GenBank-Updates@genbank.bio.net (05/27/91)
LOCUS MUSKALL 9433 bp ds-DNA ROD 27-MAY-1991 DEFINITION Mouse complete gene for a mouse kallikrein (serine protease) and fragment of a second kallikrein gene. Genes are mGK-1 (complete gene) and mGK-2 (fragment). Kallikreins are necessary for the processing of hormones, e.g., growth hormone. Gene is expre ACCESSION V00829 KEYWORDS kallikrein; serine protease; signal peptide. SOURCE Mus musculus DNA. ORGANISM Mus musculus Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae. REFERENCE 1 (bases 1 to 9433) AUTHORS Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I. TITLE Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides JOURNAL Nature 303, 300-307 (1983) STANDARD full automatic COMMENT EPD; 07096; Mm mGK-1. SWISS-PROT; P00755; KAG1$MOUSE. From EMBL entry MMKALL; dated 13-JUL-1983. FEATURES Location/Qualifiers precursor_RNA <1..724 /note="primary transcript mGK-2" intron <1..10 /note="intron III mGK-2" mRNA 11..147 /note="exon 4 mGK-2" CDS 11..147 /note="kallikrein part 4 (11 is 2nd base in codon)" /codon_start=11 intron 148..521 /note="intron IV mGK-2" mRNA 522..724 /note="exon 5 mGK-2" CDS 522..674 /note="kallikrein part 5" /codon_start=522 precursor_RNA 4471..9048 /note="primary transcript mGK-1" mRNA 4471..4558 /note="exon 1 mGK-1" precursor_RNA 4477..9048 /note="primary transcript mGK-1 (alternate start)" mRNA 4477..4558 /note="exon 1 mGK-2 (alternate start)" CDS 4513..4558 /note="kallikrein part 1 mGK-1 (4558 is 1st base in codon)" /codon_start=4513 intron 4559..6974 /note="intron I mGK-1" mRNA 6975..7134 /note="exon 2 mGK-1" CDS 6975..7134 /note="kallikrein part 2 mGK-1 (6975 is 2nd base in codon) (7134 is 2nd base in codon)" /codon_start=6975 intron 7135..7955 /note="intron II" mRNA 7956..8242 /note="exon 3" CDS 7956..8242 /note="kallikrein part 3 mGK-1 (7956 is 3rd base in codon) (8242 is 1st base in codon)" /codon_start=7956 intron 8243..8338 /note="intron III" mRNA 8339..8475 /note="exon 4" CDS 8339..8475 /note="kallikrein part 4 mGK-1 (8339 is 2nd base in codon)" /codon_start=8339 intron 8476..8847 /note="intron IV" mRNA 8848..9048 /note="exon 5" CDS 8848..9000 /note="kallikrein part 5 mGK-1" /codon_start=8848 BASE COUNT 2390 a 2421 c 2102 g 2520 t ORIGIN 1 ggatccacag tccaaaatgc aaaagatctc cagtgtgtga acctcaagct cctgcctaat 61 gagaattgtg acaaaaacca caataagaag gtgacagatg tcatggtgtg tgtaggagag 121 atggatggag gcaaagacac ttgtgtggtg agacagccac tttctgctgt gaggtgaagg 181 gctgaaagct ggaactgagg ttcttggttc ccacttcaac accctgacta ggcaggctct 241 ttttatcctt ccctatggaa gggatgtgca ctgggagggg aggatcctgt agctggcatg 301 atttctcacc ttagacttgt cttaggggac agtcttgtga gcccctcacc acaaaccaat 361 