GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMPRB4S 5813 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human PRB4 gene for proline-rich protein Po, allele S
ACCESSION X07882
KEYWORDS PRB4 gene; proline-rich protein; protein Po.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 5813)
AUTHORS Lyons,K.M.
JOURNAL Unpublished (1988)
STANDARD full automatic
REFERENCE 2 (bases 1934 to 2798)
AUTHORS Lyons,K.M., Stein,J.H. and Smithies,O.
TITLE Length polymorphisms in human proline-rich protein genes generated
by intragenic unequal crossing over
JOURNAL Genetics 120, 267-278 (1988)
STANDARD full automatic
COMMENT **map: chromosomal location=chromosome 12p13.2;
From EMBL entry HSPRB4S; dated 24-JUL-1990.
FEATURES Location/Qualifiers
promoter 564..569
/note="TATA-box"
precursor_RNA 596..3951
/note="primary transcript"
mRNA 596..692
/note="Exon 1"
CDS 629..692
/note="Po protein (AA 1 - 21) (692 is 1st base in codon)"
/codon_start=629
intron 693..1621
/note="Intron I"
mRNA 1622..1657
/note="Exon 2"
CDS 1622..1657
/note="Po protein (AA 22 - 33) (1622 is 2nd base in codon)
(1657 is 1st base in codon)"
/codon_start=1622
intron 1658..2212
/note="Intron II"
mRNA 2213..2811
/note="Exon 3"
CDS 2213..2790
/note="Po protein (AA 34 - 226) (2213 is 2nd base in
codon)"
/codon_start=2213
intron 2812..3834
/note="Intron III"
mRNA 3835..3951
/note="Exon 4"
misc_feature 3933..3938
/note="polyA signal"
polyA_site 3951..3951
/note="polyA site"
BASE COUNT 1647 a 1428 c 1094 g 1644 t
ORIGIN
1 aagcttgaac aatagttgta gcccgagcag gctgtggggc agctttctgt catctatgtg
61 tgcccaggag tgtgttgtct tcacaccatc acacaggtaa cagaaaccat ctctatcgca
121 tcaaaacttt agccaattgt gatactatct gtacacacac atcacaagag atggaaatag
181 gctctataaa gagccagaga aattgaccat cttcactgct ggctgtagct tcactgcccc
241 cacaaatatt acacagaaat aaatagtaga gtggaaagca gacatagtct taccaaaagg
301 attgaaactc taatgatgtc tgaagttcaa ttatgacaca gtgctgatag cttggacaca
361 gttcctttag aacctttatt caagtcatag tcgtaccttt tagaaataag gtacaaacaa
421 catccaaccc accccaccct ctgggctaga gtcccaaaga gaaataaggg atacacctga
481 cctgcagtaa ggaaagcaga acccgatctc tgaggtggtg aggcccaccc agggctcaaa
541 ggtgccattg ttttgctcct ctttataaag ggagttgcca cgttcctccc agcacagagt
601 tgggagtgac tccagagcct ccagcgagat gctgctgatt ctgctgtcag tggccctgct
661 ggccttgagc tcagctgaga gttcaagtga aggtaaaaca gaagggggaa aagatgcggt
721 gactgcttgg gacttaggag gtgacagtgg taattatggg gaagagagga gaatgaaaac
781 acagatgggg ctgcagagtt ttcatgccta ggatcaggag acctgttgtg ccctcattcc
841 acaataagga cttctaattt atttaatgta caatgaaatc caataacgaa tttgttccag
901 gggaatgaga aggtaagatt tgaatttata gagatagaac tgtgctgtga aggctgcagt
961 ggagagtgca aggcagattc agggaagtcc agctgtgaag atcctatact gatcccagta
1021 agtacacagg gatgatggtg gccttgctgt acggacggtc ggcattgatg atagagatac
1081 atacacatcg gagatactgc ggagacggaa ctggatagaa cacttatctc tgtctaacta
