GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMGROW2 1964 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germ line gene for growth hormone (presomatotropin).
ACCESSION V00520
KEYWORDS complementary DNA; germline; growth hormone; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1964)
AUTHORS DeNoto,F.M., Moore,D.D. and Goodman,H.M.
TITLE Human growth hormone DNA sequence and mRNA structure: possible
alternate splicing
JOURNAL Nucleic Acids Res. 9, 3719-3730 (1981)
STANDARD full automatic
COMMENT This entry was previously called <HSGROWZ1>.
See <HSGROW1> for mRNA sequence (with some differences).
From EMBL entry HSGROW2; dated 06-JUL-1989.
FEATURES Location/Qualifiers
precursor_RNA 274..1905
/note="mRNA (5' end may be at 275)"
CDS 335..344
/note="reading frame (part 1) (344 is 1st base in codon)"
/codon_start=335
intron 345..600
/note="first intron"
CDS 601..761
/note="reading frame (part 2) (601 is 2nd base in codon)"
/codon_start=601
intron 762..970
/note="second intron"
CDS 971..1080
/note="reading frame (part 3)"
/codon_start=971
intron 1081..1183
/note="third intron"
CDS 1184..1348
/note="reading frame (part 4)"
/codon_start=1184
intron 1349..1601
/note="fourth intron"
CDS 1602..1896
/note="reading frame (part 5)"
/codon_start=1602
BASE COUNT 451 a 550 c 550 g 413 t
ORIGIN
1 agggcaccca cgtgaccctt aaagagagga caagttgggt ggtattttct ggctgacact
61 ctgtgcacaa ccctcacaac actggttgac ggtgggaagg gaaagatgac aagccagggg
121 catgatccca gcatgtgtgg gaggagcttc taaattatcc attagcacaa gcccgtcagt
181 ggccccatgc ataaatgtac acagaaacag gtgggggcaa cagtgggaga gaaggggcca
241 gggtataaaa agggcccaca agagaccggc tcaaggatcc caaggcccaa ctccccgaac
301 cactcagggt cctgtggacg ctcacctagc tgcaatggct acaggtaagc gcccctaaaa
361 tccctttggg cacaatgtgt cctgagggga gaggcagcga cctgtagatg ggacgggggc
421 actaaccctc aggtttgggg cttctgaatg agtatcgcca tgtaagccca gtatggccaa
481 tctcagaaag ctcctggtcc ctggagggat ggagagagaa aaacaaacag ctcctggagc
541 agggagagtg ctggcctctt gctctccggc tccctctgtt gccctctggt ttctccccag
601 gctcccggac gtccctgctc ctggcttttg gcctgctctg cctgccctgg cttcaagagg
661 gcagtgcctt cccaaccatt cccttatcca ggctttttga caacgctagt ctccgcgccc
721 atcgtctgca ccagctggcc tttgacacct accaggagtt tgtaagctct tggggaatgg
781 gtgcgcatca ggggtggcag gaaggggtga ctttcccccg ctgggaaata agaggaggag
841 actaaggagc tcagggtttt tcccgaagcg aaaatgcagg cagatgagca cacgctgagt
901 gaggttccca gaaaagtaac aatgggagct ggtctccagc gtagaccttg gtgggcggtc
961 cttctcctag gaagaagcct atatcccaaa ggaacagaag tattcattcc tgcagaaccc
1021 ccagacctcc ctctgtttct cagagtctat tccgacaccc tccaacaggg aggaaacaca
1081 acagaaatcc gtgagtggat gccttgaccc caggcgggga tgggggagac ctgtagtcag
1141 agcccccggg cagcacaggc caatgcccgt ccttcccctg cagaacctag agctgctccg
1201 catctccctg ctgctcatcc agtcgtggct ggagcccgtg cagttcctca ggagtgtctt
1261 cgccaacagc ctggtgtacg gcgcctctga cagcaacgtc tatgacctcc taaaggacct
1321 agaggaaggc atccaaacgc tgatgggggt gggggtggcg ctaggggtcc ccaatcttgg
1381 agccccactg actttgagag ctgtgttaga gaaacactgc tgccctcttt ttagcagtcc
1441 aggccctgac ccaagagaac tcaccttatt cttcatttcc cctcgtgaat cctctagcct
1501 ttctctacac cctgaagggg agggaggaaa atgaatgaat gagaaaggga gggagcagta
1561 cccaagcgct tggcctctcc ttctcttcct tcactttgca gaggctggaa gatggcagcc
1621 cccggactgg gcagatcttc aagcagacct acagcaagtt cgacacaaac tcacacaacg
1681 atgacgcact actcaagaac tacgggctgc tctactgctt caggaaggac atggacaagg
1741 tcgagacatt cctgcgcatc gtgcagtgcc gctctgtgga gggcagctgt ggcttctagc
1801 tgcccgggtg gcatccctgt gacccctccc cagtgcctct cctggccttg gaagttgcca
1861 ctccagtgcc caccagcctt gtcctaataa aattaagttg catcattttg tctgactagg
1921 tgtcctctat aatattatgg ggtggagggg ggtggtttgg agca
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