GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK16 2375 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germ line gene for immunoglobulin kappa light chain leader
peptide and variable region (subgroup V kappa I)
ACCESSION V01577 X00898 Z00011
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin;
signal peptide; variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Zachau,H.G.
JOURNAL Unpublished (1984)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 2375)
AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S.,
Klobeck,H.-G. and Zachau,H.G.
TITLE Organization and evolution of a gene cluster for human
immunoglobulin variable regions of the kappa type
JOURNAL J. Mol. Biol. 176, 189-204 (1984)
STANDARD full automatic
REFERENCE 3 (sites)
AUTHORS Straubinger,B., Pech,M., Muehlebach,K., Jaenichen,H.R., Bauer,H.G.
and Zachau,H.G.
TITLE Molecular footprints of human immunoglobulin gene evolution: a new
sequence family
JOURNAL Nucleic Acids Res. 12, 5265-5275 (1984)
STANDARD full staff_review
COMMENT From EMBL entry HSIGK16; dated 07-NOV-1985.
FEATURES Location/Qualifiers
repeat_unit 865..956
/note="imperfect inverted repeat 1"
misc_feature 1041..1055
/note="put. regulatory element pd"
misc_feature 1073..1082
/note="put. regulatory element dc"
promoter 1115..1122
/note="pot. TATA-box"
CDS 1170..1224
/note="pot. signal peptide (aa -22 to -5) (1224 is 1st
base in codon)"
/codon_start=1170
intron 1225..1348
/note="pot. intron I"
CDS 1349..1359
/note="pot. signal peptide (aa -4 to -1) (1349 is 2nd base
in codon)"
/codon_start=1349
CDS 1360..1644
/note="variable region"
/codon_start=1360
misc_feature 1647..1653
/note="pot. V/J joining signal"
misc_feature 1666..1674
/note="pot. V/J joining signal"
repeat_unit 2113..2281
/note="imperfect inverted repeat 1'"
misc_feature 2337..>2375
/note="L-sequence region"
BASE COUNT 697 a 514 c 523 g 641 t
ORIGIN
1 ctgcagcact gtgatttggc tcccctagtc aggcatcagt aaaattttgt ggagtcctag
61 gtggcagccc actgatgctg atgtagttgg atccactttc cctgctactg agtcaggctg
121 ggacattttt gggcacatta gagatatgag atataacgag tgcaaatccc tgtccagttt
181 catctggatc caagtgattt ctccatgtac ataggcaact gcttgataag agattcagtg
241 tctctttcct aaagcagtta acagggaggc tgttgcctgg gtcaggatga tttccccaat
301 cactgataaa aagtaaaaga ggaaagtgtc attgatggtg catggcaggg acatgctcca
361 tgcagtggtc accctcagta agagagatga actttgggaa ataatactga atggcagaaa
421 agaaggtaga ctatgaaggt gcccaaaaca agaataaggt gcaacccatt tagtgtctga
481 gtactataga gacctgtcgc tcttgataat tgtggatctg tgactgctgc atgcatcgag
541 aaaacacggt atcatctttg tgtatctata gtacatagtt tgatctcata ctggtaagaa
601 caatggcata acaccattac ctgatactta caaatgtatg taccatcatg tcaataaatt
661 ttatttttaa tttttttaca taggaacaat gttaaactca cagaaatgtt gcatgtatac
721 gacaaatacc cccttcccta gccggaatca tataagagtc ttttgaagac ttgagaattg
781 taccgtctaa cattttacta tgtgtttcct acaaacaaca atattctcct aaataatccc
841 catacaccaa tgaaatacat tagtccatca actcctgagg aatatttcaa atcgtcaaaa
901 agaaaccaaa aaatgttact cacaacaaaa tagttcccag tagaaacaca ttctctgcag
961 acaaatttgt gctaccctgg tcttacctgg gacacctggg gacactgagc tggtgctgag
1021 ttactgagat gagccagccc tgcagctgcg cccagcctgc cccatcccct gctcatttgc
1081 atgttcccag agcacagtct cctgacctga agacttatta acaggctgat cacaccctgt
1141 gcaggagtca gacccagtca ggacacagca tggacatgag ggtccccgct cagctcctgg
1201 ggctcctgct gctctggttc ccaggtaaga aaggagaaca ctaggattat actcggtcag
