GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMHLIA 3717 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human gene for histocompatibility antigen HLA-A3
ACCESSION X00492
KEYWORDS histocompatibility antigen; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3717)
AUTHORS Strachan,T., Sodoyer,R., Damotte,M. and Jordan,B.R.
TITLE Complete nucleotide sequence of a functional class I HLA gene,
HLA-A3: implications for the evolution of HLA genes
JOURNAL EMBO J. 3, 887-894 (1984)
STANDARD full automatic
COMMENT SWISS-PROT; P04439; HA1C$HUMAN.
From EMBL entry HSHLIA; dated 20-FEB-1985.
FEATURES Location/Qualifiers
promoter 163..167
/note="put. CAAT-box"
promoter 189..194
/note="TATA-like sequence"
mRNA 241..327
/note="exon 1"
CDS 241..327
/note="signal peptide (327 is 1st base in codon)"
/codon_start=241
intron 328..457
/note="intron I"
mRNA 458..727
/note="exon 2"
CDS 458..727
/note="alpha 1 (458 is 2nd base in codon) (727 is 1st base
in codon)"
/codon_start=458
intron 728..968
/note="intron II"
mRNA 969..1244
/note="exon 3"
CDS 969..1244
/note="alpha 2 (969 is 2nd base in codon) (1244 is 1st
base in codon)"
/codon_start=969
CDS 969..1244
/note="alpha 2 (969 is 2nd base in codon) (1244 is 1st
base in codon)"
/codon_start=969
intron 1245..1820
/note="intron III"
mRNA 1821..2096
/note="exon 4"
CDS 1821..2096
/note="alpha 3 (1821 is 2nd base in codon) (2096 is 1st
base in codon)"
/codon_start=1821
intron 2097..2198
/note="intron IV"
mRNA 2199..2315
/note="exon 5"
CDS 2199..2315
/note="TM (transmembrane region) (2199 is 2nd base in
codon) (2315 is 1st base in codon)"
/codon_start=2199
intron 2316..2757
/note="intron V"
mRNA 2758..2790
/note="exon 6"
CDS 2758..2790
/note="C1 (cytoplasmatic region) (2758 is 2nd base in
codon) (2790 is 1st base in codon)"
/codon_start=2758
intron 2791..2932
/note="intron VI"
mRNA 2933..2970
/note="exon 7"
CDS 2933..2970
/note="C2 (2933 is 2nd base in codon) (2970 is 1st base in
codon)"
/codon_start=2933
intron 2971..3149
/note="intron VII"
mRNA 3150..3151
/note="exon 8"
CDS 3150..3151
/note="C3"
/codon_start=3150
misc_feature 3548..3555
/note="polyadenylation signal"
BASE COUNT 715 a 1042 c 1121 g 839 t
ORIGIN
1 cccgaaggct gtgtaaggat tggggagtcc cagccttggg attccccaac tccgcagttt
61 cttttctccc ctgctcccaa cctacgtagg gtccttcatc ctggatactc acggacgcgg
121 acccagttct cactcccatt gggtgtcggg tttccagaga agccaatcag tgtcgtcgcg
181 gtcgctgttc taaagcccgc acgcacccac cgggactcag attctcccca gacgccgagg
241 atggctcgtg gagaccaggc cgtcatggcg ccccgaaccc tcctcctgct actctcgggg
301 gccctggccc tgacccagac ctgggcgggt gagtgcgggg tcgggaggga cacacgcctc
361 tgcggggaga agcaaggggc ctcctggcgg gggcgcagga ccgggggagc cgcgccggga
421 cgagggtcgg gcaggtctca gccactgctc cccccaggct cccactccat gaggtatttc
481 ttcacatccg tgtcccggcc cggccgcggg gagccccgct tcatcgccgt gggctacgtg
541 gacgacacgc agttcgtgcg gttcgacagc gacgccgcga gccagaggat ggagccgcgg
601 gcgccgtgga tagagcagga ggggccggag tattgggacc aggagacacg gaatgtgaag
661 gcccagtcac agactgaccg agtggacctg gggaccctgc gcggctacta caaccagagc
721 gaggccggtg agtgaccccg gccgggggcg caggtcagga cccctcatcc cccacggacg
781 ggccaggtcg cccacagtct ccgggtccga gatccacccc gaagccgcgg gaccccgaga
841 cccttgcccc gggagaggcc caggcgcctt tacccggttt cattttcagt ttaggccaaa
901 aatccccccg ggttggtcgg ggctgggcgg ggctcggggg actgggctga ccgcggggtc
