GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HUMACTSA 5594 bp ds-DNA PRI 27-MAY-1991 DEFINITION Human gene for vascular smooth muscle alpha-actin (ACTSA), 5' upstream and first intron regions. ACCESSION D00618 KEYWORDS ACTSA; vascular smooth muscle alpha-actin. SOURCE Human (cell line HUT-14) genomic DNA, clone Ha201. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (sites) AUTHORS Ueyama,H., Hamada,H., Battula,N. and Kakunaga,T. TITLE Structure of a human smooth muscle actin gene (aortic type) with a unique intron site JOURNAL Mol. Cell. Biol. 4, 1073-1078 (1984) STANDARD full staff_review REFERENCE 2 (sites) AUTHORS Kamada,S. and Kakunaga,T. TITLE The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA JOURNAL Nucleic Acids Res. 17, 1767-1767 (1989) STANDARD full staff_review REFERENCE 3 (sites) AUTHORS Reddy,S., Ozgur,K., Lu,M., Chang,W., Mohan,S.R., Kumar,C.C. and Ruley,H.E. TITLE Structure of the human smooth muscle alpha-actin gene: Analysis of a cDNA and 5' upstream region JOURNAL J. Biol. Chem. 265, 1683-1687 (1990) STANDARD full staff_review REFERENCE 4 (bases 1 to 5594) AUTHORS Nakano,Y., Nishihara,T., Sasayama,S., Miwa,T. and Kamada,S. TITLE Transcriptional regulatory elements in the 5' upstream and first intron regions of the human smooth muscle (aortic type) alpha-actin-encoding gene JOURNAL Gene 99, 285-289 (1991) STANDARD full staff_review COMMENT [1] sites. [2] sites. [3] sites. These data kindly submitted in computer readable form by: Takeshi Miwa Department of Oncogene Research Research Institute for Microbial Diseases Osaka University 3-1 Yamadaoka, Suita Osaka 565 Japan Phone: 06-875-2470 Fax: 06-875-1292 FEATURES Location/Qualifiers misc_signal 1629..1635 /note="CArG box2" misc_signal 1676..1685 /note="CArG box1" misc_signal 1717..1723 /note="TATA box" precursor_RNA 1747..>5594 /note="mRNA and intron" intron 1789..5559 /note="intron 1" misc_signal 2844..2853 /note="CArG box0" variation 5434..5434 /note="C in [Gene 99, 285-289 (1991)], G in [Mol. Cell. Biol. 4, 1073-1078 (1984)]" variation 5488..5488 /note="G in [Gene 99, 285-289 (1991)], C in [Mol. Cell. Biol. 4, 1073-1078 (1984)]" CDS 5583..>5594 /note="ACTSA, coding region of exon 2." BASE COUNT 1598 a 1143 c 1108 g 1745 t ORIGIN chromosome 10; map position q22-q24. 1 aatccttcct ctactcaaat tgccctccta ctcaagaaaa tatggaaatt ttgcttcaca 61 tgattcctgt gatgaaaatt aatgaattaa ccccaaatgc ccaactttat gttgtactgt 121 gtagatttta tattttaaca ttctaatggc cgtgttttct ggttggtaaa agctagacaa 181 atcccgagca gtatagagaa atcctgttat gatttagtct taagctattt aaaattttct 241 aatcaatagt gcaattcttc aaagatatat atgtatgtat atgtgtgggc accattaatc 301 aaacagatct gacatagtaa catgagtgaa cagctggtca tggctgtaaa ataaagccac 361 tcattttggg atttttctca catgtccaca gtccagaaat actcacagta cccacaaaaa 421 tatttcttta tgagtttagt gagaacctag tagacaaata taaaatcact gaagctattc 481 attgatgctt gagatgaggg cttatatctt tgagaaatga gagggtcacc tggtatctta 541 gtccattttc acattgctat aaagacatac ccaagactgg