GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMPNMTB 3799 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human gene for phenylethanolamine N-methylase (PNMT) (EC 2.1.1.28)
ACCESSION X52730
KEYWORDS methylase; phenylethanolamide N-methylase.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3799)
AUTHORS Sasaoka,T., Kaneda,N., Kurosawa,Y., Fujita,K. and Nagatsu,T.
TITLE Human phenylethanolamine n-methyltranserase gene: existence of two
types of mRNA with different transcription initiation sites
JOURNAL Neurochem. Int. 15, 555-565 (1989)
STANDARD full automatic
REFERENCE 2 (bases 1 to 3799)
AUTHORS Nagatsu,T.
JOURNAL Unpublished (1990)
STANDARD full automatic
COMMENT *source: tissue=placenta; library=ghPNMT1101; **map: chromosome=17;
See also <J03727> for mRNA sequence and <J03280> for overlapping
genomic sequence.
Data kindly reviewed (20-AUG-1990) by Nagatsu T.
From EMBL entry HSPNMTB; dated 25-SEP-1990.
FEATURES Location/Qualifiers
misc_feature 814..829
/note="pot. glucocorticoid response element"
misc_feature 998..1012
/note="pot. glucocorticoid response element"
misc_feature 1027..1037
/note="pot. Sp1 binding site"
misc_feature 1395..1404
/note="pot. Sp1 binding site"
misc_feature 1407..1416
/note="pot. Sp1 binding site"
promoter 1640..1648
/note="pot. TATA box"
mRNA 1670..1894
/note="exon 1"
CDS 1693..1894
/note="phenylethanolamine N-methyltransferase (AA 1-67)
(1894 is 1st base in codon)"
/codon_start=1693
intron 1895..2845
/note="intron I"
misc_feature 2243..2597
/note="Alu sequence"
misc_feature 2392..2406
/note="pot. glucocorticoid response element"
mRNA 2846..3053
/note="exon 2"
CDS 2846..3053
/note="phenylethanolamine N-methyltransferase (AA 68-137)
(2846 is 2nd base in codon) (3053 is 2nd base in codon)"
/codon_start=2846
intron 3054..3167
/note="intron II"
mRNA 3168..3688
/note="exon 3"
CDS 3168..3603
/note="phenylethanolamine N-methyltransferase (AA 139-282)
(3168 is 3rd base in codon)"
/codon_start=3168
misc_feature 3671..3676
/note="pot. polyadenylation signal"
BASE COUNT 733 a 1024 c 1363 g 679 t
ORIGIN
1 ctggcactgg gtggtaacca gcaagccagc tggcatccgc atccagggtt tgtttcaatg
61 atgtctcgtg gagaatatgg aggggctggt gccaggactg tccttggctt tgcctcgggg
121 tgtgaacggg gtcagtgacc tctaaaacta acctgcctct cagttctgaa tccagacaga
181 atcaatcctc agctgtgtct cgctccacac cccctgccct ggaagccagg gaaggttgga
241 ggtgctaggg ggtcaggctc ccctctgtga cccctgcagc tgttgtggtg actcatgtcc
301 caacctagct gcctctccca aggagacttt cccctgggac aagggggagg gaatggcatg
361 gaggaggccc acatcaagcg gggccaggaa cccacggtgg caggagctgg gctggtgacc
421 tacccagggc agaagggccc gggactcatc cagaggggaa ggaaggggtc ttcaggaaga
481 ccacggagat gccacaggca gaattggctt cccatctggg agataggtgg ggagaccctg
541 gcattttgac agccagaacc tggggtgctg agcagaatct tcatgcctgg cctggccgcc
601 ttcggaggga agctggaggg ttgggtgcga gaggagtggg gtcagagccc ctacatccgc
661 aggaccccaa atcggctggg ccccaaggcc cggactgcgc tccccggtgg ccccggcggc
721 cctccgcgaa tgcgtcctgc ccctcccctg cccaagccct ctgccctcac ccgggtccgg
781 cgccgccccc gaagtggcgg gaacaacccg aacccgaacc ttctgtcctc gggagccccc
841 agataagcgg ctgggaaccc gcggggcccg caggggaggc ccggctgttc cgcccgctaa
901 gtgcattagc acagctcacc tcccctatcg cgcctgccat cggacgggca gtgccgcgcc
961 ctgctctggg gcccccggag cgaccacagc ggaggccgga acggactgtc ctttctgggg
