GenBank-Updates@genbank.bio.net (04/18/91)
LOCUS MUSIGHVBR 282 bp ds-DNA ROD 18-APR-1991
DEFINITION Mouse (strain BALB.B) Ig germline H-chain V-region gene, partial
cds.
ACCESSION M61217
KEYWORDS germline; immunoglobulin heavy chain; variable region.
SOURCE Mouse, DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 282)
AUTHORS Press,J.L., Giorgetti,C.A. and Busby,W.F.III.
TITLE A new germline VH36-60 Gene is used in the Neonatal primary and
adult memory response to (T,G)-A--L
JOURNAL Mol. Immunol. (1991) In press
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 1..282
/product="immunoglobulin heavy chain V region"
/gene="VH3A1"
/codon_start=1
/partial
BASE COUNT 82 a 78 c 58 g 64 t
ORIGIN
1 gatgtgcagc ttcaggagtc aggacctggt ctggtgaaac cttctcagac agtgtccctc
61 acctgcactg tcactggcat ctccatcacc actggaaatt acagatggag ctggatccgg
121 cagtttccag gaaacaaact ggagtggata gggtacatat actacagtgg taccattacc
181 tacaatccat ctctcacaag tcgaaccacc atcactagag acacttccaa gaaccaattc
241 ttcctggaaa tgaactcttt gactgctgaa gacacagcca ca
//GenBank-Updates@genbank.bio.net (04/18/91)
LOCUS MUSIGHAHE 351 bp ss-mRNA ROD 18-APR-1991
DEFINITION Mouse (strain BALB.B) Ig active H chain mRNA, V-D-J region.
ACCESSION M61218
KEYWORDS diversity region; immunoglobulin heavy chain; joining region;
variable region.
SOURCE Mouse, cDNA to mRNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 351)
AUTHORS Press,J.L., Giorgetti,C.A. and Busby,W.F.III.
TITLE A new germline VH36-60 Gene is used in the Neonatal primary and
adult memory response to (T,G)-A--L
JOURNAL Mol. Immunol. (1991) In press
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 1..351
/gene="C72-3A1"
/codon_start=1
/partial
BASE COUNT 99 a 97 c 73 g 82 t
ORIGIN
1 gatgtgcagc ttcaggagtc aggacctggt ctggtgaaac cttctcagac agtgtccctc
61 acctgcactg tcactggcat ctccatcacc actggaaatt acagatggag ctggatccgg
121 cagtttccag gaaacaaact ggagtggata gggtacatat actacagtgg taccattacc
181 tacaatccat ctctcacaag tcgaaccacc atcactagag acacttccaa gaaccaattc
241 ttcctggaaa tgaactcttt gactgctgaa gacacagcca catactactg tgcacgagat
301 tactatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc a
//GenBank-Updates@genbank.bio.net (04/19/91)
LOCUS MUSIGHAM1 540 bp ds-DNA ROD 19-APR-1991
DEFINITION Mouse (BMA 031) Ig active H-chain gene V-region, complete cds.
ACCESSION M63668
KEYWORDS immunoglobulin heavy chain; joining region; processed gene;
variable region.
SOURCE Mouse, DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 540)
AUTHORS Shearman,C.W., Kanzy,E.J., Lawrie,D.K., Li,Y.-W., Thammana,P.,
Moore,G.P. and Kurrle,R.
