GenBank-Updates@genbank.bio.net (05/26/91)
LOCUS HUMHL02 1027 bp ss-mRNA PRI 26-MAY-1991
DEFINITION Human mRNA for histocompatibility antigen HLA-DR (fragment). The
alpha chain.
ACCESSION V00523
KEYWORDS complementary DNA; histocompatibility antigen.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1027)
AUTHORS Larhammar,D., Gustafsson,K., Claesson,L., Bill,P., Wiman,K.G.,
Schenning,L., Sundelin,J., Widmark,E., Peterson,P.A. and Rask,L.
TITLE Alpha chain of HLA-DR transplantation antigens is a member of the
same protein superfamily as the immunoglobulins
JOURNAL Cell 30, 153-161 (1982)
STANDARD full automatic
COMMENT The N-terminal protein sequence has also been obtained and gives
information about the 6 N-terminal amino acids. The complete amino
acid sequence is: IKEDHVIIQA EFYLNPDQDG EFMFDFDGDE IFHVDMAKKE
TVWRLEEFGR FACFEAQGAL ANIAVDKANL EIMTKRSNYT PITNVPPEVT VLTNSPVELR
EPNVLICFID KFTPPVVNVT WLRNGKPVTT GVSETVFLPR EDHLFRKFHY LPFLPSTEDV
YDCRVEHWGL DEPLLKHWEF DAPSPLPETT ENVVCALGLT VGLVGIIIGT IFIIKGVRKS
NAAERRGPL The W in position 178 corresponds to a termination codon
in the nucleotide sequence which may be a cloning or splicing
artefact. Data kindly reviewed (15-JUL-1983) by D. Larhammar
From EMBL entry HSHL02; dated 06-JUL-1989.
FEATURES Location/Qualifiers
mRNA <1..>1027
/note="messenger RNA"
CDS <1..671
/note="reading frame HLA-DR (1 is 2nd base in codon) (671
is 3rd base in codon)"
/codon_start=1
BASE COUNT 248 a 259 c 240 g 280 t
ORIGIN
1 tgatcatcca ggccgagttc tatctgaatc ctgaccaatc aggcgagttt atgtttgact
61 ttgatggtga tgagattttc catgtggata tggcaaagaa ggagacggtc tggcggcttg
121 aagaatttgg acgatttgcc agctttgagg ctcaaggtgc attggccaac atagctgtgg
181 acaaagccaa cctggaaatc atgacaaagc gctccaacta tactccgatt accaatgtac
241 ctccagaggt aactgtgctc acgaacagcc ctgtggaact gagagagccc aacgtcctca
301 tctgtttcat cgacaagttc accccaccag tggtcaatgt cacgtggctt cgaaatggaa
361 aacctgtcac cacaggagtg tcagagacag tcttcctgcc cagggaagac caccttttcc
421 gcaagttcca ctatctcccc ttcctgccct caactgagga cgtttacgac tgcagggtgg
481 agcactgggg cttggatgag cctcttctca agcactagga gtttgatgct ccaagccctc
541 tcccagagac tacagagaac gtggtgtgtg ccctgggcct gactgtgggt ctggtgggca
601 tcattattgg gaccatcttc atcatcaagg gagtgcgcaa aagcaatgca gcagaacgca
661 gggggcctct gtaaggcaca tggaggtgat ggtgtttctt agagagaaga tcactgaaga
721 aacttctgct ttaatgactt tacaaagctg gcaatattac aatccttgac ctcagtgaaa
781 gcagtcatct tcagcgtttt ccagccctat agccacccca agtgtggtta tgcctcctcg
841 attgctccgt actctaacat ctagctggct tccctgtcta ttgccttttc ctgtatctat
901 tttcctctat ttcctatcat tttattatca ccatgcaatg cctctggaat aaaacataca
961 ggagtctgtc tctgctatgg aatgccccat ggggcatctc ttgtgtactt attgtttaag
1021 gtttcct
//