GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMFBRGG 10564 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human gene for fibrinogen gamma chain
ACCESSION X02415
KEYWORDS fibrinogen; glycoprotein; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 10564)
AUTHORS Rixon,M.W., Chung,D.W. and Davie,E.W.
TITLE Nucleotide sequence of the gene for the gamma-chain of human
fibrinogen
JOURNAL Biochemistry 24, 2077-2086 (1985)
STANDARD full automatic
COMMENT EPD; 11087; Hs g'-fibrinogen. SWISS-PROT; P02679; FIBG$HUMAN.
SWISS-PROT; P04469; FIBH$HUMAN.
From EMBL entry HSFBRGG; dated 02-JUL-1986.
FEATURES Location/Qualifiers
repeat_region 1280..1309
/note="direct repeat"
repeat_region 1310..1339
/note="direct repeat"
promoter 1691..1694
/note="pot. CAT-box"
promoter 1724..1728
/note="pot. TATA-box"
precursor_RNA 1748..10271
/note="fibrinogen gamma chain primary transcript"
precursor_RNA 1748..9825
/note="fibrinogen gamma chain variant gamma' primary
transcript"
mRNA 1748..1876
/note="exon 1"
CDS 1799..1876
/note="signal peptide (aa -26 to -1)"
/codon_start=1799
intron 1877..1972
/note="intron I"
CDS 1973..2017
/note="mat. gamma chain (aa 1-15),exon 2"
/codon_start=1973
intron 2018..2206
/note="intron II"
CDS 2207..2390
/note="mat. gamma chain (aa 16-76),exon 3 (2390 is 1st
base in codon)"
/codon_start=2207
intron 2391..2509
/note="intron III"
CDS 2510..2603
/note="mat. gamma chain (aa 77-108),exon 4 (2510 is 2nd
base in codon) (2603 is 2nd base in codon)"
/codon_start=2510
intron 2604..4210
/note="intron IV"
CDS 4211..4341
/note="mat. gamma chain (aa 109-151),exon 5 (4211 is 3rd
base in codon) (4341 is 1st base in codon)"
/codon_start=4211
intron 4342..4644
/note="intron V"
CDS 4645..4778
/note="mat. gamma chain (aa 152-196),exon 6 (4645 is 2nd
base in codon)"
/codon_start=4645
intron 4779..5757
/note="intron VI"
CDS 5758..5942
/note="mat. gamma chain (aa 197-258),exon 7 (5942 is 2nd
base in codon)"
/codon_start=5758
intron 5943..7425
/note="intron VII"
CDS 7426..7703
/note="mat. gamma chain (aa 259-350),exon 8 (7426 is 3rd
base in codon) (7703 is 1st base in codon)"
/codon_start=7426
intron 7704..9341
/note="intron VIII"
misc_feature 8324..8468
/note="region identical to exon 9 coding region 9367.3 to
9524.1 (aa 360-410)"
mRNA 9342..9825
/note="exon 9'"
CDS 9342..9571
/note="mature gamma' chain (aa 351-427)"
/codon_start=9342
CDS 9342..9511
/note="mat. gamma chain (aa 351-407),exon 9 (9342 is 2nd
base in codon)"
/codon_start=9342
intron 9512..10053
/note="intron IV"
misc_feature 9808..9813
/note="pot. polyA signal for gamma' chain"
polyA_site 9825..9825
/note="polyA site of gamma' chain"
mRNA 10054..10271
/note="exon 10"
CDS 10054..10065
/note="mat. gamma chain (aa 408-411)"
/codon_start=10054
misc_feature 10247..10252
/note="pot. polyA signal"
polyA_site 10271..10271
/note="polyA site"
BASE COUNT 3337 a 1936 c 1991 g 3300 t
ORIGIN
1 ctacacactt cttgaaggca aaggcaatgc tgaagtcacc tttcatgttc aaatcatatt
61 aaaaagttag caagatgtaa ttatcagtgt actatgtaaa tctttgtgaa tgatcaataa
121 ttacatattt tcattatata tattttagta gataatattt atatacattc aacattctaa