gttctcatac gatctgaggt cccaagagct agattccctc acctactgac tagagctgcc 421 tcttaagagt ccctgtgttc ctccctgggg tcagttccag gttgtcaagt aggactccaa 481 agtcaggtcc tccattactg ctgtcccttt ccttctttca gggagactca ggaggcccac 541 tgatatgtga tggtgttcta caaggtatca catcatgggg ctctatccca tgcagtaaac 601 ccaatgcgcc gggcatctac accaaactta ttaagtttaa ctcctggata aaagacacta 661 tgacgaaaaa tgcctaagtg tcacattatc ctctgttctc aataaaatcc actatgcaac 721 aaatgagtca aggtctgaca gtctctatcc tactggaata cagtacacaa ccaaggtccc 781 aactaaggtg agggcttcca aagtagatca gcaagggaca ggtgtacatg tactgttggt 841 taaggacatg gggttgagac aaatgcagac aaaaggctca gaccaactca aggattccac 901 ttgagtctcc tctggcaaag aaaatgttca tatcacagag gaaaagtcta aagagatcag 961 aatgggagac tccagctagg cctgatccta tactggaagc cgaagggatg ataaacagtc 1021 agacgctccg aattcagact gcctacctga gtttcttagg ttgggctggg gtgttttgtt 1081 aatacagcct tggctcgctg gagaagaatt tgtgcacaga agggcaggga ctgccaaagg 1141 ctaggtaggc tgcagtgtct ctgctcccag tggccactgg agggggtttc tttggtaggg 1201 ctggatcaaa ggatgaagag tgacttagaa ccatgtcctg tgggcagagt aatacccatc 1261 ttaggaaaag ggccacactg ctgctgcaca ggaccacaaa ccactgtctg ttttagaggg 1321 gacataacca cagctaagag tatcagagat ccgaagaagg gccagagaag gtcagaaaga 1381 tagacagaac tggaaatcta ccaacaactc tgggtaggag gaggcactgg ggttaaatgg 1441 aggatcccca gacacccttg tccttgccaa cacatattga ttccaatgct aaggaaactg 1501 aagatgaagt ctatcttctt caggcagcag cagactggtc gaaaggagaa gaacatggtg 1561 ggcaggagga tgaagcatag ttccagggcc agaattatga agcccttgct catgtgaatg 1621 tgaactgggg aggaaagttg gaaagataac tacagtcatt agtcattcaa acctctctct 1681 ctctctctct ttctctctct ctctctctct ctctctctct ctctctctct ctctctctct 1741 ctctcccccc ctctctctct ccctcccccc cagtctagct tcctctctcc ttcctctcac 1801 accattggag cacaacctaa gtactccagc acgctggaag ggagtggggg aatgtctttt 1861 catgttctga ctgtgaagtt agagacacat tgatcttttc ttgttctaaa tacaaggtaa 1921 aagcagtcga gggtcttgat gtatcttttt ttggcagaat atttgcatac gttgagcagc 1981 ctgcatttca ttctcaacac tgtgctgagc tgagtctgca gcacatgcct gtgatccctg 2041 caactgggag gaggatcaga aaatcatggt tgtccacaga tacacattga gttggaggtc 2101 agcctgggct aaacagacat gttacaaaga gtgcagaaga agggaatgta gctgtctaga 2161 atccatccca caatgagggt caggaaatgg ttctgagtac agcaagtcct agagtctcaa 2221 taggtggagt tctttggggg tgtgggcttc aagtagatag agaccctgtg gagtgtttgt 2281 gtggcgactg ggtgctgact tcagaaattc ccataaaaga ggtataagaa aaacaccacc 2341 ctccacttca cattaacaaa atcattccct agaaattcta aagtaactct actgcaactc 2401 attgaatgac ctaccatcga tgatgtcccc actgtgagcc caaacctaga cccccagaaa 2461 gagtcctggg agagtgggag tataccaccc acacagccac ctctagaata caatggaatg 2521 aacccccagt ctatatattc actgaccaga gatttgtccc acgttgtcat atttatgccc 2581 cctgcagcca atccagaggc tatgaatcca gtgtatgttc ggtgcgcata ggtattcaca 