GenBank-Updates@genbank.bio.net (02/21/91)
LOCUS PPHIJ1 200 bp ds-DNA VRL 21-FEB-1991
DEFINITION Human papillomavirus (HPV) type 16 genome, 5' virus-host integrated
junction.
ACCESSION D00486
KEYWORDS flanking sequences; integration; virus-host junction.
SEGMENT 1 of 2
SOURCE Integrated human papillomavirus type 16 genome DNA in the cervical
carcinoma cell line QG-U, clone UV411, BglII-SpeI fragment.
ORGANISM Human papillomavirus
Viridae; ds-DNA nonenveloped viruses; Papovaviridae;
Papillomavirus.
REFERENCE 1 (bases 1 to 200)
AUTHORS Shirasawa,H., Tomita,Y., Fuse,A., Yamamoto,T., Tanzawa,H.,
Sekiya,S., Takamizawa,H. and Simizu,B.
TITLE Structure and expression of an integrated human papillomavirus type
16 genome amplified in a cervical carcinoma cell line
JOURNAL J. Gen. Virol. 70, 1913-1919 (1989)
STANDARD full staff_entry
COMMENT Sequence analyses revealed that the virus-host junctions reside at
nucleotide positions 3741 and 4416. Part, 674 bp, of the viral
genome (nucleotides 3742 to 4415) containing the putative early
polyadenylation signal, was deleted.
FEATURES Location/Qualifiers
cellular <1..186
/note="QG-U cellular DNA"
misc_feature 111..186
/note="AT-rich region"
provirus 187..>200
/note="HPV DNA (containing L2 ORF region)"
BASE COUNT 88 a 30 c 31 g 51 t
ORIGIN Several bp downstream of BglII site.
1 catcagtacc atggaaccct actcagcaat aaaaagaaaa aactattgat aaatgcaaca
61 acttagatga acatcaagga aattatactg agtgaaagaa gccaatcccc aaaagataca
121 tatggcataa ttcaatttat tgaattatta ttattaattt catgaataaa attatagaga
181 tgaacagaac agggtcgggt
//GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS PPHVLCR 758 bp ds-DNA VRL 28-MAY-1991
DEFINITION Human papillomavirus (HPV) long control region
ACCESSION X52062
KEYWORDS E2-dependent enhancer; long control region; promoter.
SOURCE Human papillomavirus DNA.
ORGANISM Human papillomavirus
Viridae; ds-DNA nonenveloped viruses; Papovaviridae;
Papillomavirus.
REFERENCE 1 (bases 1 to 758)
AUTHORS Ensser,A.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Ensser,A. and Pfister,H.
TITLE Epidermodysplasia verruciformis associated human papillomaviruses
present a subgenus-specific organisation of the regulatory genome
region
JOURNAL Nucleic Acids Res. 18, 3919-3922 (1990)
STANDARD full staff_review
COMMENT *source: strain=HPV type 9. See <X52059>-<X52062>.
From EMBL entry HPVLCR; dated 13-JUL-1990.
FEATURES Location/Qualifiers
misc_feature 241..243
/note="ORF L1 transcription stop"
misc_feature 243..254
/note="E2-binding site (E2-BS)"
misc_feature 313..319
/note="AP1 binding site"
misc_feature 343..354
/note="E2-binding site (E2-BS)"
misc_feature 472..483
/note="E2-binding site (E2-BS)"
promoter 521..540
/note="CAAT box"
misc_feature 562..573
/note="E2-binding site (E2-BS)"
misc_feature 610..612
/note="ORF E6 transcription start"
BASE COUNT 248 a 145 c 137 g 228 t
ORIGIN
1 atctacagat atattgcttc aaaagccaca aaatgcccag atgctgttga gcctacagaa
61 aaagaagatc cctttgccaa atactcattt tggaaagtgg atctaactga aagattatcg
121 ttggatcttg atcaatatcc tttaggtaga aaatttcttt ttcaagctgg tttgcaaaca
181 cgaaaacgtc ctattaaaac atctgttaaa acatctaaaa atgctaagag aaggcgaacc
241 taaccgatat cggtttccaa taaaatttaa gttatccaat ttggtatgtg aagcattttt
301 taaccatctt cgtgactaaa ccgtacaagt caacacagag cgaccgcacc cggtttatct
361 gattataaag tgcacctggt gcaatttgaa caatactatc gtggaatcac cgcaggcaac
421 cgccaatttc actgccaagg ttcgttggca gaccgtcctg gcttcaaaac gaccgataac
481 ggtaagtctt ggcacgtagg tggttatttg atcgttggga tgattgtggt taacaacaat
541 ctacatacac attttcatat gaccgccttc gttaataagc ttatatagac ataaatatat
601 aaaggtgcca tgtatttaac agagcagatt atggacaggc caaaacctag aacagtaaag
661 gaactagcag acactcttgt gattccttta atagatttgt tgataccttg taaattttgc
721 aatagatttt tatcttattt tgagctactt aattttga
//GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS PPHVLCR2 653 bp ds-DNA VRL 28-MAY-1991
DEFINITION Human papillomavirus (HPV) long control region
ACCESSION X52059
KEYWORDS E2-dependent enhancer; long control region; promoter.
