GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS HEFL122 3384 bp ds-DNA VRT 28-MAY-1991
DEFINITION Heterodontus fransciscii lambda 122 gene for immunoglobulin light
chain
ACCESSION X15316 X17646
KEYWORDS immunoglobulin; immunoglobulin light chain.
SOURCE Heterodontus francisci DNA.
ORGANISM Heterodontus francisci
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Chondrichthyes;
Elasmobranchii; Euselachii; Neoselachii; Galeomorphii;
Heterodontiformes; Heterodontidae.
REFERENCE 1 (bases 1 to 3384)
AUTHORS Litman,G.W.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (bases 245 to 3384)
AUTHORS Shamblott,M.J. and Litman,G.W.
TITLE Genomic organization and sequences of immunoglobulin light chain
genes in a primitive vertebrate suggest coevolution of
immunoglobulin gene organisation
JOURNAL EMBO J. 8, 3733-3739 (1989)
STANDARD full automatic
COMMENT *source: developmental stage=germ line; tissue=liver; *source:
library=lambda-DASH; See also <X51315>.
From EMBL entry HFL122; dated 30-JUL-1990.
FEATURES Location/Qualifiers
misc_feature 289..296
/note="regulatory octamer"
CDS 431..467
/note="variable region (AA 1-12) (467 is 1st base in
codon)"
/codon_start=431
intron 468..627
/note="intron I"
CDS 628..953
/note="variable region (AA 13-121) (628 is 2nd base in
codon)"
/codon_start=628
conflict 633..633
/note="c is absent in [1]"
CDS 1337..1373
/note="joining region (AA 122-133) (1373 is 1st base in
codon)"
/codon_start=1337
intron 1374..2706
/note="intron II"
CDS 2707..3032
/note="constant region (AA 134-242) (2707 is 2nd base in
codon)"
/codon_start=2707
misc_feature 3365..3370
/note="polyA signal"
BASE COUNT 899 a 803 c 724 g 958 t
ORIGIN
1 gaattcaagg cactggattc tgaagggctt ttgtttttgt ccatctggga taaaatgtgc
61 aatttcgaca gttgttcttt taaatctcac actcttgaca tgagaaggag gggttaaaat
121 cagaaattat tgtgaattaa ccctcaactc ggtggaaata aatacatgga aatgtttaat
181 tggggaccaa aagaggctca atcaaaaaaa tctggtctgg tccaccaccc ccccaccccc
241 ccgccccccc aaccccccgc cgcccctgct cctctcaacc ctccctgtat ttgcatacag
301 gttcatataa tagatactgg tctcaccttg tccggcactg taactggatc cactttctgg
361 aattacagta aaaccctgct ctctaattct tcacggtttt ttttcccccc cagaggggat
421 ggctgcagta atgtatctcc tggggaccct gctactccat ttaacaggtg agagacttat
481 gttaacagaa cgttactcaa tatcatttgt aaaccattag attaggaagc aaagggattt
541 ggtagcccgg cctgtttatt tatcagtgtg tttttttgct ccaataaact gaatgtgttt
601 ttctctctct tgtgttttgt gttgaaggtg tcctggcggt tcctgtcctc aatcagaccc
661 caatttcaga cccagtctcc gccggtgaga cctccgagtt aaagtgtgcg atgcagaacg
721 gcaaaatggg cagttactac atgagctggt accgacagag acccggggag gctccggtgt
781 gggtgttagc ccactctaca agtggtagca tctatcgagg caccggcttc acggaccgtt
841 ttaaaccttc cagagacacc tccagtaaca gtcacattct gaccatcggc agcttggaac
901 cgggagactc cgccgtctat tactgtgctg cctgggatag ctcagcagct acatacacag
961 tgagacaggg caatacaaaa actgcaccaa cagaaccact cagaattcca acagcaactg