2641 catccattat actgaacacc aacaaggtta ccgagaggat gaacatgagg gaccagtttc 2701 gtaggacaag atttcagtcc tcctccccag gaatagagca ggacagcagg ggagggaaaa 2761 aattctggga cctggatctt ttctcccctc tctctcaatg catacaaacc tccatcttct 2821 tcctcattta catattcccc ctcatctaca acctgttccc tgtggatgct gtttggagct 2881 cgtctccagc accacttcat ctctttctat tctcatgcac tggactcttc cggtgcagta 2941 cacctatctc aaactccagc atgattatgt gtgcttgaag acatacaaaa agatcaagtg 3001 catggatgta ctcacaagtg gatgaatgca ggcttcctct cttgtccttt agagcaaaga 3061 acagtgcaat tttcagaaaa acttcagcac agaggcctag ggccagagga gaacttggtg 3121 gccagttgat caccaagtcc tcacttaccc tagattaggg ttagcctagc cttcttggag 3181 cttacagggc acacaggaat acacccaagt caaatgtgct aactgtcatg agagctgaaa 3241 tagtctagat gctcaacaag aggggatggg tctgaaacct gcaacagtaa gtaggtgtca 3301 aaggctgggt atttcccctt ctctgtacca gaacccatgc tgacttcttg atgttttaac 3361 gtttgagaca aagtcgtctc ctgtgtagtt tcactggcct aaatacacta tgtgcacagt 3421 ctaacctgga cctcaccaag atccaccagc ccctgactcc taagttctgg gatcaaggtg 3481 tgcaccaaaa tatgcagctg ccaagctgaa cccttaatga ggctcttgga gggaagtgac 3541 attttctggt tgctgtttct tgagaaaggg tctcacatga accttggctt ggctaacctc 3601 aaaatgtagc tcctgatcta ggagatgagg aagggaaaag tcatagtgac cccaacattg 3661 ttcaggacag gtgacactcc cctggaataa cctgaatttt catacttttg aataaaagac 3721 tgatcaggcc atggtaatgt gcaccataac ttttattcat tttattttat aggtttgttt 3781 tgagacagct ctatatataa ccttggctgt cttgaaagtc actatgtaga ctaggttggt 3841 ctacatcaca gaatactaga gcctagaatc acacagatcc acctggcttc aaagtactgg 3901 tattagagga gtgcactgct atacactgct cccaagcttc tcttagaaac aataaaatca 3961 gtgatccaga gttccaagtc caaaaaggaa gcattttggc attctccaag aaaggatttg 4021 tatctgcagg gagcttgcag ccctctaggc tatcacttgt gaaagactct gttctaactg 4081 caactttctg ggataatctt ggacttgagg tacaggacct tccttaaagt tgtgggttag 4141 gcagcacttg ctccactacc caccattcat accaagtcac catttccacg accttgccat 4201 ctggctccca gtacccggaa cactaacagt tccagaaaca gcaggaattg ccctcccaat 4261 ctcattcttg ggaatgtatc cagggtgacc tagagccttc tggacagtgg gtgcaacgag 4321 gtcatccctt accacagcca ggatggtgca agtagagaat cctaaccctg tcagcaaggg 4381 cagggctttg tcagcatctg ggtggcaaca ggacagagga ggggctgtgg ggagaatggg 4441 ggatttaaag tctccccagg gagcctcaat agctccaagc tcactgcctg ctgctcctga 4501 acacctgtta ccatgtggtt cctgatcctg ttcctagccc tgtccctagg agggattggt 4561 gagatgaggg aatgggaggg gacacagccc tcactcccct gcttacttag gccctggctg 4621 tccctttccc cttgcccctc tccccagcta catcatgagc accacctgct cctccttttc 4681 tggccctgta cactgccagg tccctcacat tccttgctcc cgggacaggc ccctgttccc 4741 tcccactttc cagtaatttc tcctcttcct tggacacata accatctctg gtcttctcca 4801 gtctttctaa ggaacccaac ctcttaccaa acttaggacc tcagatttcc ctacagttca 4861 ttatttttcc tagagcctca taacacaaac tctaagtcag aggcctgctt