GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGF2G 8837 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human gene for insulin-like growth factor II
ACCESSION X03562
KEYWORDS growth factor; hormone; insulin super family;
insulin-like growth factor ii; signal peptide; somatomedin.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 8837)
AUTHORS Dull,T.J., Gray,A., Hayflick,J.S. and Ullrich,A.
TITLE Insulin-like growth factor II precursor gene organization in
relation to insulin gene family
JOURNAL Nature 310, 777-781 (1984)
STANDARD full automatic
COMMENT EPD; 17072; Hs IGF II E2.
Data kindly reviewed (24-OCT-1986) by A. Ullrich
From EMBL entry HSIGF2G; dated 06-JUL-1989.
FEATURES Location/Qualifiers
mRNA <2980..2979
/note="put. exon 1"
intron 2980..5690
/note="put. intron I"
CDS 5647..5804
/note="put. IGF-II precursor (aa -24 to 29) (5804 is 2nd
base in codon)"
/codon_start=5647
CDS 5647..5718
/note="put. signal peptide (aa -24 to -1)"
/codon_start=5647
mRNA 5691..5804
/note="put. exon 2"
CDS 5719..5804
/note="put. mature IGF-II (aa 1-29) (5804 is 2nd base in
codon)"
/codon_start=5719
CDS 5719..5804
/note="B-chain, part 1 (aa 1-29) (5804 is 2nd base in
codon)"
/codon_start=5719
intron 5805..7505
/note="put. intron II"
CDS 7506..7653
/note="put. mature IGF-II (exon 3) (aa 30-78)"
/codon_start=7506
CDS 7506..7565
/note="B-chain, part 2 (aa 30-32)"
/codon_start=7506
CDS complement(7539..7566)
/note="C-peptide (aa 33-40)"
/codon_start=7566
CDS 7540..7605
/note="A-chain (aa 41-62)"
/codon_start=7540
CDS 7606..7620
/note="D-peptide (aa 63-67)"
/codon_start=7606
CDS 7621..7653
/note="E-peptide part 1 (aa 68-78)"
/codon_start=7621
intron 7654..7946
/note="put. intron III"
CDS 7947..8180
/note="put. mature IGF-II (exon 4) (aa 79-156)"
/codon_start=7947
CDS 7947..8180
/note="E-peptide, part 2 (aa 79-156)"
/codon_start=7947
BASE COUNT 1388 a 3037 c 2697 g 1685 t 30 others
ORIGIN
1 cccaaccccg cgcacagcgg gcactggttt cgggcctctc tgtctcctac gaagtccgta
61 gagcaactcg gatttgggaa atttctctct agcgttgccc aaacacactt gggtcggccg
121 cgcgccctca ggacgtggac agggagggct tccccgtgtc caggaaagcg accgggcatt
181 gcccccagtc tcccccaaat ttgggcattg tccccgggtc ttccaacgga ctgggcgnng
241 ctcccggaca ctgaggactg gccccggggt ctcgctcacc ttcagcagcg tccaccgcct
301 gccacagagc gttcgatcgc tcgctgcctg agctcctggt gcgcccgcgg acgcagcctc
361 cagcttcgcg gtgagctccc cgccgcgccg atcccctccg cctctgcgcc cctgaccggc
421 tctcggcccg catctgctgc tgtcccgccg gtgctggcgc tcgtccgctg cgccggggag
