GenBank-Updates@genbank.bio.net (05/30/91)
LOCUS HUMRAS1 6453 bp ds-DNA PRI 30-MAY-1991
DEFINITION Human germ line gene homologous to bladder carcinoma oncogene T24
(Gene code c-Ha-ras-1) with four exons.
ACCESSION V00574
KEYWORDS germ line; oncogene.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 6453)
AUTHORS Capon,D.J., Chen,E.Y., Levinson,A.D., Seeburg,P.H. and Goeddel,D.V.
TITLE Complete nucleotide sequences of the T24 human bladder carcinoma
oncogene and its normal homologue
JOURNAL Nature 302, 33-37 (1983)
STANDARD full automatic
COMMENT EPD; 11149; Hs c-Ha-ras P3. EPD; 16063; Hs c-Ha-ras P1.
EPD; 16064; Hs c-Ha-ras P2. SWISS-PROT; P01112; RASH$HUMAN.
The paper lists the oncogene, with the differences to the wild type
gene, here the sequence of the wild type gene c-Ha-ras-1 is given.
From EMBL entry HSRAS1; dated 03-JAN-1991.
FEATURES Location/Qualifiers
CDS join(1664..1774,2042..2220,2374..2533,3231..3347)
/gene="c-Ha-ras-1"
/codon_start=1664
mutation 678..678
/note="G is GCGGCGG in oncogene T24"
mutation 1692..1692
/note="G is T in oncogene T24"
mutation 1783..1783
/note="A is G in oncogene T24"
mutation 2707..2707
/note="A is G in oncogene T24"
misc_feature 3722..3727
/note="other site (polyA signal)"
polyA_site 3744..3744
/note="polyA addition site"
BASE COUNT 946 a 2287 c 2113 g 1107 t
ORIGIN
1 ggatcccagc ctttccccag cccgtagccc cgggacctcc gcggtgggcg gcgccgcgct
61 gccggcgcag ggagggcctc tggtgcaccg gcaccgctga gtcgggttct ctcgccggcc
121 tgttcccggg agagcccggg gccctgctcg gagatgccgc cccgggcccc cagacaccgg
181 ctccctggcc ttcctcgagc aaccccgagc tcggctccgg tctccagcca agcccaaccc
241 cgagaggccg cggccctact ggctccgcct cccgcgttgc tcccggaagc cccgcccgac
301 cgcggctcct gacagacggg ccgctcagcc aaccggggtg gggcggggcc cgatggcgcg
361 cagccaatgg taggccgcgc ctggcagacg gacgggcgcg gggcggggcg tgcgcaggcc
421 cgcccgagtc tccgccgccc gtgccctgcg cccgcaaccc gagccgcacc cgccgcggac
481 ggagcccatg cgcggggcga accgcgcgcc cccgcccccg ccccgccccg gcctcggccc
541 cggccctggc cccgggggca gtcgcgcctg tgaacggtga gtgcgggcag ggatcggccg
601 ggccgcgcgc cctcctcgcc cccaggcggc agcaatacgc gcggcgcggg ccgggggcgc
661 ggggccggcg ggcgtaagcg gcggcggcgg cggcgggtgg gtggggccgg gcggggcccg
721 cgggcacagg tgagcgggcg tcgggggctg cggcgggcgg gggccccttc ctccctgggg
781 cctgcgggaa tccgggcccc acccgtggcc tcgcgctggg cacggtcccc acgccggcgt
841 acccgggagc ctcgggcccg gcgccctcac acccgggggc gtctgggagg aggcggccgc
901 ggccacggca cgcccgggca cccccgattc agcatcacag gtcgcggacc aggccggggg
961 cctcagcccc agtgcctttt ccctctccgg gtctcccgcg ccgcttctcg gccccttcct
1021 gtcgctcagt ccctgcttcc caggagctcc tctgtcttct ccagctttct gtggctgaaa
1081 gatgcccccg gttccccgcc gggggtgcgg ggcgctgccc gggtctgccc tcccctcggc
1141 ggcgcctagt acgcagtagg cgctcagcaa atacttgtcg gaggcaccag cgccgcgggg
1201 cctgcaggct ggcactagcc tgcccgggca cgccgtggcg cgctccgccg tggccagacc
1261 tgttctggag gacggtaacc tcagccctcg ggcgcctccc tttagccttt ctgccgaccc
1321 agcagcttct aatttgggtg cgtggttgag agcgctcagc tgtcagccct gcctttgagg
1381 gctgggtccc ttttcccatc actgggtcat taagagcaag tgggggcgag gcgacagccc
