GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK10 1154 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germline gene for the leader peptide and variable region of a
kappa immunoglobulin (subgroup V kappa I)
ACCESSION Z00008 X00750
KEYWORDS germline; immunoglobulin; kappa-immunoglobulin; variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1154)
AUTHORS Wildgruber,N.
JOURNAL Unpublished (1984)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1154)
AUTHORS Jaenichen,H.R., Pech,M., Lindenmaier,W., Wildgruber,N. and
Zachau,H.G.
TITLE Composite human V kappa genes and a model of their evolution
JOURNAL Nucleic Acids Res. 12, 5249-5263 (1984)
STANDARD full automatic
COMMENT The sequence is designated V13 in refs. [1] and [2].
From EMBL entry HSIGK10; dated 03-JAN-1991.
FEATURES Location/Qualifiers
CDS join(305..359,484..779)
/codon_start=305
misc_feature 176..190
/note="put. regulatory element pd"
misc_feature 208..217
/note="put. regulatory element dc"
promoter 250..257
/note="TATA-box"
intron 360..483
/note="first intron"
misc_feature 782..788
/note="heptanucleotide box"
BASE COUNT 313 a 291 c 247 g 303 t
ORIGIN
1 gtcgactcct gaggaatatt tcaaattttc aaaaaaatac ataaaaaatg tttctcataa
61 caaactactc tccagtagaa acacattcac tgcagacaaa tttgtgctac cctggtcttt
121 cctgggacac ctggggacac tgagctggtg ctgagttact gagatgagcc agctctgcag
181 ctgtgcccag tcagccccat cccctgctca tttgcatgtt cccagagcac aacctcctgc
241 actgaagcct tattaatagg ctggccacac ttcatgcagg agtcagaccc agtcaggaca
301 cagcatggac atgagggtcc ccgctcagct cctggggctc ctgctgctct ggctcccagg
361 taaggaagga gaacactatg aatttactca gccaatgtgc tcagtacagc ctggcccttc
421 agggaaattc tcttactaca tgattaattg tatggatatt tgtttttatg tttccaatct
481 caggtgccag atgtgtcatc tggatgaccc agtctccatc cttactctct gcatctacag
541 gagacagagt caccatcagt tgtcggatga gtcagggcat tagcagttat ttagcctggt
601 atcagcaaaa accagggaaa gcccctgagc tcctgatcta tgctgcatcc actttgcaaa
661 gtggggtccc atcaaggttc agtggcagtg gatctgggac agatttcact ctcaccatca
721 gttgcctgca gtctgaagat tttgcaactt attactgtca acagtattat agtttccctc
781 ccacagtgtt acacacccga acaaaaaccc ccagggaagc agatgtgtaa ggctgggctg
841 ccccagctgc tcctcctgat tccttcattg cctgagagtg ttcctcagat gcagccacac
901 tctgatggta ttggtagagg gggacctgaa atcacctctg caacccaatt ccttttgctt
961 tgtaagcccc agctgcacag acatagcaat gcctctcctg atgtaataaa ggcagagatc
1021 ttgacaccta aggagtctag tttagggctt tggttggaat tcaaataaca gagaagaaac
1081 cactatagat attctaagca ggaattgtct taatacagaa aattagagtc taaactactg
1141 aagtctaaat aaaa
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK14 1970 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germline gene for the leader peptide and variable region of a
kappa immunoglobulin (subgroup V kappa I)
ACCESSION Z00013 X00902
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin;
signal peptide.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Zachau,H.G.
JOURNAL Unpublished (1984)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 1970)
AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S.,
Klobeck,H.-G. and Zachau,H.G.
TITLE Organization and evolution of a gene cluster for human
immunoglobulin variable regions of the kappa type
JOURNAL J. Mol. Biol. 176, 189-204 (1984)
STANDARD full automatic
REFERENCE 3 (bases 1771 to 1970)
AUTHORS Straubinger,B., Pech,M., Muehlebach,K., Jaenichen,H.R., Bauer,H.G.
and Zachau,H.G.
TITLE Molecular footprints of human immunoglobulin gene evolution: a new
sequence family
JOURNAL Nucleic Acids Res. 12, 5265-5275 (1984)
STANDARD full automatic
COMMENT The sequence is designated Vd in refs. [1] and [2]; the gaps are
not included into the numbering.
From EMBL entry HSIGK14; dated 03-JAN-1991.
