GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMMYCD 8082 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human c-myc oncogene
ACCESSION X00364 K01908 V00501
KEYWORDS myc cellular oncogene; oncogene cellular.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 3507 to 7559)
AUTHORS Colby,W.W., Chen,E.Y., Smith,D.H. and Levinson,A.D.
TITLE Identification and nucleotide sequence of a human locus homologous
to the v-myc oncogene of avian myelocytomatosis virus MC29
JOURNAL Nature 301, 722-725 (1983)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Saito,H., Hayday,A.C., Wiman,K.G., Hayward,W.S. and Tonegawa,S.
TITLE Activation of the c-myc gene by translocation: a model for
translational control
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80, 7476-7480 (1983)
STANDARD full staff_review
REFERENCE 3 (bases 1 to 8082)
AUTHORS Gazin,C., Dupont,S., de,D.D., Hampe,A., Masson,J.M., Martin,P.,
Stehelin,D. and Galibert,F.
TITLE Nucleotide sequence of the human c-myc locus: provocative open
reading frame within the first exon
JOURNAL EMBO J. 3, 383-387 (1984)
STANDARD full automatic
REFERENCE 4 (sites)
AUTHORS Gazin,C., Rigolet,M., Briand,J.P., Van,R.M.H. and Galibert,F.
TITLE Immunochemical detection of proteins related to the human c-myc
exon 1
JOURNAL EMBO J. 5, 2241-2250 (1986)
STANDARD full staff_review
COMMENT EPD; 11146; Hs c-myc P1. EPD; 11148; Hs c-myc P2+.
SWISS-PROT; P01106; MYC$HUMAN.
From EMBL entry HSMYCC; dated 06-JUL-1989.
FEATURES Location/Qualifiers
mRNA <2882..2881
/note="exon 1"
CDS 2304..2876
/note="pot. ORF (aa 1-188)"
/codon_start=2304
intron 2882..4505
/note="intron"
mRNA 4506..5277
/note="exon 2"
CDS 4521..5277
/note="48K protein part 1 (5277 is 1st base in codon)"
/codon_start=4521
intron 5278..6653
/note="intron"
mRNA 6654..>6653
/note="exon 3"
CDS 6654..7213
/note="48K protein part 2 (6654 is 2nd base in codon)"
/codon_start=6654
misc_feature 7511..7516
/note="pot. polyA signal"
misc_feature 7652..7657
/note="pot. polyA signal"
BASE COUNT 1850 a 2115 c 2135 g 1982 t
ORIGIN
1 agcttgtttg gccgttttag ggtttgttgg aatttttttt tcgtctatgt acttgtgaat
61 tatttcacgt ttgccattac cggttctcca tagggtgatg ttcattagca gtggtgatag
121 gttaattttc accatctctt atgcggttga atagtcacct ctgaaccact ttttcctcca
181 gtaactcctc tttcttcgga ccttctgcag ccaacctgaa agaataacaa ggaggtggct
241 ggaaacttgt tttaaggaac cgcctgtcct tcccccgctg gaaaccttgc acctcggacg
301 ctcctgctcc tgcccccacc tgacccccgc cctcgttgac atccaggcgc gatgatctct
361 gctgccagta gagggcacac ttactttact ttcgcaaacc tgaacgcggg tgctgcccag
421 agagggggcg gagggaaaga cgctttgcag caaaatccag catagcgatt ggttgctccc
481 cgcgtttgcg gcaaaggcct ggaggcagga gtaatttgca atccttaaag ctgaattgtg
541 cagtgcatcg gatttggaag ctactatatt cacttaacac ttgaacgctg agctgcaaac
601 tcaacgggta ataacccatc ttgaacagcg tacatgctat acacacaccc ctttcccccg
661 aattgttttc tcttttggag gtggtggagg gagagaaaag tttacttaaa atgcctttgg