TITLE Construction, expression, and biologic activity of murine/human
chimeric antibodies with specificity for the human alpha/beta T
cell receptor
JOURNAL J. Immunol. 146, 928-935 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
exon <7..50
/product="Ig heavy chain VJ region"
CDS join(7..50,139..512)
/product="Ig heavy chain VJ region"
/codon_start=7
/partial
exon 139..512
/product="Ig heavy chain VJ region"
BASE COUNT 137 a 125 c 138 g 140 t
ORIGIN
1 ctaaccatgg aatggagttg gatatttctc tttctcctgt caggaactgc aggtaagggg
61 ctcaccagtt cagtcaaatc tgaagtggag acacaggacc tgaggtgaca atgacatcta
121 ctctgacatt ctctcctcag gtgtccactc tgaggtccag ctgcagcagt ctggacctga
181 gctggtaaag cctggggctt cagtgaagat gtcctgcaag gcttctggat ataaattcac
241 tagctatgtt atgcactggg tgaagcagaa gcctgggcag ggccttgagt ggattggata
301 tattaatcct tacaatgatg ttactaagta caatgagaag ttcaaaggca aggccacact
361 gacttcagac aaatcctcca gtacagccta catggagctc agcagcctga cctctgagga
421 ctctgcggtc cattactgtg caagagggag ctactatgat tacgacgggt ttgtttactg
481 gggccaaggg actctggtca ctgtctctgc aggtgagtcc taacttctcc cattctaaat
//GenBank-Updates@genbank.bio.net (04/19/91)
LOCUS MUSIGULVJ 600 bp ds-DNA ROD 19-APR-1991
DEFINITION Mouse (BMA 031) Ig active H-light gene V-region, complete cds.
ACCESSION M63673
KEYWORDS immunoglobulin light chain; joining region; processed gene;
variable region.
SOURCE Mouse, DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 600)
AUTHORS Shearman,C.W., Kanzy,E.J., Lawrie,D.K., Li,Y.-W., Thammana,P.,
Moore,G.P. and Kurrle,R.
TITLE Construction, expression, and biologic activity of murine/human
chimeric antibodies with specificity for the human alpha/beta T
cell receptor
JOURNAL J. Immunol. 146, 928-935 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
exon <4..51
/product="Ig light chain V-J region"
CDS join(4..51,224..559)
/product="Ig light chain V-J region"
/codon_start=4
/partial
exon 224..559
/product="Ig light chain V-J region"
BASE COUNT 153 a 139 c 122 g 186 t
ORIGIN
1 aaaatggatt ttcaagtgca gattttcagc ttcctgctaa tcagtgcctc aggtaacaga
61 gggcagggaa tttgagatca gaatacaacc aaaattattt tccctgggga atttgtgtcc
121 aaaatacagt tttttctttt tcttttatct aaatgttggg tggtataaaa ttatttttta
181 tctctatttc tactaatccc tctctctttt ttgctttttt ctagtcataa tatccagagg
241 acaaattgtt ctcacccagt ctccagcaat catgtctgca tctccagggg agaaggtcac
301 catgacctgc agtgccacct caagtgtaag ttacatgcac tggtaccagc agaagtcagg
361 cacctccccc aaaagatgga tttatgacac atccaaactg gcttctggag tccctgctcg
421 cttcagtggc agtgggtctg ggacctctta ctctctcaca atcagcagca tggaggctga
481 agatgctgcc acttattact gccagcagtg gagtagtaac ccgctcacgt tcggtgctgg
541 gaccaagctg gagctgaaac gtaagtacac ttttctcatc tttttttatg tgtaagacac
//GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS MUSENDOA2 239 bp ds-DNA ROD 10-MAY-1991
DEFINITION Mouse (M. musculus) endo (cytokeratin) A, third intron of alpha 1,
B2 repetitive element, partial sequence.
ACCESSION K02784
KEYWORDS B2 repetitive sequence; repetitive sequence.
SEGMENT 2 of 2
SOURCE Mouse (BALB/c) DNA, clone alpha-1.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 239)
AUTHORS Vasseur,M., Duprey,P., Brulet,P. and Jacob,F.
TITLE One gene and one pseudogene for the cytokeratin endo A
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 1155-1159 (1985)
STANDARD full staff_review
FEATURES Location/Qualifiers
intron <1..>239
/note="cytokeratin A intron C"
repeat_region 21..180
/note="B2 repeat"
BASE COUNT 83 a 48 c 57 g 51 t
ORIGIN 220 bp downstream of EcoRI site.