SOURCE Human papillomavirus DNA.
ORGANISM Human papillomavirus
Viridae; ds-DNA nonenveloped viruses; Papovaviridae;
Papillomavirus.
REFERENCE 1 (bases 1 to 653)
AUTHORS Ensser,A.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Ensser,A. and Pfister,H.
TITLE Epidermodysplasia verruciformis associated human papillomaviruses
present a subgenus-specific organisation of the regulatory genome
region
JOURNAL Nucleic Acids Res. 18, 3919-3922 (1990)
STANDARD full staff_review
COMMENT *source: strain=HPV type 17, subtype 17a. See <X52059>-<X52062>.
From EMBL entry HPVLCR2; dated 06-DEC-1990.
FEATURES Location/Qualifiers
misc_feature 144..146
/note="ORF L1 transcription stop"
misc_feature 146..157
/note="E2-binding site (E2-BS)"
misc_feature 214..220
/note="AP1 binding site"
misc_feature 242..253
/note="E2-binding site (E2-BS)"
misc_feature 367..378
/note="E2-binding site (E2-BS)"
misc_feature 395..406
/note="E2-binding site (E2-BS)"
promoter 426..445
/note="CAAT box"
misc_feature 467..478
/note="E2-binding site (E2-BS)"
misc_feature 526..528
/note="ORF E6 transcription start"
BASE COUNT 191 a 134 c 133 g 195 t
ORIGIN
1 taaaccttac atttagaatg actccagatt tagatcagta tcccctagga cgaaaattta
61 tttttcagtc aggtttgcag gcaaggccca gaactattcg gacctctgta aaagtgccca
121 agggtattaa acgcaaacgt tcatgaccgc tttcggtctc tcaataaaca aataaaccaa
181 aatggtatgt gaagtatttt tttaccatgt tcgtgactaa acgtcttcgt caacgccaga
241 aaccgcaccc ggttaatcag attataaatg cacctggtgc gattttatca ctgcttttgt
301 ggaagcaccg caggcgcccg ccgaaactgg agccaaggtt ttggcagaac accatcttgg
361 aacagcaccg ataacggtaa gattatatct tggaaccgta ggcggtactt tctgattggt
421 ttggctgata gtagttaaca acaatcttct ctcataaata tatgtgaccg ccttcgttac
481 cttaaatgat ctacatacaa tatgagagct cttacttaag agcatatgga taggccaaaa
541 cctcaaacag tgagggagct tgctgatacc ttgtgtattc cattagtgga tattttatta
601 ccttgcagat tttgtaatag gtttttagct tacatagaat tggtggcgtt tga
//GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS PPHVLCR3 1038 bp ds-DNA VRL 28-MAY-1991
DEFINITION Human papillomavirus (HPV) long control region
ACCESSION X52060
KEYWORDS E2-dependent enhancer; long control region; promoter.
SOURCE Human papillomavirus DNA.
ORGANISM Human papillomavirus
Viridae; ds-DNA nonenveloped viruses; Papovaviridae;
Papillomavirus.
REFERENCE 1 (bases 1 to 1038)
AUTHORS Ensser,A.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Ensser,A. and Pfister,H.
TITLE Epidermodysplasia verruciformis associated human papillomaviruses
present a subgenus-specific organisation of the regulatory genome
region
JOURNAL Nucleic Acids Res. 18, 3919-3922 (1990)
STANDARD full staff_review
COMMENT *source: strain=HPV type 20. See <X52059>-<X52062>.
From EMBL entry HPVLCR3; dated 13-JUL-1990.
