GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGFIG4 175 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human IGF-I gene exon 3 for insulin-like growth factor I located on
chromosome 12
ACCESSION X03420 X00362
KEYWORDS growth factor; insulin-like growth factor i; signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 100 to 175)
AUTHORS Ullrich,A., Berman,C.H., Dull,T.J., Gray,A. and Lee,J.M.
TITLE Isolation of the human insulin-like growth factor I gene using a
single synthetic DNA probe
JOURNAL EMBO J. 3, 361-364 (1984)
STANDARD full automatic
REFERENCE 2 (bases 1 to 175)
AUTHORS de Pagter-Holthuizen,P., van Schaik,F.M., Verduijn,G.M., van
Ommen,G.J., Bouma,B.N., Jansen,M. and Sussenbach,J.S.
TITLE Organization of the human genes for insulin-like growth factors I
and II
JOURNAL FEBS Lett. 195, 179-184 (1986)
STANDARD full automatic
COMMENT SWISS-PROT; P01343; IGFA$HUMAN. SWISS-PROT; P05019; IGFB$HUMAN.
Exon 3 is designated exon 1 in [1].
Data kindly reviewed (01-DEC-1986) by de Pagter-Holthuizen P.
From EMBL entry HSIGFIG3; dated 06-JUL-1989.
FEATURES Location/Qualifiers
intron <1..12
/note="intron"
mRNA 13..169
/note="exon 3 (exon 1 in [1])"
CDS 19..169
/note="put. IGF-I precursor (169 is 1st base in codon)"
/codon_start=19
CDS 19..93
/note="put. signal peptide (aa -25 to -1)"
/codon_start=19
CDS 94..169
/note="put. mature IGF-I (aa 1-25) (169 is 1st base in
codon)"
/codon_start=94
intron 170..>175
/note="intron"
BASE COUNT 26 a 49 c 51 g 49 t
ORIGIN
1 tttcttgggc aggtgaagat gcacaccatg tcctcctcgc atctcttcta cctggcgctg
61 tgcctgctca ccttcaccag ctctgccacg gctggaccgg agacgctctg cggggctgag
121 ctggtggatg ctcttcagtt cgtgtgtgga gacaggggct tttatttcag taagt
//