481 gccggcgtgg ggcgcgggac acggctgcgg acttgcggct gcgctgcgct cgctcctgct
541 gggcgccccg aaatccgcgc cactttcgtt tgctcattgc aaagatctca tttgtgggga
601 aagcggctgg agggtcccaa agtggggcgg gcagggggct ggggcgaggg acgcggagga
661 gaggcgctcc cgccgggcgg taaagtgcct ctagcccgcg ggcctaggac tccgccggga
721 gggcgcgcgg agngcgaagt gattgatggc ggaagcgggg gggcaagggg ggcagggggg
781 cgcgggattc cgccggcgac cccttcccct tggctaggct taggcggcgg ggggctggcg
841 gggtgcggga ttttgtgcgt ggtttttgac ttggtaaaaa tcacagtgct ttcttacatc
901 gttcaaactc tccaggagat ggtttcccca gacccccaaa ttatcgtggt ggcccccgag
961 accgaactcg cgtctatgca agtccaacgc actgaggacg gggtaaccat tatccagata
1021 ttttgggtgg gccgcaaagg cgagctactt agacgcaccc cggtgagctc ggccatgcag
1081 gtaggatttg agctgtgttt cccgccctga tcctctctcc tctggcggcc ggagcctccg
1141 taggctccaa gcctggccca gattcggcgg cgcagccggc cttccgcgcg tccgcaccta
1201 gcgggggctc cggggctccg gcgcggcacc ggggggcgct cgggatctgg ctgaggctcc
1261 aaggcccgcg tggccggctc ctcctgctgg ggcaggtggc ggctgcgcgc cccgcccgag
1321 cccaggggcc ccctcagccg caacaaccag caaggacccc ccgactcagc cccaagccac
1381 ctgcatctgc actcagacgg ggcgcacccg cagtgcagcc tcctggtggg gcgctgggag
1441 cccgcctgcc cctgcctgcc cggagacccc agctcacgag cacaggccgc ccgggcaccc
1501 cagaaacccg ggatggggcc cctgaattct ctaggacggg cattcagcat ggccttggcg
1561 ctctgcggct ccctgccccc cacccagcct cgcccccgcg caccccccag cccctgcgac
1621 cgccgccccc ccccccgggg ccccagggcc ccagcccgca ccccccgccc cgctcttggc
1681 tcgggttgcg ggggcgggcc gggggcgggg cgagggctcc gcgggcgccc attggcgcgg
1741 gcgcgaggcc agcggccccg cgcggccctg ggccgcggct ggcgcgacta taagagccgg
1801 gcgtgggcgc ccgcagttcg cctgctctcc ggcggagctg cgtgaggccc ggccggcccc
1861 ggcccccccc ttccggccgc ccccgcctcc tggcccacgc ctgcccgcgc tctgcccacc
1921 agcgcctcca tcgggcaagg cggccccgcg tcgacgccgc ccgctgcctc gctgctgact
1981 cccgtcccgg gcgccgtccg cggggtcgcg ctccgccggg cctgcggatt ccccgccgcc
2041 tcctcttcat ctacctcaac tccccccatc cccgcttcgc ccgaggaggc ggttcccccc
2101 gcaggcagtc cggctcgcag gccgccggcg ttgtcacccc ccccgcgctc cccctccagc
2161 cctccccccg gcgcgcagcc tcgggccgct cccctttccg cgctgcgtcc cggagcggcc
2221 ccggtgccgc caccgcctgt ccccctcccg aggcccgggc tcgcgacggc agagggctcc
2281 gtcggcccaa accgagctgg gcgcccgcgg tccgggtgca gcctccactc cgccccccag
2341 tcaccgcctc ccccggcccc tcgacgtggc gcccttccct ccgcttctct gtgctccccg
2401 cgcccctctt ggcgtctggc cccggccccc gctctttctc ccgcaacctt cccttcgctc
2461 cctcccgtcc cccccagctc ctagcctccg actccctccc cccctcacgc ccgccctctc
2521 gccttcgccg aaccaaagtg gattaattac acgctttctg tttctctccg tgctgttctc
