GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMACTSA 5594 bp ds-DNA PRI 27-MAY-1991
DEFINITION Human gene for vascular smooth muscle alpha-actin (ACTSA), 5'
upstream and first intron regions.
ACCESSION D00618
KEYWORDS ACTSA; vascular smooth muscle alpha-actin.
SOURCE Human (cell line HUT-14) genomic DNA, clone Ha201.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Ueyama,H., Hamada,H., Battula,N. and Kakunaga,T.
TITLE Structure of a human smooth muscle actin gene (aortic type) with a
unique intron site
JOURNAL Mol. Cell. Biol. 4, 1073-1078 (1984)
STANDARD full staff_review
REFERENCE 2 (sites)
AUTHORS Kamada,S. and Kakunaga,T.
TITLE The nucleotide sequence of a human smooth muscle alpha-actin
(aortic type) cDNA
JOURNAL Nucleic Acids Res. 17, 1767-1767 (1989)
STANDARD full staff_review
REFERENCE 3 (sites)
AUTHORS Reddy,S., Ozgur,K., Lu,M., Chang,W., Mohan,S.R., Kumar,C.C. and
Ruley,H.E.
TITLE Structure of the human smooth muscle alpha-actin gene: Analysis of
a cDNA and 5' upstream region
JOURNAL J. Biol. Chem. 265, 1683-1687 (1990)
STANDARD full staff_review
REFERENCE 4 (bases 1 to 5594)
AUTHORS Nakano,Y., Nishihara,T., Sasayama,S., Miwa,T. and Kamada,S.
TITLE Transcriptional regulatory elements in the 5' upstream and first
intron regions of the human smooth muscle (aortic type)
alpha-actin-encoding gene
JOURNAL Gene 99, 285-289 (1991)
STANDARD full staff_review
COMMENT
[1] sites.
[2] sites.
[3] sites.
These data kindly submitted in computer readable form by:
Takeshi Miwa
Department of Oncogene Research
Research Institute for Microbial Diseases
Osaka University
3-1 Yamadaoka, Suita
Osaka 565
Japan
Phone: 06-875-2470
Fax: 06-875-1292
FEATURES Location/Qualifiers
misc_signal 1629..1635
/note="CArG box2"
misc_signal 1676..1685
/note="CArG box1"
misc_signal 1717..1723
/note="TATA box"
precursor_RNA 1747..>5594
/note="mRNA and intron"
intron 1789..5559
/note="intron 1"
misc_signal 2844..2853
/note="CArG box0"
variation 5434..5434
/note="C in [Gene 99, 285-289 (1991)], G in [Mol. Cell.
Biol. 4, 1073-1078 (1984)]"
variation 5488..5488
/note="G in [Gene 99, 285-289 (1991)], C in [Mol. Cell.
Biol. 4, 1073-1078 (1984)]"
CDS 5583..>5594
/note="ACTSA, coding region of exon 2."
BASE COUNT 1598 a 1143 c 1108 g 1745 t
ORIGIN chromosome 10; map position q22-q24.
1 aatccttcct ctactcaaat tgccctccta ctcaagaaaa tatggaaatt ttgcttcaca
61 tgattcctgt gatgaaaatt aatgaattaa ccccaaatgc ccaactttat gttgtactgt
121 gtagatttta tattttaaca ttctaatggc cgtgttttct ggttggtaaa agctagacaa
181 atcccgagca gtatagagaa atcctgttat gatttagtct taagctattt aaaattttct
241 aatcaatagt gcaattcttc aaagatatat atgtatgtat atgtgtgggc accattaatc
301 aaacagatct gacatagtaa catgagtgaa cagctggtca tggctgtaaa ataaagccac
361 tcattttggg atttttctca catgtccaca gtccagaaat actcacagta cccacaaaaa
421 tatttcttta tgagtttagt gagaacctag tagacaaata taaaatcact gaagctattc
481 attgatgctt gagatgaggg cttatatctt tgagaaatga gagggtcacc tggtatctta
541 gtccattttc acattgctat aaagacatac ccaagactgg gtaatttata aagaaaagag