1441 tcccgcacgc tgggttgcag ctgcacaggt aggcacgctg cagtccttgc tgcctggcgt
1501 tggggcccag ggaccgctgt gggtttgccc ttcagatggc cctgccagca gctgccctgt
1561 ggggcctggg gctgggcctg ggcctggctg agcagggccc tccttggcag gtggggcagg
1621 agaccctgta ggaggacccc gggccgcagg cccctgagga gcgatgacgg aatataagct
1681 ggtggtggtg ggcgccggcg gtgtgggcaa gagtgcgctg accatccagc tgatccagaa
1741 ccattttgtg gacgaatacg accccactat agaggtgagc ctggcgccac cgtccaggtg
1801 ccagcagctg ctgcgggcga gcccaggaca cagccaggat agggctggct gcagcccctg
1861 gtcccctgca tggtgctgtg gccctgtctc ctgcttcctc tagaggaggg gagtccctcg
1921 tctcagcacc ccaggagagg agggggcatg aggggcatga gaggtaccag ggagaggctg
1981 gctgtgtgaa ctccccccac ggaaggtcct gagggggtcc ctgagccctg tcctcctgca
2041 ggattcctac cggaagcagg tggtcattga tggggagacg tgcctgttgg acatcctgga
2101 taccgccggc caggaggagt acagcgccat gcgggaccag tacatgcgca ccggggaggg
2161 cttcctgtgt gtgtttgcca tcaacaacac caagtctttt gaggacatcc accagtacag
2221 gtgaaccccg tgaggctggc ccgggagccc acgccgcaca ggtggggcca ggccggctgc
2281 gtccaggcag gggcctcctg tcctctctgc gcatgtcctg gatgccgctg cgcctgcagc
2341 ccccgtagcc agctctcgct ttccacctct cagggagcag atcaaacggg tgaaggactc
2401 ggatgacgtg cccatggtgc tggtggggaa caagtgtgac ctggctgcac gcactgtgga
2461 atctcggcag gctcaggacc tcgcccgaag ctacggcatc ccctacatcg agacctcggc
2521 caagacccgg caggtgaggc agctctccac cccacagcta gccagggacc cgccccgccc
2581 cgccccagcc agggagcagc actcactgac cctctccctt gacacagggc agccgctctg
2641 gctctagctc cagctccggg accctctggg accccccggg acccatgtga cccagcggcc
2701 cctcgcgctg taagtctccc gggacggcag ggcagtgagg gaggcgaggg ccggggtctg
2761 ggctcacgcc ctgcagtcct gggccgacac agctccgggg aaggcggagg tccttgggga
2821 gagctgccct gagccaggcc ggagcggtga ccctggggcc cggcccctct tgtccccaga
2881 gtgtcccacg ggcacctgtt ggttctgagt cttagtgggg ctactgggga cacgggccgt
2941 agctgagtcg agagctgggt gcagggtggt caaaccctgg ccagacctgg agttcaggag
3001 ggccccgggc caccctgacc tttgaggggc tgctgtagca tgatgcgggt ggccctgggc
3061 acttcgagat ggccagagtc cagcttcccg tgtgtgtggt gggcctgggg aagtggctgg
3121 tggagtcggg agcttcgggc caggcaaggc ttgatcccac agcagggagc ccctcaccca
3181 ggcaggcggc cacaggccgg tccctcctga tcccatccct cctttcccag ggagtggagg
3241 atgccttcta cacgttggtg cgtgagatcc ggcagcacaa gctgcggaag ctgaaccctc
3301 ctgatgagag tggccccggc tgcatgagct gcaagtgtgt gctctcctga cgcaggtgag
3361 ggggactccc agggcggccg ccacgcccac cggatgaccc cggctccccg cccctgccgg
3421 tctcctggcc tgcggtcagc agcctccctt gtgccccgcc cagcacaagc tcaggacatg
3481 gaggtgccgg atgcaggaag gaggtgcaga cggaaggagg aggaaggaag gacggaagca
3541 aggaaggaag gaagggctgc tggagcccag tcaccccggg accgtgggcc gaggtgactg
3601 cagaccctcc cagggaggct gtgcacagac tgtcttgaac atcccaaatg ccaccggaac
3661 cccagccctt agctcccctc ccaggcctct gtgggccctt gtcgggcaca gatgggatca
3721 cagtaaatta ttggatggtc ttgatcttgg ttttcggctg agggtgggac acggtgcgcg
3781 tgtggcctgg catgaggtat gtcggaacct caggcctgtc cagccctggg ctctccatag
3841 cctttgggag ggggaggttg ggagaggccg gtcaggggtc tgggctgtgg tgctctctcc
3901 tcccgcctgc cccagtgtcc acggcttctg gcagagagct ctggacaagc aggcagatca