2581 tcccgctgtg cgcctgcccg cctctcgctg tcctctctcc ccctcgccct ctcttcggcc
2641 cccccctttc acgttcactc tgtctctccc actatctctg cccccctcta tccttgatac
2701 aacagctgac ctcatttccc gatacctttt cccccccgaa aagtacaaca tctggcccgc
2761 cccagcccga agacagcccg tcctccctgg acaatcagac gaattctccc ccccccccca
2821 aaaaaaagcc atccccccgc tctgccccgt cgcacattcg gcccccgcga ctcggccaga
2881 gcggcgctgg cagaggagtg tccggcagga gggccaacgc ccgctgttcg gtttgcgaca
2941 cgcagcaggg aggtgggcgg cagcgtcgcc ggcttccagg taagcggcgt gtgcgggccg
3001 ggccggggcc ggggctgggg cggcgcgggc ttgcggcgac gcccggccct tcctccgccc
3061 gctcccggcc cggggcctgc ggggctcggc ggggcggctg agccgggggg gaggaggagg
3121 aggaggagga ggacggacgg ctgcgggtcc cgttccctgc gcggagcccg cgctaccnnn
3181 nnnnnnnnnn nnnnnnnnnn nnngacgtcc ccgctgaagg gggtcggtct gtgggtgcag
3241 ggggtgccgc ctcacatgtg tgattcgtgc cttgcgggcc ctggcctccg gggtgctggg
3301 taacgaggag gggcgcggag ccgcagaagc ccaccctggt gtcgttgacg ccggtgccag
3361 cgagaccgcg agaggaagac gggggcgggc ggggccagga tggagagggg ccgagttggc
3421 aggagtcatg gcagacgcca cactcgcgac catctccccc acacccctct ggcctctgtc
3481 cgcaacattt ccaaacagga gtcccgggag agggggagag gggctgctgg tctgaggcta
3541 agaagggcag agccttcgac ccggagagag gccgcggccg cctgccccag tggcaacgtt
3601 gaagttttcc atacaacgga ggtcgggaag gagacccccc ccccccttca ctgccctgtg
3661 aagagatgag ccgggggtgc aggatgggag cccatggcac ttcgctacgg gatgtccagg
3721 gctccggttg ggggtgcagg agagaagaga ctggctggga ggagggagag ggcgggagca
3781 aaggcgcggg ggtgtggtca gagggagagg ggtgggggtt aggtggagcc cgggctggga
3841 ggagtcggct cacacataaa actgaggcac tgaccagcct gcaaactgga tattagcttc
3901 tcctgtgaaa gagacttcca gcttcctcct cctcctcttc ctcctcctcc tcctgcccca
3961 gcgagccttc tgctgagctg taggtaacca gggctgtgga gtgaaggacc cccgctgcca
4021 tcccactcca gcctgaggca gggcagcagg gggcacggcc cacgcctggg cctcgggccc
4081 tgcagccgcc agcccgctgc ctctcggaca gcacccccct cccctctttt cctctgcccc
4141 tgcccccacc tggcgtctct gctccctcac ctgctccttc cctttctgtt ccttcccttc
4201 ggccccctcc ttgcccagct caggactttt cctgggccct cacctgctcc gcaccgctgc
4261 atgcttcctg tcctgctttc tgccggtccc ctgacccgga cctccaagcg cagagtggtg
4321 gggcttgttg cggaagcgcg gcgagggcta gagtggccag ctggcggagt gtgctcttag
4381 aatttggaag ggggtggcag agggggcggt gagaggactg gccagggtcc gccatgtcaa
4441 ggagatgacc aaggaggctt tcagatcctc ggcgcagtcg cccactagtc tttagagagg
4501 gcatgcaaag ttgtgcttct gtcccactgc ctgctcagtc gctcacataa tttattgcat
4561 caaaaactcc cctgggtctg cggagcaagg ctggggctgc ccgcctggag ggtaccacct
4621 tctgcaggag cagggccaac ttgctgtggt ggctcccggc ctcccacccc cgagtgggta