1 agagataaag aaacatggct gaggctggtg agatggctca gtggtaagag cacccgactg
61 ctcttccgaa ggtccagagt tcgaatccca gcaccacatg gtggctcacg accatctgtg
121 atgagatctg acttcctctt ctggtgtctg aggacagcta cagtgtacat catataaaat
181 agataaatct ttaaaaaaaa aaaaaaaaaa aagaaacatg gctggaaatg gctcagcag
//GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS MUSPLPA5JI 174 bp ds-DNA ROD 10-MAY-1991
DEFINITION Mouse (Jimpy mice) myelin proteolipid protein exon 5 and flanks.
ACCESSION X06375
KEYWORDS myelin proteolipid protein; proteolipid protein.
SOURCE Mus musculus DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 174)
AUTHORS Macklin,W.B., Gardinier,M.V., King,K.D. and Kampf,K.
TITLE An AG to a GG transition at a splice site in the myelin proteolipid
protein gene in jimpy mice results in the removal of an exon
JOURNAL FEBS Lett. 223, 417-421 (1987)
STANDARD simple automatic
REFERENCE 2 (bases 1 to 174)
AUTHORS Macklin,W.B.
JOURNAL Unpublished (1988) see COMMENT for author address
STANDARD simple automatic
COMMENT
[FEBS Lett. 223, 417-421 (1987)] no enum..
[Unpublished (1988) see COMMENT for author address] enum. 1 to
174.
*source: strain=jimpy mice; library=genomic; clone=KKjp7 and KKjp9;
The transition at position 49 causes the loss of exon 5 from myelin
proteolipid protein mRNA of jimpy mice.
Data kindly reviewed (21-JUN-1988) by Macklin W.B.
EMBL features not translated to GenBank features:
key from to description
IVS <1 50 intron IV
MUTANT 49 49 G is A in wildtype mice
MSG 51 125 exon 5
IVS 126 >174 intron V
REVISION 50 52 ggt was gt in [FEBS Lett. 223,
417-421 (1987)]
Submitted (21-JUN-1988) to the EMBL data library.
FEATURES Location/Qualifiers
CDS <51..>125
/partial
/note="myelin proteolipid protein (AA at 51)"
BASE COUNT 41 a 35 c 41 g 57 t
ORIGIN
1 catgcctcta gccttatgaa gtttactctg gctgctttta tgtatcttgg gtgttctccc
61 atggaatgct ttccctggca aggtttgtgg ctccaacctt ctgtccatct gcaaaacagc
121 tgaggtaagt gaatgagaag agtgcttttt aaaaaataga ttggctagac atgg
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS MUSIG10VH 970 bp ds-DNA ROD 27-MAY-1991
DEFINITION Mouse (GAT-specific) subgroup II germline Ig V(H)10 gene related to
anti-GAT Ab1 sequences
ACCESSION X03571
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup VH-II; signal peptide;
variable region.
SOURCE Mus musculus DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 970)
AUTHORS Schiff,C., Milili,M., Hue,I., Rudikoff,S. and Fougereau,M.
TITLE Genetic basis for expression of the idiotypic network: One unique
Ig VH germline gene accounts for the major family of Ab1 and Ab3
(Ab1') antibodies of the GAT system
JOURNAL J. Exp. Med. 163, 573-587 (1986)
STANDARD full automatic
COMMENT EPD; 11151; Mm Ig VH10.
The V(H)10 germline sequence is identical to the anti-GAT (Ab1)
V(H) cDNA sequence of G8 Ca 1.7 <MMIGVK1>/<X00894>. See also
<X03572> and <X03573>.
From EMBL entry MMIG10VH; dated 10-JAN-1991.