721 gtgagggacc aaggatgaga agaatgtttt ttgtttttca tgccgtggaa taacacaaaa
781 taaaaaatcc cgagggaata tacattatat attaaatata gatcatttca gggagcaaac
841 aaatcatgtg tggggctggg caactagctg agtcgaagcg taaataaaat gtgaatacac
901 gtttgcgggt tacatacagt gcactttcac tagtattcag aaaaaattgt gagtcagtga
961 actaggaaat taatgcctgg aaggcagcca aattttaatt agctcaagac tccccccccc
1021 ccccaaaaaa aggcacggaa gtaatactcc tctcctcttc tttgatcaga atcgatgcat
1081 tttttgtgca tgaccgcatt tccaataata aaaggggaaa gaggacctgg aaaggaatta
1141 aacgtccggt ttgtccgggg aggaaagagt taacggtttt tttcacaagg gtctctgctg
1201 actcccccgg ctcggtccac aagctctcca cttgcccctt ttaggaagtc cggtcccgcg
1261 gttcgggtac cccctgcccc tcccatattc tcccgtctag cacctttgat ttctcccaaa
1321 cccggcagcc cgagactgtt gcaaaccggc gccacagggc gcaaagggga tttgtctctt
1381 ctgaaacctg gctgagaaat tgggaactcc gtgtgggagg cgtgggggtg ggacggtggg
1441 gtacagactg gcagagagca ggcaacctcc ctctcgccct agcccagctc tggaacaggc
1501 agacacatct cagggctaaa cagacgcctc ccgcacgggg ccccacggaa gcctgagcag
1561 gcggggcagg aggggcggta tctgctgctt tggcagcaaa ttgggggact cagtctgggt
1621 ggaaggtatc caatccagat agctgtgcat acataatgca taatacatga ctccccccaa
1681 caaatgcaat gggagtttat tcataacgcg ctctccaagt atacgtggca atgcgttgct
1741 gggttatttt aatcattcta ggcatcgttt tcctccttat gcctctatca ttcctcccta
1801 tctacactaa catcccacgc tctgaacgcg cgcccattaa tacccttctt tcctccactc
1861 tccctgggac tcttgatcaa agcgcggccc tttccccagc cttagcgagg cgccctgcag
1921 cctggtacgc gcgtggcgtg gcggtgggcg cgcagtgcgt tctctgtgtg gagggcagct
1981 gttccgcctg cgatgattta tactcacagg acaaggatgc ggtttgtcaa acagtactgc
2041 tacggaggag cagcagagaa agggagaggg tttgagaggg agcaaaagaa aatggtaggc
2101 gcgcgtagtt aattcatgcg gctctcttac tctgtttaca tcctagagct agagtgctcg
2161 gctgcccggc tgagtctcct ccccaccttc cccaccctcc ccaccctccc cataagcgcc
2221 cctcccgggt tcccaaagca gagggcgtgg gggaaaagaa aaaagatcct ctctcgctaa
2281 tctccgccca ccggcccttt ataatgcgag ggtctggacg gctgaggacc cccgagctgt
2341 gctgctcgcg gccgccaccg ccgggccccg gccgtccctg gctcccctcc tgcctcgaga
2401 agggcagggc ttctcagagg cttggcggga aaaagaacgg agggagggat cgcgctgagt
2461 ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc gagaggcaga
2521 gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct gcgctgcggg
2581 cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc agccctcccg
2641 ctgatccccc agccagcggt ccgcaaccct tgccgcatcc acgaaacttt gcccatagca
2701 gcgggcgggc actttgcact ggaacttaca acacccgagc aaggacgcga ctctcccgac
2761 gcggggaggc tattctgccc atttggggac acttccccgc cgctgccagg acccgcttct
2821 ctgaaaggct ctccttgcag ctgcttagac gctggatttt tttcgggtag tggaaaacca
2881 ggtaagcacc gaagtccact tgccttttaa tttatttttt tatcacttta atgctgagat
2941 gagtcgaatg cctaaatagg gtgtcttttc tcccattcct gcgctattga cacttttctc
3001 agagtagtta tggtaactgg ggctggggtg gggggtaatc cagaactgga tcggggtaaa
3061 gtgacttgtc aagatgggag aggagaaggc agagggaaaa cgggaatggt ttttaagact
3121 accctttcga gatttctgcc ttatgaatat attcacgctg actcccggcc ggtcggacat