aaatcctcta 4921 actgccacgc ttcaactgtg tttgccacat cctgacaact ggtgctactc ttcttaaatt 4981 gcccagtttc taccaaaact ttcacttctc aaattggctt gtgatataag atgggttact 5041 cccctttgtg ctgtgggaaa aatgtgcata tacctatcca atgacttttt ggtttcgtct 5101 ggttttttag agaagggatc aggttggaga caccagacat ggacatcatg tatcttcatc 5161 aatcactcgc cacctgagac tgggtctctc actgtatgga gagttcctgt taggctaaga 5221 tgactgtgca gcaagcctcg ggggaatctt cctgtttcca cctcccctag atctggggtt 5281 acaggtgcac agcatcacac ctgacttttt gccttggggt ctggaaggtt tagctccagt 5341 cttaaggttt acatgagcaa tcttgtagca accaagccat ctccagtcca gcattttgga 5401 ataagatctg agttagtgtc tcatgatgta gcccaggctt ctcttccgtc catggcaatt 5461 cttttgcctc agcctgctgt ttactggggt tacagagaag tgcggcttat gcatggcttg 5521 ccaagatttc ctgtttccaa atgctgtggc ttggcctgct cttccctctc atgccttact 5581 gcctgagagt aaggctgcca tcccatctcc ctagagctcc actgcacagt tctagctccc 5641 actctgtgca ggacaccaca aagaccccaa tgcttaaccc tagtacctca catcagcttg 5701 gcttgcctct ctacctcaga gtggcctgac ttgctgtaac tatgtttcca gtcttgtcct 5761 gaggctgcct caaaaagaac tctgagcctc tccaatactc atattacttg ttccacatcc 5821 acaagaagca gatcctgtct gtcacagact ttccagattt tccacctcta actgctcgca 5881 ccatatcaaa ctcctttctt agggagatcc acacctctta gatgccatct ccaccacaga 5941 cacaaacagg agcccacgca ccttttatcg gatcccctca ctctctccat tccagctgcc 6001 acttcacacc caaccaaaga aaccaaaaat caaccccagc tccctttcct ggattcattt 6061 attcattgag atccagtttc ctgcgacctc accctttcca gaattcccaa aacccagcca 6121 aggcagtggt cttttctcaa gccttggaga ctctaaattc caaatcagag gattctcatt 6181 ggaataaaaa tgaacaggaa gtctctctct gtctctctct gtcagtgtct ttgtctcatg 6241 ctctctctgt ctctttttct cactgtctct ctctctctct gtctctctct ctgtccctct 6301 ctctttctct ctttctcatt gcccatctgt cctttagtca aaaactataa agtgatttcc 6361 acagtggttg tacaagcttg caatcccacc aacaatggag gagtgttcct ctttctccat 6421 atcctcgcca gcatctgctg tcacctgaat ttttgatctt agccattctg attggtgtga 6481 ggtggagtct cagggttgtt ttgatttgca attccctgat gattaaggat gctgaacatt 6541 ttatcaggtg cttctcagcc attcggtatt cctcaggtgg aaagagaggc ccataggtct 6601 tgcaaacttt atatgcctca gtacagggga acaccagggc caagaagtgt gagtgggtgg 6661 gtaggggaat gtggggggag ggtatggggg acttttggga tagcattgga aatttaaatg 6721 aagaaaatac ctaataaaaa ataataataa ttaaaaaaaa ctataaagtg gcctgatact 6781 atacccaatt cttgattcta gagttatttc tgtacccaca gcatagatct ccctatccaa 6841 gaccagccat atacgggtcc tttgcccaga tcacctgaca atgtcccctg aaccctgtcc 6901 tgcttaactt tgtcccccaa aagtgcacct ccctacatgt gccaactctc ccctccccca 6961 ttgccacttt gcagatgctg cacctcctgt ccagtctcga atagttggag gatttaaatg 7021 tgagaagaac tcccagccct ggcatgtggc tgtgtaccgc tacaaggaat atatatgcgg 7081 gggagtcctg ttggatgcca actgggttct cacagctgcc cactgctatt atgagtgagt 7141 aagggtggag acagaaaagc agggtggcag