctttgagaag gataggcctt cattaacaaa atgtatgtct ggttccccag tagagctcta
1981 ctgcctcaac ccaaggggat ttttatgtct ggggcagaaa cactcaagtt gattagaaag
2041 accaggccaa tgtcagggta cctggggcca aacccacctg ctagtgtgaa ttaaagtact
2101 ttaattttgt tttctgtgga ggtggaaaag caacattcat agtctttgga gaaatgctta
2161 gaaattcagc atttgaccct tgctgtgaat taagcccaat taattcctgt ttgtctacat
2221 atgatctgtc tgtggcaaaa gtttaatcag aggaaattct ttcccagtct gtcgatttat
2281 gcctcagcca cttgcctgtg ctacaattca ttgtgttacc tgtagattca ggtaatacaa
2341 actatatata atcatcaagt aatacaaact aatttagtaa tagcctgggt taagtattat
2401 tagggccctg tgtctgctgt agaaaaaaaa ttcacatgat gcacttcaaa ttcaaataaa
2461 aatccttttg gcatgttccc atttttgctt agctcaatta gtgtggctaa ccaagagata
2521 actgtaaatg tgacattgat ttgctcttac tacagcttca gtgattgggg gaggaaaagt
2581 cccaacccaa tgggctcaaa cttctaaggg gtactcctct catcccctta tccttctccc
2641 tcgacatttt ctccctcttt cttcccatga ccccaaagcc aagggcaaca gatcagtaaa
2701 gaacgtggtc agagtagaac ccctgaagta ttttttaatc ctacctcaaa atttaacagt
2761 tacctgagag atttaacatt atctagttca tgaatcatgt atgtggtcat ggataaattg
2821 cacaccttgg aattcgcttt ctaaaggaaa tcaaatgaat ggaggaactt tccaaacacc
2881 actttacttg tgttatatag ccaatataac tatctctact gaatgtcatt gaaaaactaa
2941 aaaattaaac ttatttacaa ataggt
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