GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMHLIC 3714 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human gene for class I histocompatibility antigen HLA-CW3
ACCESSION X00495
KEYWORDS histocompatibility antigen; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3714)
AUTHORS Sodoyer,R., Damotte,M., Delovitch,T.L., Trucy,J., Jordan,B.R. and
Strachan,T.
TITLE Complete nucleotide sequence of a gene encoding a functional human
class I histocompatibility antigen (HLA-CW3)
JOURNAL EMBO J. 3, 879-885 (1984)
STANDARD full automatic
COMMENT SWISS-PROT; P04222; HA1Y$HUMAN.
Data kindly reviewed (09-MAY-1985) by T. Strachan
From EMBL entry HSHLIC; dated 20-FEB-1985.
FEATURES Location/Qualifiers
promoter 46..49
/note="put. CAAT box"
promoter 79..82
/note="TATA box like sequence"
CDS 163..235
/note="signal peptide (235 is 1st base in codon)"
/codon_start=163
intron 236..366
/note="intron I"
CDS 367..636
/note="alpha 1 domain (367 is 2nd base in codon) (636 is
1st base in codon)"
/codon_start=367
intron 637..878
/note="intron II"
CDS 879..1154
/note="alpha 2 domain (879 is 2nd base in codon) (1154 is
1st base in codon)"
/codon_start=879
intron 1155..1741
/note="intron III"
CDS 1742..2017
/note="alpha 3 domain (1742 is 2nd base in codon) (2017 is
1st base in codon)"
/codon_start=1742
intron 2018..2148
/note="intron IV"
CDS 2149..2258
/note="transmembrane segment (TM) (2149 is 2nd base in
codon) (2258 is 1st base in codon)"
/codon_start=2149
intron 2259..2699
/note="intron V"
CDS 2700..2732
/note="cytoplasmatic segment C1 (2700 is 2nd base in
codon) (2732 is 1st base in codon)"
/codon_start=2700
intron 2733..2886
/note="intron VI"
CDS 2887..2934
/note="cytoplasmatic segment C2 (2887 is 2nd base in
codon) (2934 is 1st base in codon)"
/codon_start=2887
intron 2935..3098
/note="intron VII"
CDS 3099..3100
/note="cytoplasmatic segment C3 (3099 is 2nd base in
codon)"
/codon_start=3099
BASE COUNT 706 a 1034 c 1149 g 823 t 2 others
ORIGIN
1 aatctgcgtc gggtccttct tcctgaatga ctcatgacgc gtccccaatt cccactccca
61 ttgggtgtcg gaccnntcta gaaggccggt cagcgtctcc gcagtcccgg ttctgaagtc
121 cccagtcacc cacccggact cagattctcc ccagacgccg agatgcgggt catggcgccc
181 cggaccctca tcctgctgct ctcgggagcc ctggccctga ccgagacctg ggccggtgag
241 tgcggggttg ggagggaatc ggcctcttgc ggagaggagc gaggggcccg cccggcggag
301 ggcgcaggac ccggggagcc gcgcagggag gagggtcggg cgggtctcag cccctcctcg
361 ccccaggctc ccactccatg aggtatttct gcaccgctgt gtcccggccc ggacgcgggg
421 agccccactt catcgccgtg ggctacgtgg acgacacgca gttcgtgcgg ttcgacagcg
481 acgacgagag tccgagaggg gagccgaggg cgccgtgggt ggagcggaag gggccggagt
541 attgggaccg ggagacacag aagtacaagc cccaggcaca gactgaccga gtgagcctgc
601 ggaacctgcg cggctactac aaccagagcg aggccggtga gtggaccccg gcccggggcg
661 caggtcacga cccctcctca tcccccacgg acggcccggg tcgccccaag tctcccggtc
721 tgagatccac cccgaggctg cggaacccga gaccctcgac cggagagagc cccagtcacc
781 tttacccggt ttcattttca gtttaggcca aaatccccgc gggttggtcg gggcggggcg
841 gggctcgggg gacggggctg accgcggggg cgggccaggg tctcacatca tccagaggat
901 gtatggctgc gacgtggggc ccgacgggcg cctcctccgc gggtatgacc agcacgccta
961 cgacggcaag gattacatcg ccctgaacga ggatctgcgc tcctggaccg ccgcgaacac
