GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS HUMHEPSL 1199 bp ss-mRNA PRI 28-MAY-1991
DEFINITION Human liver mRNA for serine protease hepsin
ACCESSION X07002
KEYWORDS hepsin; membrane protein; serine protease; zymogen.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1199)
AUTHORS Leytus,S.P., Loeb,K.R., Hagen,F.S., Kurachi,K. and Davie,E.W.
TITLE A novel trypsin-like serine protease (hepsin) with a putative
transmembrane domain expressed by human liver and hepatoma cells
JOURNAL Biochemistry 27, 1067-1074 (1988)
STANDARD full automatic
COMMENT SWISS-PROT; P05981; HEPS$HUMAN.
*source: tissue=liver; clone HUW 1250; library=pBR322; see x07732
for hepatoma hepsin full length cDNA
From EMBL entry HSHEPSL; dated 16-JUL-1988.
FEATURES Location/Qualifiers
mRNA <1..1199
/note="hepsin mRNA"
CDS <1..902
/note="prohepsin (AA 114 - 417)"
/codon_start=1
CDS <1..147
/note="propeptide (AA (114-162)"
/codon_start=1
CDS 148..902
/note="mat. hepsin (AA 163-417)"
/codon_start=148
polyA_site 1199..1199
/note="polyA site"
BASE COUNT 205 a 374 c 370 g 250 t
ORIGIN
1 acgtcgggct tcttctgtgt ggacgagggg aggctgcccc acacccagag gctgctggag
61 gtcatctccg tgtgtgattg ccccagaggc cgtttcttgg ccgccatctg ccaagactgt
121 ggccgcagga agctgcccgt ggaccgcatc gtgggaggcc gggacaccag cttgggccgg
181 tggccgtggc aagtcagcct tcgctatgat ggagcacacc tctgtggggg atccctgctc
241 tccggggact gggtgctgac agccgcccac tgcttcccgg agcggaaccg ggtcctgtcc
301 cgatggcgag tgtttgccgg tgccgtggcc caggcctctc cccacggtct gcagctgggg
361 gtgcaggctg tggtctacca cgggggctat cttccctttc gggaccccaa cagcgaggag
421 aacagcaacg atattgccct ggtccacctc tccagtcccc tgcccctcac agaatacatc
481 cagcctgtgt gcctcccagc tgccggccag gccctggtgg atggcaagat ctgtaccgtg
541 acgggctggg gcaacacgca gtactatggc caacaggccg gggtactcca ggaggctcga
601 gtccccataa tcagcaatga tgtctgcaat ggcgctgact tctatggaaa ccagatcaag
661 cccaagatgt tctgtgctgg ctaccccgag ggtggcattg atgcctgcca gggcgacagc
721 ggtggtccct ttgtgtgtga ggacagcatc tctcggacgc cacgttggcg gctgtgtggc
781 attgtgagtt ggggcactgg ctgtgccctg gcccagaagc caggcgtcta caccaaagtc
841 agtgacttcc gggagtggat cttccaggcc ataaagactc actccgaagc cagcggcatg
901 gtgacccagc tctgaccggt ggcttctcgc tgcgcagcct ccagggcccg aggtgatccc
961 ggtggtggga tccacgctgg gccgaggatg ggacgttttt cttcttgggc ccggtccaca
1021 ggtccaagga caccctccct ccagggtcct ctcttccaca gtggcgggcc cactcagccc
1081 cgagaccacc caacctcacc ctcctgaccc ccatgtaaat attgttctgc tgtctgggac
1141 tcctgtctag gtgcccctga tgatgggatg ctctttaaat aataaagatg gttttgatt
//