1141 aagatgtaga aatatcagag ccaatcatta caatttttct ctcccctaca tgcagtattt
1201 caatgtgctg ggagtggaat gggttagatt gtattgaaat gattacttct ggttacccct
1261 attgagaaaa catgtgtatg tatgcaatat attaacagga gatggagggc ataagaacac
1321 caaaatatca cattgaagta cctggcatgc ataaactaaa taagcattaa gtctcgaggg
1381 atgctaggga ggaaaaaaag gggctgttct atgtcgaact cattgctgtt gctctgtgtg
1441 gtaacaaccc tgcctcctct tacaccttcc accccttcca gcaccttcac agatggtggc
1501 tgatgagtta acctagggga tgcatggggt gtggtgagaa gacaattttc cctgtagaac
1561 acttgtgagt cttgaagatt tgagatgtaa catttcccat catcctgtgc ttctcttcta
1621 gatgtcagcc aggaagaatc tctcttccta atatcaggta aatcccaatt cattctcaat
1681 ctgttttgac tccctttttc tgcttacaaa tgggtcattt ctccagtgtc ttcttatcaa
1741 cactttcctt tcaggaattg attaatgtta ttgcccctaa tgatataggc aatcttcatg
1801 caaacttgat tctgggacca tgagcaggcc accaaatgga atgtcagaga tgcttgggtt
1861 ggatgacaac aggagtgggt tgacatcccc ctgggagatg acagacaaat ggccagtgtc
1921 cttattctga ctccttccta gactgggcct attctcctcc ttagactgag agcccctcaa
1981 cttctccctt ttcccccagc gttccactcc agagttctag ggcttcactg aaaatgcaaa
2041 gaaattagta tctgggtctc atttttgtgc atttccccat ttagctccat tactgtaaaa
2101 atttgtggca actattcagt gaatgccgta tgtcccccac ctcctccagg aaagccagaa
2161 ggacgacgcc cacaaggagg aaaccagccc caacgtcccc cacctcctcc aggaaagcca
2221 caaggaccac ccccacaagg aggaaaccag tcccaaggtc ccccacctcc tccaggaaag
2281 ccagaaggac gacccccaca aggaggcaac cagtcccaag gtcccccacc tcatccagga
2341 aagccagaaa gaccaccccc acaaggagga aaccagtccc aaggtacccc acctcctcca
2401 ggaaagccag aaagaccacc cccacaagga ggcaaccagt cccaccgtcc cccacctcct
2461 ccaggaaagc cagaaagacc acccccacaa ggaggtaacc agtcccaagg tcccccacct
2521 catccaggaa agccagaagg accaccccca caggaaggaa acaagtcccg aagtgcccga
2581 tctcctccag gaaagccaca aggaccaccc caacaagaag gcaacaagcc tcaaggtccc
2641 ccacctcctg gaaagccaca aggcccaccc ccagcaggag gcaatcccca gcagcctcag
2701 gcacctcctg ctggaaagcc ccaggggcca cctccacctc ctcaaggggg caggccaccc
2761 agacctgccc agggacaaca gcctccccag taatctagga ttcaatgaca ggtatgattc
2821 cactttatta ttcatcagga ctctaattgc acagttctcc aactttattg tgccaatgaa
2881 tcaactaaaa cccattgaca ttgtattgtc ctggaaccca tttctaaaaa tttgtattca
2941 gatactctgg aatagggtaa ggggaccctg tatttctaac aaaatcgttt aaggaattct
3001 gatgttgaga aacaacatac catatgatct gtcttaaatt gtgttggcaa tgaggaggta
3061 gtaccatgtt cattcttggc gttctgtttt ctatccacta actcagagac ctcccattta
3121 aagttttcac ctgagcacca tttgctcagt cctgcctcac accagcctct cgagtccagt
3181 attcctgcca aatggtccct gatctttcag cagctaaatg gcgtgtcact ttttagatac
3241 ttaacttttc aatacgtaca tgattaagct aacaaaaaat atctaatgga atggaaaaat
3301 atgaagctaa ttttaaaggc ctaacacatc ctaccccacc ttccttcctt caaaaagctc
3361 ccagtggtta accttatggg atcttttctt tgaaatattt atgtgtgcat agacatatag
3421 cattctttta ccctaccact aatgccataa cttatatgca ggtatatatg ttagtcattt