601 gtttaattta ctcacagttc tgcatggctg gggaggcctc aagaaactta aactcatcgc
661 aaaaggggaa gaggcgtgtc ttacatggca gcaggcgaga gagagcaagc aagagcaggg
721 aaaactgcct tataaaacca tcagatatcg tgagaactca ctcactttca tgagaacagc
781 atggtataaa acgcccccat cgatccagtc acctcccacc atgcctttct ctggacatgg
841 gattatggag attagaattc gagacgagat ttgggtgggg acgtagaacc aaaccatatc
901 acctggtctc tctacttcct gtcaaggagg ttagtgggca gagaggaggg ctacagaggc
961 ttcctttgaa caatctcctt tcttttccaa actacttctt tgacaggctg ctgggtagac
1021 tctctggtca aaggatggtc cctacttatg ctgctaaatt gctcggtgac aaattagtag
1081 acaaagctaa tgcaccaaaa aaatgaatgt agttatagta atgctaacat ccaaattcct
1141 ctttgtaaga cataggcctg tcaaccttgt ctccatactt caattcctat ttccactcac
1201 ctccctcaag aacttgattt ataaacagtg tgcctaccat aaaatcatca ctccctctat
1261 gtatttatag acgactgaag gaatatcttt cttctttgca tgctaccgtg gtagaaggat
1321 tttaaaagtc catgctaggc agaggcagcc ctttctgccc ctttctgttc tcagtttatt
1381 aggaaatagc ctgaaattcc agcatgatag caactggcat ccgtctgtga atgtgcaaac
1441 catgcctgca tctgcccatt acccgtagct cagtgtctct gggcatttct gcagttgttc
1501 tgaaggcttg gcgtgtttat ctcccacagg cggctgaacc gctcccgttt catgagcaga
1561 ccagtggaat gcagtggaag agacccaggc ctccggcacc agattagaga gttttgtgct
1621 gaggtcccta tatggttgtg ttagactgaa cgacaggctc aagtctgtct ttgctccttg
1681 tttgggaagc aagtgggagg agagcaggcc aagggctata taacccttca gctttcagct
1741 tccctgaaca ccacccagtg tggagcagcc cagccaagca ctgtcagggt aagtgcgcca
1801 ggccaaggat gtgacttata gattccagtg gctcttttaa ttacccggta taataagaca
1861 ccatctgcag ggatttggct gggttcatgc actgatattt ctgaatgaag attgtactac
1921 taaaatgatt gtagcttttg gctttaatga tctaacgtta aagacagggc taatatgtag
1981 tttggtatga tggaaggggt agagaagaat atgaaaattt tattaatgca tgtcttctgt
2041 aaaatgttca tcctaaacaa acagcccaga tcttgcagca caatacaggt atgcaggtta
2101 gctgtgtgca gtaagttata catttatttg tatttaggca ctggaaactc agatttcttt
2161 ctggttctga tttgttgtag gggttttctt tcactgggct gtatttttgg tgcagcttag
2221 gtgtctggaa gtcggatttt ggaagtgaac agaagaatag ttgcctagtc tttgattgtg
2281 cctgaatttg tgtattccct tctggtttcc ctgctctaac tggtagtgtc ttttgttgga
2341 aatgtatatc tcttttttgt tggaaatgtg tatgtgtgac cttacaagtt tggatctaca
2401 tcattggtca tttgcagcag agcgcagcag gtgacctgct gaatttttct ctggaaagaa
2461 agatttaggg agcagagcct gcatctgaca gctgtgtgtc ctcccggccg gatatctggt
2521 tgcatctccc tcagcttaaa gctcccttca gcctggtgag gcaagtgtga ctgtgcagcc
2581 agccctgcca acccaggctg agtttcactg caaatcaagg tttggcagct tcagcccaga
2641 ctggagtttt catgctgaga ttttcctagc attttgtgtt tcatggacta aatatggttt
2701 gtgtttcaag accaatgagc tgggaactgt actgttcttt cccctcccat caactcattt
2761 ttggcacaag acgcactcta gtcagttgga gcaaacccct gacccgggtg cagttccaaa
2821 agcagacact cgagcgtgtt ttacctaatt aggaaatgct ttgctccaaa ccgaactgct
2881 cattcaggtt agagaggagc tgtaaaccac tgagctcgac tctttccggg gacacagtga
2941 cttcttcaat gacagtgctc cttttggaca ttataacatt cttcctagat tttctttttc
3001 tttttctttt ttttttggcc aagtaaaaaa catttttctg cattcttgct gatgctgagg
3061 gccagtctcc tttttctgag tatagtcaac ccctcctccc aagccatcac tgcccaacaa
