GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS MUSIGG10G 7715 bp ds-DNA ROD 27-MAY-1991
DEFINITION Mouse gene IgG-3 heavy chain constant region (exon 3-8)
ACCESSION X00915
KEYWORDS constant region; gamma-immunoglobulin; immunoglobulin;
immunoglobulin heavy chain.
SOURCE Mus musculus DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 7715)
AUTHORS Wels,J.A., Word,C.J., Rimm,D., Der-Balan,G.P., Martinez,H.M.,
Tucker,P.W. and Blattner,F.R.
TITLE Structural analysis of the murine IgG3 constant region gene
JOURNAL EMBO J. 3, 2041-2046 (1984)
STANDARD full automatic
COMMENT From EMBL entry MMIGG10G; dated 10-JAN-1991.
FEATURES Location/Qualifiers
CDS join(2010..2298,2664..2711,2811..3140,3253..3567,
5019..5150,5698..5778)
/product="immunoglobulin heavy chain constant region"
/gene="IgG-3"
/codon_start=2010
misc_feature 1503..1509
/note="pot. polyA signal"
misc_feature 1563..1616
/note="(GA) 27 repeat"
exon 2010..2298
/number=1
exon 2010..2298
/note="heavy chain constant region domain 1 (exon 3) (2298
is 1st base in codon)"
intron 2299..2663
/note="intron"
misc_feature 2319..2324
/note="pot. polyA signal"
exon 2664..2711
/number=2
exon 2664..2711
/note="heavy chain constant region hinge (exon 4) (2664 is
2nd base in codon) (2711 is 1st base in codon)"
intron 2712..2810
/note="intron IV"
exon 2811..3140
/number=3
exon 2811..3140
/note="domain 2 (exon 5) (2811 is 2nd base in codon) (3140
is 1st base in codon)"
misc_feature 3073..3075
/note="stop codon (secreted form)"
intron 3141..3252
/note="pot. intron V"
misc_feature 3186..3191
/note="pot. polyA signal"
exon 3253..3567
/number=4
exon 3253..3672
/note="pot. domain 3 (secreted form) (3253 is 2nd base in
codon)"
exon 3253..3567
/note="pot. domain 3 (membrane bound form) (exon 6) (3253
is 2nd base in codon) (3567 is 1st base in codon)"
intron 3568..5018
/note="pot. intron VI"
misc_feature 3644..3649
/note="polyA signal (secreted form)"
exon 5019..5150
/number=5
exon 5019..5150
/note="pot. membrane region 1 (exon 7)"
intron 5151..5697
/note="pot. intron VII"
exon 5698..5778
/number=6
mRNA 5698..>5697
/note="pot exon 8"
exon 5698..5778
/note="pot. membrane region 2"
misc_feature 6961..6966
/note="polyA signal (membrane bound form)"
BASE COUNT 2135 a 2011 c 1879 g 1690 t
ORIGIN
1 aagtagatag gacagatgga gcagttacag aggaaaaggt ttgtagaagc ttgaatgtcc
61 aggctgagta tctacatggt gactggaaaa ggtgggcgtt tggggagggg gaccagatca
121 agctaagggt tctggggcag ataggagtgt ggaaaagtgg actgggttat cacaagggaa
181 ctaggacagg tggttgtggg ggaagccagt gtgagtgacc acagtgtact gaggcaggct
241 ggagtgctag ggtaccaggt caagcacagg aactcagtag gtctagccag ggcaactagg
301 aacactctga caggaaaggg tacatgaacc agcctgagac ctttgaagac ctgagatggc
361 tcaggcagca gtggcaagtg aggatgtggg aatccagtga ggtgagagaa ctggagacag
421 ctccagggaa actagtcgtc tcacctccct gctgcaggcc tctcctgtag ccactctgca