1021 aaatattcct gcctgagact gtgtgatgag cttcagaaat attccatatg taacttgtgg
1081 aaaatctcac tggaattcca tgggtttatt tggattttcc ccaatatttg ggctattagc
1141 tgggtaggta aacactgatt ttctcaaggt ttcctcactg atatgtgaaa atctttctcc
1201 agcctctcag cattccggcc cctgtgaaag gcagaatgtg aaagggaatg tgataaagga
1261 cagattatta atatttcccc tccttcttcc cagcctgggt tttaagtgac ccgtcccatt
1321 aaaacactgc actgtgttta ccttcggacc tgggaccgcc ctgagtttac ggagtaagta
1381 attccttcat cctatcattc atattgtttc aattatttat tcatttattg ttgcagaatc
1441 ggatctgccc tgataacggt gaaaacaaat tgggtcagat ttttattttt ctgtccactg
1501 attcagtgct gggaatttgg attctggagg gtagaaaaat aaacacaaaa atagcagcaa
1561 aacaattgcg gatgctggaa atctgaaata aaaaaaacag aagatgctgg aaatactcag
1621 caggtctggg cagcctctgc ggagagagag ggagaaacgg tgaacagttt cgggtctctg
1681 acctttcctc agaaccgaag aaaaactcca ttggcaaaaa aaaatgcaga atgaacaggg
1741 gagaaaggcc attcagcccc tcgagtctgt tcggccaagt ctgctgtgag ctggcgtgga
1801 attccgtcta ttcgctgcac tgttgtataa atagcgagcc tgccccgggt gttgctggaa
1861 gatttacaaa caggaatttt actcacactg aaagggggtc gagtttgaca ctagcacccc
1921 ctcccccacc tcaaaaaaag actcccaaag ttgggaagtg ggttaggctg cggcacggac
1981 tcgatggacc gcatggcctc attctgcgcc ccccccccat cttgtctgtt cccaacgcac
2041 cccggtccca ctagccccga ccccccgtct cccttcccaa acccctcctt ccggctgtca
2101 ttccttcatg tgaagtgtct aacctacttt ctaaatggaa accgccccga actttattac
2161 ttttaaaact ctttttttta taaataaata atttttccta gtgaggtgat caccgaactc
2221 tgagtgtgga tctgggaggt tgagttactc ccaatacata ctccgagcac ctccataaga
2281 cctccagtac agcctatccg aaatgtgaaa cttcctcaaa ttttaaactt ttgattttaa
2341 tctgcccctg aattttaaac aattcgatat tgtctgatga atttaatatt cagttaatta
2401 atttatctga atgtctcgaa tccatgtaca agtccagctc tcaattgaca gggagttaag
2461 attggactaa atatttaatt ttaatccaat caaagcaaaa tcctgcagat gctggaaatc
2521 tgaaatcgag tgctggaaac actcaggcta ttatattatt tactgtctct acctaagtct
2581 gaagtcaagt taaatgtttg ttttaaatta tagtatgtgt tactaattct ggatgtgcct
2641 tttagaaaaa atgattgata ctaacagtga gattcctttc ttccaccctg tctctcacac
2701 acacaggtag tgaggatcgg aaaccatcag ttctcctgct ccctccttcc tcggaagaaa
2761 tagactccgg atgggctact ctgtcctgcc tggtgagccg ctttaagccg ggtttcgtgc
2821 gggttctctg gagagtggat gataaagaga cagacagcgg ggtgaccaca ggcaccgtgt
2881 ccacggacag tgatcaaagc tacagcctga gcagttacct gagagtcccc gccactgcct
2941 ggaataaggg ctccagctat acctgcagtg tggaccacgg ctctctgagc tcacctctcc
3001 tcaaaaccat cagctccacc gcttgttccg actgagaggg agcaactggg gtttagagtt
3061 tgatttattg ctgatgaaat attattcaat atgtggaatg ttgttgttgt tgttttacaa
3121 tgtaatcact gtagcaaatg tggccaacga tgttgaaaca gtcactacaa tcgcagttta
3181 acgatccaat tttggattca attttaactg gggggcgcag gtgggtgaca gtgaatatca
3241 ggaccaccta tcccgggagt acattcccat ttggagctgg atgggttctg ctccctctct
3301 cctttctctc agtagtacca tttgttagaa ttgaaaagtg tatctctgtg tgtgtgactg
3361 ttttaataaa gatgacatga attc
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