GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMOP1 1878 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human OP-1 mRNA for osteogenic protein
ACCESSION X51801
KEYWORDS OP-1 gene; osteogenic protein.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1878)
AUTHORS Oppermann,H.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1878)
AUTHORS Oezkaynak,E., Rueger,D.C., Drier,E.A., Corbett,C., Ridge,R.J.,
Sampath,T.K. and Oppermann,H.
TITLE OP-1 cDNA encodes an osteogenic protein in the TGF-beta family
JOURNAL EMBO J. 9, 2085-2093 (1990)
STANDARD full automatic
COMMENT *source: tissue=placenta;
From EMBL entry HSOP1; dated 12-SEP-1990.
FEATURES Location/Qualifiers
CDS 123..1415
/note="pre-propolypeptide (AA -29 to 402)"
/codon_start=123
CDS 123..209
/note="signal peptide (AA -29 to -1)"
/codon_start=123
CDS 210..1037
/note="propeptide (AA 1-276)"
/codon_start=210
CDS 210..1020
/note="propeptide (alt.) (AA 1-270)"
/codon_start=210
CDS 1021..1415
/note="mature osteogenic protein (AA 271-402)"
/codon_start=1021
CDS 1038..1415
/note="mature osteogenic protein (AA 277-402)"
/codon_start=1038
misc_feature 1850..1855
/note="polyA signal"
misc_feature 1862..1867
/note="polyA signal"
polyA_site 1878..1878
/note="polyA site"
BASE COUNT 411 a 592 c 541 g 334 t
ORIGIN
1 gggcgcagcg gggcccgtct gcagcaagtg accgacggcc gggacggccg cctgccccct
61 ctgccacctg gggcggtgcg ggcccggagc ccggagcccg ggtagcgcgt agagccggcg
121 cgatgcacgt gcgctcactg cgagctgcgg cgccgcacag cttcgtggcg ctctgggcac
181 ccctgttcct gctgcgctcc gccctggccg acttcagcct ggacaacgag gtgcactcga
241 gcttcatcca ccggcgcctc cgcagccagg agcggcggga gatgcagcgc gagatcctct
301 ccattttggg cttgccccac cgcccgcgcc cgcacctcca gggcaagcac aactcggcac
361 ccatgttcat gctggacctg tacaacgcca tggcggtgga ggagggcggc gggcccggcg
421 gccagggctt ctcctacccc tacaaggccg tcttcagtac ccagggcccc cctctggcca
481 gcctgcaaga tagccatttc ctcaccgacg ccgacatggt catgagcttc gtcaacctcg
541 tggaacatga caaggaattc ttccacccac gctaccacca tcgagagttc cggtttgatc
601 tttccaagat cccagaaggg gaagctgtca cggcagccga attccggatc tacaaggact
661 acatccggga acgcttcgac aatgagacgt tccggatcag cgtttatcag gtgctccagg
721 agcacttggg cagggaatcg gatctcttcc tgctcgacag ccgtaccctc tgggcctcgg
781 aggagggctg gctggtgttt gacatcacag ccaccagcaa ccactgggtg gtcaatccgc
841 ggcacaacct gggcctgcag ctctcggtgg agacgctgga tgggcagagc atcaacccca
901 agttggcggg cctgattggg cggcacgggc cccagaacaa gcagcccttc atggtggctt
961 tcttcaaggc cacggaggtc cacttccgca gcatccggtc cacggggagc aaacagcgca
1021 gccagaaccg ctccaagacg cccaagaacc aggaagccct gcggatggcc aacgtggcag
1081 agaacagcag cagcgaccag aggcaggcct gtaagaagca cgagctgtat gtcagcttcc
1141 gagacctggg ctggcaggac tggatcatcg cgcctgaagg ctacgccgcc tactactgtg
1201 agggggagtg tgccttccct ctgaactcct acatgaacgc caccaaccac gccatcgtgc
1261 agacgctggt ccacttcatc aacccggaaa cggtgcccaa gccctgctgt gcgcccacgc
1321 agctcaatgc catctccgtc ctctacttcg atgacagctc caacgtcatc ctgaagaaat
1381 acagaaacat ggtggtccgg gcctgtggct gccactagct cctccgagaa ttcagaccct
1441 ttggggccaa gtttttctgg atcctccatt gctcgccttg gccaggaacc agcagaccaa
1501 ctgccttttg tgagaccttc ccctccctat ccccaacttt aaaggtgtga gagtattagg
1561 aaacatgagc agcatatggc ttttgatcag tttttcagtg gcagcatcca atgaacaaga
1621 tcctacaagc tgtgcaggca aaacctagca ggaaaaaaaa acaacgcata aagaaaaatg
1681 gccgggccag gtcattggct gggaagtctc agccatgcac ggactcgttt ccagaggtaa
1741 ttatgagcgc ctaccagcca ggccacccag ccgtgggagg aagggggcgt ggcaaggggt
1801 gggcacattg gtgtctgtgc gaaaggaaaa ttgacccgga agttcctgta ataaatgtca
1861 caataaaacg aatgaatg
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