GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMASM1MR 1879 bp ss-mRNA PRI 26-MAY-1991
DEFINITION Human ASM-1 mRNA for sphingomyelin phosphodiesterase (EC 3.1.4.12)
ACCESSION X52678 X16307
KEYWORDS ASM gene; acid sphingomyelinase; alternative splicing; hydrolase;
lysosomal hydrolase; sphingomyelin phosphodiesterase.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1879)
AUTHORS Quintern,L.E., Schuchman,E.H., Levran,O., Suchi,M., Ferlinz,K.,
Reinke,H., Sandhoff,K. and Desnick,R.J.
TITLE Isolation of cDNA clones encoding human acid sphingomyelinase:
occurrence of alternatively processed transcripts.
JOURNAL EMBO J. 8, 2469-2473 (1989)
STANDARD full automatic
COMMENT SWISS-PROT; P17405; ASM1$HUMAN.
*source: library=pcD; tissue=fibroblast; clone=pASM-1. See
<X52679>.
From EMBL entry HSASM1MR; dated 13-JUN-1990.
FEATURES Location/Qualifiers
CDS <1..1506
/note="acid sphingomyelinase (502 AA)"
/codon_start=1
BASE COUNT 370 a 585 c 512 g 412 t
ORIGIN
1 cctgccgtgt gccaatccat tgtccacctc tttgaggatg acatggtgga ggtgtggaga
61 cgctcagtgc tgagcccatc tgaggcctgt ggcctgctcc tgggctccac ctgtgggcac
121 tgggacattt tctcatcttg gaacatctct ttgcctactg tgccgaagcc gccccccaaa
181 ccccctagcc ccccagcccc aggtgcccct gtcagccgca tcctcttcct cactgacctg
241 cactgggatc atgactacct ggagggcacg gaccctgact gtgcagaccc actgtgctgc
301 cgccggggtt ctggcctgcc gcccgcatcc cggccaggtg ccggatactg gggcgaatac
361 agcaagtgtg acctgcccct gaggaccctg gagagcctgt tgagtgggct gggcccagcc
421 ggcccttttg atatggtgta ctggacagga gacatccccg cacatgatgt ctggcaccag
481 actcgtcagg accaactgcg ggccctgacc accgtcacag cacttgtgag gaagttcctg
541 gggccagtgc cagtgtaccc tgctgtgggt aaccatgaaa gcatacctgt caatagcttc
601 cctcccccct tcattgaggg caaccactcc tcccgctggc tctatgaagc gatggccaag
661 gcttgggagc cctggctgcc tgccgaagcc ctgcgcaccc tcagaattgg ggggttctat
721 gctctttccc cataccccgg tctccgcctc atctctctca atatgaattt ttgttcccgt
781 gagaacttct ggctcttgat caactccacg gatcccgcag gacagctcca gtggctggtg
841 ggggagcttc aggctgctga ggatcgagga gacaaagtgc atataattgg ccacattccc
901 ccagggcact gtctgaagag ctggagctgg aattattacc gaattgtagc caggtatgag
961 aacaccctgg ctgctcagtt ctttggccac actcatgtgg atgaatttga ggtcttctat
1021 gatgaagaga ctctgagccg gccgctggct gtagccttcc tggcacccag tgcaactacc
1081 tacatcggcc ttaatcctgg ttaccgtgtg taccaaatag atggaaacta ctccaggagc
1141 tctcacgtgg tcctggacca tgagacctac atcctgaatc tgacccaggc aaacataccg
1201 ggagccatac cgcactggca gcttctctac agggctcgag aaacctatgg gctgcccaac
1261 acactgccta ccgcctggca caacctggta tatcgcatgc ggggcgacat gcaacttttc
1321 cagaccttct ggtttctcta ccataagggc cacccaccct cggagccctg tggcacgccc
1381 tgccgtctgg ctactctttg tgcccagctc tctgcccgtg ctgacagccc tgctctgtgc
1441 cgccacctga tgccagatgg gagcctccca gaggcccaga gcctgtggcc aaggccactg
1501 ttttgctagg gccccagggc ccacatttgg gaaagttctt gatgtaggaa agggtgaaaa
1561 agcccaaatg ctgctgtggt tcaaccaggc aagatcatcc ggtgaaagaa ccagtccctg
1621 ggccccaagg atgccgggga aacaggacct tctcctttcc tggagctggt ttagctggat
1681 atgggagggg gtttggctgc ctgtgcccag gagctagact gccttgaggc tgctgtcctt
1741 tcacagccat ggagtagagg cctaagttga cactgccctg ggcagacaag acaggagctg
1801 tcgccccagg cctgtgctgc ccagccagga accctgtact gctgctgcga cctgatgctg
1861 ccagtctgtt aaaataaag
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