GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGCMUS 2378 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human C mu gene for IgM heavy chain exons CH1-4, secretory ACCESSION X14940 KEYWORDS alternative splicing; constant region; immunoglobulin; immunoglobulin heavy chain; mu-immunoglobulin; rearranged DNA. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 2378) AUTHORS Dorai,H. JOURNAL Unpublished (1989) STANDARD full automatic REFERENCE 2 (bases 1 to 2378) AUTHORS Dorai,H. and Gillies,S.D. TITLE The complete nucleotide sequence of human genomic C mu gene. JOURNAL Nucleic Acids Res. 17, 6412-6412 (1989) STANDARD full automatic COMMENT *source: cell-line=HeLa; cell-type=fibroblast;tissue=muscle; *source:library=lambda phage EMBL 3; clone=2; **map: chromosome no= 14q32 see X14939 for M1 and M2 membrane exons, located approximately 1.9kb downstream from CH4; From EMBL entry HSIGCMUS; dated 20-JUN-1990. FEATURES Location/Qualifiers precursor_RNA <1..>2209 /note="mu heavy chain transcript" mRNA 233..544 /note="exon CH1" CDS 233..544 /note="IgM hv, C mu (104 AA) (233 is 2nd base in codon) (544 is 1st base in codon)" /codon_start=233 intron 545..630 /note="intron I" mRNA 631..966 /note="exon CH2" CDS 631..966 /note="IgM hv, C mu (112 AA) (631 is 2nd base in codon) (966 is 1st base in codon)" /codon_start=631 intron 967..1211 /note="intron II" mRNA 1212..1531 /note="exon CH3" CDS 1212..1531 /note="IgM hv, C mu (107 AA) (1212 is 2nd base in codon)" /codon_start=1212 intron 1532..1709 /note="intron III" mRNA 1710..2096 /note="exon CH4" mRNA 1710..2036 /note="alternative exon 4," CDS 1710..2096 /note="IgM hv, C mu secreted form (129 AA)" /codon_start=1710 CDS 1710..2036 /note="IgM hv, C mu membrane form (109 AA)" /codon_start=1710 misc_feature 2036..2037 /note="alternative splice site for membrane exon" misc_feature 2202..2209 /note="polyA signal" BASE COUNT 473 a 840 c 653 g 412 t ORIGIN 1 cccagcagcc cagcagcctt ggacaaagac ctgaggcctc accacgcccc gccacccctg 61 atagccatga cagtctgggc tttggaggcc tgcaggtggg ctcggccttg gtggggcagc 121 cacagcggga cgcaagtagt gagggcactc agaacgccac tcagccccga caggcagggc 181 acgaggaggc agctcctcac cctccctttc tcttttgtct gcgggtcctc agggagtgca 241 tccgccccaa cccttttccc cctcgtctcc tgtgagaatt ccccgtcgga tacgagcagc 301 gtggccgttg gctgcctcgc acaggacttc cttcccgact ccatcacttt gtcctggaaa 361 tacaagaaca actctgacat cagcagtacc cggggcttcc catcagtcct gagagggggc 421 aagtacgcag ccacctcaca ggtgctgctg ccttccaagg acgtcatgca gggcacagac 481 gaacacgtgg tgtgcaaagt ccagcacccc aacggcaaca aagaaaagaa cgtgcctctt 541 ccaggtgagg gccgggcagc caccgggaca gagagggagc cgaaggggcg ggagtggcgg 601 gcaccgggct gacacgtgtc ctcactgcag tgattgccga gctgcctccc aaagtgagcg 661 tcttcgtccc accccgcgac ggcttcttcg gcaacccccg caagtccaag ctcatctgcc 721 aggccacggg tttcagtccc cggcagattc aggtgtcctg gctgcgcgag gggaagcagg 781 tggggtctgg cgtcaccacg gaccaggtgc aggctgaggc caaagagtct gggcccacga 841 cctacaaggt gaccagcaca ctgaccatca aagagagcga ctggctcggc cagagcatgt 901 tcacctgccg cgtggatcac aggggcctga ccttccagca gaatgcgtcc tccatgtgtg 961 tccccggtga gtgacctgtc cctcaggggc agcacccacc gacacacagg ggtccactcg 1021 ggtctcgatt cgccaccccg gatgcagcca tctactccct gagccttggc ttcccagagc 1081 ggccaagggc aggggctcgg gcggcaggac ccctgggctc ggcagaggca gttgctactc 1141 tttgggtggg aaccatgcct ccgcccacat ccacacctgc cccacctctg actcccttct 1201 cttgactcca gatcaagaca cagccatccg ggtcttcgcc atccccccat cctttgccag 1261 catcttcctc accaagtcca ccaagttgac ctgcctggtc acagacctga ccacctatga 1321 cagcgtgacc atctcctgga cccgccagaa tggcgaagct gtgaaaaccc acaccaacat 1381 ctccgagagc caccccaatg ccactttcag cgccgtgggt gaggccagca tctgcgagga 1441 tgactggaat tccggggaga ggttcacgtg caccgtgacc cacacagacc tgccctcgcc 1501 actgaagcag accatctccc ggcccaaggg taggccccac tcttgcccct cttcctgcac 1561 tccctgggac ctcccttggc ctctggggca tggtggaaag cacccctcac tcccccgttg 1621 tctgggcaac tggggaaaag gggactcaac cccagcccac aggctgtccc cccactgccc 1681 cgccctcacc accatctctg ttcacagggg tggccctgca caggcccgat gtctacttgc 1741 tgccaccagc ccgggagcag ctgaacctgc gggagtcggc caccatcacg tgcctggtga 1801 cgggcttctc tcccgcggac gtcttcgtgc agtggatgca gagggggcag cccttgtccc 1861 cggagaagta tgtgaccagc gccccaatgc ctgagcccca ggccccaggc cggtacttcg 1921 cccacagcat cctgaccgtg tccgaagagg aatggaacac gggggagacc tacacctgcg 1981 tggcccatga ggccctgccc aacagggtca ccgagaggac cgtggacaag tccaccggta 2041 aacccaccct gtacaacgtg tccctggtca tgtccgacac agctggcacc tgctactgac 2101 cctgctggcc tgcccacagg ctcggggcgg ctggccgctc tgtgtgtgca tgcaaactaa 2161 cccgtgtcaa cggggtgaga tgttgcatct tataaaatta gaaataaaaa gatccattca 2221 aaagatactg gtcctgagtg cacgatgctc tggcctactg gggcggcggc tgtgctgcac 2281 ccaccctgcg cctcccctgc agaacacctt cctccacagc ccccacccct gcctcaccca 2341 cctgcgtgcc tcagtggctt ctagaaaccc ctgaattc //