GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS RATMSAR 1740 bp ss-mRNA ROD 27-MAY-1991
DEFINITION Rat mRNA for multiplication stimulating activity (MSA)
ACCESSION X00911
KEYWORDS growth factor; insulin super family; insulin-like growth factor II;
multiplication stimulating activity; somatomedin.
SOURCE Rattus norvegicus RNA.
ORGANISM Rattus norvegicus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 1740)
AUTHORS Dull,T.J., Gray,A., Hayflick,J.S. and Ullrich,A.
TITLE Insulin-like growth factor II precursor gene organization in
relation to insulin gene family
JOURNAL Nature 310, 777-781 (1984)
STANDARD full automatic
COMMENT See also <ARIN01> Data kindly reviewed (24-OCT-1986) by A. Ullrich
From EMBL entry HSMSAR; dated 03-JAN-1991.
FEATURES Location/Qualifiers
CDS 1031..1603
/note="pot. MSA-precursor"
/codon_start=1031
CDS 1064..1603
/note="put. MSA-precursor"
/codon_start=1064
CDS 1064..1135
/note="put. signal peptide (aa -24 to -1)"
/codon_start=1064
CDS 1088..1603
/note="pot. MSA-precursor"
/codon_start=1088
CDS 1136..1603
/note="(aa 1-156)"
/product="mature MSA"
/codon_start=1136
CDS 1136..1231
/note="B-chain (aa 1-32)"
/codon_start=1136
CDS 1232..1255
/note="C-peptide (aa 33-40)"
/codon_start=1232
CDS 1256..1271
/note="A-chain (aa 41-62)"
/codon_start=1256
CDS 1272..1286
/note="D-peptide (aa 63-67)"
/codon_start=1272
CDS 1287..1603
/note="E-peptide (aa 68-156)"
/codon_start=1287
BASE COUNT 264 a 690 c 420 g 366 t
ORIGIN
1 cctggcccac gcccgcccgc gctcggcccg ccagcgcctc catccgggct ggcggccccg
61 cgtcgacgcc gtccgccacc tcgctgctaa ctcccgtgca gggcgccgtc ggcggggcct
121 cgctccgtcg ggcctgcgga tctccccacc gcctcctcct ctatctacct caacacccca
181 ttcctgcttc gccagaggag gcggtcccca ccgcaggcag tccggcttgc aggtcgccgg
241 cgttgtcatc ccccgcgctc cccctcccag ccctccccgg cgcgcagccc ggcagctcct
301 ctcttttcgc tgcagtcccg agcagccgcg gcgccgccac gcctgacccc cccacaagaa
361 gccggggctt acgacggctg agggctccgt cggccctaac cgagctgggt gcccgtggcc
421 ggggtgacgc ctccattcct cccccctcaa caccgtcctc gatccttcga agttgcatcc
481 tttcctctgc ttagagtgcg ccccccctcg cgcactcgct tacccgccac ctttcctagg
541 ctcccctcct gccccctccc cgttcctcct cgcctcagac tccctccccc tcacgtccgc
601 cctctgcctt cgcctaccca agtggattaa ttatacgctt tctgtttctc tccgtgctgt
661 cctctcccgc tgtgagccta cccgcctctc gctgtcctct ctccctctct ccctctctgt
721 ggtccccccc ctttcacgtt cactctgtct ctctcactat ctctgccccc caactatcct
781 tgatacaaca gctgacctca tttcccgata cctttccccc ccccgaaaat acagtatctg
841 gcccgcccca gccctaagat accctaaaga agcagaagag acgcccccct ccccatcaaa
901 aaaagccatc tccccgttct gtcccgtcgc acattcggcc tctgcgactt ggacagagcg
961 gcgctggcag aggagtgccc ggcagaaggg ccttcgcccg ctgttcggtt tgcatacccg
1021 cagcagggag atgggcggca gcgtcgccgg cttccaggta ccaatgggga tcccagtggg
1081 gaagtcgatg ttggtgcttc tcatctcttt ggccttcgcc ttgtgctgca tcgctgctta
1141 ccgccccagc gagactctgt gcggagggga gcttgttgac acgcttcagt ttgtctgttc
1201 ggaccgcggc ttctacttca gcaggccttc aagccgtgcc aaccgtcgca gccgtggcat
1261 cgtggaagag tgctgcttcc gcagctgcga cttggccctc ctggagacat actgtgccac
1321 ccccgccaag tccgagaggg acgtgtctac ctctcaggcc gtacttccgg acgacttccc
1381 cagatacccc gtgggcaagt tcttcaaatt cgacacctgg agacagtccg cgggacgcct
1441 gcgcagaggc ctgcctgccc tcctgcgtgc ccgccggggt cgcatgcttg ccaaagagct
1501 cgaagcgttc agagaggcca agcgccaccg tcccctgatc gtgttaccac ccaaagaccc
1561 cgcccacggg ggagcctctt cggagatgtc cagcaaccat cagtgaacca aattatgtgg
1621 taattctgca atgtagtacc atcagtctgt gacctcctct tgagcaggga cagctccatc
1681 atgtcccaca ctaaggtctc tctgctccac ttcccttcct aggtaagcac tctaccactg
//