4681 acccggccct gtgacctgca gcctgtggag ggggtgtgcc taagactggc ctccccttcc
4741 agattgtagt ctggggaacc tggtgtcgga cttcccaggt ggcctgagct ggtctcttca
4801 gctccacggg gagagtttgg tagcgcaaat agggagatgt tctgggcccc tggccttact
4861 ggttcgattt gaggcctgga aaggaggctc tgggcgtgtg tgtgtgtgtt tgggggtacc
4921 caaggcagac tggagttgga gaactgggtg actgggaaaa caaggtttct agagcatggg
4981 tggcgtggtt gtgttaacca ttggagtcgc ttgacccagg cctggctcag ctgcagactg
5041 gaaaggtgga aaagccaggg ggaggggcgg ggctggccca gcaggactgg cctgctgctt
5101 tgagggcgat ggtcctcctg gaccccccct gctcagctgg gggttgtggg gaggaagggg
5161 ctggtcctcc ttggagcaca tgctctgtag gggtggggct gtctgccatc ttggcggcgc
5221 tggaggcctg agaagtggcg atgtaacgct gggctggccc tgcccccatg gtgtcatagg
5281 acggaggcag gtcgggtgtc cagcctgggc ccctgcagct gtggatgccg ctgagctcct
5341 gcaataatga ccgtgcagat ggtcacccct cgtgtaaaat tactagtgct tcttgcaaat
5401 ggaaggaact gggccttttc tgtgtgcttc tggacgcttc attctgcaca tggccctgcg
5461 ccctcacctc ggcattatga cctgtgtgtt acttttgtaa taaaaataat gtttatagga
5521 aagccgtgct ttcaattttc aactgaattt gtaggttggc aaatttggtt tgggaggggc
5581 acctctggcc tggggcttgg cctggctgcc ccgctcacgc cacttctctc ccgcccccag
5641 acaccaatgg gaatcccaat ggggaagtcg atgctggtgc ttctcacctt cttggccttc
5701 gcctcgtgct gcattgctgc ttaccgcccc agtgagaccc tgtgcggcgg ggagctggtg
5761 gacaccctcc agttcgtctg tggggaccgc ggcttctact tcagtaagta gcagggaggg
5821 gcttcctcag acctggtcag gcccctagag tgaccggtga ggatctccca tcctcaagcc
5881 aggggagcac actcctaggt cagcagccca gccgcttgct ctgagacttt gaccttcccg
5941 ccgcgtttct gagcacgtgc ggtgtcccag ggcatccaca ccagctgcct ttcccatcac
6001 acgcctcctt cgaagggtgg gccagaggtg ccccctagac gtcaggggca tctacagggg
6061 tctccctggg catcagaatt tctgttgggg gccgtgaggc tcctgctcct gaggcaccgc
6121 acgcctagtg cagggcttca ggctctggag gaagagcctg cctttcttcc tgcacctttt
6181 ggacattttg acaagggacg tgcgttcggt gaatgatcag aattaaaatc aataaagtga
6241 tttatataat taaaatcaat aagacaagtg cagttggtgg gtggcagggg tgagcggtgc
6301 atgcgcctcc ttgggcccca aggctgccgt ggggggtgcc cacctgctga cctcaaggac
6361 gcttcagcct ttcctcatgt ttctctcttg gttctccagc ctgggggctg gcaggtgggt
6421 gcatggccca ttgtccttga gaccccaccc ccagataggg gggctgggtg gatgcagagg
6481 caggcatggt gcctgggcat gcctgatggg gcaggggagg ggccgctcct tactggcaga
6541 ggccgcaact tattccacct gacactcacc acgtgacatc tttaccacca ctgcttactc
6601 acgctgtgaa atgggctcac aggatgcaaa tgcacttcaa agcttctctc tgaaaagttc
6661 ctgctgcttg actctggaag cccctgcccg ccctggcctc tcctgtgccc tctctcttgc
6721 ctgccccatt tgggggtagg aagtggcact gcagggcctg gtgccagcca gtccttgccc