3961 taaggacaga gagcttactg tgcttctacc aactaggagg gcgtcctggt cctccagagg
4021 gaggtggttt caggggttgg ggatctgtgc cggtggctct ggtctctgct gggagccttc
4081 ttggcggtga gaggcatcac ctttcctgac ttgctcccag cgtgaaatgc acctgccaag
4141 aatggcagac atagggaccc cgcctcctgg gccttcacat gcccagtttt cttcggctct
4201 gtggcctgaa gcggtctgtg gaccttggaa gtagggctcc agcaccgact ggcctcaggc
4261 ctctgcctca ttggtggtcg ggtagcggcc agtagggcgt gggagcctgg ccatccctgc
4321 ctcctggagt ggacgaggtt ggcagctggt ccgtctgctc ctgccccact ctcccccgcc
4381 cctgccctca ccctaccctt gccccacgcc tgcctcatgg ctggttgctc ttggagcctg
4441 gtagtgtcac tggctcagcc ttgctgggta tacacaggct ctgccaccca ctctgctcca
4501 aggggcttgc cctgccttgg gccaagttct aggtctggcc acagccacag acagctcagt
4561 cccctgtgtg gtcatcctgg cttctgctgg gggcccacag cgcccctggt gcccctcccc
4621 tcccagggcc cgggttgagg ctgggccagg ccctctggga cggggacttg tgccctgtca
4681 gggttcccta tccctgaggt tgggggagag ctagcagggc atgccgctgg ctggccaggg
4741 ctgcagggac actccccctt ttgtccaggg aataccacac tcgcccttct ctccagcgaa
4801 caccacactc gcccttctct ccaggggacg ccacactccc ccttctgtcc aggggacgcc
4861 acactccccc ttctctccag gggacgccac actcgccctt ctctccaggg gacgccacac
4921 tcgcccttct ctccagggga cgccacactc gcccttctgt ccaggggacg ccacactcgc
4981 ccttctctcc aggggacgcc acactcgccc ttctctccag gggacgccac actccccctt
5041 ctgtccaggg gacgccacac tcccccttct ctccagggga cgccacactc ccccttctct
5101 ccaggggacg ccacactcgc ccttctctcc aggggacgcc acactccccc ttctgtccag
5161 gggacgccac actcgccctt ctctccaggg gacgccacac tcgcccttct ctccagggga
5221 cgccacactc ccccttctct ccaggggacg ccacactccc ccttctctcc aggggacgcc
5281 acactccccc ttctgtccag gggacgccac actcgccctt ctctccaggg gacgccacac
5341 tcccccttct ctccagggga cgccacactc ccccttctct ccaggggacg ccacactccc
5401 ccttctgtcc aggggacgcc acactcgccc ttctctccag gggacgccac actcgccctt
5461 ctctccaggg gacgccacac tcgcccttct ctccagggga cgccacactt gcccttctgt
5521 ccagggaatg ccacactccc ccttctcccc agcagcctcc gagtgaccag cttccccatc
5581 gatagacttc ccgaggccag gagccctcta gggctgccgg gtgccaccct ggctccttcc
5641 acaccgtgct ggtcactgcc tgctgggggc gtcagatgca ggtgaccctg tgcaggaggt
5701 atctctggac ctgcctcttg gtcattacgg ggctgggcag ggcctggtat cagggccccg
5761 ctggggttgc agggctgggc ctgtgctgtg gtcctggggt gtccaggaca gacgtggagg
5821 ggtcagggcc cagcacccct gctccatgct gaactgtggg aagcatccag gtccctgggt
5881 ggcttcaaca ggagttccag cacgggaacc actggacaac ctggggtgtg tcctgatctg
5941 gggacaggcc agccacaccc cgagtcctag ggactccaga gagcagccca ctgccctggg
6001 ctccacggaa gccccctcat gccgctaggc cttggcctcg gggacagccc agctaggcca
6061 gtgtgtggca ggaccaggcc cccatgtggg agctgacccc ttgggattct ggagctgtgc
6121 tgatgggcag gggagagcca gctcctcccc ttgagggagg gtcttgatgc ctggggttac
6181 ccgcagaggc ctgggtgccg ggacgctccc cggtttggct gaaaggaaag cagatgtggt
6241 cagcttctcc actgagccca tctggtcttc ccggggctgg gccccataga tctgggtccc
6301 tgtgtggccc ccctggtctg atgccgagga tacccctgca aactgccaat cccagaggac
6361 aagactggga agtccctgca gggagagccc atccccgcac cctgacccac aagagggact
6421 cctgctgccc accaggcatc cctccaggga tcc
//