GenBank-Updates@genbank.bio.net (05/29/91)
LOCUS HUMIL4R 3597 bp ss-mRNA PRI 28-MAY-1991
DEFINITION Human IL-4-R mRNA for the interleukin 4 receptor
ACCESSION X52425
KEYWORDS B cell growth factor; IL-4-R gene; interleukin;
interleukin-4 receptor.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3597)
AUTHORS Idzerda,R.L., March,C.J., Mosley,B., Lyman,S.D., Bos,T.V.,
Gimpel,S.D., Din,W.S., Grabstein,K.H., Widmer,M.B., Park,L.S.,
Cosman,D. and Beckmann,M.P.
TITLE Human interleukin 4 receptor confers biological responsiveness and
defines a novel receptor superfamily
JOURNAL J. Exp. Med. 171, 861-873 (1990)
STANDARD full automatic
COMMENT *source: cell type=T cell, tissue=peripheral blood, clone=T22-8;
From EMBL entry HSIL4R; dated 19-NOV-1990.
FEATURES Location/Qualifiers
mRNA <1..3597
/gene="IL-4-R gene"
sig_peptide 176..250
/product="interleukin 4 receptor"
CDS 176..2653
/product="interleukin 4 receptor"
/gene="IL-4-R gene"
/codon_start=176
mat_peptide 251..2650
/product="interleukin 4 receptor"
/gene="IL-4-R gene"
misc_feature 872..943
/note="putative transmembrane region"
/product="interleukin 4 receptor"
polyA_signal 3579..3584
BASE COUNT 794 a 1034 c 1039 g 730 t
ORIGIN
1 ggcgaatgga gcaggggcgc gcagataatt aaagatttac acacagctgg aagaaatcat
61 agagaagccg ggcgtggtgg ctcatgccta taatcccagc acttttggag gctgaggcgg
121 gcagatcact tgagatcagg agttcgagac cagcctggtg ccttggcatc tcccaatggg
181 gtggctttgc tctgggctcc tgttccctgt gagctgcctg gtcctgctgc aggtggcaag
241 ctctgggaac atgaaggtct tgcaggagcc cacctgcgtc tccgactaca tgagcatctc
301 tacttgcgag tggaagatga atggtcccac caattgcagc accgagctcc gcctgttgta
361 ccagctggtt tttctgctct ccgaagccca cacgtgtatc cctgagaaca acggaggcgc
421 ggggtgcgtg tgccacctgc tcatggatga cgtggtcagt gcggataact atacactgga
481 cctgtgggct gggcagcagc tgctgtggaa gggctccttc aagcccagcg agcatgtgaa
541 acccagggcc ccaggaaacc tgacagttca caccaatgtc tccgacactc tgctgctgac
601 ctggagcaac ccgtatcccc ctgacaatta cctgtataat catctcacct atgcagtcaa
661 catttggagt gaaaacgacc cggcagattt cagaatctat aacgtgacct acctagaacc
721 ctccctccgc atcgcagcca gcaccctgaa gtctgggatt tcctacaggg cacgggtgag
781 ggcctgggct cagtgctata acaccacctg gagtgagtgg agccccagca ccaagtggca
841 caactcctac agggagccct tcgagcagca cctcctgctg ggcgtcagcg tttcctgcat
901 tgtcatcctg gccgtctgcc tgttgtgcta tgtcagcatc accaagatta agaaagaatg
961 gtgggatcag attcccaacc cagcccgcag ccgcctcgtg gctataataa tccaggatgc
1021 tcaggggtca cagtgggaga agcggtcccg aggccaggaa ccagccaagt gcccacactg
1081 gaagaattgt cttaccaagc tcttgccctg ttttctggag cacaacatga aaagggatga
1141 agatcctcac aaggctgcca aagagatgcc tttccagggc tctggaaaat cagcatggtg
1201 cccagtggag atcagcaaga cagtcctctg gccagagagc atcagcgtgg tgcgatgtgt
1261 ggagttgttt gaggccccgg tggagtgtga ggaggaggag gaggtagagg aagaaaaagg