ccatagatca tgacgacggg acaagctggg 7201 tactgtaggg caggtggtta ggactggatg aaagtctatc catgatatcc tgggtctctc 7261 tttgctcctc caatccagcc ttgggttcag agtactgttt ctttcttttc tgtcttattt 7321 tttgtctgtc tgtctgtctg tctgtctgtc tgtctgtctg tctgtctact gtctgtatca 7381 catcagagtg tcttcctggc catctctact gtgtgtctct tccttggaac tctgacaaca 7441 tctgtctggg tctgggtctc atgtgttctc ttgtatcact actgcccata gtggggacaa 7501 atcctaacca gcccttgatg atagaaagtg ctgtccatga aggtaggctg tgagagaagt 7561 ccttactctc cttagaccag atctgcattt aggacctact gtcactctga ggacacacag 7621 agaagggctg gtcgtaactg gagctgggtg aggtaactga gttcagtgag agacctggat 7681 gctaggaagg taagagagag ctcagacctt gggctgcagg tcaggcctta cctgctgggg 7741 aagtacagac ccgtcctagc tgcacctgag cagctctcag gtctgccact cctccttact 7801 acctcttcca agtgtgtgtg tgtccgtccg ttcttgtgtt tttctctctc tgagtctttc 7861 tcttcctgct tccctctttc ccctcttctc ctatactttt taactctcct tggttgcctc 7921 ttctcaatct ctccatgtca tttcatgccc tctagaaaga acaacgtttg gctgggcaaa 7981 aacaacctat accaagatga accctctgct cagcaccgat tagtcagcaa aagcttcctt 8041 cacccttgct acaacatgag cctccatcgg aaccgcatcc aaaatcctca ggacgactac 8101 agctatgacc tgatgctgct ccgactcagc aagcctgctg acatcacaga tgttgtgaag 8161 cccatcgccc tgcccactga ggagcccaag ctggggagca catgccttgc ctcaggctgg 8221 ggcagcatta tacctgtcaa gtgtgagtct ggtccaagca acacagctgg gtgtggagga 8281 ggggcagaaa ggacttagct ggcacctgct caccaccctc ttgcctcctg atccacagtc 8341 caatatgcaa aagatctcca gtgtgtgaac ctcaagctcc tgcctaatga ggactgtgac 8401 aaagcctatg tacagaaagt cacagatgtc atgctgtgtg caggagtgaa gggtggaggc 8461 aaagacactt gtaaggtgag acagaccctc cctgcagtga ggtgaaggcc tgtaagaggg 8521 aactgaggtt cttggttccc acttcaacac cctgactaag caggctcttt gcatccttcc 8581 ctatggacgg gatgtgcact gggaggggag gatcctgtag ctggtactat ttctcctctg 8641 tgacatcgct taggggactg tctagtcaac ccctcacccc cgctccatgt ctctggaaga 8701 gatggccttc taagatctgt gttcttacct attgaacaga gctgcctctt agagtccctg 8761 tgtttatccc ctgggagtca gttccagctt gttgagtaga atccaactgc caggccctgc 8821 ttactcctgt ccctgtcctt ctttcaggga gactcaggag gcccactgat ctgtgatggt 8881 gttctccaag gtctcacatc atggggctat aacccatgtg gtgaacccaa aaagccgggc 8941 gtctacacca aacttattaa gttcacctcc tggatcaaag acactttggc ccaaaacccc 9001 tgagtgacac actgtctgtt ctcaataaaa tccaccatgc aacaaatgag ttcaaggtct 9061 gacattctct gtcctactag agtgtgacac ccaatcatga tttccctcag ctaagatcag 9121 gatttccaaa gtagatcagc aagggacagg tgtacatgta ctgttggcta aaggaacagg 9181 gttgaaacaa atgtagacaa aaggctcagg caaactcacg gatgccactt gagtctcctc 9241 tggcaaggaa aattctcaga tcacagagca aaaagttaga gacatcagaa agttcaactg 9301 tagctatgct catccacact ggaaagcaga agagatgata aacagtcaga cacagagaat 9361 ttagacagca aaccaagttg tactgtgttg gggaagccag gaaggaggca ggggtgttac 9421 gttaattaag ctt //