FEATURES Location/Qualifiers
CDS join(690..744,870..1165)
/codon_start=690
misc_feature 562..576
/note="put. regulatory element pd"
misc_feature 594..603
/note="put. regulatory element dc"
promoter 636..643
/note="TATA-box"
intron 745..869
/note="first intron"
misc_feature 1168..1174
/note="heptanucleotide box"
misc_feature 1860..>1970
/note="L-sequence region"
BASE COUNT 578 a 443 c 413 g 536 t
ORIGIN
1 tcgagcatta aagagactta tagctctgga caatgcagga actgtggatg tcatatgctt
61 taaggaatcc caatatcatc ttctttgtca atctgcagta aacctcttca gcttagactg
121 gtaataacat tggtttaggg ccattacaaa atgcttttga gaacatttta cttgctcatg
181 actaagtgtt cttttttact taaaaaaaga tcaatttcat gcttacaaaa atgtagtatg
241 tatgtcacaa agtatcgctc ccaactggaa caatttcaca gtgtgttgaa gacctgatag
301 ccccactctc taagacttta ttaagaattc tctacaaaca aggatattct cctacttatg
361 cccaatacgg cattgaaata tattattcca tctagttctc acaaccactt cgagatttgc
421 caataaatgc tcaaaaatgt acttggtaac aaaatatcct ttaggaagaa acattctctg
481 caggcaaatc taggtgccct ggtctgacct gggacactgg ggacactgcc cctgtgctga
541 gttactgaga taagccagcc acgcagctgt atccagcctg ccccaccccc tgccgatttg
601 cttgttccca gagcaccacc ccctgcccta aagacttctt aataggctgg tcacacctgt
661 gcaggagtca gtcccagtca ggacacagca tggacatgag ggtccccgct cagctcctgg
721 ggctcctgct gctctggctc ccaggtaagg aaggagaaca ctaggaattt actcagccca
781 gtgtgttccg tacagcctgg ctcttgaggg aagttctctt acaacatgat taattctatg
841 gacatttgtg tttatatttc caatctcagg tgccagatgt gacatccagt tgacccagtc
901 tccatccttc ctgtctgcat ctgtaggaga cagagtcacc atcacttgcc gggccagtca
961 gggcattagc agttatttag cctggtatca gcaaaaacca gggaaagccc ctaagctcct
1021 gatctatgct gcatccactt tgcaaagtgg ggtcccatca aggttcagcg gcagtggatc
1081 tgggacagaa ttcactctca caatcagcag cctgcagcct gaagattttg caacttatta
1141 ctgtcaacag cttaatagtt accctcccac agtgttacaa acctgaacat aaacccccag
1201 ggaagcagac atgtgaggcc gggctgcccc agctgctcct cctgattcct ccatcagctg
1261 agagtgttcc tcagatgcag gcacactctg atggtgttgg tagaggggga tgtgaagtca
1321 cctctgcatc ccaatttctt tttctttctc agcaccaggt gcacagacat aacagttcct
1381 ctcctgattt aaaaaaggca gggatcatga cacctgagga gtctagttta tggcttcagt
1441 tggaattcag ttaacagaga agaagccact atagatatcc taagcaggaa ttgtcttgat
1501 acagagaaat agagtataaa ctatggaagt ctaaataaaa atatagagat gaatctcaaa
1561 tttcatgttt tatttgctaa gaaatatttg ctaaatgggg catacagaaa aactcaatgg
1621 tcttcaatat gttgaaagaa caaagagaag cttagagttt catgaaaaaa ggaaaatgtt
1681 acctattgct ctttgagaaa gtttattggc tccagaaaat tttgggagct ggcaagctca
1741 gaatggtaag cactgatgga caaactgaat cctagaatta tgttaaatta ttcagaagtt
1801 ggggttgaat ttgatttccg gttacaagag gccaaagcag tgaagcttgc agagaatctt
1861 gttagtgaaa tgccagggat ttggtgtaga tcctgctgct caccacatat aaaaccaatc
1921 actaagacaa caagtattgc caagaaacag gctttaatca ggtgctgcag
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK15 2908 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germline gene for the leader peptide and variable region of a
kappa immunoglobulin (subgroup V kappa I)
ACCESSION Z00014 X00901
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin;
signal peptide; variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Zachau,H.G.
JOURNAL Unpublished (1984)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 2908)
AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S.,
Klobeck,H.-G. and Zachau,H.G.
TITLE Organization and evolution of a gene cluster for human
immunoglobulin variable regions of the kappa type
JOURNAL J. Mol. Biol. 176, 189-204 (1984)
STANDARD full automatic
REFERENCE 3 (bases 2047 to 2749)
AUTHORS Straubinger,B., Pech,M., Muehlebach,K., Jaenichen,H.R., Bauer,H.G.
and Zachau,H.G.
TITLE Molecular footprints of human immunoglobulin gene evolution: a new
sequence family
JOURNAL Nucleic Acids Res. 12, 5265-5275 (1984)
STANDARD full automatic
COMMENT The sequence is designated Ve in refs. [1] and [2]; the gaps are
not included into the numbering.
From EMBL entry HSIGK15; dated 03-JAN-1991.