1021 cggggtgggg agggggtgtc gctggagggc ccggtggcat agcaacggac gagagaggcc
1081 tggaggaggg gcggggaggg ggagttgtgt ggcagttcta agggaagggt gggtgctggg
1141 acgggtgtcc gggagggagg ggagcctggc ggggtctggg gcctcgtcgc ggagggcgct
1201 gcgaggggga aactggggaa agggcctaat tccccagtct ccacctcgaa tcaggaaaga
1261 gaaggggcgg gctgctgggc aaaagaggtg aatggctgcg gggggctgga gaagagagat
1321 gggaggggcc ggccggcggg ggtgaggggg tctaaagatt gtgggggtga ggaactgagg
1381 gtggggggcg cccagaggcg ggactcgggg cggggcaggc gaggcggagg gcgagggctg
1441 cgggagcaag tacggagccg ggggtgtggg ggacgattgc cgctgcagcc gccgccccac
1501 tcacctccgg tgtgtctgca gcccggacac taagggagat ggatgaatgg gtggggagga
1561 tgcggcgcac atggccccgg gcggctcggc ggtcagctgc cgcccccaca gcggaccggt
1621 cggggcgggg gtcgggcggt agaaaaaagg gccgcgaggc gagcggggca ctgggcggac
1681 cgcggcggca gcatgagcgg cgcagaccgt agccccaatg cgggcgcagc ccctgactcg
1741 gccccgggcc aggcggcggt ggcttcggcc taccagcgct tcgagccgcg cgcctacctc
1801 cgcaacaact acgcgccccc tcgcggggac ctgtgcaacc cgaacggcgt cgggccgtgg
1861 aagctgcgct gcttggcgca gaccttcgcc accggtgagc gggggaaact gaggcacgag
1921 ggacaagagg tcgtcgggga gtgaaagcag gcgcagggaa ataaaaagaa ggaaagggag
1981 acagaccagg cgcctaacag atggggacca agaaacaaga gatagctgag aggtgcaaac
2041 agaagagaaa aaggagcaac atcccttagg agaggggcag aggagagaga ggtggagaga
2101 gggggcggag agtgctcaga attgagagct aaggtggggg atgcaggaca gactgaggtg
2161 gagatgcata ggaggaaatg gaggcagatg tgggacaggg gtgagaaact ccaggatttc
2221 ctcgctgagc ctggctggta ggtatagttg ttttctttct ttttctttat tttattttca
2281 tttatttact tatttttatt ttttatttgt tttgagacgg agtttcgctc ttgttgccca
2341 ggctggagta caatggcgcc atctcggctc actgcaacct ccgcctcccc gggttcaagc
2401 gattctcttg cctcagcttc cctagtagct gggattacag gcatgcgccc ccatgcctgg
2461 ctaatttatt tgtattttta gtagagacgg gacttctcca tgttggtcag gctggtctcg
2521 aactcccaac cttaggatcc acccaccccg gcctcccaaa gtgctgggat tacaggtgtg
2581 agccactgcg cccggccagt aggtatagtc ttctagatgt gaaacctgag tctcagagcg
2641 gtgaagttcc cttccgaagg gcagcccatg ttggagctgg gttcagtcta actctggggc
2701 caatgctttt tccagatgga gacacatttg cagaggagaa ggaagaacta gagagaggca
2761 gggagatgca ggggagggaa gggtaaggag gcaggggctg cctgggctgg ctggcaccag
2821 gaccctcttc ctctgccctg cccaggtgaa gtgtccggac gcaccctcat cgacattggt
2881 tcaggcccca ccgtgtacca gctgctcagt gcctgcagcc actttgagga catcaccatg
2941 acagatttcc tggaggtcaa ccgccaggag ctggggcgct ggctgcagga ggagccgggg
3001 gccttcaact ggagcatgta cagccaacat gcctgcctca ttgagggcaa ggggtaagga
3061 ctggggggtg agggttgggg aggaggcttc ccatagagtg gctggttggg gcaacagagg
3121 cctgagcgta gaacagcctt gagccctgcc ttgtgcctcc tgcacaggga atgctggcag
3181 gataaggagc gccagctgcg agccagggtg aaacgggtcc tgcccatcga cgtgcaccag
3241 ccccagcccc tgggtgctgg gagcccagct cccctgcctg ctgacgccct ggtctctgcc
3301 ttctgcttgg aggctgtgag cccagatctt gccagctttc agcgggccct ggaccacatc
3361 accacgctgc tgaggcctgg ggggcacctc ctcctcatcg gggccctgga ggagtcgtgg
3421 tacctggctg gggaggccag gctgacggtg gtgccagtgt ctgaggagga ggtgagggag
3481 gccctggtgc gtagtggcta caaggtccgg gacctccgca cctatatcat gcctgcccac
3541 cttcagacag gcgtagatga tgtcaagggc gtcttcttcg cctgggctca gaaggttggg
3601 ctgtgagggc tgtacctggt gccctgtggc ccccacccac ctggattccc tgttctttga
3661 agtggcacct aataaagaaa taataccctg ccgctgcggt cagtgctgtg tgtggctctc
3721 ctgggaagca gcaagggccc agagatctga gtgtccgggt aggggagaca ttcaccctag
3781 gctttttttc cagaagctt
//