GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMECP1 1452 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human DNA for eosinophil cationic protein ECP
ACCESSION X16545
KEYWORDS cytotoxin; eosinophil cationic protein; helminthotoxin; neurotoxin.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1452)
AUTHORS Barker,R.L.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1452)
AUTHORS Hamann,K.J., Ten,R.M., Loegering,D.A., Jenkins,R.B., Heise,M.T.,
Schad,C.R., Pease,L.R., Gleich,G.J. and Barker,R.L.
TITLE Structure and chromosome localization of the human
eosinophil-derived neurotoxin and eosinophil cationic protein
genes: evidencefor intronless coding sequences in the ribonuclease
gene superefamily
JOURNAL Genomics 7, 535-546 (1990)
STANDARD full automatic
COMMENT *source: library=ATCC 37333; cell type=eosinophil; *source: cell
line=human fetal liver charon 4A. see X15161 for human ECP cDNA seq
From EMBL entry HSECP1; dated 09-NOV-1990.
FEATURES Location/Qualifiers
promoter 225..231
/note="TATA box"
mRNA 279..320
/note="exon 1"
intron 321..550
/note="intron I"
mRNA 551..1217
/note="exon 2"
CDS 556..1035
/note="eosinophil cationic protein precursor"
/codon_start=556
CDS 556..636
/note="signal peptide (AA -27 to -1)"
/codon_start=556
CDS 637..1035
/note="mat. eosinophil cationic protein (AA 1 - 133)"
/codon_start=637
misc_feature 1196..1201
/note="polyA signal"
BASE COUNT 380 a 376 c 323 g 373 t
ORIGIN
1 ctgccagcag cgtatagttt tcacccagag tccagatccc accggcaaaa ctctgtctaa
61 cacaggatga cttggaatta gagtccgtat agcagaaaga gcagcagggc tgtccttggg
121 tatccgttgc tcagccaagt catcaaataa aaaggatgat tgcacaagtg gaccatgtgt
181 caatctgtgg gtttctgcat ggccagaccc accaagggaa gctttattta aacagttcca
241 agtaggggag accagctgcc cctgaacccc agaacaacca gctggatcag ttctcacagg
301 agccacagct cagagactgg gtaagtcaac aatccccaga gctgggacag gaggggcagc
361 gacagggcag cacctgaggg agaggtgagc tgaagttagt gcttaggaga tgtggcacac
421 tttggggaca ggaagaaaag gaaatgcgac cccagagtgg cagcagaggg gcctgtgggt
481 tgagacacta tagagtgtgt cataaccgag accggatagg ggagtagtta cttctcttct
541 tttcttacag gaaacatggt tccaaaactg ttcacttccc aaatttgtct gcttcttctg
601 ttggggctta tgggtgtgga gggctcactc catgccagac ccccacagtt tacgagggct
661 cagtggtttg ccatccagca catcagtctg aacccccctc gatgcaccat tgcaatgcgg
721 gcaattaaca attatcgatg gcgttgcaaa aaccaaaata cttttcttcg tacaactttt
781 gctaatgtag ttaatgtttg tggtaaccaa agtatacgct gccctcataa cagaactctc
841 aacaattgtc atcggagtag attccgggtg cctttactcc actgtgacct cataaatcca
901 ggtgcacaga atatttcaaa ctgcaggtat gcagacagac caggaaggag gttctatgta
961 gttgcatgtg acaacagaga tccacgggat tctccacggt atcctgtggt tccagttcac
1021 ctggatacca ccatctaagc tcctgtatca gcagtcctca tcatcactca tctgccaagc
1081 tcctcaatca tagccaagat cccatccctc catgtactct gggtatcagc aactgtcctc
1141 atcagtctcc ataccccttc agctttcctg agctgaagtc ccttgtgaac cctgcaataa
1201 actgctttgc aaattcatct ggaagtgtct gtgtgtcttc ctcggccgct ctgctgtcat
1261 ttagtgacaa tctgctctag agatttgggt ttatcatgaa tctctccccc tcaatatctg
1321 accaaattcc ttgattcccc catcatcctt catgtgatac ctgattccag gcctgcctta
1381 aaaaaaaatc caattgagtc aacttagcat tggtctccct agccttaata tctcctctaa
1441 gcaattttcc at
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