GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMHLAA1 3840 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human HLA-A1 gene
ACCESSION X55710
KEYWORDS HLA-A1 gene; immunoglobulin; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3840)
AUTHORS Girdlestone,J.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 3840)
AUTHORS Girdlestone,J.
TITLE Nucleotide sequence of an HLA-A1 gene
JOURNAL Nucleic Acids Res. 18, 6701-6701 (1990)
STANDARD full automatic
COMMENT From EMBL entry HSHLAA1; dated 20-NOV-1990.
FEATURES Location/Qualifiers
mat_peptide join(523..597,726..995,1236..1511,2091..2366,2469..2585,
3028..3060,3203..3250,3420..3421)
/product="HLA-A1 Class I Antigen precursor"
/gene="HLA-A1, MHC Class I precusor"
CDS join(523..597,726..995,1236..1511,2091..2366,2469..2585,
3028..3060,3203..3250,3420..3424)
/product="HLA-A1 Class I Antigen precursor"
/gene="HLA-A1, MHC Class I precusor"
/codon_start=523
CAAT_signal 445..449
TATA_signal 471..475
exon 523..597
/number=1
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 523..597
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 523..597
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
sig_peptide 523..597
intron 598..725
/number=1
exon 726..995
/number=2
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 726..995
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 726..995
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
intron 996..1235
/number=2
exon 1236..1511
/number=3
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 1236..1511
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 1236..1511
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
intron 1512..2090
/number=3
exon 2091..2366
/number=4
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 2091..2366
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 2091..2366
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
intron 2367..2468
/number=4
exon 2469..2585
/number=5
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 2469..2585
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 2469..2585
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
intron 2586..3027
/number=5
exon 3028..3060
/number=6
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 3028..3060
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 3028..3060
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
intron 3061..3202
/number=6
exon 3203..3250
/number=7
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 3203..3250
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 3203..3250
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
intron 3251..3419
/number=7
exon 3420..3421
/number=8
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
exon 3420..3421
/product="HLA-A1 Class I Antigen"
/gene="HLA-A1, MHC Class I"
misc_signal 3422..3424
/note="termination codon"
polyA_signal 3718..3724
BASE COUNT 769 a 1072 c 1164 g 835 t
ORIGIN
1 aagcttactc tctggcacca aactccatgg ggtgattttt cttctagaag agtccaggtg
61 gacaggtaag gagtgggagt cagggagtcc agttcaggga cagagataat gggatgaaaa
121 gtgaaaggag agggacgggg cccatgccga gggtttctcc cttgtttctc agacagctcc
181 tgggccaaga ctcagggaga cattgagaca gagcgcttcg cacaggagca gaggggtcag
241 ggcgaagtcc cagggcccca ggcgtggctc tcagggtctc aggccccgaa ggcggtgtat
301 ggattgggga gtcccagcct tggggattcc ccaactccgc agtttctttt ctccctctcc
361 caacctacgt agggtccttc atcctggata ctcacgacgc ggacccagtt ctcactccca
421 ttgggtgtcg ggtttccaga gaagccaatc agtgtcgtcg cggtcgctgt tctaaagtcc
481 gcacgcaccc accgggactc agattctccc cagacgccga ggatggccgt catggcgccc
541 cgaaccctcc tcctgctact ctcgggggcc ctggccctga cccagacctg ggcgggtgag
601 tgcggggtcg ggagggaaac cgcctctgcg gggagaagca aggggccctc ctggcggggg
661 cgcaggaccg ggggagccgc gccgggagga gggtcgggca ggtctcagcc actgctcgcc