1021 ggcggctcag atcacccagc gcaagtggga ggcggcccgt gaggcggagc agctgagagc
1081 ctacttggag ggcctgtgcg tggagtggct ccgcagatac ctgaagaatg ggaaggagac
1141 gctgcagggc gcgggtacca ggggcagtgg gagcgttccc catctcctgt agatctcccg
1201 ggatggcctc ccacgaggag gggaggaaaa tgggatcagc gctagaatat cgccctccct
1261 tgaatggaga atgggatgag ttttcctgag tttcctctga gggccccctc tgctctctga
1321 ggacaattaa gggatgaagt ccttgaagaa atggagggga agacagtccc tagaatactc
1381 atcaggggtc ccctttgacc actttgacca ctgcagcagc tgtggtcagg ctgctgacct
1441 ttctctcagg ccttgttctc tgcctcacgc tcaatgtgtt tgaaggtttg attccagctt
1501 ttctgagtcc ttcggcctcc actcaggtca ggaccagaag tcgctgttcc tccctcagag
1561 actagaactt tccaatgaat aggagattat cccaggtgcc tgtgtccagg ctggcgtctg
1621 ggttctgtgc ccccttcccc accccaggtg tcctgtccgt tctcaggatg gtcacatggg
1681 cgctgttgga gtgtcgcaag agagatacaa agtgtctgaa ttttctgact cttcccgtca
1741 gaacacccaa agacacacgt gacccaccat cccgtctctg accatgaggc caccctgagg
1801 tgctgggccc tgggcttcta ccctgcggag atcacactga cctggcagtg ggatggggag
1861 gaccaaactc aggacactga gcttgtggag accaggccag caggagatgg aaccttccag
1921 aagtgggcag ctgtggtggt gccttctgga gaagagcaga gatacacgtg ccatgtgcag
1981 cacgaggggc tgccggagcc cctcaccctg agatggggta aggaggggga tgaggggtga
2041 tgtgtcttct cagggaaagc agaagtcctg gagcccttca gccaggtcag ggctgaggct
2101 tgggggtcag ggcccctcac cttcccctcc tttcccagag ccgtcttccc agcccaccat
2161 ccccatcgtg ggcatcgttg ctggcctggc tgtcctggct gtcctagctg tcctaggagc
2221 tgtggtggct gttgtgatgt gtaggaggaa gagctcaggt agggaagggg tgaggagtgg
2281 ggtctgggtt ttcttgttcc actgggagtt tcaagcccca ggtagaagtg tgccccacct
2341 cgttactgga agcaccatcc acacatgggc cccatcccag cctgggaccc tatgtgccag
2401 cacttactct gttgtgaagc acatgacaat gaaggacaga tgtatcacct tgatgattat
2461 ggtgttgggg tccttgattc cagcattcat gagtcagggg aaggtccctg ctaaggacag
2521 accttaggag ggcagttgct ccaacaacca cagctgcttt ccccgtgttt cctgatcctg
2581 ccctgggtct gcagtcatag ttctggaaac ttctcttggg tccaagacta ggaggttccc
2641 ctaagatcgc atggccctga ctcctccctg tcccctcaca gggcattttc ttcccacagg
2701 tggaaaagga gggagctgct ctcaggctgc gtgtaagtga tggcggtggg cgtgtggagg
2761 agctgctctc aggctgcgtg taagtgatgg cggtgggcgt gtggaggagc tcacccaccc
2821 cataattcct cttgtcccac atctcctgcg ggctctgacc aggtcttttt ttttgttcta
2881 ccccagccag caacagtgcc cagggctctg atgagtctct catcgcttgt aaaggtgaga
2941 ttctggggag ctgaagtggt cgggggtggg gcagagggaa aaggcctagg taatggggat
3001 cctttgattg ggacgtttcg aatgtgtggt gagctgttca gagtgtgatc acttaccatg
3061 actgacctga atttgttcat gactattgtg ttctgtagcc tgagacagct gcctgtgtgg
3121 gactgagatg caggatttct tcacacctct cctttgtgac ttcaagagcc tctggcatct
3181 ctttctgcaa aggcatctga atgtgtctgc gttcctgtta gcataatgtg aggaggtgga
3241 gagacagccc accccctgtc caccgtgacc cctgtcccca cactgacctg tgttccctcc
3301 ccgatcatct ttcctgttcc agagaagtgg gctggatgtc tccatctctg tctcaacttc
3361 atggtgcgct gagctgcaac ttcttacttc cctaatgaag ttaggaacct gaatataaat
3421 ttgttttctc aaatatttgc tatgaagggt tgatggatta attaaataag tcaattcctg
3481 gaagttgaga gagcaaataa agacctgaga agctttccag aatccgcatg ttctctgtgg
3541 ctgagtctgt tgcaggtggg ggtggggaag gctgtgagga gccgagtgtg gacgggggcc
3601 tgtgcctagt tgctgttcag ttcttcatgg gctttatgta gtcagtcctt agctgggtca
3661 ccttcactgc tccattgtcc ttgtcccttc agtggaaact tgtccagcag gagc
//