GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS MUSIGGNP5 417 bp ss-mRNA ROD 27-MAY-1991
DEFINITION Mouse mRNA for idiotypic anti-NP IgM heavy chain V-D-J (hybridoma
P.9.37.1/group VI)
ACCESSION X02566
KEYWORDS diversity region; immunoglobulin; immunoglobulin heavy chain;
joining region; mu-immunoglobulin; signal peptide; variable region.
SOURCE Mus musculus RNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 417)
AUTHORS Boersch-Supan,M.E., Agarwal,S., White-Scharf,M.E. and
Imanishi-Kari,T.
TITLE Heavy chain variable region Multiple gene segments encode
anti-4-(hydroxy-3-nitropheny)acetyl idiotypic antibodies
JOURNAL J. Exp. Med. 161, 1272-1292 (1985)
STANDARD full automatic
COMMENT Serological analysis of hybridomaproteins resulting from the immune
response to the hapten NP reveals NP(a) idiotypes expressed by
Balb/C mice and NP(b) idiotypes expressed by C57 BL/6 mice. The
NP(b) family of antibodies consists of 6 subgroups (I-VI) with I-IV
sharing more determinants than V and VI which appear quite
distinct.
From EMBL entry MMIGGNP5; dated 10-JAN-1991.
FEATURES Location/Qualifiers
mat_peptide join(58..147,352..373,374..417)
/product="idiotypic anti-NP IgM heavy chain V-D-J"
CDS join(1..147,352..373,374..417)
/product="idiotypic anti-NP IgM heavy chain V-D-J"
/codon_start=1
sig_peptide 1..57
misc_feature 58..147
misc_feature 58..147
/note="variable region (aa 1-98)"
misc_feature 148..162
/note="CDR I"
misc_feature 205..255
/note="CDR II"
misc_feature 352..373
misc_feature 352..373
misc_feature 352..373
/note="D-region (aa 99-105)"
misc_feature 374..>417
/note="J-region (aa 106-120)"
BASE COUNT 101 a 106 c 107 g 103 t
ORIGIN
1 atgaaattca gctgggtcat gttcttcctg atggcagtgg ttacaggggt caattcagag
61 gttcagctgc agcagtctgt ggcagagctt gtgaggccag gggcctcagt caagttgtcc
121 tgcacagctt ctggcttcaa cattaaaaac acctatatcc actgggtgaa gcagaggcct
181 gaacagggcc tggagtggat tggcaggatt gatcctgcga atggtaatac taaatatgcc
241 ccgaagttcc aggtcaaggc cactataact gcagacacat cctccaacac aacctacctg
301 cagctcagca gcctgacatc tgaggacact gccatctatt actgtgccct ctattactac
361 gttagtagct acgggtttgc ttactggggc caagggactc tggtcactgt ctctgca
//