FEATURES Location/Qualifiers
sig_peptide join(445..490,570..580)
mRNA <491..490
/note="exon 1"
misc_signal 342..351
/note="conserved element; pot. cell type specific
transcription control"
promoter 367..374
/note="pot. TATA-box"
intron 491..569
/note="intron I"
mRNA 570..874
/note="exon 2"
CDS 581..874
/product="H10 coding region"
/codon_start=581
misc_feature 875..881
/note="7 bp recombination signal"
misc_feature 905..913
/note="9 bp recombination signal"
BASE COUNT 272 a 211 c 217 g 270 t
ORIGIN
1 ggccattatt atttaaatat atatgagaga agattgctaa ctctcataaa tgtattggtt
61 ttttttttaa atttccagta agcgttatcc tcattgctac taccaccaat caattttttc
121 actaagacaa gtgagtgtct caggttagga ttctatttta agattgagat attaggcttg
181 atactacatc taaatggtct gtacatgtct cgaagaaagt tcttcagaca gagttaggac
241 ttggatccca ggagttagga cttggactga ctcaggagga ctctagtttc ttcttctcca
301 gctggaatgt ccttatgtaa gaaaagcctt gcctcatgag tatgcaaatc atgtgcgact
361 gtgatgatta atatagggat atccacacca aacatcatat gagccctatc ttctctacag
421 acactgaatc tcaaggtcct tacaatgaaa tgcagctggg ttatcttctt cctgatggca
481 gtggttacag gtaaggggct cccaagtccc aaacttgagg gtccataaac tctgtgacag
541 tggcaatcac tttgcctttc tttctacagg ggtcaattca gaggttcagc tgcagcagtc
601 tggggcagag cttgtgaagc caggggcctc agtcaagttg tcctgcacag cttctggctt
661 caacattaaa gacacctata tgcactgggt gaagcagagg cctgaacagg gcctggagtg
721 gattggaagg attgatcctg cgaatggtaa tactaaatat gacccgaagt tccagggcaa
781 ggccactata acagcagaca catcctccaa cacagcctac ctgcagctca gcagcctgac
841 atctgaggac actgccgtct attactgtgc tagacacagt gttgcaacca catcctgagc
901 gtgtcagaaa ccatagaact gcaggaagct gcctgagact gagatgacag acaatattat
961 tgtgttagct
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS MUSIGVH2B 628 bp ds-DNA ROD 27-MAY-1991
DEFINITION Mouse (GAT-specific) subgroup II germline Ig V(H)2b-3 gene related
to anti-GAT Ab1 sequences
ACCESSION X03573
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup VH-II; signal peptide;
variable region.
SOURCE Mus musculus DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 628)
AUTHORS Schiff,C., Milili,M., Hue,I., Rudikoff,S. and Fougereau,M.
TITLE Genetic basis for expression of the idiotypic network: One unique
Ig VH germline gene accounts for the major family of Ab1 and Ab3
(Ab1') antibodies of the GAT system
JOURNAL J. Exp. Med. 163, 573-587 (1986)
STANDARD full automatic
COMMENT EPD; 14072; Mm Ig VH4b-3.
See also <X03571> and <X03572>
From EMBL entry MMIGVH2B; dated 16-JAN-1991.
FEATURES Location/Qualifiers
sig_peptide join(144..189,269..279)
mRNA <190..189
/note="exon 1"
CDS join(144..189,269..573)
/product="H2b-3 coding region"
/codon_start=144
misc_signal 43..52
/note="conserved element; pot. cell type specific
transcription control"
promoter 66..73
/note="pot. TATA-box"
intron 190..268
/note="intron I"
mRNA 269..573
mRNA 269..573
/note="exon 2"
mat_peptide 280..573
/product="H2b-3 coding region"
misc_feature 574..580
/note="7 bp recombination signal"
misc_feature 604..612
/note="9 bp recombination signal"
BASE COUNT 177 a 151 c 147 g 153 t
ORIGIN
1 agctagaaca tccttatgta agaaagatcc tgccacatga atatgcaaat catgagtctg
61 tgattataaa tacgtgcata tccacaccaa acaacatatg aacactgttt tctctacagt
121 cactgaatct caaggtcctt acaatgaaat gcagctgggt catcttcttc ctgatggcag
181 tggttatagg taaggggctc ccaagtccca aacttgaggg gccacacact ctgtgacagt
241 ggcaatcact ttgtctttct ttctacagga atcaattcag aggttcagct gcagcagtct
301 ggggcagagc ttgtgaggtc aggggcctca gtcaagttgt cctgcacagc ttctggcttc
361 aacattaaag actactatat gcactgggtg aagcagaggc ctgaacaggg cctggagtgg
421 attggatgga ttgatcctga gaatggtgat actgaatatg ccccgaagtt ccagggcaag
481 gccactatga ctgcagacac atcctccaac acagcctacc tgcagctcag cagcctgaca
541 tctgaggaca ctgccgtcta ttactgtaat gcacacagtg ttgcaaccac atcctgagag
601 tgtcagaaac cataaagtgc aggaagct
//GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS MUSIGVH4A 1009 bp ds-DNA ROD 27-MAY-1991
DEFINITION Mouse (GAT-specific) subgroup II germline Ig V(H)4a-3 gene related
to anti-GAT Ab1 sequences
ACCESSION X03572
KEYWORDS germline; immunoglobulin; immunoglobulin heavy chain;
immunoglobulin heavy chain subgroup VH-II; signal peptide;
variable region.