1261 tgtgctgagt actgctttac tattcaggga acttctctta cagcatgatt aattgtgtgg
1321 acatttgttt ttatgtttcc aatctcaggt tccagatgcg acatccagat gacccagtct
1381 ccatcttccg tgtctgcatc tgtaggagac agagtcacca tcacttgtcg ggcgagtcag
1441 ggtattagca gctggttagc ctggtatcag cagaaaccag ggaaagcccc taagctcctg
1501 atctatgctg catccagttt gcaaagtggg gtcccatcaa ggttcagcgg cagtggatct
1561 gggacagatt tcactctcac catcagcagc ctgcagcctg aagattttgc aacttactat
1621 tgtcaacagg ctaacagttt ccctcccaca gtgttaccaa cccgaacata aacccccagg
1681 gaagcagatg tgtgaagctg ggctgcccca gctgctcctc ctgatgcctc cattggctga
1741 gagtgttgct cagatgcagc cacactctga tggtgttggt agaggggtac gtgaaatcgc
1801 ctctgcaccc taattctttt ctctttctca gccccaactg cacagacata gcaatgcatc
1861 tcctgatttg ataaatacag agatcatgac acttgaggag tctagtttat ggcttcagct
1921 tgaattcata taacacagaa gaagccacta tagatattct aagcaggaat tgtcttaata
1981 cagagaatta aagtaaacta ctaaagtcaa aataaaatgt agagatgaat ctctaaattt
2041 aagttttatt tgcaaagaaa tatttgccag gtggggcata caggaaaact cagtggtctt
2101 caagatattg gaagaacgaa gagaaaatta gcattttatg aaaaagggaa aatgttacct
2161 gtggctcttt gagaaagttc attggcacta ggaagggttg ggagctggca agctcagact
2221 ggtaagcagt ggtggacaaa atgaatccta gaattatatc aagttatctc agaagttgtg
2281 gacaaatttg atttcaggtt acaataagcc aaagcagtga aggttgcaga gaattttgtt
2341 actgaaatgc cagggattca gtgaagactc tgcag
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK8 2470 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germ line gene for immunoglobulin kappa light chain leader
peptide and variable region (subgroup V kappa I)
ACCESSION Z00006 X00900
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin;
signal peptide; variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2470)
AUTHORS Jaenichen,H.R.
JOURNAL Unpublished (1984)
STANDARD full automatic
REFERENCE 2 (bases 1 to 2470)
AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S.,
Klobeck,H.-G. and Zachau,H.G.
TITLE Organization and evolution of a gene cluster for human
immunoglobulin variable regions of the kappa type
JOURNAL J. Mol. Biol. 176, 189-204 (1984)
STANDARD full automatic
COMMENT From EMBL entry HSIGK8; dated 06-JUL-1989.
FEATURES Location/Qualifiers
repeat_unit 442..533
/note="imperfect inverted repeat 1"
unsure 582..582
/note="may be C or T"
promoter 692..699
/note="pot. TATA-box"
CDS 747..801
/note="pot. signal peptide (aa -22 to -5) (801 is 1st base
in codon)"
/codon_start=747
intron 802..927
/note="pot. intron I"
unsure 824..824
/note="not determined"
CDS 928..938
/note="pot. signal peptide (aa -4 to -1) (928 is 2nd base
in codon)"
/codon_start=928
CDS 939..1223
/note="variable region"
/codon_start=939
misc_feature 1225..1232
/note="pot. V/J joining signal"
misc_feature 1226..1232
/note="heptanucleotide box"
misc_feature 1245..1253
/note="pot. V/J joining signal"
repeat_unit 1688..1845
/note="imp. inverted repeat"
BASE COUNT 729 a 517 c 523 g 699 t 2 others
ORIGIN
1 ggatccactt cccctgctac tgagctaggc tgggacagtt ttgggcacat tagatatgtg
61 cgatataatg attgcaaatc atttccagtt tcatctgtat caaactgctt tctccatgta
121 cataggcatc atctctgtgg atctgtagta aattgcttga tcttatagtg gtaagaacaa
181 tggcataaca ccattaccga atactgacat gtatatatag catcatgtca ataaatttta
241 tttttgattt ttttagaaag gaacaatgtt aaactcacag aaatgttcca agtataggca
301 aagtaacccc ttccctaacc gggatcatat gagagtcttt tggagacctg ataatcatac
