GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS HAMPRQ 1918 bp ss-mRNA ROD 27-MAY-1991
DEFINITION Syrian golden hamster scrapie (prion) protein PrP 27-30 mRNA.
ACCESSION K02234
KEYWORDS prion.
SOURCE Mesocricetus auratus RNA.
ORGANISM Mesocricetus auratus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 1918)
AUTHORS Oesch,B., Westaway,D., Waelchli,M., McKinley,M.P., Kent,S.B.,
Aebersold,R., Barry,R.A., Tempst,P., Teplow,D.B., Hood,L.E.,
Prusiner,S.B. and Weissmann,C.
TITLE A cellular gene encodes scrapie PrP 27-30 protein
JOURNAL Cell 40, 735-746 (1985)
STANDARD full staff_review
COMMENT SWISS-PROT; P04273; PRIO$MESAU.
Sequence submitted on magnetic tape by S. Prussiner (27-NOV-1984).
The open reading frame shown in the features table could possibly
extend further upstream to another Met codon; the exact COOH
terminus of the mature PrP 27-30 product is not known, but the
terminus indicated below is most consistent with the available
amino acid compositional data [1]. PrP-related mRNA is expressed in
both scrapie-infected and normal brain tissue, and in other normal
tissues. There appears to be only one copy of this gene per haploid
hamster genome.
From EMBL entry MAPRP; dated 24-APR-1990.
FEATURES Location/Qualifiers
mRNA <1..1918
/note="PrP 27-30 mRNA"
mRNA <1..1918
/note="PrP 27-30 mRNA"
CDS 11..733
/note="PrP 27-30 protein precursor"
CDS 11..733
/note="PrP 27-30 protein precursor"
/codon_start=11
mat_peptide 236..673
/note="PrP 27-30 protein"
CDS 236..673
/note="PrP 27-30 protein"
/codon_start=236
BASE COUNT 490 a 463 c 479 g 486 t
ORIGIN
1 ctttgtggct atgtggactg atgttggcct ctgcaagaag cggccaaagc ctggagggtg
61 gaacactggc ggaagccgat accctgggca gggcagccct ggaggcaacc gttacccacc
121 tcagggtggc ggcacatggg ggcaacccca tggtggtggc tggggacagc cccatggtgg
181 tggctgggga cagccccatg gtggtggctg gggtcagccc catggtggtg gctggggtca
241 aggaggtggc acccacaatc agtggaacaa gcccagtaag ccaaaaacca acatgaagca
301 catggccggc gctgctgcgg caggggccgt ggtggggggc cttggtggct acatgctggg
361 gagtgccatg agcaggccca tgatgcattt tggcaatgac tgggaggacc gctactaccg
421 tgaaaacatg aaccgctacc ctaaccaagt gtattaccgg ccagtggacc agtacaacaa
481 ccagaacaac tttgtgcacg attgtgtcaa catcaccatc aagcagcaca cagtcaccac
541 caccaccaag ggggagaact tcacggagac cgacatcaag ataatggagc gcgtggtgga
601 gcagatgtgt accacccagt atcagaagga gtcccaggcc tactacgatg gaagaaggtc
661 cagcgcggtg ctgttctcct cccctcctgt gatcctcctc atttcctttc tcatcttcct
721 gatggtggga tgaaggaagc ctccctgctt gtacttcctc gttcttgtgg tctaggctgg
781 gggaggggtt atccaccgta gctcttttaa ttgaggtggt gtctcattcc tgcttctctt
841 tgtcccccat aggctaatgc ccttggcact agtgggccct gggaatgtac agtagaccag
901 atgctattcg atccagagcc tttgaattga gtccatcacg ggccagcact aacaccaggc
961 ctatctgaat ataacagcaa gtaatggctg gctagtcagg gctttgtttt ggtctagtga
1021 gtaaatactg atgtgaccct ctgacttcca cacagagtac gcagtgacag acacacctaa
1081 ctgttaaaat aggcgaaggg ttctacagcc aaagaagtca ctgtttggca tggtccctaa
1141 gaaacagcct cccatttggg atatttaaag catccatatg aggcattcct ccttcactaa
1201 caaactctag ctgagtaagg caacgggaaa aaaacaaaat taccctacta acatggaaag
1261 caaacctgtg ttcatttcct aggaactaga atgatgtttt agccttgctt ggattgaacc
1321 aggagatttt ggctctgaag agccaacact gtaaaaatgt ggtcctcctg caaagggaga
1381 gatggttagg acacaaagtc acggcgcttg gcgtttcttc atttctgtct cataattgtc
1441 aaaagtcaca attaggtcat gcccttagtt aatatacttg tatttgaatc ggacgacaag
1501 agacaatcta aaaattctcc taggttgtag atgaaatagg ctccattcaa ggtgaaaaga
1561 cagtttgtta gcgttgctta tgtaaggcaa actttgttcc ttaagttgct ccgtgtttcc
1621 ctgaccagac ataaccactc tgcaacagca ttgccctgct gtagaatata taaagtgtaa
1681 ctacaagctt agaccttctg ttctgatgca tccgaagtac gtaatgcact gaccatttca
1741 cccggtatca gatgttttct gtgtggcccc tagctttcct tcaacatgca ttcggttcca
1801 tatatgaatc caaagtggac cccctaactg gtctctgaaa tctgcatgta cttcacattt
1861 tctatatttg taactttgca tgtccttgtt ttgtcatata aaaagtttat aaatgttt
//