gtaatttata aagaaaagag 601 gtttaattta ctcacagttc tgcatggctg gggaggcctc aagaaactta aactcatcgc 661 aaaaggggaa gaggcgtgtc ttacatggca gcaggcgaga gagagcaagc aagagcaggg 721 aaaactgcct tataaaacca tcagatatcg tgagaactca ctcactttca tgagaacagc 781 atggtataaa acgcccccat cgatccagtc acctcccacc atgcctttct ctggacatgg 841 gattatggag attagaattc gagacgagat ttgggtgggg acgtagaacc aaaccatatc 901 acctggtctc tctacttcct gtcaaggagg ttagtgggca gagaggaggg ctacagaggc 961 ttcctttgaa caatctcctt tcttttccaa actacttctt tgacaggctg ctgggtagac 1021 tctctggtca aaggatggtc cctacttatg ctgctaaatt gctcggtgac aaattagtag 1081 acaaagctaa tgcaccaaaa aaatgaatgt agttatagta atgctaacat ccaaattcct 1141 ctttgtaaga cataggcctg tcaaccttgt ctccatactt caattcctat ttccactcac 1201 ctccctcaag aacttgattt ataaacagtg tgcctaccat aaaatcatca ctccctctat 1261 gtatttatag acgactgaag gaatatcttt cttctttgca tgctaccgtg gtagaaggat 1321 tttaaaagtc catgctaggc agaggcagcc ctttctgccc ctttctgttc tcagtttatt 1381 aggaaatagc ctgaaattcc agcatgatag caactggcat ccgtctgtga atgtgcaaac 1441 catgcctgca tctgcccatt acccgtagct cagtgtctct gggcatttct gcagttgttc 1501 tgaaggcttg gcgtgtttat ctcccacagg cggctgaacc gctcccgttt catgagcaga 1561 ccagtggaat gcagtggaag agacccaggc ctccggcacc agattagaga gttttgtgct 1621 gaggtcccta tatggttgtg ttagactgaa cgacaggctc aagtctgtct ttgctccttg 1681 tttgggaagc aagtgggagg agagcaggcc aagggctata taacccttca gctttcagct 1741 tccctgaaca ccacccagtg tggagcagcc cagccaagca ctgtcagggt aagtgcgcca 1801 ggccaaggat gtgacttata gattccagtg gctcttttaa ttacccggta taataagaca 1861 ccatctgcag ggatttggct gggttcatgc actgatattt ctgaatgaag attgtactac 1921 taaaatgatt gtagcttttg gctttaatga tctaacgtta aagacagggc taatatgtag 1981 tttggtatga tggaaggggt agagaagaat atgaaaattt tattaatgca tgtcttctgt 2041 aaaatgttca tcctaaacaa acagcccaga tcttgcagca caatacaggt atgcaggtta 2101 gctgtgtgca gtaagttata catttatttg tatttaggca ctggaaactc agatttcttt 2161 ctggttctga tttgttgtag gggttttctt tcactgggct gtatttttgg tgcagcttag 2221 gtgtctggaa gtcggatttt ggaagtgaac agaagaatag ttgcctagtc tttgattgtg 2281 cctgaatttg tgtattccct tctggtttcc ctgctctaac tggtagtgtc ttttgttgga 2341 aatgtatatc tcttttttgt tggaaatgtg tatgtgtgac cttacaagtt tggatctaca 2401 tcattggtca tttgcagcag agcgcagcag gtgacctgct gaatttttct ctggaaagaa 2461 agatttaggg agcagagcct gcatctgaca gctgtgtgtc ctcccggccg gatatctggt 2521 tgcatctccc tcagcttaaa gctcccttca gcctggtgag gcaagtgtga ctgtgcagcc 2581 agccctgcca acccaggctg agtttcactg caaatcaagg tttggcagct tcagcccaga 2641 ctggagtttt catgctgaga ttttcctagc attttgtgtt tcatggacta aatatggttt 2701 gtgtttcaag accaatgagc tgggaactgt actgttcttt cccctcccat caactcattt 2761 ttggcacaag acgcactcta gtcagttgga gcaaacccct gacccgggtg cagttccaaa 2821 agcagacact cgagcgtgtt ttacctaatt aggaaatgct ttgctccaaa ccgaactgct 2881 cattcaggtt agagaggagc tgtaaaccac tgagctcgac tctttccggg gacacagtga 2941 cttcttcaat gacagtgctc cttttggaca ttataacatt cttcctagat tttctttttc 3001 tttttctttt ttttttggcc aagtaaaaaa catttttctg cattcttgct gatgctgagg 3061 gccagtctcc tttttctgag tatagtcaac