GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMCFOT 3565 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human cellular oncogene c-fos (complete sequence)
ACCESSION V01512
KEYWORDS oncogene.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3565)
AUTHORS van Straaten,F., Mueller,R., Curran,T., Van Beveren,C. and
Verma,I.M.
TITLE Complete nucleotide sequence of a human c-onc gene: Deduced amino
acid sequence of the human c-fos protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80, 3183-3187 (1983)
STANDARD full automatic
COMMENT EPD; 11145; Hs c-fos. SWISS-PROT; P01100; FOS$HUMAN.
Data kindly reviewed (10-OCT-1983) by F. van Straaten
From EMBL entry HSCFOS; dated 18-DEC-1990.
FEATURES Location/Qualifiers
CDS join(289..429,1183..1434,1866..1973,2088..2726)
/codon_start=289
precursor_RNA 132..>3515
/note="possible transcript"
precursor_RNA 132..>3259
/note="possible transcript"
mRNA 132..429
/note="exon 1 (alternate start site)"
precursor_RNA 136..>3515
/note="possible transcript"
precursor_RNA 136..>3259
/note="possible transcript"
mRNA 136..429
/note="exon 1 (alternate start site)"
intron 430..1182
/note="intron I"
mRNA 1183..1434
mRNA 1183..1434
/note="exon 2"
intron 1435..1865
/note="intron II"
mRNA 1866..1973
mRNA 1866..1973
/note="exon 3"
intron 1974..2087
/note="intron III"
mRNA 2088..>3515
/note="exon 4 (alternate stop site)"
mRNA 2088..>3239
/note="exon 4 (alternate stop site)"
BASE COUNT 780 a 954 c 978 g 853 t
ORIGIN
1 gcagccgggc ggccgcagaa gcgcccaggc ccgcgcgcca cccctctggc gccaccgtgg
61 ttgagcccgt gacgtttaca ctcattcata aaacgcttgt tataaaagca gtggctgcgg
121 cgcctcgtac tccaaccgca tctgcagcga gcaactgaga agccaagact gagccggcgg
181 ccgcggcgca gcgaacgagc agtgaccgtg ctcctaccca gctctgcttc acagcgccca
241 cctgtctccg cccctcggcc cctcgcccgg ctttgcctaa ccgccacgat gatgttctcg
301 ggcttcaacg cagactacga ggcgtcatcc tcccgctgca gcagcgcgtc cccggccggg
361 gatagcctct cttactacca ctcacccgca gactccttct ccagcatggg ctcgcctgtc
421 aacgcgcagg taaggctggc ttcccgtcgc cgcggggccg ggggcttggg gtcgcggagg
481 aggagacacc gggcgggacg ctccagtaga tgagtagggg gctcccttgt gcctggaggg
541 aggctgccgt ggccggagcg gtgccggctc gggggctcgg gacttgctct gagcgcacgc
601 acgcttgcca tagtaagaat tggttccccc ttcgggaggc aggttcgttc tgagcaacct
661 ctggtctgca ctccaggacg gatctctgac attagctgga gcagacgtgt cccaagcaca
721 aactcgctaa ctagagcctg gcttcttcgg ggaggtggca gaaagcggca atcccccctc
781 ccccggcagc ctggagcacg gaggagggat gagggaggag ggtgcagcgg gcgggtgtgt
841 aaggcagttt cattgataaa aagcgagttc attctggaga ctccggagcg gcgcctgcgt
901 cagcgcagac gtcagggata tttataacaa accccctttc aagcaagtga tgctgaaggg
961 ataacgggaa cgcagcggca ggatggaaga gacaggcact gcgctgcgga atgcctggga
1021 ggaaaagggg gagacctttc atccaggatg agggacattt aagatgaaat gtccgtggca
1081 ggatcgtttc tcttcactgc tgcatgcggc actgggaact cgccccacct gtgtccggaa
1141 cctgctcgct cacgtcggct ttccccttct gttttgttct aggacttctg cacggacctg