361 cgtctaacat tttattatat atttcctaca aacaagaata ttctcctaaa taatccccat
421 acaccaatga aatacattac tccatcaact cctgaggaat atttcaaatc gtcaaaaaaa
481 aactaaaaaa tgtctctcat aataaaatag ttcccagtag aaacacattc tctggagaca
541 aatttgtgct accctggtct tacctgggac acctggggac aytgaactgg tgctgagtta
601 ctgagatgag ccagccctgc agctgtgccc agcctgcccc atcctctgct catttgcata
661 ttcccagaac acaacctcct gccctgaaga cttcttaata ggctggtcac acttcttgca
721 ggagtcagac ccactcagga cacagcatgg acatgagggt ccccgctcag ctcctggggc
781 ttctgctgct ctggctccca ggtaaggaag gagaacacta gcantttact cagcccaggg
841 ggctcagtac agcctggcta ttcagggaaa ttctcttact acatgattaa ttgtgtggac
901 catttgtgtt tatgcttcca atctcaggtg ccagatgtgc catccagttg acccagtctc
961 catcctccct gtctgcatct gtaggagaca gagtcaccat cacttgccgg gcaagtcagg
1021 gcattagcag tgctttagcc tggtatcagc agaaaccagg gaaagctcct aagctcctga
1081 tctatgatgc ctccagtttg gaaagtgggg tcccatcaag gttcagcggc agtggatctg
1141 ggacagattt cactctcacc atcagcagcc tgcagcctga agattttgca acttattact
1201 gtcaacagtt taatagttac cctcacacag tgttacaaac ccgaacataa acccccaggg
1261 aagcagatgt gtgagactgg gctgccccag ctgcttctcc ttatgcctcc attggctgag
1321 agtgttcctc agatgcagcc acactctgat ggtgttggta gaggaggata tgagatcacc
1381 tctgcatccc aatttctttt tcttttctca gccccagctg cacagacata acaatgcctc
1441 tgctgattta ataaagatag agatcatgac acctgaagag tctagtttat ggctttggtt
1501 agaattcata taacagagaa gaagccatta tagatatcct aagcaggaat agtcttaata
1561 gatagaattg gagtctaaag tattgaagtc taaataaaat gtacagataa atttaatgtt
1621 ttatttgcta agaaattttt gccaaatggg gcatacagga aaactcaatg gtcttcaata
1681 tgttggaaga gcaaagagtt ttataaaaag ggaaattatt acctattgtt ctttgagaaa
1741 ttttgttggc tgtagtaagg gttgggagct ggcaagctca gactggtaag cagtggtggt
1801 caaactgaat cctagaatta tattaagtta tctcagaagt tgtgggtaaa tttgctttca
1861 ggttacaata agccaaagca gtgaagcttg cagagaattt tgttactgaa atgccaggga
1921 ttcagtatag atcctgcggc tcaccacaca gaaagccaat cactaagaca acaagtgttg
1981 ccaaagaaca ggctttaatc aggtgctgca gccgaggaga cgggacacca ttctcaaatg
2041 tatctccctg acaaaataaa ttaggggttt atatagcagg gaagaaatgt ggaaaacagg
2101 aattagagag gggtaaggaa gataatttag tcaacaggaa gctggaggtc agttaggcaa
2161 tcataatggg tgaagggtct gatgtctcac tgtccccatt cagtgatata taactttcag
2221 ctccttgata gtatctagag gcctgatggt tggtttcctg aaaaaagaac tcagattaac
2281 aaatgtaact accttgagtt ttaagactgg gggagtcagt ttctatgttt attcaaaaaa
2341 tcataaacat tagttccatg ggataatagg gcctatttca attgcattct tcagacaata
2401 ttttgcaccc tgagtggttt tccctcctgg tttcttggct ctgttgggta tgtcaagaat
2461 gaccgaattc
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMIGK9 2376 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human germ line gene for immunoglobulin kappa light chain leader
peptide and variable region (subgroup V kappa I)
ACCESSION V01576 X00899 Z00007 Z00011
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin;
signal peptide; variable region.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2376)
AUTHORS Jaenichen,H.R.
JOURNAL Unpublished (1984)
STANDARD full automatic
REFERENCE 2 (bases 1 to 2376)
AUTHORS Pech,M., Jaenichen,H.-R., Pohlenz,H.-D., Neumaier,P.S.,
Klobeck,H.-G. and Zachau,H.G.
TITLE Organization and evolution of a gene cluster for human
immunoglobulin variable regions of the kappa type
JOURNAL J. Mol. Biol. 176, 189-204 (1984)
STANDARD full automatic
COMMENT From EMBL entry HSIGK9; dated 06-JUL-1989.