481 cctcatatct gtacatgcct attagcaaga agatagtaag agctgggttc agatataaga
541 ctgtgtgcaa gaactagatg gggtactggg taggaatgat gaagaaagag aaagggaaag
601 tgctcagggc ctgtctaacc cacaggcaag agagaatcag taatgagaga caaggaaggc
661 cttggctgag cagagcaggg aaagtccctg aggctaacac tctcaaaagg accatataga
721 cagcagttct cagtcggggg cccatcttgg ttcctggaga tggaggggaa cttaccatag
781 gaaggtcaaa cttgttacag ccgttatgta tacagagttg gatgcacaga gggaaggaag
841 aaggaggcac atcagggtct gagcagtgga agccagcagc tgtggttcga agaaggatga
901 ccctgaagct gagaggagac ctgggttgga gaaaagacag cctgacagcc agttttctca
961 tgaatggcag catatcctaa actcaagggc tcatggcttc tagaaagaaa tggggaactc
1021 attggaatct ggagacactg gcacctgtga cataggagaa ggcaggggtg agtgtggggt
1081 tcagggtaag agaagaggca gtagtggagc tagagctgag atcatttggt tcccattaga
1141 aaaataccct gcagaggaca agaagcacag agacatccag ggaagtcagg ccaggccagg
1201 gatgcccatg ccaggaaggt tcatgacaga cttactgggt gtgaacctca ggaggaagtc
1261 aaggaggaag attcaaggag ggctgaggtc aagctggagc ccagagccca gatttaggaa
1321 tcaaagtagc aggcaggctg aggaagtgtc ccgtggacac tgtgtcagtg cagaatctag
1381 cagtggtatt tgttcaccct ctgtagccaa gagccaactc agatggctta gcctgtatga
1441 tcagggtcat ggacatgagt ttgtgaagag ctcgtggggc ctgagactag gggccgccta
1501 ttaattaaaa acaggtcaca gagagaggga gagagagaga gagaaagaga gagagagaga
1561 aagagagaga gagagagaga gagagagaga gagagagaga gagagagaga gagagaggaa
1621 tcaaaggaca gcaggaacca acatgccagg agctagagaa ggaaatgaag gctccattga
1681 ggggaaacat gaatgatgtc tacagcttca agcacaggtg caagagacta tagaacagta
1741 catacaaacc agctttctga aaatatgttc aggatagagc tgggctcaga aattctactg
1801 atcaaaccta gctgctaatt ctggggtgga gggggtgtaa ggtgaggcaa ttggaaccat
1861 caaggttgct atatgatgcc ctgacctagg tgatatatcc tacatgctct ttgcagaacc
1921 ctggcatcct tgtaggacca aggctgaact cctccaggtg cctggatcca gctgtctgat
1981 aacctcactc atcctcctat cttgcagcta caacaacagc cccatctgtc tatcccttgg
2041 tccctggctg cagtgacaca tctggatcct cggtgacact gggatgcctt gtcaaaggct
2101 acttccctga gccggtaact gtaaaatgga actatggagc cctgtccagc ggtgtgcgca
2161 cagtctcatc tgtcctgcag tctgggttct attccctcag cagcttggtg actgtaccct
2221 ccagcacctg gcccagccag actgtcatct gcaacgtagc ccacccagcc agcaagactg
2281 agttgatcaa gagaatcggt gagagggtaa ctaagggaaa taaaatttaa ccaggaggtc
2341 aagttggggt caacctctta tataaaacaa ccaaactgaa cagaccttgg cagagaggca
2401 atgccaatca gggcagttgg gttcctttgt gtctacctcc tagaagcctc ttttcatgtt
2461 cctcatattc agaaagtagt gctctggaat ggtcaccagt atttcacatc atggacaaac
2521 agaagtagac atgggtctca acctgtcaat gatcatatcc aggaacacct tgacctaagc
2581 caacactagg accatctttc ttctccctgg tttggtgcct tctctcctct aaaccccatt
2641 aatgcccagt cttttctctg cagagcctag aatacccaag cccagtaccc ccccaggttc
2701 ttcatgccca cgtaagtcat ttaagtctct agtcccagaa catgattgtc ccaaaagcca
2761 catgttggag gatggtacag ttgctaaccc atcctatctc tccccaccag ctggtaacat
2821 cttgggtgga ccatccgtct tcatcttccc cccaaagccc aaggatgcac tcatgatctc
