GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMPNMTB 3799 bp ds-DNA PRI 30-MAY-1991 DEFINITION Human gene for phenylethanolamine N-methylase (PNMT) (EC 2.1.1.28) ACCESSION X52730 KEYWORDS methylase; phenylethanolamide N-methylase. SOURCE Homo sapiens DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 3799) AUTHORS Sasaoka,T., Kaneda,N., Kurosawa,Y., Fujita,K. and Nagatsu,T. TITLE Human phenylethanolamine n-methyltranserase gene: existence of two types of mRNA with different transcription initiation sites JOURNAL Neurochem. Int. 15, 555-565 (1989) STANDARD full automatic REFERENCE 2 (bases 1 to 3799) AUTHORS Nagatsu,T. JOURNAL Unpublished (1990) STANDARD full automatic COMMENT *source: tissue=placenta; library=ghPNMT1101; **map: chromosome=17; See also <J03727> for mRNA sequence and <J03280> for overlapping genomic sequence. Data kindly reviewed (20-AUG-1990) by Nagatsu T. From EMBL entry HSPNMTB; dated 25-SEP-1990. FEATURES Location/Qualifiers misc_feature 814..829 /note="pot. glucocorticoid response element" misc_feature 998..1012 /note="pot. glucocorticoid response element" misc_feature 1027..1037 /note="pot. Sp1 binding site" misc_feature 1395..1404 /note="pot. Sp1 binding site" misc_feature 1407..1416 /note="pot. Sp1 binding site" promoter 1640..1648 /note="pot. TATA box" mRNA 1670..1894 /note="exon 1" CDS 1693..1894 /note="phenylethanolamine N-methyltransferase (AA 1-67) (1894 is 1st base in codon)" /codon_start=1693 intron 1895..2845 /note="intron I" misc_feature 2243..2597 /note="Alu sequence" misc_feature 2392..2406 /note="pot. glucocorticoid response element" mRNA 2846..3053 /note="exon 2" CDS 2846..3053 /note="phenylethanolamine N-methyltransferase (AA 68-137) (2846 is 2nd base in codon) (3053 is 2nd base in codon)" /codon_start=2846 intron 3054..3167 /note="intron II" mRNA 3168..3688 /note="exon 3" CDS 3168..3603 /note="phenylethanolamine N-methyltransferase (AA 139-282) (3168 is 3rd base in codon)" /codon_start=3168 misc_feature 3671..3676 /note="pot. polyadenylation signal" BASE COUNT 733 a 1024 c 1363 g 679 t ORIGIN 1 ctggcactgg gtggtaacca gcaagccagc tggcatccgc atccagggtt tgtttcaatg 61 atgtctcgtg gagaatatgg aggggctggt gccaggactg tccttggctt tgcctcgggg 121 tgtgaacggg gtcagtgacc tctaaaacta acctgcctct cagttctgaa tccagacaga 181 atcaatcctc agctgtgtct cgctccacac cccctgccct ggaagccagg gaaggttgga 241 ggtgctaggg ggtcaggctc ccctctgtga cccctgcagc tgttgtggtg actcatgtcc 301 caacctagct gcctctccca aggagacttt cccctgggac aagggggagg gaatggcatg 361 gaggaggccc acatcaagcg gggccaggaa cccacggtgg caggagctgg gctggtgacc 421 tacccagggc agaagggccc gggactcatc cagaggggaa ggaaggggtc ttcaggaaga 481 ccacggagat gccacaggca gaattggctt cccatctggg agataggtgg ggagaccctg 541 gcattttgac agccagaacc tggggtgctg agcagaatct tcatgcctgg cctggccgcc 601 ttcggaggga agctggaggg ttgggtgcga gaggagtggg gtcagagccc ctacatccgc 661 aggaccccaa atcggctggg ccccaaggcc cggactgcgc tccccggtgg ccccggcggc 721 cctccgcgaa tgcgtcctgc ccctcccctg cccaagccct ctgccctcac ccgggtccgg 781 cgccgccccc gaagtggcgg gaacaacccg aacccgaacc ttctgtcctc gggagccccc 841 agataagcgg ctgggaaccc gcggggcccg caggggaggc ccggctgttc cgcccgctaa 901 gtgcattagc acagctcacc tcccctatcg cgcctgccat cggacgggca gtgccgcgcc 961 ctgctctggg gcccccggag cgaccacagc ggaggccgga acggactgtc ctttctgggg 1021 cggggtgggg