GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGCMUS 2378 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human C mu gene for IgM heavy chain exons CH1-4, secretory
ACCESSION X14940
KEYWORDS alternative splicing; constant region; immunoglobulin;
immunoglobulin heavy chain; mu-immunoglobulin; rearranged DNA.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2378)
AUTHORS Dorai,H.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (bases 1 to 2378)
AUTHORS Dorai,H. and Gillies,S.D.
TITLE The complete nucleotide sequence of human genomic C mu gene.
JOURNAL Nucleic Acids Res. 17, 6412-6412 (1989)
STANDARD full automatic
COMMENT *source: cell-line=HeLa; cell-type=fibroblast;tissue=muscle;
*source:library=lambda phage EMBL 3; clone=2; **map: chromosome no=
14q32 see X14939 for M1 and M2 membrane exons, located
approximately 1.9kb downstream from CH4;
From EMBL entry HSIGCMUS; dated 20-JUN-1990.
FEATURES Location/Qualifiers
precursor_RNA <1..>2209
/note="mu heavy chain transcript"
mRNA 233..544
/note="exon CH1"
CDS 233..544
/note="IgM hv, C mu (104 AA) (233 is 2nd base in codon)
(544 is 1st base in codon)"
/codon_start=233
intron 545..630
/note="intron I"
mRNA 631..966
/note="exon CH2"
CDS 631..966
/note="IgM hv, C mu (112 AA) (631 is 2nd base in codon)
(966 is 1st base in codon)"
/codon_start=631
intron 967..1211
/note="intron II"
mRNA 1212..1531
/note="exon CH3"
CDS 1212..1531
/note="IgM hv, C mu (107 AA) (1212 is 2nd base in codon)"
/codon_start=1212
intron 1532..1709
/note="intron III"
mRNA 1710..2096
/note="exon CH4"
mRNA 1710..2036
/note="alternative exon 4,"
CDS 1710..2096
/note="IgM hv, C mu secreted form (129 AA)"
/codon_start=1710
CDS 1710..2036
/note="IgM hv, C mu membrane form (109 AA)"
/codon_start=1710
misc_feature 2036..2037
/note="alternative splice site for membrane exon"
misc_feature 2202..2209
/note="polyA signal"
BASE COUNT 473 a 840 c 653 g 412 t
ORIGIN
1 cccagcagcc cagcagcctt ggacaaagac ctgaggcctc accacgcccc gccacccctg
61 atagccatga cagtctgggc tttggaggcc tgcaggtggg ctcggccttg gtggggcagc
121 cacagcggga cgcaagtagt gagggcactc agaacgccac tcagccccga caggcagggc
181 acgaggaggc agctcctcac cctccctttc tcttttgtct gcgggtcctc agggagtgca
241 tccgccccaa cccttttccc cctcgtctcc tgtgagaatt ccccgtcgga tacgagcagc
301 gtggccgttg gctgcctcgc acaggacttc cttcccgact ccatcacttt gtcctggaaa
361 tacaagaaca actctgacat cagcagtacc cggggcttcc catcagtcct gagagggggc
421 aagtacgcag ccacctcaca ggtgctgctg ccttccaagg acgtcatgca gggcacagac
481 gaacacgtgg tgtgcaaagt ccagcacccc aacggcaaca aagaaaagaa cgtgcctctt
541 ccaggtgagg gccgggcagc caccgggaca gagagggagc cgaaggggcg ggagtggcgg
601 gcaccgggct gacacgtgtc ctcactgcag tgattgccga gctgcctccc aaagtgagcg
661 tcttcgtccc accccgcgac ggcttcttcg gcaacccccg caagtccaag ctcatctgcc
721 aggccacggg tttcagtccc cggcagattc aggtgtcctg gctgcgcgag gggaagcagg
781 tggggtctgg cgtcaccacg gaccaggtgc aggctgaggc caaagagtct gggcccacga
841 cctacaaggt gaccagcaca ctgaccatca aagagagcga ctggctcggc cagagcatgt
901 tcacctgccg cgtggatcac aggggcctga ccttccagca gaatgcgtcc tccatgtgtg
961 tccccggtga gtgacctgtc cctcaggggc agcacccacc gacacacagg ggtccactcg
1021 ggtctcgatt cgccaccccg gatgcagcca tctactccct gagccttggc ttcccagagc
1081 ggccaagggc aggggctcgg gcggcaggac ccctgggctc ggcagaggca gttgctactc
1141 tttgggtggg aaccatgcct ccgcccacat ccacacctgc cccacctctg actcccttct
1201 cttgactcca gatcaagaca cagccatccg ggtcttcgcc atccccccat cctttgccag
1261 catcttcctc accaagtcca ccaagttgac ctgcctggtc acagacctga ccacctatga
1321 cagcgtgacc atctcctgga cccgccagaa tggcgaagct gtgaaaaccc acaccaacat
1381 ctccgagagc caccccaatg ccactttcag cgccgtgggt gaggccagca tctgcgagga
1441 tgactggaat tccggggaga ggttcacgtg caccgtgacc cacacagacc tgccctcgcc
1501 actgaagcag accatctccc ggcccaaggg taggccccac tcttgcccct cttcctgcac
1561 tccctgggac ctcccttggc ctctggggca tggtggaaag cacccctcac tcccccgttg
1621 tctgggcaac tggggaaaag gggactcaac cccagcccac aggctgtccc cccactgccc
1681 cgccctcacc accatctctg ttcacagggg tggccctgca caggcccgat gtctacttgc
1741 tgccaccagc ccgggagcag ctgaacctgc gggagtcggc caccatcacg tgcctggtga
1801 cgggcttctc tcccgcggac gtcttcgtgc agtggatgca gagggggcag cccttgtccc
1861 cggagaagta tgtgaccagc gccccaatgc ctgagcccca ggccccaggc cggtacttcg
1921 cccacagcat cctgaccgtg tccgaagagg aatggaacac gggggagacc tacacctgcg
1981 tggcccatga ggccctgccc aacagggtca ccgagaggac cgtggacaag tccaccggta
2041 aacccaccct gtacaacgtg tccctggtca tgtccgacac agctggcacc tgctactgac
2101 cctgctggcc tgcccacagg ctcggggcgg ctggccgctc tgtgtgtgca tgcaaactaa
2161 cccgtgtcaa cggggtgaga tgttgcatct tataaaatta gaaataaaaa gatccattca
2221 aaagatactg gtcctgagtg cacgatgctc tggcctactg gggcggcggc tgtgctgcac
2281 ccaccctgcg cctcccctgc agaacacctt cctccacagc ccccacccct gcctcaccca
2341 cctgcgtgcc tcagtggctt ctagaaaccc ctgaattc
//