3481 aaaaaataca tttttttaaa atttccacat cagtttatga aggtcactac atatcttcag
3541 tggttttctg tttgctttta catttttata ctactctatt gtgtagctgt gccatgattt
3601 cgttaaccaa tccctgtcac tggacactga gggtggtttt agcttctcag tattatagaa
3661 tatgttccag ttaccatctg tgtaaatata tccctgaaca aattcaacag caatgagtca
3721 cagcaaccta aggatggtct tttctcttca tcttctaagc cacaatttgg agcacattgt
3781 gtgcaagggc atcaaaagag tgaatctatg aacttgcttg tttgtttatt tcaggaagtg
3841 aataagaaga tatcagtgaa ttcaaataat tcaattgcta caaatgccgt gacattggaa
3901 caaggtcatc atagctctaa ctttaatata ccaataaaat aatcagcttg caatttctga
3961 ttgtggtgtt ctttctcagt gtttgcggaa tgtggaatgt gaggaccaag aacacattat
4021 aagaacatct aggacccctt ctgtctgatg cttccaagga gtttcccttc tctttaatcc
4081 taacttagcc agctgccatg aaaaatgttt tgctgtttat ctctttccct gacttcaatt
4141 tttttttctt tttctgagat ggagtcttgc tctatcacct aggttggaat gcagtggcgt
4201 gatcttggct aactgcaacc tgcacctcca gggttcaagc tattctcctg cctcaccctt
4261 cacagtagct gggattacag gttcccacca tcacaccagg gtaatctttg taattttagt
4321 tgagatgtgt tttcaccctg ttggcaggct aggctagaaa ttctgacttc aggtcatccg
4381 cttgccttgg cctccaaatg tgttgggatt acaggcatga gccaccacac ctagctcctt
4441 tctgacttct acagcacaaa ttgaaaatct aaaattattt tcagattgtt tactgatatt
4501 ccagtaattt taaggacaaa aaccacaaca aatggaaaat aagtcacaga aactaaaaga
4561 aatccttata atttctgagt ttggtttcaa gggaacaaac agggttctat gcttcttatt
4621 cccagagccc tctctatccc attgacccta ttttaacagt gatcacttcc ctccctccct
4681 atgttcctca cctttcttta atgaaacctg aatggatttc atcaaggagg cagcatgact
4741 tttaggagca aagaattggg acactctcag attttagtta agacataact ctttcttgct
4801 agcctgaact cttaaaaagc tacttggtct ctcagagctt caatttcctc atctacaatg
4861 agaagaatca aaacaactac cttagaatat ggagactatt cagataacat atgtaccaaa
4921 aaccttgcag agattggcat gtctgcttct caagcaagga aggttcaata ttagaaaact
4981 gcccctgtgc ccaccgatag cctcagataa ttcactatga atttcagaaa tttcagaata
5041 gaaggatctc actgtaacca tcaccaagtt gagcaaccca cattcagttc aatcccagtt
5101 ctctgacttc tctcctatta tcatagttga aggctcccta cccctatctc ttatctttcc
5161 tcttgattct gaaccacatt acccagtcaa ggattttgct tctgtatgtg acccttttgt
5221 ctcctgattc ttacatctat gctctatggg attacctcaa tcagcaaaag cctgctgaaa
5281 catcacccat ttttacagag attttgctaa gactcttagt gtttctttcc taccctatta
5341 tttgtctgcc atttttattg caaaagttct tgaaacatat gtatgtgatt atttccccat
5401 cccctccctt ccattttctt tttaaacaca cattaaagat gcttttgttc tttccactcc
5461 aagtctgtca aggtcatcta ctgcctgcat tccactcatt tcaggaatcg attatcagtc
5521 ctgcatctcc tgtgacccct tggcagttta acaccattga tcctacaatt cttttgggaa
5581 cactctatca atctttccgg gaacctccca ctctctcctc gggtttctcc tacctctgcc
5641 tcttccctcc tgtaactaca aagttactcc tcttccaact ctatttggtc ttggtaaatt
5701 attcatctaa ttaattaagg aaactaggat ttattctaga ctcttctctt ttcctcttac
5761 atcacattac atctagtcaa atcagctatg ttatcattgt gaaattcaag ctt
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