961 ggggccaggt tctcacacca tccagataat gtatggctgc gacgtggggt cggacgggcg
1021 cttcctccgc gggtaccggc aggacgccta cgacggcaag gattacatcg ccctgaacga
1081 ggacctgcgc tcttggaccg cggcggacat ggcggctcag atcaccaagc gcaagtggga
1141 ggcggcccat gaggcggagc agttgagagc ctacctggat ggcacgtgcg tggagtggct
1201 ccgcagatac ctggagaacg ggaaggagac gctgcagcgc acgggtacca ggggccacgg
1261 gcgcctccct gatcgcctgt agatctcccg ggctggcctc ccacaaggag gggagaccat
1321 tgggacccac actaggatat cacccttcct ttggttctga gggaggggaa ttcttcttgg
1381 tttcaggacc tggaccagag agtgactctg aggtttcggc ctgctcacag gcacaattaa
1441 gggataaatc tctgaaggag tgacgggaag acgattcctt ggattctggt gagtggttcc
1501 ctttggcacc ggcgacggcc ttgggcccgt gacttttcct ctcaggcctt gttctctgct
1561 tcacactcaa tgtgtgtggg ggtctgagtc cagcacttct gagtccctca gcctccactc
1621 aggtcaggac cagaagtcgc tgttcccttc tcagggaata gaagattatc ccaggtgcct
1681 gtgtccaggc tggtgtctgg gttctgtgct ctcttcccca tcccgggtgt cctgtccatt
1741 ctcaagatgg ccacatgcgt gctggtggag tgtcccatga cagatgcaaa atgcctgaat
1801 tttctgactc ttcccgtcag acccccccaa gacacatatg acccaccacc ccatctctga
1861 ccatgaggcc accctgaggt gctgggccct gggcttctac cctgcggaga tcacactgac
1921 ctggcagcgg gatggggagg accagaccca ggacacggag ctcgtggaga ccaggcctgc
1981 aggggatgga accttccaga agtgggcggc tgtggtggtg ccttctggag aggagcagag
2041 atacacctgc catgtgcagc atgagggtct gcccaagccc ctcaccctga gatggggtaa
2101 ggagggagat gggggtgtca tgtctcttag ggaaagcagg agcctctctg gagaccttta
2161 gcagggtcag ggcccctcac cttcccctct tttcccagag ctgtcttccc agcccaccat
2221 ccccatcgtg ggcatcattg ctggcctggt tctccttgga gctgtgatca ctggagctgt
2281 ggtcgctgcc gtgatgtgga ggaggaagag ctcaggtgga gaaggggtga agggtggggt
2341 ctgagatttc ttgtctcact gagggttcca agccccagct agaaatgtgc cctgtctcat
2401 tactgggaag caccgtccac aatcatgggc ctacccagtc tgggccctgt gtgccagcac
2461 ttactctttt gtaaagcacc tgttaaaatg aaggacagat ttatcacctt gattacggcg
2521 gtgatgggac ctgatcccag cagtcacaag tcacagggga aggtccctga ggacagacct
2581 caggagggct attggtccag gacccacacc tgctttcttc atgtttcctg atcccgccct
2641 gggtctgcag tcacacattt ctggaaactt ctctggggtc caagactagg aggttcctct
2701 aggaccttaa ggccctggct cctttctggt atctcacagg acattttctt ctcacagata
2761 gaaaaggagg gagttacact caggctgcaa gtaagtatga aggaggctga tgcctgaggt
2821 ccttgggata ttgtgtttgg gagcccatgg gggagcccac ccacctcaca attcctcctc
2881 tagccacatc ttctgtggga tctgaccagg ttctgttttt gttctacccc aggcagtgac
2941 agtgcccagg gctctgatgt gtccctcaca gcttgtaaag gtgagagctt ggaggaccta
3001 atgtgtgttg ggtgttgggc ggaacagtgg acacagctgt gctatggggt ttctttgcat
3061 tggatgtatt gagcatgcga tgggctgttt aaggtgtgac ccctcactgt gatggatatg
3121 aatttgttca tgaatatttt tttctatagt gtgagacagc tgccttgtgt gggactgaga
3181 ggcaagagtt tgttcctgcc cttccctttg tgacttgaag aaccctgact ttgtttctgc
3241 aaaggcacct gcatgtgtct gtgttcgtgt aggcataatg tgaggaggtg gggagaccac
3301 cccaccccca tgtccaccat gaccctcttc ccacgctgac ctgtgctccc tccccaatca
3361 tctttcctgt tccagagagg tggggctgag gtgtctccat ctctgtctca acttcatggt
3421 gcactgagct gtaacttctt ccttccctat taaaattaga accttagtat aaatttactt
3481 tctcaaattc ttgccatgag aggttgatga gttaattaaa ggagaagatt cctaaaattt
3541 gagagacaaa ataaatggaa gacatgagaa ccttccagag tccacgtgtt tcttgtgctg
3601 atttgttgca ggggaggaga gtagatgggg ctgtgcccag tttctgttct ggccaccatg
3661 ggctttatgt ggtcacagct cacctgggtc atctttgctg ctccattgtc cttggcc
//