FEATURES Location/Qualifiers
misc_feature 251..262
/note="E2-binding site (E2-BS)"
misc_feature 320..322
/note="ORF L1 transcription stop"
misc_feature 328..339
/note="E2-binding site (E2-BS)"
misc_feature 388..394
/note="AP1 binding site"
misc_feature 610..621
/note="E2-binding site (E2-BS)"
promoter 670..688
/note="CAAT box"
misc_feature 817..819
/note="ORF E6 transcription start"
BASE COUNT 331 a 202 c 204 g 301 t
ORIGIN
1 gaattcaaat atattagagg agtggcagtt aggatttgtt cctgcaccag ataatcctat
61 ccacgataca tacagatata ttaattctgc agctactaga tgtcctgaca aaaatcctcc
121 aaaagaaaga gaagatcctt acaaggatct aaacttttgg aatgttgacc tatcagaaag
181 attgtcctta gaattggatc aatattctct aggactcaaa ttcttatttc aagcaggttt
241 acaacaggcg accgtaaacg gtacaaaaac tgtatcttca aggttatcta ctaggggcgt
301 caaacgaaaa cgcaaaaatt aaactcgacc gttttcggta caataaagtc aacttttaca
361 cggtattcaa ggaatgttta tttactctga ctaactaaga taccaaccgc acccgacaca
421 taaaggtgag ttgtgtgcca aatgaggtga gttgtgagcc agaagagatc acagccaagt
481 caggcttgag ccaaatcaga tacactgcgt gccagagttg gctcaagctt catcgtccca
541 acacgttcgg aacaggagga aatgtaaggc tgccaacgct tttggctctt ctttttggca
601 cagcagaaga ccgttaacgg taagttttta tttgtatcgg gcgcggtcgt acattactca
661 tttggtagtt gttgttgcca gctaccatca agcatagcat gtttttgcct gtaacgttat
721 cggcacagtg attaatatat atatatatat atatatatat atatatatat atatatatat
781 ataaatagat acatatagac agatatcata gagctaatgc agagagtgca ggctcatggc
841 tacacctcct tcttcagaag acagcgctga tgaaggacca tccaatattg gagagacaaa
901 accttttatt ctagagccac cattgcctgc aacaatctgt ggcctagcga accttttaga
961 aataccgcta gatgattgtt tgataccttg taacttctgc ggtaattttc ttacacattt
1021 agaagtttgt gagtttga
//GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS PPHVLCR4 962 bp ds-DNA VRL 28-MAY-1991
DEFINITION Human papillomavirus (HPV) long control region
ACCESSION X52061
KEYWORDS E2-dependent enhancer; long control region; promoter.
SOURCE Human papillomavirus DNA.
ORGANISM Human papillomavirus
Viridae; ds-DNA nonenveloped viruses; Papovaviridae;
Papillomavirus.
REFERENCE 1 (bases 1 to 962)
AUTHORS Ensser,A.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Ensser,A. and Pfister,H.
TITLE Epidermodysplasia verruciformis associated human papillomaviruses
present a subgenus-specific organisation of the regulatory genome
region
JOURNAL Nucleic Acids Res. 18, 3919-3922 (1990)
STANDARD full staff_review
COMMENT *source: strain=HPV type 36. See <X52059>-<X52062>.
From EMBL entry HPVLCR4; dated 13-JUL-1990.
FEATURES Location/Qualifiers
misc_feature 251..262
/note="E2-binding site (E2-BS)"
misc_feature 320..322
/note="ORF L1 transcription stop"
misc_feature 327..338
/note="E2-binding site (E2-BS)"
misc_feature 387..393
/note="AP1 binding site"
misc_feature 417..428
/note="E2-binding site (E2-BS)"
misc_feature 499..510
/note="E2-binding site (E2-BS)"
misc_feature 594..605
/note="E2-binding site (E2-BS)"
misc_feature 624..635
/note="E2-binding site (E2-BS)"
promoter 658..676
/note="CAAT box"
misc_feature 803..805
/note="ORF E6 transcription start"
BASE COUNT 299 a 178 c 191 g 294 t
ORIGIN
1 gaattcttct ttattggaag attggcagtt aggttttgta cctactccag ataaccctat
61 tcaagacacc tatcgatata ttgattcatt agccactcgc tgtcctgata aaaccccccc
121 taaggaaaaa gaggatccct acaaggggtt aaagttctgg gatgtggatc ttactgaacg
181 gttgtcacta gatttggatc aatactcttt aggtagaaag tttctatttc aagccggctt
241 acagcagacg accgtaagcg gtacaaaatc agtgtcttat cgagggttca ccagaggaac
301 caagcgcaag cgaaaacagt aatatgaccg tttttggtac agatttataa acttttacac
361 agtattcaag gaatgtttgt ttactctgac taagtataac tctaccaagg gaaccgaccg
421 cacccggtac agtcaacgat actgctgcca atatagactc tgtttagtgc cagaacatat
481 catcttggaa gcagatcgac cgtgttcgtt gtaacacgct cggattagag acattgccaa
541 ggaagattta atctacaatc gctgttggca atcgcttttg gctgagatag ctgaccggta
601 acggtaagtt atttaattta tgtaccaggt gcggtactgg aatttcacaa taataattgt
661 tgttgccaac taccattgct atattcaagt ttttgcctgt atcgttttcg tatcatgtga
721 ataatatact gtatagtata aataaataaa taaatatata tatatatgct tcaaaggttg
781 ggttttttaa taattaaggc aaatggcaga gcaagcctcc gaacagcaga atattacaga
841 aaaagaaaaa gaacagctgc ctttaactat taagggcctg tcagaatcat taggcattcc
901 gtttgtagac tgtctaatac cttgtaactt ttgtggcaaa tttttagatt atttagaagc
961 tt
//