2881 cctaaccccc aaggttacgt gtgtggtggt ggatgtgagc gaggatgacc cagatgtcca
2941 tgtcagctgg tttgtggaca acaaagaagt acacacagcc tggacacagc cccgtgaagc
3001 tcagtacaac agtaccttcc gagtggtcag tgccctcccc atccagcacc aggactggat
3061 gaggggcaag gagttcaaat gcaaggtcaa caacaaagcc ctcccagccc ccatcgagag
3121 aaccatctca aaacccaaag gtgagagctg cagcctgact gcatgggggc tgggatgggc
3181 ataagaataa aggtctgtgt ggacagcctt ctgcttcagc cacgacctct gtgtatgctt
3241 ctaaccccac aggaagagcc cagacacctc aagtatacac cataccccca cctcgtgaac
3301 aaatgtccaa gaagaaggtt agtctgacct gcctggtcac caacttcttc tctgaagcca
3361 tcagtgtgga gtgggaaagg aacggagaac tggagcagga ttacaagaac actccaccca
3421 tcctggactc agatgggacc tacttcctct acagcaagct cactgtggat acagacagtt
3481 ggttgcaagg agaaattttt acctgctccg tggtgcatga ggctctccat aaccaccaca
3541 cacagaagaa cctgtctcgc tcccctggta aatgagaaca gcacctagcc attcctcggg
3601 tcttacaaga cactgatacc agctctaact ggtgaaccct ataaataaag cacccagaga
3661 tgggaccttg tgagattatc ttggttcttt acatggcaca tagttcatga tacacctcag
3721 ccacaggctg tggggtctgg ccagggttca aggtgtaagt taacatccaa gaaagaacaa
3781 ggtcttatac tgccagaccc agggcatgca agtggacctg cccttgccag agatcatccc
3841 tctctgcata gcaagtttga cccaaggggc cctcttcata ctcttcccca caaccagcaa
3901 ctgttctgtg atgagtctgg agatagaaat atcgccctag aaaatatcca aagaaaggaa
3961 cacagaaagt gtatcccacc tcaacacgaa ccccaccttc atttgtctgt ccttccctct
4021 accgtgactc ccctaccttg acctaggagg tctctgtatg tattacatag acaggcagga
4081 agactcatac atgaagcctg ttcatctcca ccacaccccc agcgataggg atagggatga
4141 gtactcctaa gagactacct cccatatgac attcactcac acctaagttc caagacactg
4201 agagacttat gaccctagct gcccccaagg aagtaactaa tcaaatacct acatagatgc
4261 tgagaccaga actattagaa ccagcctgct aagcatcact caacccacat ggtacctcca
4321 agcctacata catccactga tacctcacct aggcagcatg aatagcaacc aaacccatct
4381 tagtgtcggg atatccctag acactaccta aatgtacaca tttggaccag tgaagatgaa
4441 atagctctca tgggtaccta actgttttcc cctaacacac acaagtacct tcagacccat
4501 tctgtccctc tatgcctaag cccctatttt catcccttac agttaacact ctcccatagc
4561 tgtataacat gactcacttc ccaatgtgga ccttctagga agcccaggta tcatcaaacg
4621 caggccctac tctcactctg tccctctgta ctcagtcacc agggaacaag cagtaggtca
4681 ggcaggctgc agagctatta cctacagggc ttccaagcct tgaatcagcc aagccagacc
4741 cagtactgag ggatagggta gacaaaaagg gctcctgcat agcccaggcc agcatcaggt
4801 ccagtgtatc tggctgtacc cagggacaaa acggcagcac gttggggagc tgaggtttct
4861 ggttcacaga gaacataaag gagagatggc cccagggagg gtctgctgac ccagtcaggc
4921 tgcagctttc tcctgggcct ccatgcagcc tcctgccaca cagggaatgg ccctagctct
4981 accttgttgg gacaaacact gactttcctc tctgttcaga gctggaactg aatgagacct
5041 gtgctgaggc ccaggatggg gagctggacg ggctctggac gaccatcacc atcttcatca
5101 gcctcttcct gctcagcgtg tgctacagcg cctctgtcac cctcttcaag gtcatcccta
5161 tttcctccac catcctcaca atatctacac tatactcaag ctgtctccat agtgattcat
5221 gctatcccta cctgtcccat actgtctcaa tgtctttccc atgtcatcat atgtcatctt
5281 ccacatagtc atccactgta cttacaccac cctctccctg tccctctgtt ctatactgtg