181 atatagaaag tttacagaga aaaataaagc ctttttttcc aatcctgtcc tccacctctg
241 catcccattc ttcttcacag aggcaactga ttcaagtcat tacatagtta ttgagtgtta
301 actacaacta tgttaagtac agctatatat gttagatgcc gtagccacag aaatcagttt
361 acaatctaat gcagtggata cagcatgtat acatataata taaggttgct acaaatgcta
421 tctgaggtag agctgtttga aagaatacta atacttaaat gtttaattca actgacttga
481 ttgacaactg attagctgag tggaaaagat ggatgagaaa gattgtgaga cttaattggc
541 tggtggtatg gtgatatgat tgacaataac tgctaagtca gagagggata tattaaggag
601 gagaagaaaa gcaacaaatc tggttttgat gtgttcactt tgttataatt attgattatt
661 tactgaatat gaatatttat ctttgttttt gagtcaataa atataccttt gtaaagacag
721 aattaaagta ttagtatttc tttcaaactg gaggcatttc tcccactaac atatttcatc
781 aaaacttata ataagcttgg ttccagagga agaaatgagg gataaccaaa aatagagaca
841 ttaataatag tgtaacgccc agtgataaat ctcaataggc agtgatgaca gacatgtttt
901 cccaaacaca aggatgctgt aagggccaaa cagaaatgat ggcccctccc cagcacctca
961 ttttgcccct tccttcagct atgcctctac tctcctttag atacaaggga ggtggatttt
1021 tctcttctct gagatagctt gatggaacca caggaacaat gaagtgggct cctggctctt
1081 ttctctgtgg cagatggggt gccatgccca ccttcagaca aagggaagat tgagctcaaa
1141 agctccctga gaagtgagag cctatgaaca tggttgacac agagggacag gaatgtattt
1201 ccagggtcat tcattcctgg gaatagtgaa ctgggacatg ggggaagtca gtctcctcct
1261 gccacagcca cagattaaaa ataataatgt taactgatcc ctaggctaaa ataatagtgt
1321 taactgatcc ctaagctaag aaagttcttt tggtaattca ggtgatggca gcaggaccca
1381 tcttaaggat agactaggtt tgcttagttc gaggtcatat ctgtttgctc tcagccatgt
1441 actggaagaa gttgcatcac acagcctcca ggactgccct cctcctcaca gcaatggata
1501 atgcttcact agcctttgca gataattttg gatcagagaa aaaaccttga gctgggccaa
1561 aaaggaggag cttcaacctg tgtgcaaaat ctgggaacct gacagtatag gttgggggcc
1621 aggatgagga aaaaggaacg ggaaagacct gcccaccctt ctggtaagga ggccccgtga
1681 tcagctccag ccatttgcag tcctggctat cccaggagct tacataaagg gacaattgga
1741 gcctgagagg tgacagtgct gacactacaa ggctcggagc tccgggcact cagacatcat
1801 gagttggtcc ttgcaccccc ggaatttaat tctctacttc tatgctcttt tatttctctc
1861 ttcaacatgt gtagcagtaa gtgtgctctt cacaaaacgt tgtttaaaat ggaaagctgg
1921 aaaataaaac agataataaa ctagtgaaat tttcgtattt tttctctttt agtatgttgc
1981 taccagagac aactgctgca tcttagatga aagattcgta agtagttttt atgtttctcc
2041 ctttgtgtgt gaactggaga ggggcagagg aatagaaata attccctcat aaatatcatc
2101 tggcacttgt aactttttaa aaacatagtc taggttttac ctatttttct taatagattt
2161 taagagtagc atctgtctac atttttaatc actgttatat tttcagggta gttattgtcc
2221 aactacctgt ggcattgcag atttcctgtc tacttatcaa accaaagtag acaaggatct
2281 acagtctttg gaagacatct tacatcaagt tgaaaacaaa acatcagaag tcaaacagct
2341 gataaaagca atccaactca cttataatcc tgatgaatca tcaaaaccaa gtgagaaaat
2401 aaagactact gaccaaaaaa taataataat aatctgtgaa gttcttttgc tgttgtttta
2461 gttgttctat ttgcttaagg atttttatgt ctctgatcct atattacaga tatgatagac
2521 gctgctactt tgaagtccag gataatgtta gaagaaatta tgaaatatga agcatcgatt
2581 ttaacacatg actcaagtat tcggtaagga tttttgtttt aatttgctct gcaagactga
2641 tttagttttt atttaatatt ctatacttga gtgaaagtaa tttttaatgt gttttcccca
2701 tttataatat cccagtgaca ttatgcctga ttatgttgag catagtagag atagaagttt
2761 ttagtgcaat ataaattata ctgggttata attgcttatt aataatcaca ttgaagaaag