6781 agggagaagc ttccctgcac caggctttcc tgagaggagg ggagggccaa gcccccactt
6841 gggggccccc gtgacggggc ctcctgctcc ctcctccggc tgatggcacc tgccctttgg
6901 caccccaagg tggagccccc agcgaccttc cccttccagc tgagcattgc tgtgggggag
6961 agggggaaga cgggaggaaa gaagggagtg gttccatcac gcctcctcag cctcctctcc
7021 tcccgtcttc tcctctcctg cccttgtctc cctgtctcag cagctccagg ggtggtgtgg
7081 gcccctccag cctcccaggt ggtgccaggc cagagtccaa gctcacggac agcagtcctc
7141 ctgtgggggc cctgaactgg gctcacatcc cacacatttt ccaaaccact cccattgtga
7201 gcctttggtc ctggtggtgt ccctctggtt gtgggaccaa gagcttgtgc ccatttttca
7261 tctgaggaag gaggcagcag aagtcacggg ctggtctggg ccccactcac ctcccctctc
7321 acctctcttc ttcctgggac gcctctgcct gccggctctc acttccctcc cctgacccgc
7381 agggtggctg cgnccttcca gggcctggcc tgagggcagg ggtggtttgc tgggggttcg
7441 gcctccgggg gctgggggtc ggtgcggtgc taacacggct ctctctgtgc tgtgggactt
7501 ccaggcaggc ccgcaagccg tgtgagccgt cgcagccgtg gcatcgttga ggagtgctgt
7561 ttccgcagct gtgacctggc cctcctggag acgtactgtg ctacccccgc caagtccgag
7621 agggacgtgt cgacccctcc gaccgtgctt ccggtgaggg tcctgggccc ctttcccact
7681 ctctagagac agagaaatag ggcttcgggc gcccagcgtt tcctgtggcc tctgggacct
7741 cttggccagg gacaaggacc cgtgacttcc ttgcttgctg tgtggcccgg gagcagctca
7801 gacgctggct ccttctgtcc ctctgcccgt ggacattagc tcaagtcact gatcagtcac
7861 aggggtggcc tgtcaggtca ggcgggcggc tcaggcggaa gagcgtggag agcaggcacc
7921 tgctgaccag ccccttcccc tcccaggaca acttccccga gatacccctg ggcaagttct
7981 tccaatatga cacctggaag cagtccaccc agcgcctgcg caggggcctg cctgccctcc
8041 tgcgtgcccg ccggggtcac gtgctcgcca aggagctcga ggcgttcagg gaggccaaac
8101 gtcaccgtcc cctgattgct ctacccaccc aagaccccgc ccacgggggc gcccccccag
8161 agatggccag caatcggaag tgagcaaaac tgccgcaagt ctgcagcccg gcgccaccat
8221 cctgcagcct cctcctgacc acggacgttt ccatcaggtt ccatcccgaa aatctctcgg
8281 ttccacgtcc cctggggctt ctcctgaccc agtccccgtg ccccgcctcc ccgaaacagg
8341 ctactctcct cggccccctc catcgggctg aggaagcaca gcagcatctt caaacatgta
8401 caaaatcgat tggctttaaa cacccttcac ataccctccc cccaaattat ccccaattat
8461 ccccacacat aaaaaatcaa aacattaaac taaccccctt cccccccccc cacaacaacc
8521 ctcttaaaac taattggctt tttagaaaca ccccacaaaa gctcagaaat tggctttaaa
8581 aaaaacaacc accaaaaaaa atcaattggc taaaaaaaaa aagtattaaa aacgaattgg
8641 ctgagaaaca attggcaaaa taaaggaatt tggcactccc cacccccctc tttctcttct
8701 cccttggact ttgagtcaaa ttggcctgga cttgagtccc tgaaccagca aagagaaaag
8761 aagggcccca gaaatcacag gtgggcacgt cgcgtctacc gccatctccc ttctcacggg
8821 aattttcagg gtaaact
//