FEATURES Location/Qualifiers
repeat_unit 866..957
/note="imp. inverted repeat 1"
promoter 1115..1122
/note="pot. TATA-box"
CDS 1170..1224
/note="pot. signal peptide (aa -22 to -5) (1224 is 1st
base in codon)"
/codon_start=1170
intron 1225..1349
/note="pot. intron I"
CDS 1350..1360
/note="pot. signal peptide (aa -4 to -1) (1350 is 2nd base
in codon)"
/codon_start=1350
CDS 1361..1645
/note="variable region"
/codon_start=1361
misc_feature 1648..1654
/note="pot. V/J joining signal"
misc_feature 1667..1675
/note="pot. V/J joining signal"
repeat_unit 2114..2282
/note="imp. inverted repeat 1'"
BASE COUNT 698 a 512 c 519 g 647 t
ORIGIN
1 ctgcagcact gtgatttggc tcccctagtc aggcatcagt aaaattttgt ggagtcctag
61 gtggcagccc actgatgctg atgtagttgg atccactttc cctgctacta agtcaggctg
121 ggacattttt gggcacatta gagatatgag atataacgag tgcaaatccg tgtccagttt
181 catctggatc caagtgattt ctccatgtac ataggcaact gcttgataag agattcagtg
241 tctctttcct aaagcagtta acagggaggc tggtgtctgg gtcaggatga tttccccaat
301 cactgataaa aagtaaaaga ggaaagtgtc attgatggtg catggcaggg acatgctcca
361 tgcagtggtc accctcagta agagagatga actttgggaa ataatattga atggcagaaa
421 agaaggtaga ctatgaaggt gcccaaaaca agaataaggt gcagcccatt tagtgtctga
481 gtactataga gacctgtcgc tcttgataat tgtggatctg tgactgctgc atgcatcaag
541 aaaacacggt atcatctttg tgtatctata gtacatagtt tgatcgcata ctggtaagaa
601 caatggcata acaccattac ctgatactta caaatgtatg taccatcatg tcaataaatt
661 ttatttttaa ttttttttac ataggaacaa tgttaaactc acagaaatgt tgcatgtata
721 tgacaaatac ccccttccct aaccggaatc atataagagt cttttgaaga cttgagaatt
781 gtaccgtcta acattttact atgtgtttcc tacaaacaac aatattctcc taaataatcc
841 ccatacacca atgaaataca ttagtccatc aactcctgag gaatatttca aatcgtcaaa
901 aagaaaccaa aaaatgttac tcacaacaaa atagttccca gtagaaacac attctctgca
961 gacaaatttg tgctaccctg gtcttacctg ggacacctgg ggacactgaa ctggtgctga
1021 gttactgaga tgagccagcc ctgcagctgt gcccagcctg ccccatcctc tgctcatttg
1081 catattccca gaacacaacc tcctgcctga agacttctta ataggctggt cacacttctt
1141 gcaggagtca gacccactca ggacacagca tggacatgat ggtccccgct cagctcctgg
1201 ggctcctgct gctctggttc ccaggtaaga aaggagaaca ctaggaattt actcagccca
1261 gtgtgctgag tactgcttta ctattcaggg aacttctctt acagcatgat taattgtgtg
1321 gacatttgtt tttatgtttc caatctcagg ttccagatgc gacatccaga tgacccagtc
1381 tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc atcacttgtc gggcgagtca
1441 gggtattagc agctggttag cctggtatca gcagaaacca gggaaagccc ctaagctcct
1501 gatctatgct gcatccagtt tgcaaagtgg ggtcccatca aggttcagcg gcagtggatc
1561 tgggacagat ttcactctca ccatcagcag cctgcagcct gaagattttg caacttacta
1621 ttgtcaacag gctaacagtt tcccttccac agtgttacca acccgaacat aaacccccag
1681 ggaagcagat gtgtgaagct gggctgcccc agctgctcct cctgatgcct ccattggctg
1741 agagtgttgc tcagatgcag ccacactctg atggtgttgg tagaggggta cgtgaaatcg
1801 cctctgcacc ctaattcttt tctctttctc agccccaact gcacagacat agcaatgcat
1861 ctcctgattt gataaataca gagatcatga cacttgagga gtctagttta tggcttcagc
1921 ttgaattcat ataacacaga agaagccgct atagatattc taagcaggaa tcgtcttaat
1981 acagagaatt aaagtaaact actaaagtca aaataaaatg tagagatgaa tctctaaatt
2041 taagttttat ttgcaaagaa atatttgcca ggtggggcat acaggaaaac tcagtggtct
2101 tcaagatatt ggaagaacga agagaaaatt agcattttat gaaaaaggga aaatgttacc
2161 tgtggctctt tgagaaagtt cattggctct aggaagggtt gggagctggc aagctcagac
2221 tggtaagcag tggtgggcaa aatgaatcct agaattatat caagttatct cagaagttgt
2281 ggacaaattt gatttcaggt tacaataagc caaagcagtg aaggttgcag agaattttgt
2341 tactgaaatg ccagggattc agtgaagacc ctgcag
//