GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUM242G2 458 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human Hs242 oncogene (c-bas/has) for p21 protein (exon 2)
ACCESSION X01228
KEYWORDS c-has/bas oncogene; oncogene.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 458)
AUTHORS Yuasa,Y., Srivastava,S.K., Dunn,C.Y., Rhim,J.S., Reddy,E.P. and
Aaronson,S.A.
TITLE Acquisition of transforming properties by alternative point
mutations within c-bas/has human proto-oncogene
JOURNAL Nature 303, 775-779 (1983)
STANDARD full automatic
COMMENT Data kindly reviewed (06-MAR-1986) by S.A. Aaronson
From EMBL entry HS242G2; dated 06-JUL-1989.
FEATURES Location/Qualifiers
intron <1..79
/note="intron I"
mRNA 80..258
/note="exon 2"
CDS 80..258
/note="p21 protein (aa 38-97) (258 is 2nd base in codon)"
/codon_start=80
mutation 150..150
/note="point mutation (aa 61; A is T; Gln is Leu)
responsible for the transforming activity of the Hs242
oncogene"
intron 259..412
/note="intron II"
mRNA 413..>458
/note="exon 3"
CDS 413..>458
/note="p21 protein (aa 98-112) (413 is 3rd base in codon)"
/codon_start=413
BASE COUNT 80 a 143 c 151 g 84 t
ORIGIN
1 ggtaccaggg agaggctggc tgtgtgaact ccccccacgg aaggtcctga gggggtccct
61 gagccctgtc ctcctgcagg attcctaccg gaagcaggtg gtcattgatg gggagacgtg
121 cctgttggac atcctggata ccgccggcct ggaggagtac agcgccatgc gggaccagta
181 catgcgcacc ggggagggct tcctgtgtgt gtttgccatc aacaacacca agtcttttga
241 ggacatccac cagtacaggt gaaccccgtg aggctggccc gggagcccac gccgcacagg
301 tggggccagg ccggctgcgt ccaggcaggg gcctcctgtc ctctctgcgc atgtcctgga
361 tgccgcctgc gcctgcagcc cccgtagcca gctctcgctt tccacctctc agggagcaga
421 tcaaacgggt gaaggactcg gatgacgtgc ccatggtg
//