GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMBPPTK 1021 bp ss-mRNA PRI 27-MAY-1991
DEFINITION Human mRNA for beta-preprotachykinin
ACCESSION X54469 M28019
KEYWORDS neurokinin A; neuropeptide; neuropeptide K; substance K;
substance P; substance P receptor; substance-K receptor;
tachykinin.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Harmar,A.J., Armstrong,A., Pascall,J.C., Chapman,K., Rosie,R.,
Curtis,A., Going,J., Edwards,C.R. and Fink,G.
TITLE cDNA sequence of human beta-preprotachykinin, the common precursor
to substance P and neurokinin A
JOURNAL FEBS Lett. 208, 67-72 (1986)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 1021)
AUTHORS Harmar,A.J.
JOURNAL Unpublished (1990)
STANDARD full automatic
COMMENT *source: developmental stage=adult; tissue type=carcinoid tumor;
*source: library=cDNA in pBR322; clone=phE293, ph8.216;
From EMBL entry HSBPPTK; dated 09-JAN-1991.
FEATURES Location/Qualifiers
mRNA <1..1021
sig_peptide 82..138
CDS 82..471
/product="beta-preprotachykinin"
/codon_start=82
misc_feature 139..249
/note="N-flanking peptide"
mat_peptide 253..285
/product="substance P"
mat_peptide 295..402
/product="neuropeptide K"
mat_peptide 373..402
/product="neurokinin A (substance K)"
misc_feature 412..459
/note="C-flanking peptide"
polyA_site 1021..1021
BASE COUNT 322 a 176 c 212 g 311 t
ORIGIN
1 gagagtgcgg agcgaccacg tgcgctcgga ggaaccagag aaactcagca ccccgcggga
61 ctgtccgtcg caaaatccaa catgaaaatc ctcgtggcct tggcagtctt ttttcttgtc
121 tccactcagc tgtttgcaga agaaatagga gccaatgatg atctgaatta ctggtccgac
181 tggtacgaca gcgaccagat caaggaggaa ctgccggagc cctttgagca tcttctgcag
241 agaatcgccc ggagacccaa gcctcagcag ttctttggat taatgggcaa acgggatgct
301 gattcctcaa ttgaaaaaca agtggccctg ttaaaggctc tttatggaca tggccagatc
361 tctcacaaaa gacataaaac agattccttt gttggactaa tgggcaaaag agctttaaat
421 tctgtggctt atgaaaggag tgcaatgcag aattatgaaa gaagacgtta ataaactacc
481 taacattatt tattcagctt catttgtgtc aatgggcaat gacaggtaaa ttaagacatg
541 cactatgagg aataattatt tatttaataa caattgttta gggttgaaaa ttcaaaaagt
601 gtttattttt catattgtgc caatatgtat tgtaaacatg tgttttaatt ccaatatgat
661 gactccctta aaatagaaat aagtggttat ttctcaacaa agcacagtgt taaatgaaat
721 tgtaaaacct gtcaatgata cagtccctaa agaaaaaaaa tcattgcttt gaagcagttg
781 tgtcagctac tgcggaaaag gaaggaaact cctgacagtc ttgtgctttt cctatttgtt
841 ttcatggtga aaatgtactg agattttggt attacactgt atttgtatct ctgaagcatg
901 tttcatgttt tgtgactata tagagatgtt tttaaaagtt tcaatgtgat tctaatgtct
961 tcatttcatt gtatgatgtg ttgtgatagc taacatttta aataaaagaa aaaatatctt
1021 g
//