FEATURES Location/Qualifiers
CDS join(957..1005,1131..1426)
/codon_start=957
misc_feature 843..857
/note="put. regulatory element pd"
misc_feature 875..877
/note="put. regulatory element dc defective (due to a
deletion)"
promoter 896..903
/note="TATA-box"
intron 1006..1130
/note="first intron"
misc_feature 1429..1435
/note="heptanucleotide box"
misc_feature 2137..2619
/note="L-sequence region"
BASE COUNT 885 a 592 c 638 g 793 t
ORIGIN
1 ggatccagct gatttctcca tgtaagttgg caattgcttg ataagggatt gtctctttcc
61 taaagatgtt aacagggagg atggtgtctg ggtcaggatg atgtccctga taaaacgtaa
121 aagaagaaag tggcattgtt ggtgcatgac agggacatgc tccatgcagt ggtcaccctc
181 aataagagag aagaactttg gaaagtaata ctcaatgaca gaaaagaagg tagacaatga
241 aggtgcccaa aacaagaata aggtgaagtg aatttagtct ctgggtatta aagagacctg
301 tagctcttga taatggtgga tgtgtgagtg ctgcatgcat tgaggaaact cggtatcatc
361 tctctgtatc tgtagtaaat tgcttggtct tatagtggta agaacaatgg cataacacca
421 ttacctaata cttacaaata tgtatagcat catgtcaata aattttattt ttaatatttt
481 tagaaaggaa cagtgttaaa actcacagaa atgttgaagt ataggacaaa gtacctcctt
541 ccctaacccg aatcatatga gagtcttttg aagtcctgag aatcatactg tttaacattt
601 tactatgtat ttcctacaaa caagatattc caaataatcc ccatgtgcca atgaaataca
661 ttactccgtc gactcctgag gaatatttca aattttcaaa aaaatacata aaaaatgttt
721 ctcataacaa actactctcc agtagaaaca cattcaccac agacaaattt gtgctaccct
781 ggtctttcct gggacacctg gggatactga gctggtgctg agttactgag atgagccagc
841 cctgcagctg tgcccagtca gccccatccc ctgctcaacc tcctgccctg aagacttatt
901 aataggctgg acacacttca tgcaggagtc agaccctgtc aggacacagc atagacatga
961 gggtccccgc tcagctcctg gggctcctgc tgctctggct cccaggtaag gaaggagaac
1021 actaggaatt tactcagccc agtgtgcttg gtacagcctg gcccttcagg gaagttctct
1081 tacaacatga ttaattgtat ggacatttgt ttttatgttt ccaatctcag gtgccagatg
1141 tgccatccgg atgacccagt ctccatcctc attctctgca tctacaggag acagagtcac
1201 catcacttgt cgggcgagtc agggtattag cagttattta gcctggtatc agcaaaaacc
1261 agggaaagcc cctaagctcc tgatctatgc tgcatccact ttgcaaagtg gggtcccatc
1321 aaggttcagc ggcagtggat ctgggacaga tttcactctc accatcagct gcctgcagtc
1381 tgaagatttt gcaacttatt actgtcaaca gtattatagt taccctccca cagtgttaca
1441 cacccaaaca aaaaccccca gggaagcaaa tgtgtgaggc tgggctgccc cagctgctcc
1501 tcctgatgcc tccatcgcct gagagtgttc ctcagatgca accacactct gatggtgttg
1561 gtagaggggg acctgaaatc acctctgcaa cccaattcct ttttctttgt aagccccagc
1621 tgcacagaca taacaatgcc tctcctgatt taataaaggc agagatcttg acacctaagg
1681 agtctagttt agggctttgg ttggaattca aataacagag aagaaaccac tatagatatt
1741 ctaagcagga aatgtcttaa tacagaaaat tagagtctaa actactgaag tctaaataaa
1801 atgtagagcg gaatctctaa atttcatgtt ttatttgcaa agaaatgttt gccaaattgg
1861 acacacagga aaactcagtg gtcttcaata tattggaagt acgaagagaa ggttagtgtt
1921 ttatgaaaaa gggaaaatat taccttttgc attttcagaa agttcactgg cactagtaag
1981 ggttgggagc tggcaagctc agactggtaa gcagtggtgg acaaagtgaa ttaggattca
2041 ctaattatat caattatatc aagttgtctc agaagttgca gttaaatgtg aattcaggtt
2101 acaagaagcc aaagcagtga aggttgcaga gaattttctt actaaaatgc caaggattca
2161 ttgtacaccc tgctgctcac cacgcagaaa gccaatctct aaaacaagta ttgccaagaa
2221 acaggcttta atcaggtact gcagccgagg agatgggaca ccatttgcga atgtatctcc
2281 ctgaccaact aaaattaaga ctttatataa cagggacaaa atgtgggaaa acaggaattt
2341 gggaggggta aggaagataa tttggtcaac aggaagcaag aggtcagtta tgcaatcata
2401 atgggtgaag gttctgatgt ctcagtgtcc ggattcagtg atatgtatgt ttcagctcct
2461 tgatagtatc tacgaggcct gatggttggt ttactgaaaa aagaactcag ataagacaaa
2521 tgtaactatc ttgagtttta agactggggg agtcaatttc tgtttattca aaaaaccata
2581 aaccttagtt ccatgggata acagggccta tttcaattgc attctagaaa caatatttta
2641 caccctgagt gcctttcccc actgggtgtc ttggctcttt tgggtataac aagaatgaac
2701 cgatgcctat gattaacgtt cagactacaa cctttcaaag ccaaggatat agtagtcagg
2761 aaagttgata ttagaagcag gattgaatgg cgctcactca gaaaacagaa tgcatctgcc
2821 cttgaagtat gggctatcta accatgtggt cctcagtcct gtctggaagc ttaggggtgg
2881 gagtgttgat gttctcagct tcctgcag
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK3 1181 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germline gene for the leader peptide and variable region of a
kappa immunoglobulin (subgroup V kappa I)
ACCESSION Z00001 V00559
KEYWORDS germline; immunoglobulin; kappa-immunoglobulin; variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 176 to 975)
AUTHORS Bentley,D.L. and Rabbitts,T.H.