agggggtgtc gctggagggc ccggtggcat agcaacggac gagagaggcc 1081 tggaggaggg gcggggaggg ggagttgtgt ggcagttcta agggaagggt gggtgctggg 1141 acgggtgtcc gggagggagg ggagcctggc ggggtctggg gcctcgtcgc ggagggcgct 1201 gcgaggggga aactggggaa agggcctaat tccccagtct ccacctcgaa tcaggaaaga 1261 gaaggggcgg gctgctgggc aaaagaggtg aatggctgcg gggggctgga gaagagagat 1321 gggaggggcc ggccggcggg ggtgaggggg tctaaagatt gtgggggtga ggaactgagg 1381 gtggggggcg cccagaggcg ggactcgggg cggggcaggc gaggcggagg gcgagggctg 1441 cgggagcaag tacggagccg ggggtgtggg ggacgattgc cgctgcagcc gccgccccac 1501 tcacctccgg tgtgtctgca gcccggacac taagggagat ggatgaatgg gtggggagga 1561 tgcggcgcac atggccccgg gcggctcggc ggtcagctgc cgcccccaca gcggaccggt 1621 cggggcgggg gtcgggcggt agaaaaaagg gccgcgaggc gagcggggca ctgggcggac 1681 cgcggcggca gcatgagcgg cgcagaccgt agccccaatg cgggcgcagc ccctgactcg 1741 gccccgggcc aggcggcggt ggcttcggcc taccagcgct tcgagccgcg cgcctacctc 1801 cgcaacaact acgcgccccc tcgcggggac ctgtgcaacc cgaacggcgt cgggccgtgg 1861 aagctgcgct gcttggcgca gaccttcgcc accggtgagc gggggaaact gaggcacgag 1921 ggacaagagg tcgtcgggga gtgaaagcag gcgcagggaa ataaaaagaa ggaaagggag 1981 acagaccagg cgcctaacag atggggacca agaaacaaga gatagctgag aggtgcaaac 2041 agaagagaaa aaggagcaac atcccttagg agaggggcag aggagagaga ggtggagaga 2101 gggggcggag agtgctcaga attgagagct aaggtggggg atgcaggaca gactgaggtg 2161 gagatgcata ggaggaaatg gaggcagatg tgggacaggg gtgagaaact ccaggatttc 2221 ctcgctgagc ctggctggta ggtatagttg ttttctttct ttttctttat tttattttca 2281 tttatttact tatttttatt ttttatttgt tttgagacgg agtttcgctc ttgttgccca 2341 ggctggagta caatggcgcc atctcggctc actgcaacct ccgcctcccc gggttcaagc 2401 gattctcttg cctcagcttc cctagtagct gggattacag gcatgcgccc ccatgcctgg 2461 ctaatttatt tgtattttta gtagagacgg gacttctcca tgttggtcag gctggtctcg 2521 aactcccaac cttaggatcc acccaccccg gcctcccaaa gtgctgggat tacaggtgtg 2581 agccactgcg cccggccagt aggtatagtc ttctagatgt gaaacctgag tctcagagcg 2641 gtgaagttcc cttccgaagg gcagcccatg ttggagctgg gttcagtcta actctggggc 2701 caatgctttt tccagatgga gacacatttg cagaggagaa ggaagaacta gagagaggca 2761 gggagatgca ggggagggaa gggtaaggag gcaggggctg cctgggctgg ctggcaccag 2821 gaccctcttc ctctgccctg cccaggtgaa gtgtccggac gcaccctcat cgacattggt 2881 tcaggcccca ccgtgtacca gctgctcagt gcctgcagcc actttgagga catcaccatg 2941 acagatttcc tggaggtcaa ccgccaggag ctggggcgct ggctgcagga ggagccgggg 3001 gccttcaact ggagcatgta cagccaacat gcctgcctca ttgagggcaa ggggtaagga 3061 ctggggggtg agggttgggg aggaggcttc ccatagagtg gctggttggg gcaacagagg 3121 cctgagcgta gaacagcctt gagccctgcc ttgtgcctcc tgcacaggga atgctggcag 3181 gataaggagc gccagctgcg agccagggtg aaacgggtcc tgcccatcga cgtgcaccag 3241 ccccagcccc tgggtgctgg gagcccagct cccctgcctg ctgacgccct ggtctctgcc 3301 ttctgcttgg aggctgtgag cccagatctt gccagctttc agcgggccct ggaccacatc 3361 accacgctgc tgaggcctgg ggggcacctc ctcctcatcg gggccctgga ggagtcgtgg 3421 tacctggctg gggaggccag gctgacggtg gtgccagtgt ctgaggagga ggtgagggag 3481 gccctggtgc gtagtggcta caaggtccgg gacctccgca cctatatcat gcctgcccac 3541 cttcagacag gcgtagatga tgtcaagggc gtcttcttcg cctgggctca gaaggttggg 3601 ctgtgagggc tgtacctggt gccctgtggc ccccacccac ctggattccc tgttctttga 3661 agtggcacct aataaagaaa taataccctg ccgctgcggt cagtgctgtg tgtggctctc 3721 ctgggaagca gcaagggccc agagatctga gtgtccgggt aggggagaca ttcaccctag 3781 gctttttttc cagaagctt //