5341 cccacattgt ccatgctgtc cctaatttgt cttgacactc ccgcaagttg tcacccaccc
5401 tatccatgca ccgtctccaa tatgatctgc acactgttcc tattgccggt ccccactcta
5461 ttcacacctg gtcctcacca aatccctaca ctgtccctac aatgcccctt gctatagcta
5521 cacaccgtct caaaactcta ctcacacctt gccttacaat gtcactgtct tatcctcact
5581 ctagatatat gacatcccaa gattgggagc tgccctggct tagtgtataa tgaggcaggg
5641 atgacctgtg aagggactca ggtcaggcac ataacatctc acttttgcat ctcacaggtg
5701 aagtggatct tctcctcagt ggtgcaggtg aagcagacgg ccatccctga ctacaggaac
5761 atgattggac aaggtgccta gcctgtctct tcagaaggtg ccagagcttg ctagccctct
5821 aggaccaagt ccatgctgct gagctgccag acacacgggt tacactgcct tctcatctca
5881 gcatcctttg atcttatggc tctgactctg ctacccaggt cccttccaca tttggagcag
5941 catgtggaaa gcaggctttg ccccagacca tagccaacag gacccaagca ccactaccac
6001 agccaaaaca gtggataggg tcaaaactgc tgtgtttctt ctacatggtg tctagccctc
6061 agccaggcac tctcccaaga tgggctgcat cacctgcatc catttagatg cagatgagcc
6121 ttagagccag ccctgtctat acagtcctct gaaaaacgtg cttctctgag agaagaggaa
6181 gtttccatgt gtctctaagg ctgagaaggc ctcaaaggga actctttggg aaggactgcc
6241 aaaggtgact ctaatggcct tcacccaacc agtgccctgc cgtgtttttt cacttcttgg
6301 aatgtaagat ggggctactt gtgaagacct cttttcctgc catccatgca acatgatgaa
6361 atctcagatg caagatccca tcagacactg ctgatcccac agcttgaaga ccagggcact
6421 gttacctcag tggatgacct agagagacac tcagagggcc tgagcttcat agcctctgtt
6481 gggccctagc aggtacagga gccactgagc aaaggctggg caacccagaa aagcccgtag
6541 gagaagagca gaccccggtc agtcccaaag gtggtccagg agcaacatgg ggagagagag
6601 aaaggatgct taaaaagcca ggcaggaatg ggcctttcct gcagcctggc atccggactg
6661 ggccactgac agcagagaat accagttaga gtagatatcc agagagagag cccaggcctg
6721 gggcactgag gctgactgac tgctggcatt ggagaggcac tgtggctgtt tctccatttc
6781 atatcaaggc aaatgcaggc cagagtcccc agaaaagaca aaggagaaat ccaggaagaa
6841 aagttgggtg cccggctctt aggggactct aagagatgtt cactgacttg aagcttagct
6901 ttgccagctt tttctttaaa ttttctggaa cccagctatg tctctaatgt ccctcttcat
6961 cttttttaat aataaaacat ccttcaacat tgtaaaacac actgtgttct tcctctgtag
7021 accaaccccc actctccttg tacaaaactc acacacacac acatgcacac acatgcatgc
7081 acacatgcac actcacacac acgtacatgc atgcacacaa gcacattcac acacacatat
7141 gcacacacat gcatgcacac acacactcac acacaaatac atgcatcaca cacccacacc
7201 cacacatata ccatgctaac attcccaaag caccactcac ccagcattct gctctcagtc
7261 tcaagtcccc tccaactatc atcccataat gaggcaggga tggtctgtga gtgggaatca
7321 ctctggattt caggccatgg tgaccacgag ggagaggcag tcaggaagca gaagatagct
7381 aacatccatg tgagaggaac agatgctatg actcaagagt ggattatagc ctgatgactt
7441 gcagtagggc agatagcccg gggaacgtgg cctccacttg cactggtaca gggcgaaagc
7501 ctttctaagg cagatcaggg gactagggaa agaaagatgg agctcagaca tgtcagggtg
7561 ctctgctctc actgccttcc caaggtggag ttttgcagca ggaacatcct acaacacggg
7621 ttcaactgtt agaaactgtt tgggtctaca taggccctgg cagaggattg tgttggagac
7681 ttggggctgg actagtcaaa agactcatgc agctg
//