GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMPAUKR 1340 bp ss-mRNA PRI 30-MAY-1991
DEFINITION Human mRNA for urokinase (EC 3.4.99.26)
ACCESSION X02760
KEYWORDS plasminogen activator; serine protease; urokinase.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1340)
AUTHORS Jacobs,P., Cravador,A., Loriau,R., Brockly,F., Colau,B.,
Chuchana,P., Van,E.A., Herzog,A. and Bollen,A.
TITLE Molecular Cloning,Sequencing,and Expression in Escherichia coli of
Human Preprourokinase cDNA
JOURNAL DNA 4, 139-146 (1985)
STANDARD full automatic
COMMENT Data kindly reviewed (5-DEC-1985)) by A.Bollen
From EMBL entry HSPAUKR; dated 06-JUL-1989.
FEATURES Location/Qualifiers
CDS 41..1333
/note="urokinase precursor"
/codon_start=41
CDS 41..100
/note="signal peptide (aa -20 to -1)"
/codon_start=41
CDS 100..1333
/note="prourokinase (1-411)"
/codon_start=100
CDS 100..571
/note="A-chain (aa 1-157)"
/codon_start=100
misc_feature 572..574
/note="cleavage site (Lys-aa158)"
CDS 575..1333
/note="B-chain (aa 159-411)"
/codon_start=575
BASE COUNT 333 a 382 c 349 g 276 t
ORIGIN
1 cagccaccga gccgccgtct agcgccccga cctcgccacc atgagagccc tgctggcgcg
61 cctgcttctc tgcgtcctgg tcgtgagcga ctccaaaggc agcaatgaac ttcatcaagt
121 tccatcgaac tgtgactgtc taaatggagg aacatgtgtg tccaacaagt acttctccaa
181 cattcactgg tgcaactgcc caaagaaatt cggagggcag cactgtgaaa tagataagtc
241 aaaaacctgc tatgagggga atggtcactt ttaccgagga aaggccagca ctgacaccat
301 gggccggccc tgcctgccct ggaactctgc cactgtcctt cagcaaacgt accatgccca
361 cagatctgat gctcttcagc tgggcctggg gaaacataat tactgcagga acccagacaa
421 ccggaggcga ccctggtgct atgtgcaggt gggcctaaag ccgcttgtcc aagagtgcat
481 ggtgcatgac tgggcagatg gaaaaaagcc ctcctctcct ccagaagaat taaaatttca
541 gtgtggccaa aagactctga ggccccgctt taagattatt gggggagaat tcaccaccat
601 cgagaaccag ccctggtttg cggccatcta caggaggcac cgggggggct ctgtcaccta
661 cgtgtgtgga ggcagcctca tcagcccttg ctgggtgatc agcgccacac actgcttcat
721 tgattaccca aagaaggagg actacatcgt ctacctgggt cgctcaaggc ttaactccaa
781 cacgcaaggg gagatgaagt ttgaggtgga aaacctcatc ctacacaagg actacagcgc
841 tgacacgctt gctcaccaca acgacattgc cttgctgaag atccgttcca aggagggcag
901 gtgtgcgcag ccatcccgga ctatacagac catctgcctg ccctcgatgt ataacgatcc
961 ccagtttggc acaagctgtg agatcactgg ctttggaaaa gagaattcta ccgactatct
1021 ctatccggag cagctgaaaa tgactgttgt gaagctgatt tcccaccggg agtgtcagca
1081 gccccactac tacggctctg aagtcaccac caaaatgctg tgtgctgctg acccacagtg
1141 gaaaacagat tcctgccagg gagactcagg gggacccctc gtctgttccc tccaatgccg
1201 catgactttg actggaattg tgagctgggg ccgtggatgt gccctgaagg acaagccagg
1261 cgtctacacg agagtctcac acttcttacc ctggatccgc agtcacacca aggaagagaa
1321 tggcctggtc ctctgagggt
//