2821 atgttctaga tgtcttcaaa tgctagtttg accatattta tcaaaaattt tttccccatc
2881 ccccatttat cttacaacat aaaatcaatc tcataggaat ttgggtgttg aaaataaaat
2941 cctctttata aaaatgctga caaattggtg gttaaaaaaa ttagcaagca gaggcatagt
3001 aaggattttg gctcctaaag taaattatat tgaatgtgga gcaggaagaa acatgtcttg
3061 agagactaag tgtggcaaat attgcaaagc tcatattgat cattgcagaa tgaacctgca
3121 tagtctcttc ccttcatttg gaagtgaatg tctctgttaa agcttctcag ggactcataa
3181 actttctgaa cataaggtct cagatacagt tttaatattt ttccccaatt tttttttctg
3241 aatttttctc aaagcagctt gagaaattga gataaatagt agctagggag aagtggccca
3301 ggaaagattt ctcctctttt tgctatcaga gggcccttgt tattattgtt attattatta
3361 cttgcattat tattgtccat cattgaagtt gaaggaggtt attgtacaga aattgcctaa
3421 gacaaggtag agggaaaacg tggacaaata gtttgtctac ccttttttac ttcaaagaaa
3481 gaacggttta tgcattgtag acagttttct atcatttttg gatatttgca agccaccctg
3541 taagtaacta caaaaggagg gtttttactt cccccagtcc attcccaaag ctatgtaacc
3601 agaagcatta aagaagaaag gggaagtatc tgttgtttta ttttacatac aataacgttc
3661 cagatcatgt ccctgtgtaa gttatatttt agattgaagc ttatatgtat agcctcagta
3721 gatccacaag tgaaaggtat actccttcag cacatgtgaa ttactgaact gagcttttcc
3781 tgcttctaaa gcatcagggg gtgttcctat taaccagtct cgccactctt gcaggttgct
3841 atctgctgtc ccttatgcat aaagtaaaaa gcaaaatgtc aatgacattt gcttattgac
3901 aaggactttg ttatttgtgt tgggagttga gacaatatgc cccattctaa gtaaaaagat
3961 tcaggtccac attgtattcc tgttttaatt gattttttga tttgtttttc tttttcaaaa
4021 agtttataat tttaattcat gttaatttag taatataatt ttacattttc ctcaagaatg
4081 gaataattta tcagaaagca cttcttaaga aaatacttag cagtttccaa agaaaatata
4141 aaattactct tctgaaagga atacttattt ttgtcttctt atttttgtta tcttatgttt
4201 ctgtttgtag atatttgcag gaaatatata attcaaataa tcaaaagatt gttaacctga
4261 aagagaaggt agcccagctt gaagcacagt gccaggaacc ttgcaaagac acggtgcaaa
4321 tccatgatat cactgggaaa ggtaactgat gaaggttata ttgggattag gttcatcaaa
4381 gtaagtaatg taaaggagaa agtatgtact ggaaagtata ggaatagttt agaaagtggc
4441 tacccattaa gtctaagaat ttcagttgtc tagacctttc ttgaatagct aaaaaaaaca
4501 gtttaaaagg aatgctgatg tgaaaagtaa gaaaattatt cttggaaaat gaatagttta
4561 ctacatgtta aaagctattt ttcaaggctg gcacagtctt acctgcattt caaaccacag
4621 taaaagtcga ttctccttct ctagattgtc aagacattgc caataaggga gctaaacaga
4681 gcgggcttta ctttattaaa cctctgaaag ctaaccagca attcttagtc tactgtgaaa
4741 tcgatgggtc tggaaatgga tggactgtgt ttcagaaggt aattttttcc ccaccatgtg
4801 tatttaataa attcctacat tgtttctgcc atatggcaga tacttttcta agcaccttgt
4861 gaaccgtagc tcatttaatc cttgcaatag ccctaagagg aaggtacttc tgttactcct
4921 atttacagaa aaggaaactg aggcacacaa ggttaaataa cttgcccaag accacataac
4981 taataagcaa cagagtcagc atttgaacct aggcagtata gtttcagagt ttgtgacttg
5041 actctatatt gtactggcac tgactttgta gattcatggt ggcacataat catagtacca
5101 cagtgacaaa taaaaagaag gaaactcttt tgtcaggtag gtcaagacct gaggtttccc
5161 atcacaagat gaggaagccc aacaccaccc cccaccaccc caccaccatc accacccttt
5221 cacacaccag aggatacact tgggctgctc caagacaagg aacctgtgtt gcatctgcca
5281 cttgctgata cccactagga atcttggctc ctttactttc tgtttacctc ccaccactgt
5341 tataactgtt tctacagggg gcgctcagag ggaatgaatg gtggaagcat tagttgccag