1201 gccgtctcca gtgccaactt cattcccacg gtcactgcca tctcgaccag tccggacctg
1261 cagtggctgg tgcagcccgc cctcgtctcc tctgtggccc catcgcagac cagagcccct
1321 caccctttcg gagtccccgc cccctccgct ggggcttact ccagggctgg cgttgtgaag
1381 accatgacag gaggccgagc gcagagcatt ggcaggaggg gcaaggtgga acaggtgagg
1441 aactctagcg tactcttcct gggaatgtgg gggctgggtg ggaagcagcc ccggagatgc
1501 aggagcccag tacagaggat gaagccactg atggggctgg ctgcacatcc gtaactggga
1561 gccctggctc caagcccatt ccatcccaac tcagactctg agtctcaccc taagaagtac
1621 tctcatagtt tcttccctaa gtttcttacc gcatgctttc agactgggct cttctttgtt
1681 ctcttgctga ggatcttatt ttaaatgcaa gtcacaccta ttctgcaact gcaggtcaga
1741 aatggtttca cagtggggtg ccaggaagca gggaagctgc aggagccagt tctactgggg
1801 tgggtgaatg gaggtgatgg cagacacttt tactgaatgt cggtcttttt ttgtgattat
1861 tctagttatc tccagaagaa gaagagaaaa ggagaatccg aagggaaagg aataagatgg
1921 ctgcagccaa atgccgcaac cggaggaggg agctgactga tacactccaa gcggtaggta
1981 ctctgtgggt tgctcctttt taaaacttaa gggaaagttg gagattgagc ataagggccc
2041 ttgagtaaga ctgtgtctta tgctttcctt tatccctctg tatacaggag acagaccaac
2101 tagaagatga gaagtctgct ttgcagaccg agattgccaa cctgctgaag gagaaggaaa
2161 aactagagtt catcctggca gctcaccgac ctgcctgcaa gatccctgat gacctgggct
2221 tcccagaaga gatgtctgtg gcttcccttg atctgactgg gggcctgcca gaggttgcca
2281 ccccggagtc tgaggaggcc ttcaccctgc ctctcctcaa tgaccctgag cccaagccct
2341 cagtggaacc tgtcaagagc atcagcagca tggagctgaa gaccgagccc tttgatgact
2401 tcctgttccc agcatcatcc aggcccagtg gctctgagac agcccgctcc gtgccagaca
2461 tggacctatc tgggtccttc tatgcagcag actgggagcc tctgcacagt ggctccctgg
2521 ggatggggcc catggccaca gagctggagc ccctgtgcac tccggtggtc acctgtactc
2581 ccagctgcac tgcttacacg tcttccttcg tcttcaccta ccccgaggct gactccttcc
2641 ccagctgtgc agctgcccac cgcaagggca gcagcagcaa tgagccttcc tctgactcgc
2701 tcagctcacc cacgctgctg gccctgtgag ggggcaggga aggggaggca gccggcaccc
2761 acaagtgcca ctgcccgagc tggtgcatta cagagaggag aaacacatct tccctagagg
2821 gttcctgtag acctagggag gaccttatct gtgcgtgaaa cacaccaggc tgtgggcctc
2881 aaggacttga aagcatccat gtgtggactc aagtccttac ctcttccgga gatgtagcaa
2941 aacgcatgga gtgtgtattg ttcccagtga cacttcagag agctggtagt tagtagcatg
3001 ttgagccagg cctgggtctg tgtctctttt ctctttctcc ttagtcttct catagcatta
3061 actaatctat tgggttcatt attggaatta acctggtgct ggatattttc aaattgtatc
3121 tagtgcagct gattttaaca ataactactg tgttcctggc aatagtgtgt tctgattaga
3181 aatgaccaat attatactaa gaaaagatac gactttattt tctggtagat agaaataaat
3241 agctatatcc atgtactgta gtttttcttc aacatcaatg ttcattgtaa tgttactgat
3301 catgcattgt tgaggtggtc tgaatgttct gacattaaca gttttccatg aaaacgtttt
3361 attgtgtttt taatttattt attaagatgg attctcagat atttatattt ttattttatt
3421 tttttctacc ttgaggtctt ttgacatgtg gaaagtgaat ttgaatgaaa aatttaagca
3481 ttgtttgctt attgttccaa gacattgtca ataaaagcat ttaagttgaa tgcgaccaac
3541 cttgtgctct tttcattctg gaagt
//