GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMHSDI 1665 bp ss-mRNA PRI 27-MAY-1991
DEFINITION Human major 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4
isomerase mRNA, complete cds.
ACCESSION M67466
KEYWORDS 3-beta-hydroxysteroid dehydrogenase; delta-5-delta-4-ene-isomerase.
SOURCE Human adrenal gland, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1665)
AUTHORS Rheaume,E., Lachance,Y., Zhao,H.F., Breton,N., Dumont,M., de
Launoit,Y., Trudel,C., Luu-The,V., Simard,J. and Labrie,F.
TITLE Structure and expression of a new cDNA encoding the major
3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase
present in human adrenals and gonads
JOURNAL Unpublished (1991)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 134..1252
/function="major 3-beta-hydroxysteroid
dehydrogenase/delta-5-delta-4 isomerase catalyses
delta-5-ene, 3-beta-hydroxy-precursors to delta-4-3 keto
steroids such as: pregnenolone to progesterone,
dehydroepiandrost"
/EC_number="1.1.1.145"
/EC_number="5.3.3.1"
/product="3-beta-hydroxysteroid
dehydrogenase/delta-5-4-isomerase"
/gene="3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4
isomerase"
/codon_start=134
/partial
polyA_signal 1640..1645
/gene="3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4
isomerase"
polyA_site 1665..1665
/gene="3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4
isomerase"
BASE COUNT 438 a 426 c 378 g 423 t
ORIGIN
1 aggacttgga ctcctctgtc cagcttttaa caatctaagt tacgccctct tctgggtcac
61 gctagaatca gatctgctct ccagcatctt ctgtttcctg gcaagtgttt cctgctactt
121 tggattggcc acgatgggct ggagctgcct tgtgacagga gcaggagggc ttctgggtca
181 gaggatcgtc cgcctgttgg tggaagagaa ggaactgaag gagatcaggg ccttggacaa
241 ggccttcaga ccagaattga gagaggaatt ttctaagctc cagaacagga ccaagctgac
301 tgtacttgaa ggagacattc tggatgagcc attcctgaaa agagcctgcc aggacgtctc
361 ggtcgtcatc cacaccgcct gtatcattga tgtctttggt gtcactcaca gagagtccat
421 catgaatgtc aatgtgaaag gtacccagct actgttggag gcctgtgtcc aagccagtgt
481 gccagtcttc atctacacca gtagcataga ggtagccggg cccaactcct acaaggaaat
541 catccagaac ggccacgaag aagagcctct ggaaaacaca tggcccactc catacccgta
601 cagcaaaaag cttgctgaga aggctgtgct ggcggctaat gggtggaatc taaaaaatgg
661 tgataccttg tacacttgtg cgttaagacc cacatatatc tatggggaag gaggcccatt
721 cctttctgcc agtataaatg aggccctgaa caacaatggg atcctgtcaa gtgttggaaa
781 gttctctaca gtcaacccag tctatgttgg caacgtggcc tgggcccaca ttctggcctt
841 gagggctctg cgggacccca agaaggcccc aagtgtccga ggtcaattct attacatctc
901 agatgacacg cctcaccaaa gctatgataa ccttaattac atcctgagca aagagtttgg
961 cctccgcctt gattccagat ggagccttcc tttaaccctg atgtactgga ttggcttcct
1021 gctggaagta gtgagcttcc tactcagccc aatttactcc tatcaacccc ccttcaaccg
1081 ccacacagtc acattatcaa atagtgtgtt caccttctct tacaagaagg ctcagcgaga
1141 tctggcgtat aagccactct acagctggga ggaagccaag cagaaaaccg tggagtgggt
1201 tggttccctt gtggaccggc acaaggagac cctgaagtcc aagactcagt gatttaagga
1261 tgacagagat gtgcatgtgg gtattgttag gaaatgtcat caaactccac ccacctggct
1321 tcatacagaa ggcaacaggg gcacaagccc aggtcctgct gcctctcttt cacacaatgc
1381 ccaacttact gtcttcttca tgtcatcaaa atctgcacag tcactggccc aaccagaact
1441 ttctgtccta atcatacacc agaagacaaa caatatgatt tgctgttacc aaatctcagt
1501 ggctgattct gaacaattgt ggtctctctt aacttgaggt tctcttttga ctaatagagc
1561 tccatttccc ctcttaaatg agaaagcatt tcttttctct ttaatctcct attccttcac
1621 acagttcaac ataaagagca ataaatgttt taatgcttaa catgg
//