5401 acaccgattg agcaatgggt tccatcataa gtgtaagaat cagtaatatc cagctagagt
5461 tctgaagtcg tctaggtgtc tttttaatat taccactcat ttagaattta tgatgtgcca
5521 gaaaccctct taagtatttc tcttatattc tctctcatga tccttgcagc aaccctaaga
5581 agtaaccatc atttttccta tttgatacat gaggaaactg aggtagcttg gccaagatca
5641 cttagttggg agttgataga accagtgctc tgtatttttg acaaaatgtt gacagcattc
5701 tctttacatg cattgatagt ctattttctc cttttgctct tgcaaatgtg taattagaga
5761 cttgatggca gtgtagattt caagaaaaac tggattcaat ataaagaagg atttggacat
5821 ctgtctccta ctggcacaac agaattttgg ctgggaaatg agaagattca tttgataagc
5881 acacagtctg ccatcccata tgcattaaga gtggaactgg aagactggaa tggcagaacc
5941 aggtactgtt ttgaaatgac ttccaacttt ttattgtaaa gattgcctgg aatgtgcact
6001 ttccaactat caatagacaa tggcaaatgc agcctgacaa atgcaaacag cacatccagc
6061 caccattttc tccaggagtc tgtttggttc ttgggcaatc caaaaaggta aattctattc
6121 aggatgaatc taagtgtatt ggtacaatct aattaccctg gaaccattca gagtaatagc
6181 taattactga acttttaatc agtcccagga attgagcata aaattataat tttatctagt
6241 ctaaattact atttcatgaa gcaggtatta ttattaatcc cattttatag attaacttgc
6301 tcaaagtcac attgctgata agtggtagag gtagaattca gactcaagta gtttaacttt
6361 agagcctgtc ctcttaacaa ctatcctggt tgaaaagcaa atacagcctc ttcagacttc
6421 tcagtgcctt gatggccatt tattctgtca aatcatgagc taccctaaaa gtaaaccagc
6481 tagctctttt gatgatctag aggcttcttt ttgcttgaga tatttgaagg ttttaagcat
6541 tgttacctaa ttaaaatgca gaaaaatatc caaccctctt gttatgttta aggaatagtg
6601 aaatatattg tcttcaaaca catggacttt tttttattgc ttggttggtt tttaatccag
6661 aaagtgctat agtcagtaga ccttcttcta ggaaaggacc ttccatttcc cagccactgg
6721 agattagaaa ataagctaaa tattttctgg aaatttctgt tcattcatta aggcccatcc
6781 tttcccccac tctatagaag tgttgtccac ttgcacaatt ttttccagga aagaatctct
6841 ctaactcctt cagctcacat gctttggacc acacagggaa gactttgatt gtgtaatgcc
6901 ctcagaagct ctccttcttg ccactaccac actgatttga ggaagaaaat ccctttagca
6961 cctaaccctt caggtgctat gagtggctaa tggaactgta cctccttcaa gttttgtgca
7021 ataattaagg gtcactcact gtcagatact ttctgtgatc tatgataatg tgtgtgcaac
7081 acataacatt tcaataaaag tagaaaatat gaaattagag tcatctacac atctggattt
7141 gatcttagaa tgaaacaagc aaaaaagcat ccaagtgagt gcaattatta gttttcagag
7201 atgcttcaaa ggcttctagg cccatcccgg gaagtgttaa tgagctgtgg actggttcac
7261 atatctattg cctcttgcca gatttgcaaa aaacttcact caatgagcaa atttcagcct
7321 taagaaacaa agtcaaaaat tccaaggaag catcctacga aagagggaac ttctgagatc
7381 cctgaggagg gtcagcatgt gatggttgta tttccttctt ctcagtactg cagactatgc
7441 catgttcaag gtgggacctg aagctgacaa gtaccgccta acatatgcct acttcgctgg
7501 tggggatgct ggagatgcct ttgatggctt tgattttggc gatgatccta gtgacaagtt
7561 tttcacatcc cataatggca tgcagttcag tacctgggac aatgacaatg ataagtttga
7621 aggcaactgt gctgaacagg atggatctgg ttggtggatg aacaagtgtc acgctggcca
7681 tctcaatgga gtttattacc aaggtatgtt ttcctttctt agattccaag ttaatgtata
7741 gtgtatacta ttttcataaa aaataataaa tagatatgaa gaaatgaaga ataatttata
7801 aagatagtag ggattttatc atgttcttta tttcaactaa gttctttgaa actggaagtg
7861 gataatacca agttcatgcc taaaattagc ccttctaaag aaatccacct gctgcaaaat
7921 atccagtagt ttggcattat atgtgaaact atcaccatca tagctggcac tgtgggttgt
7981 gggatctcct ttagacatac aacataaatg atctggatgg attaacatta ctacatggat