1321 gagcttctgt gcatcgcctg agagcagcag ggatgacttc caggagggaa gggagggcat
1381 tgtggcccgg ctaacagaga gcctgttcct ggacctgctc ggagaggaga atgggggctt
1441 ttgccagcag gacatggggg agtcatgcct tcttccacct tcgggaagta cgagtgctca
1501 catgccctgg gatgagttcc caagtgcagg gcccaaggag gcacctccct ggggcaagga
1561 gcagcctctc cacctggagc caagtcctcc tgccagcccg acccagagtc cagacaacct
1621 gacttgcaca gagacgcccc tcgtcatcgc aggcaaccct gcttaccgca gcttcagcaa
1681 ctccctgagc cagtcaccgt gtcccagaga gctgggtcca gacccactgc tggccagaca
1741 cctggaggaa gtagaacccg agatgccctg tgtcccccag ctctctgagc caaccactgt
1801 gccccaacct gagccagaaa cctgggagca gatcctccgc cgaaatgtcc tccagcatgg
1861 ggcagctgca gcccccgtct cggcccccac cagtggctat caggagtttg tacatgcggt
1921 ggagcagggt ggcacccagg ccagtgcggt ggtgggcttg ggtcccccag gagaggctgg
1981 ttacaaggcc ttctcaagcc tgcttgccag cagtgctgtg tccccagaga aatgtgggtt
2041 tggggctagc agtggggaag aggggtataa gcctttccaa gacctcattc ctggctgccc
2101 tggggaccct gccccagtcc ctgtcccctt gttcaccttt ggactggaca gggagccacc
2161 tcgcagtccg cagagctcac atctcccaag cagctcccca gagcacctgg gtctggagcc
2221 gggggaaaag gtagaggaca tgccaaagcc cccacttccc caggagcagg ccacagaccc
2281 ccttgtggac agcctgggca gtggcattgt ctactcagcc cttacctgcc acctgtgcgg
2341 ccacctgaaa cagtgtcatg gccaggagga tggtggccag acccctgtca tggccagtcc
2401 ttgctgtggc tgctgctgtg gagacaggtc ctcgccccct acaacccccc tgagggcccc
2461 agacccctct ccaggtgggg ttccactgga ggccagtctg tgtccggcct ccctggcacc
2521 ctcgggcatc tcagagaaga gtaaatcctc atcatccttc catcctgccc ctggcaatgc
2581 tcagagctca agccagaccc ccaaaatcgt gaactttgtc tccgtgggac ccacatacat
2641 gagggtctct taggtgcatg tcctcttgtt gctgagtctg cagatgagga ctagggctta
2701 tccatgcctg ggaaatgcca cctcctggaa ggcagccagg ctggcagatt tccaaaagac
2761 ttgaagaacc atggtatgaa ggtgattggc cccactgacg ttggcctaac actgggctgc
2821 agagactgga ccccgcccag cattgggctg ggctcgccac atcccatgag agtagagggc
2881 actgggtcgc cgtgccccac ggcaggcccc tgcaggaaaa ctgaggccct tgggcacctc
2941 gacttgtgaa cgagttgttg gctgctccct ccacagcttc tgcagcagac tgtccctgtt
3001 gtaactgccc aaggcatgtt ttgcccacca gatcatggcc cacgtggagg cccacctgcc
3061 tctgtctcac tgaactagaa gccgagccta gaaactaaca cagccatcaa gggaatgact
3121 tgggcggcct tgggaaatcg atgagaaatt gaacttcagg gagggtggtc attgcctaga
3181 ggtgctcatt catttaacag agcttcctta ggttgatgct ggaggcagaa tcccggctgt
3241 caaggggtgt tcagttaagg ggagcaacag aggacatgaa aaattgctat gactaaagca
3301 gggacaattt gctgccaaac acccatgccc agctgtatgg ctgggggctc ctcgtatgca
3361 tggaaccccc agaataaata tgctcagcca ccctgtgggc cgggcaatcc agacagcagg
3421 cataaggcac cagttaccct gcatgttggc ccagacctca ggtgctaggg aaggcgggaa
3481 ccttgggttg agtaatgctc gtctgtgtgt tttagtttca tcacctgtta tctgtgtttg
3541 ctgaggagag tggaacagaa ggggtggagt tttgtataaa taaagtttct ttgtctc
//