3121 aacagttatt aaaaatatcc cacattcatg gtaaccatac cttcccattt tcagagacca
3181 tcctaatttg aaatgtttta tcctcttttc agcccttact tttggtttgg aaaatgcact
3241 tagcacatcc atagagtgcc tgcttatccc ctggggctgg ctgcttctga cagatacccc
3301 aggctcttag gcttcttccc ttttttctcc tttatagttc tcgcctcttt tctaaagctt
3361 cttaatctgc tctgagggaa gccaaatcac aggaatgcca aaataattca gcatctggaa
3421 agggaaaaga agggtgggaa aggaaagggc aagccattca tgagtcccat gtccattctt
3481 gcaagtggaa tccacacgtt gattattttt attctaagcc tggagcagtg tggaaagaaa
3541 gcaaaggtta gaaacaaaga gttctggata ctgaaaataa tcacacagtg atagtaataa
3601 taatgatgat gaaattagta tttattgaga acttagagta tctctgccac tataaattat
3661 tttaaacact ttaaaaaacc caatctctat aagaactcca tgaggtatgt cctgatatca
3721 ttactgtttt atagtaagga aattgtggtt tagagatgtt aaataactga aatcacacag
3781 cttttaactg ttggagcctg gactcaaatc caggctttct gacttcagag tctaagctca
3841 taatcatgtg atctgaaatc ttcgttgtcc taaatgtatc agttcaaggc tcttggacaa
3901 gtcacttcaa ctccttaagc cttggtttcc ttgtcagctg aagataatat tacatgcctt
3961 gactttaaaa tatgtcatct caattgcagt tttatgttct ttgcaaagag ttattttaca
4021 tgaagcactg ctaaggaagt tttaggcctt tggcaagatg caggtttgat tttgtgggaa
4081 tgttttggca gaactccaac tctgtaatag ctattttatt tccctacttc tcagatgttt
4141 ccttaaaaga actgcctttt ttatatggat ttggaggtgc aatcagttaa cccatttaga
4201 agaagaaatt ttctcaattt gaaatcctaa ttgagatctc aatgccaggc agataactct
4261 gggtgtcctt ctcttaacgg aacatttcga cctaattgtg attagaaaag tggaagaggt
4321 cttgaactgg aagccaaggg gtggctaaag agtacctgat gtctggctgg agctctcctc
4381 taatgccctg tgtgcccttg agcaatcact tcctgatttt cttatttgtg aaaatgagag
4441 cattggatga aaatgtcctc taatatgcct tcaatttctc aaatttgtaa gttgataggc
4501 tgctccagcc tttctaattt tatgaaagga tccaagtata agatccaagt ataaaatggg
4561 ttatttaaaa ttttgtttta ttaccaaaga aatacacatt caatatagaa aattaaaaaa
4621 atatgacaga accatgggaa aataattaaa aacacctata aaacccacca cttcataata
4681 acctcagtca acatcttggt aaatatgatt aatctttttg caatgcataa aaaatacatt
4741 tttaatgaga tttacaatgt tactttttct aacctattac tcttacataa gaactacctt
4801 ttgcttatcc tcttactcta cctttttaat ggcagtaaag tattctacca tatgatatat
4861 aatccatcag gctcaccctc acttgttgga ctgttagctt aacagtgact tttattaacg
4921 gtggataatt gcagccccta aaatttaaag caccttctca gaaaatttta tttcaaagct
4981 tctctgaggg taaagtaaaa gtcctcatga ttcaaaaaga tttttccatt aaacacttga
5041 ccattttaac atttctaaat ttttacatgc tgcctgtccc tcaaaaatct agctttttga
5101 aaaaatttca aaaaggtata gcatatctag aaaaatgtgc atttgggttg atacagacag
5161 gaaaatctag atgcttcttt aacataaggt aggcaacttg tctctgcaaa gatctggtct
5221 cagactctgg atttcccatc tgtgctctgc agtttgttta ttcattcact ggctctatcc
5281 acctttaaag tgctcacgag aacacatgat atgccggtca ctacactaag gttgtatcaa
5341 catagaagtc agagtttcag aagtcagagt ttcagcttac tgaaagctta tagtgtaact
5401 aaagtacttc cagatacatg ctatattaga taacggtcag aggatagcac taggacacag
5461 aggagggccc ccaaacccag ccttggaggt gggagttgtc aggtaagtgc cacaaatgcc
5521 caattacagc tgaggctgct tcctccctgt tttctataga atcctgtgaa gcagctccag
5581 ctatgtgtga agaa
//