3181 tcctgcttta ttgtgttaat tgctctctgg gttttggggg gctgggggtt gctttgcggt
3241 gggcagaaag ccccttgcat cctgagctcc ttggagtagg gaccgcatat cgcctgtgtg
3301 agccagatcg ctccgcagcc gctgacttgt ccccgtctcc gggagggcat ttaaatttcg
3361 gctcaccgca tttctgacag ccggagacgg acactgcggc gcgtcccgcc cgcctgtccc
3421 cgcggcgatt ccaacccgcc ctgatccttt taagaagttg gcatttggct ttttaaaaag
3481 caataataca atttaaaacc tgggtctcta gaggtgttag gacgtggtgt tgggtaggcg
3541 caggcagggg aaaagggagg cgaggatgtg tccgattctc ctggaatcgt tgacttggaa
3601 aaaccagggc gaatctccgc acccagccct gactcccctg ccgcggccgc cctcgggtgt
3661 cctcgcgccc gagatgcgga ggaactgcga ggagcggggc tctgggcggt tccagaacag
3721 ctgctaccct tggtggggtg gctccggggg aggtatcgca gcggggtctc tggcgcagtt
3781 gcatctccgt attgagtgcg aagggaggtg cccctattat tatttgacac cccccttgta
3841 tttatggagg ggtgttaaag cccgcggctg agctcgccac tccagccggc gagagaaaga
3901 agaaaagctg gcaaaaggag tgttggacgg gggcggtact gggggtgggg acgggggcgg
3961 tggagaggga aggttgggag gggctgcggt gccggcgggg gtaggagagc ggctagggcg
4021 cgagtgggaa cagccgcagc ggaggggccc cggcgcggag cggggttcac gcagccgcta
4081 gcgcccaggc gcctctcgcc ttctccttca ggtggcgcaa aactttgtgc cttggatttt
4141 ggcaaattgt tttcctcacc gccacctccc gcggcttctt aagggcgcca gggccgattt
4201 cgattcctct gccgctgcgg ggccgactcc cgggctttgc gctccgggct cccgggggag
4261 cgggggctcg gcgggcacca agccgctggt tcactaagtg cgtctccgag atagcagggg
4321 actgtccaaa gggggtgaaa gggtgctccc tttattcccc caccaagacc acccagccgc
4381 tttaggggat agctctgcaa ggggagaggt tcgggactgt ggcgcgcact gcgcgctgcg
4441 ccaggtttcc gcaccaagac ccctttaact caagactgcc tcccgctttg tgtgccccgc
4501 tccagcagcc tcccgcgacg atgcccctca acgttagctt caccaacagg aactatgacc
4561 tcgactacga ctcggtgcag ccgtatttct actgcgacga ggaggagaac ttctaccagc
4621 agcagcagca gagcgagctg cagcccccgg cgcccagcga ggatatctgg aagaaattcg
4681 agctgctgcc caccccgccc ctgtccccta gccgccgctc cgggctctgc tcgccctcct
4741 acgttgcggt cacacccttc tcccttcggg gagacaacga cggcggtggc gggagcttct
4801 ccacggccga ccagctggag atggtgaccg agctgctggg aggagacatg gtgaaccaga
4861 gtttcatctg cgacccggac gacgagacct tcatcaaaaa catcatcatc caggactgta
4921 tgtggagcgg cttctcggcc gccgccaagc tcgtctcaga gaagctggcc tcctaccagg
4981 ctgcgcgcaa agacagcggc agcccgaacc ccgcccgcgg ccacagcgtc tgctccacct
5041 ccagcttgta cctgcaggat ctgagcgccg ccgcctcaga gtgcatcgac ccctcggtgg
5101 tcttccccta ccctctcaac gacagcagct cgcccaagtc ctgcgcctcg caagactcca
5161 gcgccttctc tccgtcctcg gattctctgc tctcctcgac ggagtcctcc ccgcagggca
5221 gccccgagcc cctggtgctc catgaggaga caccgcccac caccagcagc gactctggta
5281 agcgaagccc gcccaggcct gtcaaaagtg ggcggctgga tacctttccc attttcattg
5341 gcagcttatt taacgggcca ctcttattag gaaggagaga tagcagatct ggagagattt
5401 gggagctcat cacctctgaa accttgggct ttagcgtttc ctcccatccc ttccccttag
5461 actgcccatg tttgcagccc ccctccccgt ttgtctccca cccctcagga atttcattta
5521 ggtttttaaa ccttctggct tatcttacaa ctcaatccac ttcttcttac ctcccgttaa
5581 cattttaatt gccctggggc ggggtggcag ggagtgtatg aatgaggata agagaggatt