8041 gcttgttgac acattaacct ggcttcccat gagctttgtg tcagatacac gcagtgaaca
8101 ggtgtttgga ggaacagaat aaagagaagg caagcactgg taagggcagg ggtttgtgaa
8161 agcttgagag aagagaccag tctgaggaca gtagacactt attttaggat gggggttgga
8221 tgaggaggct atagtttgct ataagcttgg aatggtttgg aacactggtt tcactcacct
8281 acccagcagt tatgtgtggg gaagccttac cgatgctaaa ggatccatgt tacaataatg
8341 gcattatttg gaaatcccag tggtattcca tgaataaaac cactatgaag ataatcccac
8401 tcaacagact ctccgttgga gaaggacagc aacaccaccc tgggaaagcc aaacagtcag
8461 accagacctg tttagcatca gtaggacttc cctaccatat ctgctgggta gatgagtgaa
8521 accagtgttc caaaccactc cgggcttgta gcaaaccata gtctcctcat ctaccaagat
8581 gagcaacctt acctcctgat gtcctagcca atcaccaact aggaaacttt gcacagttta
8641 tttaaagtaa cagtttgatt ttcacaatat ttttaaattg gagaaacata acttatcttt
8701 gcactcacaa accacataat gagaagaaac tctaagggaa aatgcttgat ctgtgtgacc
8761 cggggcgcca tgccagagct gtagttcatg ccagtgttgt gctctgacaa gccttttaca
8821 gaattacatg agatctgctt ccctaggaca aggagaaggc aaatcaacag aggctgcact
8881 ttaaaatgga gacataaaat aacatgccag aaccatttcc taaagctcct caatcaacca
8941 acaaaattgt gctttcaaat aacctgagtt gacctcatca ggaattttgt ggctccttct
9001 cttctaacct gcctgaagaa agatggtcca cagcagctga gtccgggatg gataagctta
9061 gggacagagg ccaattaggg aactttgggt ttctagccct actagtagtg aataaattta
9121 aagtgtggat gtgactatga gtcacagcac agatgttgtt taataatatg tttattttat
9181 aaattgatat tttaggaatc tttggagata ttttcagtta gcagataata ctataaattt
9241 tatgtaactg gcaatgcact tcgtaataga cagctcttca tagacttgca gaggtaaaaa
9301 gattccagaa taatgatatg tacatctacg acttgtttta ggtggcactt actcaaaagc
9361 atctactcct aatggttatg ataatggcat tatttgggcc acttggaaaa cccggtggta
9421 ttccatgaag aaaaccacta tgaagataat cccattcaac agactcacaa ttggagaagg
9481 acagcaacac cacctggggg gagccaaaca ggtcagacca gagcaccctg cggaaacaga
9541 atatgactca ctttaccctg aggatgattt gtagaaaatt aactgctaac ttctattgac
9601 ccacaaagtt tcagaaattc tctgaaagtt tcttcctttt ttctcttact atatttattg
9661 atttcaagtc ttctattaag gacatttagc cttcaatgga aattaaaact catttaggac
9721 tgtatttcca aattactgat atcagagtta tttaaaaatt gtttatttga ggagataaca
9781 tttcaacttt gttcctaaat atataataat aaaatgattg actttatttg catttttatg
9841 accacttgtc atttattttg tcttcgtaaa ttattttcat tatatcaaat attttagtat
9901 gtacttaata aaataggaga acattttaga gtttcaaatt cccaggtatt ttccttgttt
9961 attaccccta aatcattcct atttaattct tctttttaaa tggagaaaat tatgtctttt
10021 taatatggtt tttgttttgt tatatattca caggctggag acgtttaaaa gaccgtttca
10081 aaagagattt acttttttaa aggactttat ctgaacagag agatataata tttttcctat
10141 tggacaatgg acttgcaaag cttcacttca ttttaagagc aaaagacccc atgttgaaaa
10201 ctccataaca gttttatgct gatgataatt tatctacatg catttcaata aaccttttgt
10261 ttcctaagac tagatacatg gtacctttat tgaccattaa aaaaccacca ctttttgcca
10321 atttaccaat tacaattggg caaccatcag tagtaattga gtcctcattt tatgctaaat
10381 gttatgccta actctttggg agttacaaag gaaatagcaa ttatggcttt tgccctctag
10441 gagatacagg acaaatacag gaaaatacag caacccaaac tgacaatact ctatacaaga
10501 acataatcac taagcaggag tcacagccac acaaccaaga tgcatagtat ccaaagtgca
10561 gctg
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