SOURCE Mus musculus DNA.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 1009)
AUTHORS Schiff,C., Milili,M., Hue,I., Rudikoff,S. and Fougereau,M.
TITLE Genetic basis for expression of the idiotypic network: One unique
Ig VH germline gene accounts for the major family of Ab1 and Ab3
(Ab1') antibodies of the GAT system
JOURNAL J. Exp. Med. 163, 573-587 (1986)
STANDARD full automatic
COMMENT EPD; 14071; Mm Ig VH4a-3.
See also <X03571> and <X03573>
From EMBL entry MMIGVH4A; dated 16-JAN-1991.
FEATURES Location/Qualifiers
sig_peptide join(431..476,556..566)
mRNA <477..476
/note="exon 1"
CDS join(431..476,556..860)
/product="H4a-3 coding region"
/codon_start=431
misc_signal 331..339
/note="conserved element; pot. cell type specific
transcription control"
promoter 353..360
/note="pot. TATA-box"
intron 477..555
/note="intron I"
mRNA 556..860
mRNA 556..860
/note="exon 2"
mat_peptide 567..860
/product="H4a-3 coding region"
misc_feature 861..867
/note="7 bp recombination signal"
misc_feature 891..899
/note="9 bp recombination signal"
BASE COUNT 289 a 222 c 217 g 281 t
ORIGIN
1 ggccactatt aatttcaagt gtatgaaaaa agattgcaaa ttctcataaa tatgttttta
61 aagttccagt aaccattttc tctcattgct tctaacacca ataaatttgt caccaagtaa
121 agtgagtgtc tcaggttagg attctatttt tgaaaaatga aagattaggc ttgatattgt
181 atctaagtgg tctgcacatg tctcagggaa agttcctaag acagaattag gatttggtcc
241 ccagcatcct gttgactgac ccaggtgcac tcaacttcct tcttctccag ccagaatgtt
301 cttatgtaag aaagatcctg cctcatgaat atgcaaacat gagtctgtga ttataaatac
361 agagatatcc ataccaaaca acttatgagc actgttttct ctacagtcac tgaatctcaa
421 ggtccttaca atgaaatgca gctgggtcat cttcttcctg atggcagtgg ttacaggtaa
481 ggagctccca agtcccaaac ttgaggggcc atacactctg tgacagtggc agtcactttg
541 cctttctttc tacaggggtc aattcagagg ttcagctgca gcagtctggg gctgagcttg
601 tgaggccagg ggccttagtc aagttgtcct gcaaagcttc tggcttcaac attaaagact
661 actatatgca ctgggtgaag cagaggcctg aacagggcct ggagtggatt ggatggattg
721 atcctgagaa tggtaatact atatatgacc cgaagttcca gggcaaggcc agtataacag
781 cagacacatc ctccaacaca gcctacctgc agctcagcag cctgacatct gaggacactg
841 ccgtctatta ctgtgctaga cacagtgttg caaccacatc ctgagtgtgt cagaaaccat
901 agaaccgcag gaagctgcct gagactgaga tgacagacaa tattatcctg aagattttct
961 cagaaatagc cattttgtga gcctgcctat ctacagtttt aaatgctat
//