5641 gatctctgag agtgaatgaa ttgcttccct cttaacttcc gagaagtggt gggatttaat
5701 gaactatcta caaaaatgag gggctgtgtt tagaggctag gcagggcctg cctgagtgcg
5761 ggagccagtg aactgcctca agagtgggtg ggctgaggag ctgggatctt ctcagcctat
5821 tttgaacact gaaaagcaaa tccttgccaa agttggactt ttttttttct tttattcctt
5881 cccccgccct cttggacttt tggcaaaact gcaatttttt tttttttatt tttcatttcc
5941 agtaaaatag ggagttgcta aagtcatacc aagcaatttg cagctatcat ttgcaacacc
6001 tgaagtgttc ttggtaaagt ccctcaaaaa taggaggtgc ttgggaatgt gctttgcttt
6061 gggtgtgtcc aaagcctcat taagtcttag gtaagaattg gcatcaatgt cctatcctgg
6121 gaagttgcac ttttcttgtc catgccataa cccagctgtc tttcccttta tgagactctt
6181 accttcatgg tgagaggagt aagggtggct ggctagattg gttctttttt tttttttttc
6241 cttttttaag acggagtctc actctgtcac taggctggag tgcagtggcg caatcaacct
6301 ccaaccccct ggttcaagag attctcctgc ctcagcctcc caagtagctg ggactacagg
6361 tgcacaccac catgccaggc taatttttgt aattttagta gagatggggt ttcatcgtgt
6421 tggccaggat ggtctctcct gacctcacga tccgcccacc tcggcctccc aaagtgctgg
6481 gattacaggt gtgagccagg gcaccaggct tagatgtggc tctttgggga gataattttg
6541 tccagagacc tttctaacgt attcatgcct tgtatttgta cagcattaat ctggtaattg
6601 attattttaa tgtaaccttg ctaaaggagt gatttctatt tcctttctta aagaggagga
6661 acaagaagat gaggaagaaa tcgatgttgt ttctgtggaa aagaggcagg ctcctggcaa
6721 aaggtcagag tctggatcac cttctgctgg aggccacagc aaacctcctc acagcccact
6781 ggtcctcaag aggtgccacg tctccacaca tcagcacaac tacgcagcgc ctccctccac
6841 tcggaaggac tatcctgctg ccaagagggt caagttggac agtgtcagag tcctgagaca
6901 gatcagcaac aaccgaaaat gcaccagccc caggtcctcg gacaccgagg agaatgtcaa
6961 gaggcgaaca cacaacgtct tggagcgcca gaggaggaac gagctaaaac ggagcttttt
7021 tgccctgcgt gaccagatcc cggagttgga aaacaatgaa aaggccccca aggtagttat
7081 ccttaaaaaa gccacagcat acatcctgtc cgtccaagca gaggagcaaa agctcatttc
7141 tgaagaggac ttgttgcgga aacgacgaga acagttgaaa cacaaacttg aacagctacg
7201 gaactcttgt gcgtaaggaa aagtaaggaa aacgattcct tctaacagaa atgtcctgag
7261 caatcaccta tgaacttgtt tcaaatgcat gatcaaatgc aacctcacaa ccttggctga
7321 gtcttgagac tgaaagattt agccataatg taaactgcct caaattggac tttgggcata
7381 aaagaacttt tttatgctta ccatcttttt tttttcttta acagatttgt atttaagaat
7441 tgtttttaaa aaattttaag atttacacaa tgtttctctg taaatattgc cattaaatgt
7501 aaataacttt aataaaacgt ttatagcagt tacacagaat ttcaatccta gtatatagta
7561 cctagtatta taggtactat aaaccctaat tttttttatt taagtacatt ttgcttttta
7621 aagttgattt ttttctattg tttttagaaa aaataaaata actggcaaat atatcattga
7681 gccaaatctt aagttgtgaa tgttttgttt cgtttcttcc ccctcccaac caccaccatc
7741 cctgtttgtt ttcatcaatt gccccttcag agggcggtct taagaaaggc aagagttttc
7801 ctctgttgaa atgggtctgg gggccttaag gtctttaagt tcttggaggt tctaagatgc
7861 ttcctggaga ctatgataac agccagagtt gacagttaga aggaatggca gaaggcaggt
7921 gagaaggtga gaggtaggca aaggagatac aagaggtcaa aggtagcagt taagtacaca
7981 aagaggcata aggactgggg agttgggagg aaggtgagga agaaactcct gttactttag
8041 ttaaccagtg ccagtcccct gctcactcca aacccaggaa tt
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