GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMFOGBH 438 bp ss-mRNA PRI 27-MAY-1991
DEFINITION Human mRNA for immunoglobulin heavy chain VDJ region, Vh-IV family
(cell line Fog-B)
ACCESSION X52110
KEYWORDS immunoglobulin; immunoglobulin heavy chain; joining region;
variable region.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 438)
AUTHORS Hughes-Jones,N.C.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 438)
AUTHORS Hughes-Jones,N.C., Bye,J.M., Beale,D. and Coadwell,J.
TITLE Nucleotide sequences and three-dimensional modelling of the Vh and
Vl domains of two human monoclonal antibodies specific for the D
antigen of the human Rh-blood-group system.
JOURNAL Biochem. J. 268, 135-140 (1990)
STANDARD full automatic
COMMENT *source: strain=blood donor FO; cell type=B lymphocytes; *source:
cell line=Fog-B; **map: chromosome=14;
From EMBL entry HSFOGBH; dated 07-JUL-1990.
FEATURES Location/Qualifiers
CDS 1..>438
/note="precursor (AA -19 to 127)"
/codon_start=1
CDS 1..57
/note="signal peptide (AA -19 to -1)"
/codon_start=1
CDS 58..>438
/note="VDJ region (AA 1-127)"
/codon_start=58
CDS 58..351
/note="Vh region (AA 1-98)"
/codon_start=58
CDS 352..405
/note="D region (AA 99-116)"
/codon_start=352
CDS 406..>438
/note="J6 region (AA 117-127)"
/codon_start=406
BASE COUNT 83 a 126 c 131 g 98 t
ORIGIN
1 atgaagcacc tgtggttctt cctcctgctg gtggcggctc ccagatgggt cctgtcccag
61 ctgcggctgc aggagtcggg cccaggactg gtgaagcctt cggagaccct gtccctcacc
121 tgcagtgtct ctggtggctc cgtcagcagt ggtggtctct actggggctg ggtccgccag
181 cccccaggga aggggctcga atggattggc agtatatttt atagtgggag cacctactac
241 aatccctccc tcaagagccg agtcaccata tccgtagaca cgttgaagaa taacttctcc
301 ctgaagctga gttctgtgac cgccgcagac acggctgttt attactgtac gagaccaggc
361 tatggcgaca cctcggtacg gaagagggtt tggaatatgg acctctgggg ccaagggacc
421 acggtcaccg tctcctcg
//