GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS RATMTAA 1370 bp ds-DNA ROD 28-MAY-1991
DEFINITION Rat 70 kd mitochondrial autoantigen gene of primary biliary
cirrhosis (PBC), incomplete cds.
ACCESSION D00092
KEYWORDS autoantibody; autoantigen; primary biliary cirrhosis.
SOURCE Rattus norvegicus DNA.
ORGANISM Rattus norvegicus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 1370)
AUTHORS Gershwin,M.E., Mackay,I.R., Sturgess,A. and Coppel,R.L.
TITLE Identification and specificity of a cDNA encoding the 70 kd
mitochondrial antigen recognized in primary biliary cirrhosis
JOURNAL J. Immunol. 138, 3525-3531 (1987)
STANDARD full automatic
COMMENT SWISS-PROT; P08461; ODP2$RAT.
They report the identification of a cDNA clone derived from a rat
liver gene expression library that expresses the 70 kd
mitochondrial autoantigen of primary biliary cirrhosis (PBC). The
sequence does not correspond to any known protein and is encoded by
nuclear not mitochondrial DNA.
From EMBL entry RNMTAA; dated 02-APR-1988.
FEATURES Location/Qualifiers
CDS <1..>1370
/note="70 kd mitochondrial antigen of primary biliary
cirrhosis(PBC)"
/codon_start=1
BASE COUNT 368 a 348 c 335 g 319 t
ORIGIN
1 gggcctgagg cttttaaaaa ttatacattg gattcagcaa cagctgccac acaggcagcc
61 ccagccccag ctgcagctcc agctgctgcc ccagctgcac cttctgcaag tgctccaggt
121 agctcctatc ccgttcacat gcagattgtt cttcctgccc tctccccaac catgaccatg
181 ggcaccgtcc agaggtggga aaagaaagtg ggagagaagc tgagtgaagg agacttgctg
241 gcagagatag agaccgacaa ggccaccata ggctttgaag tacaagaaga aggttatctg
301 gcaaaaatcc tggtccctga aggcacaagg gatgttcctc tgggaacccc gctatgtatc
361 atagtagaaa aacaggaaga tatagcagca tttgcagact acaggccaac agaagtgacc
421 agcttaaagc cacaggcacc accacctgtc ccacccccag tggcagctgt tcctcccatc
481 ccccagcctt tagcacctac cccctcagcc gctcctgctg gaccaaaggg aagggtgttc
541 gttagccctc ttgcaaagaa attggcagca gagaaaggga ttgacctcac ccaagttaaa
601 gggacgggac cagaaggcag aatcatcaag aaggacattg actcttttgt gcctactaag
661 gctgctcctg ccgctgcagc agctgctccc ccgggtccaa gagtggcacc aactcctgca
721 ggtgtcttca tagacatccc catcagcaac attcgtcgag tgattgcgca gaggctcatg
781 cagtcgaagc agactatacc tcattattac ctttctgttg atgtaaatat gggagaggtg
841 ctgttggtgc ggaaggaact taataagatg cttgaaggta aaggaaaaat ctccgtcaat
901 gacttcatca taaaagcttc agctttggcc tgcctgaaag ttcctgaagc aaactcatct
961 tggatggaca cagttatacg acaaaatcat gtggttgatg tcagcgttgc tgtcagtacc
1021 cctgcaggac ttatcacccc tattgtgttt aatgcacaca taaaaggact ggaaaccatt
1081 gctagtgatg ttgtttcttt agcctccaaa gcaagagagg gtaaacttca gcctcacgag
1141 ttccagggtg ggacatttac aatctccaac ttagggatgt tcggaattaa gaatttctct
1201 gcgattatta acccacctca ggcatgtatt ttggcaattg gtgcttccga ggataaactg
1261 atccctgcag ataatgagaa aggctttgac gtggctagtg tgatgtctgt cacacactca
1321 gctgtgatca tcgagttgtg gatggagcag ttggagccca gtggcttgct
//