ccctcctccc aagccatcac tgcccaacaa 3121 aacagttatt aaaaatatcc cacattcatg gtaaccatac cttcccattt tcagagacca 3181 tcctaatttg aaatgtttta tcctcttttc agcccttact tttggtttgg aaaatgcact 3241 tagcacatcc atagagtgcc tgcttatccc ctggggctgg ctgcttctga cagatacccc 3301 aggctcttag gcttcttccc ttttttctcc tttatagttc tcgcctcttt tctaaagctt 3361 cttaatctgc tctgagggaa gccaaatcac aggaatgcca aaataattca gcatctggaa 3421 agggaaaaga agggtgggaa aggaaagggc aagccattca tgagtcccat gtccattctt 3481 gcaagtggaa tccacacgtt gattattttt attctaagcc tggagcagtg tggaaagaaa 3541 gcaaaggtta gaaacaaaga gttctggata ctgaaaataa tcacacagtg atagtaataa 3601 taatgatgat gaaattagta tttattgaga acttagagta tctctgccac tataaattat 3661 tttaaacact ttaaaaaacc caatctctat aagaactcca tgaggtatgt cctgatatca 3721 ttactgtttt atagtaagga aattgtggtt tagagatgtt aaataactga aatcacacag 3781 cttttaactg ttggagcctg gactcaaatc caggctttct gacttcagag tctaagctca 3841 taatcatgtg atctgaaatc ttcgttgtcc taaatgtatc agttcaaggc tcttggacaa 3901 gtcacttcaa ctccttaagc cttggtttcc ttgtcagctg aagataatat tacatgcctt 3961 gactttaaaa tatgtcatct caattgcagt tttatgttct ttgcaaagag ttattttaca 4021 tgaagcactg ctaaggaagt tttaggcctt tggcaagatg caggtttgat tttgtgggaa 4081 tgttttggca gaactccaac tctgtaatag ctattttatt tccctacttc tcagatgttt 4141 ccttaaaaga actgcctttt ttatatggat ttggaggtgc aatcagttaa cccatttaga 4201 agaagaaatt ttctcaattt gaaatcctaa ttgagatctc aatgccaggc agataactct 4261 gggtgtcctt ctcttaacgg aacatttcga cctaattgtg attagaaaag tggaagaggt 4321 cttgaactgg aagccaaggg gtggctaaag agtacctgat gtctggctgg agctctcctc 4381 taatgccctg tgtgcccttg agcaatcact tcctgatttt cttatttgtg aaaatgagag 4441 cattggatga aaatgtcctc taatatgcct tcaatttctc aaatttgtaa gttgataggc 4501 tgctccagcc tttctaattt tatgaaagga tccaagtata agatccaagt ataaaatggg 4561 ttatttaaaa ttttgtttta ttaccaaaga aatacacatt caatatagaa aattaaaaaa 4621 atatgacaga accatgggaa aataattaaa aacacctata aaacccacca cttcataata 4681 acctcagtca acatcttggt aaatatgatt aatctttttg caatgcataa aaaatacatt 4741 tttaatgaga tttacaatgt tactttttct aacctattac tcttacataa gaactacctt 4801 ttgcttatcc tcttactcta cctttttaat ggcagtaaag tattctacca tatgatatat 4861 aatccatcag gctcaccctc acttgttgga ctgttagctt aacagtgact tttattaacg 4921 gtggataatt gcagccccta aaatttaaag caccttctca gaaaatttta tttcaaagct 4981 tctctgaggg taaagtaaaa gtcctcatga ttcaaaaaga tttttccatt aaacacttga 5041 ccattttaac atttctaaat ttttacatgc tgcctgtccc tcaaaaatct agctttttga 5101 aaaaatttca aaaaggtata gcatatctag aaaaatgtgc atttgggttg atacagacag 5161 gaaaatctag atgcttcttt aacataaggt aggcaacttg tctctgcaaa gatctggtct 5221 cagactctgg atttcccatc tgtgctctgc agtttgttta ttcattcact ggctctatcc 5281 acctttaaag tgctcacgag aacacatgat atgccggtca ctacactaag gttgtatcaa 5341 catagaagtc agagtttcag aagtcagagt ttcagcttac tgaaagctta tagtgtaact 5401 aaagtacttc cagatacatg ctatattaga taacggtcag aggatagcac taggacacag 5461 aggagggccc ccaaacccag ccttggaggt gggagttgtc aggtaagtgc cacaaatgcc 5521 caattacagc tgaggctgct tcctccctgt tttctataga atcctgtgaa gcagctccag 5581 ctatgtgtga agaa //