TITLE Human immunoglobulin variable region genes - DNA sequences of two V
kappa genes and a pseudogene
JOURNAL Nature 288, 730-733 (1980)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1181)
AUTHORS Jaenichen,H.R.
JOURNAL Unpublished (1984)
STANDARD full automatic
REFERENCE 3 (bases 1 to 1181)
AUTHORS Jaenichen,H.R., Pech,M., Lindenmaier,W., Wildgruber,N. and
Zachau,H.G.
TITLE Composite human V kappa genes and a model of their evolution
JOURNAL Nucleic Acids Res. 12, 5249-5263 (1984)
STANDARD full automatic
COMMENT The sequence of this entry is identical to the published sequence
of HK102 (ref. [1] and entry HSIGK3), but it extends it in both
directions; the sequence is designated V1 in refs. [2] and [3].
From EMBL entry HSIGK3; dated 03-JAN-1991.
FEATURES Location/Qualifiers
CDS join(297..351,477..772)
/note="leader peptide"
/codon_start=297
misc_feature 168..182
/note="put. regulatory element pd"
misc_feature 200..209
/note="put. regulatory element dc"
misc_feature 242..249
/note="TATA-box"
intron 352..476
/note="intron I"
misc_feature 775..781
/note="heptanucleotide box"
BASE COUNT 318 a 296 c 259 g 308 t
ORIGIN
1 ctgaggaata tttaaaattc tcaaaaaaat acctaaaaat tgtttctcat aataaaatag
61 tccccagtag aaacacattc tctgcagaca aatttgtgct accctggtct tacctgggac
121 acctggggac actgagctgg tgctgagtta ctgagatgag ccagctctgc agctgtgccc
181 agcctgcccc atcccctgct catttgcatg ttcccagagc acaacctcct gccctgaagc
241 cttattaata ggctggtcac actttgtgca ggagtcagac tcagtcagga cacagcatgg
301 acatgagggt ccccgctcag ctcctggggc tcctgctgct ctggctccca ggtaaggaag
361 gagaacacta ggaatttact cagcccagtg tgctcagtac tgcctggtta ttcagggaag
421 tcttcctata atatgatcaa tagtatgaat atttgtgttt ctatttccaa tctcaggtgc
481 caaatgtgac atccagatga cccagtctcc ttccaccctg tctgcatctg taggagacag
541 agtcaccatc acttgccggg ccagtcagag tattagtagc tggttggcct ggtatcagca
601 gaaaccaggg aaagccccta agctcctgat ctatgatgcc tccagtttgg aaagtggggt
661 cccatcaagg ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct
721 gcagcctgat gattttgcaa cttattactg ccaacagtat aatagttatt ctcccacagt
781 gttacacacc cgaacataaa cccccaggga agcagatgtg tgaggcaggg ctgccccagc
841 tgctcctcct gatgcctcta tcagctgaga gtggtcctca gatgcagcca cactctgatg
901 gtgttggtag agggggacat ggagtcacct ctgcacccta attcttttct ctttctcagc
961 cccaactgca cagatctagc aatgcctctc ctgatttaat aaagacagag atcatgacac
1021 ctgaagagtc tagtttatgg cttcagctgg actttatata acagagaaga ggccactata
1081 gatattcaaa gcaggaattg tcttaataca gacaattaga gtctaaacta ctgaagtcta
1141 aataaaatgt agagatgaat ctctaaattt aatgttttac g
//