721 cccaggctcc cactccatga ggtatttctt cacatccgtg tcccggcccg gccgcgggga
781 gccccgcttc atcgccgtgg gctacgtgga cgacacgcag ttcgtgcggt tcgacagcga
841 cgccgcgagc cagaagatgg agccgcgggc gccgtggata gagcaggagg ggccggagta
901 ttgggaccag gagacacgga atatgaaggc ccactcacag actgaccgag cgaacctggg
961 gaccctgcgc ggctactaca accagagcga ggacggtgag tgaccccggc ccgggcgcag
1021 gtcacgaccc ctcatccccc acggacgggc caggtcgccc acagtctccg ggtccgagat
1081 ccaccccgaa gccgcgggac tccgagaccc ttgtcccggg agaggcccag gcgcctttac
1141 ccggtttcat tttcagttta ggccaaaaat ccccccgggt tggtcggggc ggggcggggc
1201 tcgggggact gggctgaccg cggggtcggg gccaggttct cacaccatcc agataatgta
1261 tggctgcgac gtggggccgg acgggcgctt cctccgcggg taccggcagg acgcctacga
1321 cggcaaggat tacatcgccc tgaacgagga cctgcgctct tggaccgcgg cggacatggc
1381 agctcagatc accaagcgca agtgggaggc ggtccatgcg gcggagcagc ggagagtcta
1441 cctggagggc cggtgcgtgg acgggctccg cagatacctg gagaacggga aggagacgct
1501 gcagcgcacg ggtaccaggg gccacggggc gcctccctga tcgcctatag atctcccggg
1561 ctggcctccc acaaggaggg gagacaattg ggaccaacac tagaatatca ccctccctct
1621 ggtcctgagg gagaggaatc ctcctgggtt tccagatcct gtaccagaga gtgactctga
1681 ggttccgccc tgctctctga cacaattaag ggataaaatc tctgaaggag tgacgggaag
1741 acgatccctc gaatactgat gagtggttcc ctttgacacc ggcagcagcc ttgggcccgt
1801 gacttttcct ctcaggcctt gttctctgct tcacactcaa tgtgtgtggg ggtctgagtc
1861 cagcacttct gagtctctca gcctccactc aggtcaggac cagaagtcgc tgttcccttc
1921 tcagggaata gaagattatc ccaggtgcct gtgtccaggc tggtgtctgg gttctgtgct
1981 ctcttcccca tcccgggtgt cctgtccatt ctcaagatgg ccacatgcgt gctggtggag
2041 tgtcccatga cagatgcaaa atgcctgaat tttctgactc ttcccgtcag acccccccaa
2101 gacacatatg acccaccacc ccatctctga ccatgaggcc accctgaggt gctgggccct
2161 gggcttctac cctgcggaga tcacactgac ctggcagcgg gatggggagg accagaccca
2221 ggacacggag ctcgtggaga ccaggcctgc aggggatgga accttccaga agtgggcggc
2281 tgtggtggtg ccttctggag aggagcagag atacacctgc catgtgcagc atgagggtct
2341 gcccaagccc ctcaccctga gatggggtaa ggagggagat gggggtgtca tgtctcttag
2401 ggaaagcagg agcctctctg gagaccttta gcagggtcag ggcccctcac cttcccctct
2461 tttcccagag ctgtcttccc agcccaccat ccccatcgtg ggcatcattg ctggcctggt
2521 tctccttgga gctgtgatca ctggagctgt ggtcgctgcc gtgatgtgga ggaggaagag
2581 ctcaggtgga gaaggggtga agggtggggt ctgagatttc ttgtctcact gagggttcca
2641 agccccagct agaaatgtgc cctgtctcat tactgggaag caccttccac aatcatgggc
2701 cgacccagcc tgggccctgt gtgccagcac ttactctttt gtaaagcacc tgttaaaatg
2761 aaggacagat ttatcacctt gattacggcg gtgatgggac ctgatcccag cagtcacaag
2821 tcacagggga aggtccctga ggacagacct caggagggct attggtccag gacccacacc
2881 tgctttcttc atgtttcctg atcccgccct gggtctgcag tcacacattt ctggaaactt
2941 ctctggggtc caagactagg aggttcctct aggaccttaa ggccctggct cctttctggt
3001 atctcacagg acattttctt cccacagata gaaaaggagg gagttacact caggctgcaa
3061 gtaagtatga aggaggctga tgcctgaggt ccttgggata ttgtgtttgg gagcccatgg
3121 gggagctcac ccaccccaca attcctcctc tagccacatc ttctgtggga tctgaccagg
3181 ttctgttttt gttctacccc aggcagtgac agtgcccagg gctctgatgt gtctctcaca
3241 gcttgtaaag gtgagagctt ggagggcctg atgtgtgttg ggtgttgggt ggaacagtgg
3301 acacagctgt gctatggggt ttctttgcgt tggatgtatt gagcatgcga tgggctgttt
3361 aaggtgtgac ccctcactgt gatggatatg aatttgttca tgaatatttt tttctatagt
3421 gtgagacagc tgccttgtgt gggactgaga ggcaagagtt gttcctgccc ttccctttgt
3481 gacttgaaga accctgactt tgtttctgca aaggcacctg catgtgtctg tgttcgtgta
3541 ggcataatgt gaggaggtgg ggagagcacc ccacccccat gtccaccatg accctcttcc
3601 cacgctgacc tgtgctccct ctccaatcat ctttcctgtt ccagagaggt ggggctgagg
3661 tgtctccatc tctgtctcaa cttcatggtg cactgagctg taacttcttc cttccctatt
3721 aaaattagaa cctgagtata aatttacttt ctcaaattct tgccatgaga ggttgatgag
3781 ttaattaaag gagaagattc ctaaaatttg agagacaaaa ttaatggaac gcatgagaac
//